Category: 666747-06-4

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 666747-06-4, name is (2,4-Dibromophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C7H6Br2O

Under a nitrogen atmosphere, to a solution of 2,4-dibromobenzyl alcohol (40 g, 0.15 mol) and 2-methoxypropene(144 mL, 1.5 mol) in THF (300 mL) was added pyridinium p-toluenesulfonicacid (75 mg, 0.30 mmol) at 0 C, and the whole wasstirred for 1 h. The reaction mixture was poured into saturatedNaHCO3 at 0 C. The resulting mixture was extracted with toluene.The organic layer was washed with saturated NaCl, and dried overNa2SO4. The solvent was removed under reduced pressure to give 2as an oil quantitatively. The product was used in the next stepwithout further purification. 1HNMR(CDCl3) d 1.44 (6H, s), 3.22 (3H,s), 4.48 (2H, s), 7.42 (1H, d, J 8.0 Hz), 7.44 (1H, dd, J 1.5, 8.0 Hz),7.68 (1H, d, J 1.5 Hz); 13C NMR (CDCl3) d 24.82, 49.16, 62.26,101.01,121.32, 122.99, 129.94, 130.85, 134.90, 137.98; IR (KBr) 2989, 2941,1581, 1464, 1375, 1080, 1059, 814 cm1; HRMS (APPI) (m/z): Calcdfor C11H14Br2NaO [MNa] 358.9253, Found 358.9244.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 666747-06-4, (2,4-Dibromophenyl)methanol.

Reference:
Article; Murakata, Masatoshi; Ikeda, Takuma; Kimura, Nobuaki; Kawase, Akira; Nagase, Masahiro; Kimura, Masahiro; Maeda, Kenji; Honma, Akie; Shimizu, Hitoshi; Tetrahedron; vol. 73; 6; (2017); p. 655 – 660;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 666747-06-4, name is (2,4-Dibromophenyl)methanol, molecular formula is C7H6Br2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of (2,4-Dibromophenyl)methanol

Zinc cyanide (1.01 g, 8.65 mmol) and tetrakis(triphenylphosphine) palladium (Pd(PPh3)4, 0.50 g, 0.43 mmol) were added into a solution of 2,4-dibromobenzyl alcohol (1-1, 2.3 g, 8.65 mmol) in DMF (20 mL). After deoxygenated via argon bubbling, the reaction mixture was heated at 80 °C and reacted for 5 hours, cooled down to room temperature, diluted with ethyl acetate (80 mL), washed successively with water (80 mLx3) and saturated brine (80 mLx3), dried with anhydrous sodium sulfate and filtered. The filtrate was concentrated to obtain a crude product. The crude product was then purified by column chromatography (elution system: petroleum ether: ethyl acetate = 15/1-4/1) to obtain a white solid product (0.81 g, 44percent yield). The molecular ion peak shown by liquid chromatography-mass spectrometry was: MS (ESI): m/z 211.9/213.9 [M+H]+. NMR: 1HNMR (400 MHz, CDCl3) delta: 7.82 (s, 1 H), 7.69 (d, J = 8.0 Hz, 1 H), 7.65 (d, J = 8.0 Hz, 1 H), 4.80 (s, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 666747-06-4.

Reference:
Patent; SUZHOU CONNECT BIOPHARMACEUTICALS, LTD.; ZHENG, Wei; PAN, Wubin; YANG, Xin; (47 pag.)EP3048103; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 666747-06-4, (2,4-Dibromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H6Br2O, blongs to alcohols-buliding-blocks compound. Formula: C7H6Br2O

To a stirred solution of commercially available 2,4-dibromobenzyl alcohol SI-i(500 mg, 1.88 mmol) in DMF (4 mL), under inert atmosphere, were added imidazole(153 mg, 2.25 mmol, i.2 eq.) and TBSC1 (340 mg, 2.25 mmol, 1.2 eq.). The resultingmixture was stirred for 12 h, then hydrolyzed with water and extracted with a mixture9:1 cyclohexane/CH2C12 (three times). The combined organic extracts were washed withwater, brine, dried over Mg504, filtered and concentrated under reduced pressure. The cmde product was then purified by chromatography (100percent petroleum ether) to afford the title compound SI-2 (638 mg, 1.68 mmol, 89percent) as a colorless oil.?H NMR (CDC13, 300 MHz): 7.66 (d, J = 1.8 Hz, 1H), 7.49-7.42 (m, 2H), 4.67 (s, 2H), 0.97 (s, 9H), 0.14 (s, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,666747-06-4, (2,4-Dibromophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DE BORDEAUX; UNIVERSITE DE RENNES 1; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; WODRICH, Harald; CHEVET, Eric; VAN DE WEGHE, Pierre; (73 pag.)WO2018/178167; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 666747-06-4, Adding some certain compound to certain chemical reactions, such as: 666747-06-4, name is (2,4-Dibromophenyl)methanol,molecular formula is C7H6Br2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 666747-06-4.

Step 2:Synthesis of 2,4-dibromo-1-(1-methoxy-1-methylethoxymethyl)benzeneUnder a nitrogen atmosphere, to a solution of 2,4-dibromobenzyl alcohol (40 g, 0.15 mol) in tetrahydrofuran (300 ml) was added 2-methoxypropene (144 ml, 1.5 mol) at room temperature, and then the mixture was cooled to 0°C.At the same temperature, pyridinium p-toluenesulfonic acid (75 mg, 0.30 mmol) was added and the mixture was stirred for 1 hour.The reaction mixture was poured into a saturated aqueous solution of sodium hydrogen carbonate cooled to 0°C, and extracted with toluene.The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the titled compound as an oil in quantitative yield.The product was used in the next step without further purification.1H-NMR (CDCl3) delta: 1.44 (6H, s), 3.22 (3H, s), 4.48 (2H, s), 7.42 (1H, d, J=8.0Hz), 7.44 (1H, dd, J=1.5, 8.0Hz), 7.68 (1H, d, J=1.5Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 666747-06-4, (2,4-Dibromophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chugai Seiyaku Kabushiki Kaisha; EP2308886; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 666747-06-4, (2,4-Dibromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of (2,4-Dibromophenyl)methanol, blongs to alcohols-buliding-blocks compound. Safety of (2,4-Dibromophenyl)methanol

To the solution of (2,4-dibromophenyl)methanol (10.0 g, 37.6 mmol) was added TBSC1 (6.8 g, 45.1 mmol), imidazole (5.1 g, 75.2 mmol). The mixture was stirred at 40 °C overnight. After the reaction completed, the mixture was washed by water and DCM was removed under vacuo. The residue was purified by column chromatography on silica gel by elution with petroleum ether : ethyl acetate =50: 1 to give tert-butyl(2,4-dibromobenzyloxy)dimethylsilane (14 g, yield 98percent) as a light yellow liquid. XH NMR (400 MHz, CDC13) delta 7.68 (d, 1 H), 7.47 (m, 2H), 4.69 (s, 2H), 0.94 (s, 9 H), 0.15 (s, 6 H).

The synthetic route of 666747-06-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ANACOR PHARMACEUTICALS, INC.; BILL AND MELINDA GATES FOUNDATION; LI, Xianfeng; LUNDE, Christopher, S.; JACOBS, Robert, T.; HERNANDEZ, Vincent, S.; XIA, Yi; PLATTNER, Jacob, J.; CAO, Kathy, Jingyuan; ZHANG, Yong-kang; Perry, Matthew; (268 pag.)WO2017/151489; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts