Category: 65-22-5

A pyridoxal-based dual chemosensor for visual detection of copper ion and ratiometric fluorescent detection of zinc ion was written by Qu, Lijun;Yin, Caixia;Huo, Fangjun;Chao, Jianbin;Zhang, Yongbin;Cheng, Fangqin. And the article was included in Sensors and Actuators, B: Chemical in 2014.Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

A pyridoxal-based fluorescein derivative was synthesized by reacting fluorescein hydrazide and pyridoxal hydrochloride in ethanol and characterized by NMR, ESI-MS and X-ray. The optical properties of probe were investigated in methanol: HEPES solution The probe displayed selectivity for Cu²⁺, which was characterized using UV-visible spectroscopy. Moreover, the process also allowed visual detection of Cu²⁺ by a colorless to yellow change. In contrast, selectivity toward Zn²⁺ was determined in the emission spectra showing OFF-ON type fluorescence changes from colorless to green. This represents the first reported pyridoxal-based sensor capable of detecting both Cu²⁺ and Zn²⁺ using two different modes. Furthermore, it can be used to bioimaging. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

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Alcohol – Wikipedia,
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A derivatisation agent selection guide was written by Tobiszewski, Marek;Namiesnik, Jacek;Pena-Pereira, Francisco. And the article was included in Green Chemistry in 2017.Electric Literature of C8H10ClNO3 The following contents are mentioned in the article:

The study reported herein is aimed at the greenness assessment of 267 derivatization agents that are frequently applied in anal. chem. and related disciplines. Multicriteria decision anal. allowed obtaining three rankings of derivatization agents applied in liquid chromatog., gas chromatog. and chiral anal. The criteria of assessment included the safety information obtained from material safety data sheets and physicochem. and environmental parameters predicted with relevant models. As for some of the agents predicted data were not available, these agents were assessed with a smaller number of criteria, within the ranking of low confidence. The results of the study will help to apply greener derivatization agents, wherever the green chem. principle of avoiding derivatization cannot be fulfilled. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Electric Literature of C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Electric Literature of C8H10ClNO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effect of vitamin derivatives on gelation rate and gel strength of methylcellulose was written by Kim, Min Hee;Park, Hanna;Shin, Ji Youn;Park, Won Ho. And the article was included in Carbohydrate Polymers in 2018.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

A thermo-sensitive methylcellulose (MC) hydrogel was prepared using three types of vitamin derivatives with or without phosphate groups. The gelation behavior of each MC hydrogel containing vitamin or vitamin derivatives was monitored using a rheometer. The gelation rate and mech. strength of the MC hydrogels were improved by vitamin derivatives with phosphate groups due to their salting-out effects, whereas their injectabilities retained proper maximum forces. Also, the vitamin derivatives with phosphate groups were released slower from the MC hydrogel than the vitamins without phosphate groups due to higher phys. crosslinking densities. Therefore, this thermo-responsive MC hydrogel containing vitamin derivatives has a great potential as an injectable hydrogel for drug delivery. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

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Alcohol – Wikipedia,
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Chemical transformations of the condensation products of structurally different amino acids with pyridoxal as a function of Ph, solvent, and temperature was written by Pishchugin, F. V.;Tuleberdiev, I. T.. And the article was included in Russian Journal of General Chemistry in 2015.Product Details of 65-22-5 The following contents are mentioned in the article:

The kinetics and mechanism of chem. transformations of condensation products of structurally different amino acids with pyridoxal as a function of pH of the medium, the solvent, and temperature were studied. The Schiff bases were found to be the most stable at pH close to neutral values. In acidic media, the condensation products of α-amino acids with pyridoxal decompose to the starting components. In alk. media, the elimination of the α-hydrogen atom from the amino acid fragment and rearrangement of the Schiff base into the quinoid form occurs, the subsequent hydrolysis leading to the formation of pyridoxamine and keto acids. The condensation products of the β- and ε-amino acids with pyridoxal decompose to the starting components in acidic media but are stable in alk. media. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Product Details of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Product Details of 65-22-5

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Alcohol – Wikipedia,
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Pyridoxal-thiosemicarbazide: its anion sensing ability and application in living cells imaging was written by Sharma, Darshna;Moirangthem, Anuradha;Kumar, Rajender;Ashok Kumar, S. K.;Kuwar, Anil;Callan, John F.;Basu, Anupam;Sahoo, Suban K.. And the article was included in RSC Advances in 2015.Formula: C8H10ClNO3 The following contents are mentioned in the article:

A new anion selective chemosensor L was derived through a direct condensation reaction between pyridoxal and thiosemicarbazide. Sensor L showed selective recognition and sensing ability towards F^– and AcO^– anions through a naked-eye detectable color change from colorless to light yellow, appearance of a new charge transfer absorption band at 404 nm and significant “turn-on” fluorescence at 506 nm. The detection limit of L as a fluorescent ‘turn-on’ sensor for the anal. of F^– and AcO^– was estimated to be 0.10 μM. The anion sensing mechanisms of L was supported by ¹H NMR and DFT results. Finally, the cytotoxicity effect of L and its ability to image intracellular F^– ions in the living HeLa cells was investigated. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Formula: C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C8H10ClNO3

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Diverse reactivity to hypochlorite and copper ions based on a novel Schiff base derived from vitamin B6 cofactor was written by Li, Xiangqian;Wen, Qin;Gu, Jiapei;Liu, Wanqiang;Wang, Qianming;Zhou, Guofu;Gao, Jinwei;Zheng, Yuhui. And the article was included in Journal of Molecular Liquids in 2020.Electric Literature of C8H10ClNO3 The following contents are mentioned in the article:

A new Schiff base receptor (2-amino-3-(((3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene) amino)maleonitrile) has been synthesized. Such diaminomaleonitrile-based mol. framework is observed to be water soluble GAL possesses both colorimetric and off-on fluorescent response in the presence of ClO^– . The response time has been controlled within 6min.The limit of detection has been calculated to be 47.5nM. The addition of Cu²⁺ can only induce clear color evolution from pale to deep yellow and no fluorescence changes are found. Moreover, its reliability and practicality are verified via the determination of ClO^– in spiked samples of tap water and pond water. The exploration of bioactive vitamin B6 cofactor as a sensing platform will open a new way for multiple target recognition in competitive medium. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Electric Literature of C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Electric Literature of C8H10ClNO3

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A new “off-on” fluorescent probe for Al³⁺ in aqueous solution based on rhodamine B and its application to bioimaging was written by Huang, Qi;Zhang, Qingyou;Wang, Enze;Zhou, Yanmei;Qiao, Han;Pang, Lanfang;Yu, Fang. And the article was included in Spectrochimica Acta in 2016.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

In this paper, a new fluorescent probe has been synthesized and applied as “off-on” sensor for the detection of Al³⁺ with a high sensitivity and excellent selectivity in aqueous media. The sensor was easily prepared by one step reaction between rhodamine B hydrazide and pyridoxal hydrochloride named RBP. The structure of the sensor has been characterized by NMR and electron spray ionization-mass spectrometry. The fluorescence intensity and absorbance for the sensor showed a good linearity with the concentration of Al³⁺ in the range of 0-12.5 μM and 8-44 μM, resp., with detection limits of 0.23 μM and 1.90 μM. The sensor RBP was preliminarily applied to the determination of Al³⁺ in water samples from the lake of Henan University and tap water with satisfying results. Moreover, it can be used as a bioimaging reagent for imaging of Al³⁺ in living cells. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

New manganese(II) and nickel(II) coordination compounds with N,O-polydentate ligands obtained from pyridoxal and tripodal units was written by Ebani, Patricia Regina;Fontana, Liniquer Andre;Campos, Patrick Teixeira;Rosso, Eduardo F.;Piquini, Paulo C.;Iglesias, Bernardo Almeida;Back, Davi Fernando. And the article was included in Journal of Molecular Structure in 2016.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

The authors have reported the synthesis involving the condensation of pyridoxal with tris(2-aminoethyl)amine obtained a tripodal ligand, as well as its subsequent complexation with the manganese(II) and nickel(II) ions. The structural anal. revealed, in the case of complex 1, the formation of a monomeric complex with Mn(II) species. In the complex 2, with Ni(II) metal ion, the authors describe the probable mechanism for the formation of hemiacetal in these complexes. Only the complex 1 catalyze the dismutation of superoxide efficiently with IC₅₀ equal to 3.38 μM, evaluated through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. D. functional theory calculations are done to characterize and compare the mol. frontier orbitals of the Mn(II) and Ni(II) complexes. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Interaction between Pyridoxal Hydrochloride and L-α-Asparagine in Comparison to L-α- and D-α-Aspartic Acids was written by Pishchugin, F. V.;Tuleberdiev, I. T.. And the article was included in Russian Journal of Physical Chemistry A in 2021.SDS of cas: 65-22-5 The following contents are mentioned in the article:

The kinetics and mechanism of condensation of pyridoxal hydrochloride with L-α-asparagine, L-α- and D-α-aspartic acids are analyzed via UV spectroscopy and polarimetry. It is found that L-α-asparagine containing α-NH₂ and γ-NH₂ groups interacts with pyridoxal via the γ-NH₂ group, forming Schiff bases that are resistant to chem. transformations. Rearrangement produces Schiff bases that form the cyclic structure from the amino acid moiety. L-α- and D-α-aspartic acids interacting with pyridoxal via α-NH₂ groups create Schiff bases that form quinoid structures after elimination of α-hydrogen or CO₂. Their subsequent hydrolysis results in pyridoxamine, α-ketoacids, and aldehyde acids, resp. Schemes of the condensation mechanisms of L-α-asparagine, L-α-, D-α-aspartic acids with pyridoxal hydrochloride are proposed. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5SDS of cas: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electrocatalytic hydrogen evolution upon reduction of pyridoxal semicarbazone and thiosemicarbazone-based Cu(II) complexes was written by Al-Zahrani, Salma A.;Jevtovic, Violeta;Alenezi, Khalaf M.;El Moll, Hani;Haque, Ashanul;Vidovic, Dragoslav. And the article was included in Journal of the Serbian Chemical Society in 2022.Quality Control of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

The growing global demand for renewable energy sources has pushed renewable, green energy sources to the forefront, among which the production of hydrogen gas from water occupies a significant place. To realize this goal, researchers across the globe are developing various systems that could swiftly catalyze the hydrogen evolution reaction (HER) in the highest possible yield. In the present work, the electrocatalytic HER performances of pyridoxal semicarbazone- and thiosemicarbazone-based Cu(II) complexes, i.e., ([Cu(PLSC)Cl₂] and [Cu(PLTSC-H)H₂O]Br·H₂O) are reported. It has been unambiguously demonstrated that the complexes exhibit enviable level of HER catalytic activity. The catalytic activity of the complexes was not only the function of central metal but it was also controlled by the nature of the coordinating ligand. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Quality Control of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts