Category: 66582-32-9

Reference of 66582-32-9 , The common heterocyclic compound, 66582-32-9, name is 3-(Benzyloxy)-2,2-dimethylpropan-1-ol, molecular formula is C12H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[00510] 3-(Benzyloxy)-2,2-dimethylpropan-l-ol 160 (2.5 g, 12.9 mmol) was dissolved in dichloromethane (50 mL). Triethylamine (2.61 g, 25.8 mmol) and methane sulfonyl chloride (1.79 g, 15.5 mmol) were added at 0 C and the reaction mixture was stirred at 0 C for 2 h. The reaction mixture was transferred into iced water and extracted with dichloromethane (40 mL X 3). The combined organic layers were washed with brine, dried over anhydrous Na2S04, and concentrated under reduced pressure to give crude 3 -(benzyl oxy)-2,2- dimethylpropyl methanesulfonate 161, which was purified by silica gel chromatography (17% ethyl acetate/petroleum ether) to give 3.2 g of 3-(benzyloxy)-2,2-dimethylpropyl methanesulfonate 3 (91% yield). LCMS: m/z 294.9 [M+Na]+, tK = 1.78 min.

The synthetic route of 66582-32-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KARYOPHARM THERAPEUTICS INC.; BALOGLU, Erkan; SHACHAM, Sharon; SENAPEDIS, William; MCCAULEY, Dilara; LANDESMAN, Yosef; GOLAN, Gali; KALID, Ori; SHECHTER, Sharon; WO2015/42414; (2015); A1;,
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Reference of 66582-32-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 66582-32-9, name is 3-(Benzyloxy)-2,2-dimethylpropan-1-ol, molecular formula is C12H18O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of oxalyl chloride (40 mmol,2 eq), in dichloromethane (20 mL) at -78C, was added DMSO (80 mmol, 4 eq) in dichloromethane(20 mL) dropwise. After stirring during 30 min, a solution of monobenzylated diol (20 mmol, 1 eq)in dichloromethane (20 mL) was added dropwise. The mixture was stirred 2 h, and triethylamine (6eq) in CH2Cl2 (15 mL) was added dropwise. The mixture was allowed to reach room temperature,and quenched with 50 mL of water. The organic layers were washed with a solution of saturated NaCl, then dried over anhydrous MgSO4, filtered and concentrated in vacuo. The yellow oil was purified by flash chromatography.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 66582-32-9, 3-(Benzyloxy)-2,2-dimethylpropan-1-ol.

Reference:
Article; Chalopin, Thibaut; Jebali, Khaoula; Gaulon-Nourry, Catherine; Denes, Fabrice; Lebreton, Jacques; Mathe-Allainmat, Monique; Tetrahedron; vol. 72; 2; (2016); p. 318 – 327;,
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Alcohols – Chemistry LibreTexts