Category: 68120-35-4

Application of 68120-35-4, Adding some certain compound to certain chemical reactions, such as: 68120-35-4, name is (3-Bromo-4-methylphenyl)methanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 68120-35-4.

A mixture of (3-Bromo-4-methyl-phenyl)-methanol (8.5 g, 42.2 mmol) and bis(pinacolato)diboron (11.8 g, 46.50 mmol) in 1 ,4-dioxane (50 ml_) was degassed under N2 atmosphere for 10 min. Potassium acetate (8.2 g, 84.55 mmol) was added to the above followed by [1 ,1 – Bis(diphenylphosphino)ferrocene]dichloropalladium(ll).CH2Cl2 (1.54 g, 2.11 mmol) and the reaction mixture was heated at 100 C for 15 h. The solvents were removed under reduced pressure, the residue obtained was diluted with water and extracted with EtOAc (2×150 mL). Combined organic phases were washed with water, brine, dried over anhydrous Na2S04, filtered and concentrated. Purification of this crude by flash chromatography on silica (EtOAc:n-hexane; 70:30) afforded the title compound as a brown liquid (5.0 g, 84%). 1H NMR (400 MHz, DMSO-d6): delta 7.59 (d, J = 1.72 Hz, 1 H), 7.25 (dd, J = 7.76, 1.88 Hz, 1 H), 7.11 (d, J = 7.76 Hz, 1 H), 5.10 (t, J = 5.72 Hz, 1 H), 4.43 (d, J = 5.72 Hz, 2H), 2.42 (s, 3H), 1.29 (s, 12H).

According to the analysis of related databases, 68120-35-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK PATENT GMBH; JORAND-LEBRUN, Catherine; KULKARNI, Santosh; CHRISTMANN-FRANCK, Serge; WO2014/121942; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68120-35-4, name is (3-Bromo-4-methylphenyl)methanol, the common compound, a new synthetic route is introduced below. Quality Control of (3-Bromo-4-methylphenyl)methanol

To a stirred solution of (3-bromo-4-methylphenyl) methanol (5.5 g, 27.4 mmol) in THF (50 mL) at -78C, n-BuLi [(18.6 g, 2.5 eq (2.5M soln) was added and the solution was stirred at same temperature for 30 mm. Then, 002 gas was purged (generated from dry ice) for about 10 mm. The reaction mixture was quenched with ammonium5 chloride and acidified with 1 N HCI, extracted with ethyl acetate, the organic layer was washed with water, brine solution. Then, it was dried over anhydrous Na2S04 and concentrated under reduced pressure and washed with n-hexane to obtain the title compound (4.0 g, 87.85%) as an off white solid. LCMS : 165.0 (M-H) 1H NMR:(CDCI3, 300MHz) 6 12.67 (5, 1H), 7.79 (5, 1H), 7.36-7.38 (d, 1H), 7.23-7.25 (d, 1H), 10 5.23 (5, 1H), 4.49 (5, 2H), 2.50 (5, 3H).

The synthetic route of 68120-35-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; MADANAHALLI RANGANATH RAO, Jagannath; GURRAM RANGA, Madhavan; PACHIYAPPAN, Shanmugam; WO2014/202528; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 68120-35-4, (3-Bromo-4-methylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (3-Bromo-4-methylphenyl)methanol, blongs to alcohols-buliding-blocks compound. name: (3-Bromo-4-methylphenyl)methanol

n-BuLi [(18.6 g, 2.5 eq (2.5M soln) was added to a stirred solution of (3-bromo-4- methylphenyl) methanol (5.5 g, 27.4 mmol) in THE (50 mL) at -78 00 and was stirred at same temperature for 30 mm. Then, 002 gas was purged (generated from dry ice)for about 10 mm. The reaction mixture thus obtained was quenched with ammonium chloride and acidified with 1 N HCI, extracted with ethyl acetate, the organic layer was washed with water, brine solution. Then the reaction mixture was dried over anhydrous Na2SO4 and concentrated under reduced pressure and washed with nhexane to obtain the title compound (4.0 g, 87.85%) as an off white solid. LOMS165.0 (M-H) 1H NMR: (ODd3, 300MHz) 6 12.67 (5, 1H), 7.79 (5, 1H), 7.36-7.38 (d,1 H), 7.23-7.25 (d, 1 H), 5.23 (5, 1 H), 4.49 (5, 2H), 2.50 (5, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,68120-35-4, (3-Bromo-4-methylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; MADANAHALLI RANGANATH RAO, Jagannath; GURRAM RANGA, Madhavan; PACHIYAPPAN, Shanmugam; WO2014/202580; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts