Category: 65-22-5

Synthesis of haptens and gold-based immunochromatographic paper sensor for vitamin B₆ in energy drinks and dietary supplements was written by Zeng, Lu;Xu, Xinxin;Song, Shanshan;Xu, Liguang;Liu, Liqiang;Xiao, Jing;Xu, Chuanlai;Kuang, Hua. And the article was included in Nano Research in 2022.Synthetic Route of C8H10ClNO3 The following contents are mentioned in the article:

We designed and synthesized novel haptens to produce monoclonal antibodies (mAb) against vitamin B₆ (VB₆). A group-specific mAb (2F9) that recognized pyridoxine (PN), pyridoxamine (PM), and pyridoxal (PL) was prepared using a homologous strategy with 50% maximal inhibitory concentration (IC₅₀) values of 106.60, 250.57, and 400.11 ng/mL, resp. Based on this, a gold nanoparticles (AuNPs)-based immunochromatog. strip (ICS) test was established for the detection of VB₆ in energy drinks and B-vitamin complex tablets. The developed ICS test results could be semi-quant. evaluated by the naked eye within 10 min, and displayed the visual limit of detection (vLOD) values of 250, 500, and 1,000 ng/mL for PN, PM, and PL, resp. For quant. anal., the results obtained by strip reader, with calculated LOD values for PN, PM, and PL were 14.10, 55.58, and 56.25 ng/mL, resp. Com. energy drinks and B-vitamin complex tablet samples were detected by the strips and the results were confirmed with high-performance liquid chromatog. Overall, the developed AuNPs-based immunochromatog. sensor was suitable and promising for the group-specific recognition and rapid detection of VB₆ in fortified foods and dietary supplements. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Synthetic Route of C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Synthetic Route of C8H10ClNO3

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Water-soluble pyridine-based colorimetric chemosensor for naked eye detection of silver ions: Design, synthesis, spectral and theoretical investigation was written by Annaraj, B.;Neelakantan, M. A.. And the article was included in Analytical Methods in 2014.SDS of cas: 65-22-5 The following contents are mentioned in the article:

A water soluble pyridine containing a Schiff base as chemosensor was designed and then synthesized. The chemosensor (L) was synthesized by reacting pyridoxal and 2-aminoethanol and then comprehensively characterized using elemental anal., spectroscopic methods (IR, UV-visible, NMR (¹H-NMR and ¹³C-NMR) spectroscopy), electrospray ionization mass spectroscopy, and single crystal X-ray crystallog. The designed compound showed excellent specificity and sensitivity (detection limit = 4.18 × 10^-6 M) towards Ag⁺ ions in preference to other interfering cations (Ca²⁺, Co²⁺, Cu²⁺, Fe²⁺, Fe³⁺, Hg²⁺, VO²⁺, K⁺, Li⁺, Mn²⁺, Na⁺, Ni²⁺, Pb²⁺ and Zn²⁺) in aqueous solution The (L) showed a selective chromogenic behavior towards Ag⁺ ions by changing the color of the solution from light yellow to red, a change which can be detected with the naked eye. A simple and cost effective test kit was prepared for the detection of silver ion in water samples. Time-dependent d. functional theory calculations were carried out to help understand the sensing mechanism. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5SDS of cas: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 65-22-5

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A protein-free chemically defined medium for the cultivation of various micro-organisms with food safety significance was written by Wang, D.;Greenwood, P.;Klein, M. S.. And the article was included in Journal of Applied Microbiology in 2021.Recommanded Product: 65-22-5 The following contents are mentioned in the article:

To develop a broadly applicable medium free of proteins with well-defined and reproducible chem. composition for the cultivation of various micro-organisms with food safety significance. The defined medium was designed as a buffered minimal salt medium supplemented with amino acids, vitamins, trace metals and other nutrients. Various strains commonly used for food safety research were selected to test the new defined medium. We investigated single growth factors needed by different strains and the growth performance of each strain cultivated in the defined medium. Results showed that the tested strains initially grew slower in the defined medium compared to tryptic soy broth, but after an overnight incubation cultures from the defined medium reached adequately high cell densities. The newly designed defined medium can be widely applied in food safety studies that require media with well-defined chem. constituents. Significance and Impact of the Study : Defined media are important in studies of microbial metabolites and physiol. properties. A defined medium capable of cultivating different strains simultaneously is needed in the food safety area. The new defined medium has broader applications in comparing different strains directly and provides more reproducible results. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Recommanded Product: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 65-22-5

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Synthesis, characterization, DFT and antibacterial studies of a novel vitamin B6 Schiff base and its Cu(II) and Zn(II) complexes was written by Omidinia, Raheleh;Ali Beyramabadi, S.;Allameh, Sadegh;Morsali, Ali;Pordel, Mehdi. And the article was included in Journal of Molecular Structure in 2022.HPLC of Formula: 65-22-5 The following contents are mentioned in the article:

In this project, condensation reaction of the pyridoxal and 3,4-diaminopyridine resulted in a novel pyridoxal Schiff base (H₂L). Synthesis and characterization by several exptl. methods have been reported for the H₂L species as well as its Cu(II) and Zn(II) complexes. Structural parameters, tautomerism, spectral properties and frontier orbitals of three synthesized compounds have been explored by using the d. functional theory (DFT) approaches. In the square geometries for both of the complexes, the dianionic form of the Schiff base, L^2- species, acts as a tetradentate ligand, coordinates to the Cu²⁺ and Zn²⁺ metal ions via two azomethine nitrogens and two phenolate oxygens. Good agreement between the exptl. values and DFT-predicted IR wavenumbers and NMR chem. shifts demonstrated validity of the optimized geometries for the studied species. Also, the Atoms In Mols. (AIM) anal. was employed to characterize bonding interactions. Use of two choline chloride based eutectic solvents, as green and environmentally friendly media, resulted in high yield synthesis of the investigated species in three cycles. In addition, among the synthesized compounds, the H₂L Schiff base shows great antibacterial activities. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5HPLC of Formula: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 65-22-5

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Synthesis of symmetric N,O-donor ligands derived from pyridoxal (vitamin B6): DFT studies and structural features of their binuclear chelate complexes with the oxofilic uranyl and vanadyl(V) cations was written by Back, Davi Fernando;Manzoni de Oliveira, Gelson;Roman, Daiane;Ballin, Marco Aurelio;Kober, Roger;Piquini, Paulo Cesar. And the article was included in Inorganica Chimica Acta in 2014.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

The synthesis and the structural characterization of sym. dimers containing uranium and vanadium atoms provide an outstanding opportunity for the study of hydrogen bonding in supramol. architectures and unusual interactions. On the search of ligands able to coordinate itself to two metal ions simultaneously, the authors synthesized the Schiff bases bis((3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene) oxalohydrazide (H₆Pyr₂oxdihyd, 3) and bis((3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene) succinohydrazide (H₁₀pyr₂sucdihyd, 4), efficient sym. ligands with an inversion center, obtained through the reaction of pyridoxine/pyridoxal hydrochloride with oxalyl dihydrazide and succinic dihydrazide. The prepared complexes are [(UO₂)₂(H₆pyr₂oxdihyd-4H⁺)(DMSO)₄] (1) and [(VO)₂(H₁₀pyr₂sucdihyd-4H⁺)(MeO)₂] (2). Their reactions and the products obtained with the oxofilic uranyl(VI) and vanadyl(V) cations are discussed, as well as computational methods were used as complementary tools in the study of intra and intermol. bonds. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

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Effects of soil salinity on nutritional compositions of fresh Jak (Nypa fruticans) sap was written by Saelee, Nisa. And the article was included in Journal of Food Composition and Analysis in 2022.Product Details of 65-22-5 The following contents are mentioned in the article:

The nutritional compositions of fresh Jak (Nypa fruticans) sap grown in mangrove environments with varying soil salinities were examined between sap from non saline (ECe < 2 dS/m), moderately saline (ECe = 4-8 dS/m), and saline soil (ECe = 8-16 dS/m). In saline sites, sap significantly (p < 0.05) increased in total soluble solids and sugar concentration The total amino acid in the saline site was higher than in the other sites. The fresh Jak sap was rich in functional nutrients such as sugars (sucrose, glucose, fructose, starchyose, galactose, arabinose, maltose), organic acids (niacin, succinic, tartaric, malic, citric, lactic, acetic acids), minerals (P, K, Na, Ca, Mg, Al, Mn, Fe, Cu, Zn, Ni, B), essential amino acids (arginine, lysine, valine, histidine, threonine), seven non-essential amino acids (i.e. glutamic acid) and vitamins (B1, B3, B6, B12, E). Furthermore, potassium was significantly increased in salinity soil, and the decrease in potassium was associated with the increase in sodium. Fresh Jak sap from all salinity soils was shown to be an excellent source of several nutritional elements in this investigation. However, it appeared that Jak sap from the non saline site would be the best choice for use in the development of healthy food products. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Product Details of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Product Details of 65-22-5

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Targeted photocytotoxicity by copper(II) complexes having vitamin B₆ and photoactive acridine moieties was written by Mukherjee, Nandini;Podder, Santosh;Banerjee, Samya;Majumdar, Shamik;Nandi, Dipankar;Chakravarty, Akhil R.. And the article was included in European Journal of Medicinal Chemistry in 2016.Formula: C8H10ClNO3 The following contents are mentioned in the article:

Copper(II) pyridoxal Schiff base complexes [Cu(L¹/L²)(B)]ClO₄ (1-4), where HL¹ is 4-(((2-(1H-imidazol-4-yl)ethyl)imino)methyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol (in 1 and 2), HL² is 2-(((2-(1H-imidazol-4-yl)ethyl)imino)methyl)phenol (in 3, 4), B is 11-(9-acridinyl)dipyrido[3,2-a:2′,3′-c]phenazine (acdppz in 1 and 3), dipyrido[3,2-a:2′,3′-c]phenazine (in 2) and 1,10-phenanthroline (in 4), were synthesized, characterized and their photocytotoxicity in visible light, intracellular localization, cellular uptake and DNA photocleavage activity were studied. Complex 4 was characterized by X-ray crystallog. Complexes 1 and 3 having acdppz as photosensitizer showed significant photocytotoxicity in visible light in HeLa and MCF7 cells giving IC₅₀ value of <0.6 μM, while being relatively nontoxic in dark. The complexes were nontoxic to nontumorigenic HPL1D cells both in light and dark conditions. Complex 1 showed significant localization in the cytoplasm of HeLa cells within 4 h of treatment, as evidenced from confocal microscopy. DCFDA assay on 1 suggested generation of intracellular reactive oxygen species in HeLa cells upon photo-exposure. Importantly, Annexin-V-FITC/PI assay indicated photo-induced apoptotic cell death. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Formula: C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C8H10ClNO3

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Ruthenium(II) carbonyl complexes containing pyridoxal thiosemicarbazone and trans-bis(triphenylphosphine/arsine): Synthesis, structure and their recyclable catalysis of nitriles to amides and synthesis of imidazolines was written by Manikandan, Rajendran;Anitha, Panneerselvam;Prakash, Govindan;Vijayan, Paranthaman;Viswanathamurthi, Periasamy;Butcher, Ray Jay;Malecki, Jan Grzegorz. And the article was included in Journal of Molecular Catalysis A: Chemical in 2015.Computed Properties of C8H10ClNO3 The following contents are mentioned in the article:

Pyridoxal N(4)-substituted thiosemicarbazone hydrochloride ligands (L^1-3) were synthesized and reacted with the ruthenium(II) starting complexes [RuHCl(CO)(EPh₃)₃] (E = P or As). The resulting complexes [Ru(CO)(L^1-3)(EPh₃)₂] were characterized by elemental analyses and spectroscopic techniques. The mol. structure of complex [Ru(CO)(L²)(AsPh₃)₂] was identified by means of single crystal X-ray diffraction anal. The catalytic activity of the new complexes was evaluated for the selective hydration of nitriles to primary amides and also the condensation of nitriles with ethylenediamine under solvent free conditions. The processes were operative with aromatic, heteroaromatic and aliphatic nitriles, and tolerated several substitutional groups. The studies on the effect of substitution over thiosemicarbazone, reaction time, temperature, solvent and catalyst loading were carried out in order to find the best catalyst in this series of complexes and favorable reaction conditions. A probable mechanism for both the catalytic reactions of nitrile has also been proposed. The catalyst was recovered and recycled in the hydration of nitriles for five times without any significant loss of its activity. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Computed Properties of C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Computed Properties of C8H10ClNO3

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Exploratory metabolomic study to identify blood-based biomarkers as a potential screen for colorectal cancer was written by Asante, Isaac;Pei, Hua;Zhou, Eugene;Liu, Siyu;Chui, Darryl;Yoo, EunJeong;Conti, David V.;Louie, Stan G.. And the article was included in Molecular Omics in 2019.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

Introduction: colorectal cancer (CRC) continues to be difficult to diagnose due to the lack of reliable and predictive biomarkers. Objective: to identify blood-based biomarkers that can be used to distinguish CRC cases from controls. Methods: a workflow for untargeted followed by targeted metabolic profiling was conducted on the plasma samples of 26 CRC cases and ten healthy volunteers (controls) using liquid chromatog.-mass spectrometry (LCMS). The data acquired in the untargeted scan was processed and analyzed using MarkerView software. The significantly different ions that distinguish CRC cases from the controls were identified using a mass-based human metabolome search. The result was further used to inform the targeted scan workflow. Results: the untargeted scan yielded putative biomarkers some of which were related to the folate-dependent one-carbon metabolism (FOCM). Anal. of the targeted scan found the plasma levels of nine FOCM metabolites to be significantly different between cases and controls. The classification models of the cases and controls, in both the targeted and untargeted approaches, each yielded a 97.2% success rate after cross-validation. Conclusion: we have identified plasma metabolites with screening potential to discriminate between CRC cases and controls. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

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Structural characterization and thermal behaviour of some azomethine compounds derived from pyridoxal and 4-aminoantipyrine was written by Mezey, Reka-Stefana;Zaharescu, Traian;Lungulescu, Marius Eduard;Marinescu, Virgil;Shova, Sergiu;Rosu, Tudor. And the article was included in Journal of Thermal Analysis and Calorimetry in 2016.Formula: C8H10ClNO3 The following contents are mentioned in the article:

Eight azomethine-type compounds derived from pyridoxal (3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde) and 4-aminoantipyrine, resp., were prepared and thoroughly characterized from structural and thermal perspective. The structures of the compounds were studied based on IR, ¹H and ¹³C NMR spectroscopy and electrospray ionization mass spectrometry. The formation of the azomethine derivatives was confirmed by the occurrence of signals typical for the imine bond. Pyrazolone derivatives feature a high crystallinity, and their structures were resolved by single-crystal X-ray diffraction. The thermal behavior of all the compounds were studied by non-isothermal chemiluminescence in static air atm. at different heating rates. The pattern of the oxidation process was described. Moreover, thermo-gravimetric and differential scanning calorimetry experiments were conducted in order to assess the thermal oxidation stability. The onset oxidation temperatures showed a high thermal stability for all the tested azomethine compounds The crystallinity degree was comparatively evaluated on the basis of melting enthalpy values and discussed in connection with the mol. structure. Pyrazolone derivatives showed the higher thermal stability and crystallinity degree. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Formula: C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C8H10ClNO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts