Category: 6642-34-8

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6642-34-8, name is (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol, molecular formula is C8H7BrO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol

General procedure: In an oven dried round bottomed flask fitted with a rubber septum, were added alcohol 1 (100 mg, 0.30-0.46 mmol), NaH (1.20-1.84 mmol) and DMF (3 mL) followed by addition of allylbromide (0.60-0.92 mmol) at room temperature under a nitrogen atmosphere. The suspension was allowed to stir at the same temperature for 1 h. Progress of the allylation was monitored by TLC till the reaction is completed.GP-3was followed to the alcohol 1f (100 mg, 0.43 mmol) with allyl bromide (104.8 mg, 0.86 mmol) and NaH (42 mg, 1.73 mmol) in DMF (3 mL) at room temperature under a nitrogen atmosphere. Then, the reaction mixture was stirred at the same temperature for 1 h.

With the rapid development of chemical substances, we look forward to future research findings about 6642-34-8.

Reference:
Article; Gopi Krishna Reddy; Krishna; Satyanarayana; Tetrahedron Letters; vol. 53; 42; (2012); p. 5635 – 5640;,
Alcohol – Wikipedia,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6642-34-8, name is (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C8H7BrO3

To a stirred solution of (6-bromo-1,3-benzodioxol-5-yl)methanol (1.27 g, 5.50 mmol) in THF (45.0 ml.) was added n-BuLi (5.00 ml_, 2.0 M, 10.0 mmol) dropwise at -75 0C. The reaction mixture was stirred at -75 0C for 45 min followed by the addition of a solution of 1-pentyl-1/-/-indole-2,3-dione (1.00 g, 4.60 mmol) in THF (20.0 ml.) at -75 0C. The resulting mixture was stirred at ambient temperature for 12 hrs and quenched with ammonium chloride solution (5.00 ml_). More ethyl acetate and water were added and separated. The organic layer was concentrated in vacuo to dryness. The residue was subjected to column chromatography eluting with 50% EtOA?Hexanes to yield the title compound (0.29 g, 25%) as a solid: 1H NMR (300 MHz, CDCI3) delta 7.38-7.24 (m, 2H), 7.11 (t, 1 H), 6.91 (d, 1 H), 6.81 (s, 1 H), 6.43 (s, 1 H), 5.90-5.87 (m, 2H), 4.77 (dd, 2H), 3.75-3.56 (m, 2H), 1.75-1.58 (m, 2H), 1.26-1.35 (m, 2H), 0.89-0.83 (m, 3H); 13C NMR (75 MHz, CDCI3) delta 177.8, 147.4, 147.2, 142.8, 133.5, 132.2, 131.1 , 130.1 , 125.3, 123.8, 111.4, 109.2, 108.1 , 101.5, 79.5, 64.7, 40.4, 29.0, 26.8, 22.3, 13.9; MS (ES+) m/z 352.1 (M – 17).

With the rapid development of chemical substances, we look forward to future research findings about 6642-34-8.

Reference:
Patent; XENON PHARMACEUTICALS INC.; WO2006/113864; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 6642-34-8 , The common heterocyclic compound, 6642-34-8, name is (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol, molecular formula is C8H7BrO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: In an oven dried round bottomed flask fitted with a rubber septum, were added alcohol 1 (100 mg, 0.31-0.53 mmol), alkyl acrylate (methyl, ethyl and tertiary butyl acrylate, or acrylo-nitrile) (1.55-2.67 mmol) and Cs2CO3 (0.62-1.07 mmol) followed by addition of toluene (2 mL) at room temperature under a nitrogen atmosphere. The stirred reaction mixture was heated in an oil bath at 50 C for 48 h. Progress of the Michael addition was monitored by TLC till the reaction is completed.GP-2 was followed to the alcohol 1f (100 mg, 0.43 mmol) with acrylonitrile (115 mg, 2.16 mmol) and Cs2CO3 (282 mg, 0.86 mmol) in toluene (2 mL) at room temperature under a nitrogen atmosphere. Then, the reaction mixture was heated in an oil bath at 50 C for 48 h.

The synthetic route of 6642-34-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gopi Krishna Reddy; Krishna; Satyanarayana; Tetrahedron Letters; vol. 53; 42; (2012); p. 5635 – 5640;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6642-34-8, name is (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol, molecular formula is C8H7BrO3, molecular weight is 231.04, as common compound, the synthetic route is as follows.Application In Synthesis of (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol

General procedure: To the solution of alcohol 4b (0.50 g, 2.67 mmol) and DMSO (0.41 g, 5.34 mmol) in ethyl acetate (5 ml) was added T3P (1.84 g, 6.68 mmol, 2.5 equiv, 50% solution in ethyl acetate) at 0 C. The resulting mixture was allowed to warm to RT and stirred for 1 h. Pyrazine-2-amine 3a (0.254 g, 2.67 mmol) was added to the above mixture and stirred for 15 min, which was followed by the addition of isocyanide 1c (0.33 g, 4.01 mmol) at room temperature and stirring for 4 h. Progress of the reaction was monitored by TLC. After the reaction was complete, the reaction mixture was diluted with ethyl acetate and neutralized with aqueous sodium bicarbonate solution. The organic layer was separated and the aqueous layer was extracted with ethyl acetate (25 mL ¡Á 2), the combined organic phases were washed with water, brine solution, dried over anhydrous sodium sulfate, and concentrated under vacuum to afford a crude product, which was purified on silica gel using ethyl acetate and petroleum ether.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6642-34-8, (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Ramesha, Ajjahalli B.; Raghavendra, Goravanahalli M.; Nandeesh, Kebbahalli N.; Rangappa, Kanchugarakoppal S.; Mantelingu, Kempegowda; Tetrahedron Letters; vol. 54; 1; (2013); p. 95 – 100;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 6642-34-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6642-34-8, name is (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: In an oven dried Schlenk tube, were added alcohol 1 (100.0mg, 0.31-0.53mmol), ethyl acrylate [155.1-265.3mg, (i.e., 1.55-2.65 mmol)], and Cs2CO3 [303.0-518.0mg, (i.e., 0.93-1.59mmol)] followed by the addition of toluene (2mL) at rt under nitrogen atmosphere. The resulted reaction mixture was stirred at 50C in an oil bath for 48h. After the completion of Michael addition (monitored by TLC) and to the cooled reaction mixture at rt, were added Pd(OAc)2 (6.9-11.9mg, 10mol%) and PPh3 (16.3-27.8mg, 20mol%) under nitrogen atmosphere. The reaction mixture was then heated at 80C in an oil bath for 24h. Once after formation intermolecular Heck coupling product, (monitored by TLC) and then to the cooled reaction mixture at rt, was added DMF (3mL) and heated to 120C, in an oil bath for 12h (monitored by TLC). The reaction mixture at rt was quenched by the addition of aqueous NH4Cl and extracted with DCM (3¡Á15mL). The organic layers were washed with saturated NaCl solution, dried (Na2SO4), and filtered. Evaporation of the solvent under reduced pressure and purification of the crude material by silica gel column chromatography (petroleum ether/ethyl acetate) furnished the lactenones 5 (40-48%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6642-34-8, (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol.

Reference:
Article; Reddy, A. Gopi Krishna; Krishna; Satyanarayana; Tetrahedron; vol. 69; 47; (2013); p. 10098 – 10107;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts