6850-39-1 Archives - Page 2 of 3 - Alcohols-buliding-blocks

Choong, Ingrid C’s team published research in Bioorganic & Medicinal Chemistry Letters in 2008-11-01 | 6850-39-1

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Synthetic Route of 6850-39-1.

Choong, Ingrid C.; Serafimova, Iana; Fan, Junfa; Stockett, David; Chan, Erica; Cheeti, Sravanthi; Lu, Yafan; Fahr, Bruce; Pham, Phuongly; Arkin, Michelle R.; Walker, Duncan H.; Hoch, Ute published the artcile< A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties>, Synthetic Route of 6850-39-1, the main research area is diaminocyclohexyl analog SNS 032 preparation permeability bioavailability CDK inhibition.

The identification of a selective CDK2, 7, and 9 inhibitor (compound 4) with improved permeability is described. Compound 4 exhibits comparable CDK selectivity profile to SNS-032, but shows improved permeability and higher bioavailability in mice.

Referemce:
Alcohol – Wikipedia,
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Poce, Giovanna’s team published research in European Journal of Medicinal Chemistry in 2018-02-10 | 6850-39-1

European Journal of Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, COA of Formula: C6H13NO.

Poce, Giovanna; Cocozza, Martina; Alfonso, Salvatore; Consalvi, Sara; Venditti, Giulia; Fernandez-Menendez, Raquel; Bates, Robert H.; Barros Aguirre, David; Ballell, Lluis; De Logu, Alessandro; Vistoli, Giulio; Biava, Mariangela published the artcile< In vivo potent BM635 analogue with improved drug-like properties>, COA of Formula: C6H13NO, the main research area is pyrrolyl methanamine preparation antimycobacterial antitumor human SAR docking pharmacokinetics; Anti-mycobacterials; Drug discovery; MmpL3; Pyrroles; Tuberculosis.

Herein an efficient method was reported for the design, synthesis, biol. evaluation, pharmacokinetic anal. as well as in vivo TB mouse efficacy studies of novel (2-methyl-1H-pyrrol-3-yl)methanamines I [R = Me, 4-i-PrC6H4, 4-F3CC6H4, etc.; R1 = i-Pr, cyclohexyl, 4-FC6H4, etc.; R2 = 4-morpholinyl, 3-hydroxy-1-piperidyl, 3-methoxy-1-piperidyl] from 2-methyl-1H-pyrroles, formaldehyde and amines under Mannich reaction conditions. These BM635 analogs I showed improved physicochem. properties and excellent antimycobacterial activity. This hit-to-lead campaign led to the identification of a new compound I [R = 4-i-PrC6H4, R1 = i-Pr, R2 = 4-morpholinyl] that showed excellent activity (MIC = 0.15 μM; SI = 133) against drug-sensitive Mycobacterium tuberculosis strains as well as efficacy in a murine model of TB infection.

Referemce:
Alcohol – Wikipedia,
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Brocklehurst, Cara E’s team published research in Organic Process Research & Development in 2011-02-28 | 6850-39-1

Organic Process Research & Development published new progress about Chiral resolution (by diastereomeric salt formation). 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, SDS of cas: 6850-39-1.

Brocklehurst, Cara E.; Laumen, Kurt; La Vecchia, Luigi; Shaw, Duncan; Vogtle, Markus published the artcile< Diastereoisomeric Salt Formation and Enzyme-Catalyzed Kinetic Resolution as Complementary Methods for the Chiral Separation of cis-/trans-Enantiomers of 3-Aminocyclohexanol>, SDS of cas: 6850-39-1, the main research area is aminocyclohexanol chiral separation diastereomeric salt formation enzymic kinetic resolution.

This contribution demonstrates the preparative-scale synthesis of (1S,3S)-3-aminocyclohexanol by either enzymic kinetic resolution of Cbz-protected 3-aminocyclohexanols or direct diastereoisomeric salt formation with (R)-mandelic acid. The salt formation demonstrates how a single enantiomer, (1S,3S)-3-aminocyclohexanol (R)-mandelate, can be effectively isolated from the cis/trans racemic mixture and subsequently converted to the free amine, (1S,3S)-3-aminocyclohexanol, by ion-exchange chromatog. We have also demonstrated how the other three enantiomers of 3-aminocyclohexanol can be prepared by either diastereoisomeric salt formation or enzymic kinetic resolution

Referemce:
Alcohol – Wikipedia,
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Han, Xu’s team published research in Journal of Medicinal Chemistry in 2021-10-14 | 6850-39-1

Journal of Medicinal Chemistry published new progress about Acute myeloid leukemia. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Recommanded Product: 3-Aminocyclohexanol.

Han, Xu; Song, Ning; Saidahmatov, Abdusaid; Wang, Peipei; Wang, Yong; Hu, Xiaobei; Kan, Weijuan; Zhu, Wei; Gao, Lixin; Zeng, Mingjie; Wang, Yujie; Li, Chunpu; Li, Jia; Liu, Hong; Zhou, Yubo; Wang, Jiang published the artcile< Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia>, Recommanded Product: 3-Aminocyclohexanol, the main research area is acute myeloid leukemia CDK9 inhibitors antiproliferative activity bioavailability SAR.

CDK9 is an essential drug target correlated to the development of acute myeloid leukemia (AML). Starting from the hit compound 10, which was discovered through a screening of our inhouse compound library, the structural modifications were carried out based on the bioisosterism and scaffold hopping strategies. Consequently, compound 37 (I) displayed the optimal CDK9 inhibitory activity with an IC50 value of 5.41 nM, which was nearly 1500-fold higher than compound 10. In addition, compound 37 exhibited significant antiproliferative activity in broad cancer cell lines. Further investigation of in vivo properties demonstrated that compound 37 could be orally administrated with an acceptable bioavailability (F = 33.7%). In MV-4-11 s.c. xenograft mouse model, compound 37 (7.5 mg/kg) could significantly suppress the tumor progression with a T/C value of 27.80%. Compound 37 represents a promising lead compound for the development of a novel class of CDK9 inhibitors for the treatment of acute myeloid leukemia.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Choong, Ingrid C’s team published research in Bioorganic & Medicinal Chemistry Letters in 2008-11-01 | 6850-39-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Poce, Giovanna’s team published research in European Journal of Medicinal Chemistry in 2018-02-10 | 6850-39-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Brocklehurst, Cara E’s team published research in Organic Process Research & Development in 2011-02-28 | 6850-39-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

10 Sep 2021 News Some scientific research about 6850-39-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6850-39-1, its application will become more common.

Electric Literature of 6850-39-1 ,Some common heterocyclic compound, 6850-39-1, molecular formula is C6H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 4; l-adamantan-l-yl-3-[3-(3-morpholin-4-yl-propoxy)cyclohexyl]urea (48); 1-Isocyanato-adamantane (180 mg, 1.02 mmol) was added to a mixture of 3- aminocyclohexanol (B-3) (123 mg, 1.07 mmol) in DMF (2.5 mL). The mixture was stirred at ambient temperature and monitored by LCMS. After 1.5 h, the reaction was determined to be complete by LCMS analysis. The mixture was chilled in an ice bath and quenched with H2O (ca. 5 mL ) and 1 N HCl (ca. 3 mL). After 30 minutes, the white solid that formed was collected by filtration, washed with H2O (ca. 20 mL), and transferred to a round-bottom flask with the aid of MeCN. The MeCN was evaporated and the solid was dried under high vacuum to provide 1 -(3 -Hydroxy eye lohexyl)-3-phenylurea (B-4) as a white solid (220 mg, 74%): LCMS m/z 293.4 [M + H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6850-39-1, its application will become more common.

Reference:
Patent; ARETE THERAPEUTICS, INC.; WO2008/116145; (2008); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

2 Sep 2021 News Simple exploration of 6850-39-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6850-39-1, its application will become more common.

Synthetic Route of 6850-39-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6850-39-1 as follows.

To a solution of 3-aminocyclohexanol (2.3 g, 20.0 mmol) in H20/1,4-dioxane (20 mL/20 mL) were added Na2CO3 (2.52 g, 30.0 mmol) and benzyl carbonochloridate (5.1 g, 30.0 mmol). The mixture was stirred at room temperature overnight. All of the volatiles were removed under reduced pressure and water (40 mL) was added. The suspension was extracted with EtOAc (2 x 100 mL). The organic phase was washed with brine, dried over Na2SO4, filtered and evaporated to give the crude compound SP-0011379-019 as colorless oil (5.0 g of the crude). LC-MS 249 (M+Na), purity 96% (UV 214 nm).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6850-39-1, its application will become more common.

Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; F.HOFFMANN-LAROCHE LTD; YUAN, Junying; HAN, Nianhe; YI, Hua; WANG, Yuguang; YANG, Song; WONG, Jason, Christopher; WO2014/145512; (2014); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple exploration of 6850-39-1

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6850-39-1, 3-Aminocyclohexanol.

Electric Literature of 6850-39-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6850-39-1, name is 3-Aminocyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 79 : N-IS-rO-hydroxycyclohexyDaminoin^^ltriazolon^-alpyridin-l- yl} nicotinamide (79); 3-amino-cyclohexanol (Betapharma, 67.33 mg; 0.58 mmol; 2.0 eq.) was added to a mixture of N-(5-chloro[l,2,4]triazolo[l,5-a]pyridin-2-yl)nicotinamide ((B4), 80 mg; 0.29 mmol; 1.0 eq.), DIEA (76 mg; 0.58 mmol; 2.0 eq.) and activated Charcoal (8 mg) in tBuOH (0.8 mL). The reaction mixture was heated at 2000C for 2 x 30 min under microwave irradiation. After this time, it was filtered on a celite pad and the cake was washed with ACN. The filtrate was directly purified by RP-HPLC (Starting with 15% ACN in water for 5 min, then up to 30% in 10 min.). The title compound was isolated after lyophilisation as a white powder (51 mg, 49%). HPLC, Rt: 2.14 min. (purity 98.0%). LC/MS, M+(ESI): 353.0, M (ESI): 351.0.

Reference:
Patent; LABORATOIRES SERONO SA; WO2009/27283; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts