Category: 65-22-5

A Bioisosteric and Scaffold Hopping Approach for the Design and Synthesis of Double Ring Replacement Analogues of 4-Aryl-4H-Chromenes and in silico Tubulin Inhibitor Studies was written by Kottha, Thirumalaswamy S.;Gnanasambandam, Vasuki. And the article was included in ChemistrySelect in 2018.Related Products of 65-22-5 The following contents are mentioned in the article:

An eco-friendly reaction protocol was developed for the synthesis of heterocyclic hybrid scaffolds through bioisosteric replacement and scaffold hopping approach. The isosteric analogs of salicylaldehyde were designed, identified/synthesized and employed in a three component reaction to afford bioisosteric analogs of 4-aryl-4H-chromenes. Thus central core swapping of benzene-pyridine/pyrazole ring on 4-aryl-4H-chromenes was achieved under simple one-pot reaction conditions and easy work-up. Docking studies show that almost all the compounds possess good binding affinities at the colchicine binding site of tubulin. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Related Products of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Related Products of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reaction of Pyridoxal with Phenols: Synthesis of Novel 1-Aryl-Substituted Furopyridines was written by Kibardina, Ludmila K.;Chumakova, Ludmila V.;Gazizov, Almir S.;Burilov, Alexander R.;Pudovik, Michail A.. And the article was included in Synthesis in 2015.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

A new method based on the acid-catalyzed reaction of pyridoxal with polyfunctional phenols was developed for the synthesis of potentially biol. active 1-aryl-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ols. Advantages of this method include a good yield of the target furopyridines and the use of readily available hydrochloric acid as a catalyst. The possibility of extending the proposed approach to nucleophiles other than phenols was demonstrated by the synthesis of the known biol. active compound 1-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochloride (TM2002). This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A Domino Reaction for the Synthesis of Novel 1,3-Dihydrofuro[3,4-c]pyridines from Pyridoxal and Ketones was written by Casadia, Izamara;Daher, Thalita O.;Moura, Sidnei;Back, Davi F.;Faoro, Eliandro;Schwalm, Cristiane S.;Casagrande, Gleison A.;Paveglio, Guilherme C.;Pizzuti, Lucas. And the article was included in Synthesis in 2021.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

A convenient domino route for the synthesis of novel 1,3-dihydrofuro[3,4- c]pyridines from pyridoxal and alkyl, aryl or heteroaryl ketones under basic conditions is reported. A series of nine derivatives is obtained in 53-90% yields after stirring reactants for 48 h at room temperature Most products are easily isolated by filtration followed by recrystallization from ethanol. All products were fully characterized by FTIR, HRMS, and ¹H and ¹³C NMR spectroscopy. The X-ray crystal structure of a representative example of the 1,3-dihydrofuro[3,4- c]pyridine series is also presented. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chemical synthesis of 5′-β-glycoconjugates of vitamin B₆ was written by Bachmann, Thomas;Schnurr, Christian;Zainer, Laura;Rychlik, Michael. And the article was included in Carbohydrate Research in 2020.Related Products of 65-22-5 The following contents are mentioned in the article:

Various 5′-β-saccharides of pyridoxine, namely the mannoside, galactoside, arabinoside, maltoside, cellobioside and glucuronide, were synthesized chem. according to Koenigs-Knorr conditions using α4,3-O-isopropylidene pyridoxine and the resp. acetobromo glycosyl donors with AgOTf (3.0 equivalent) and NIS (3.0 equivalent) as promoters at 0°C. Furthermore, 5′-β-[¹³C₆]-labeled pyridoxine glucoside (PNG) was prepared starting from [¹³C₆]-glucose and pyridoxine. Addnl., two strategies were examined for the synthesis of 5′-β-pyridoxal glucoside (PLG). This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Related Products of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Related Products of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Syntheses, crystal structures, spectral study and DFT calculation of three new copper(II) complexes derived from pyridoxal hydrochloride, N,N-dimethylethylenediamine and N,N-diethylethylenediamine was written by Mandal, Senjuti;Naskar, Barnali;Modak, Ritwik;Sikdar, Yeasin;Chatterjee, Sudipta;Biswas, Sujan;Mondal, Tapan Kumar;Modak, Debadrita;Goswami, Sanchita. And the article was included in Journal of Molecular Structure in 2015.SDS of cas: 65-22-5 The following contents are mentioned in the article:

Two pyridoxal containing Schiff bases obtained by condensation of pyridoxal hydrochloride with N,N-dimethylethylenediamine (HL¹) and N,N-diethylethylenediamine (HL²) were used for the syntheses of three new copper(II) complexes [Cu(HL¹)(H₂O)Cl]Cl (1), [Cu(L¹)Cl] (2) and [Cu(L²)Cl] (3). The single crystal x-ray structures of all the three copper(II) complexes are determined Redox potentials for the mononuclear complexes were measured by cyclic voltammetry experiments The DFT and TDDFT results have been used to interpret the exptl. properties. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5SDS of cas: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Azomethines Based on Pyridoxal-Derived Aromatic Aldehydes was written by Kibardina, L. K.;Trifonov, A. V.;Ivanova, Yu. I.;Pudovik, M. A.;Pudovik, E. M.;Burilov, A. R.. And the article was included in Russian Journal of General Chemistry in 2018.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

The reaction of pyridoxal with 2,4-dihydroxybenzaldehyde in a hydrochloric acid solution gave 1-(5-formyl-2,4-dihydroxyphenyl)-7-hydroxy-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-5-ium chloride. Treatment of the latter with sodium hydride in ethanol afforded a free aldehyde, 2,4-dihydroxy-5-(7-hydroxy-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-1-yl)benzaldehyde in 85% yield. A series of azomethines I [R = (CH₂)₃NMe, Ph, 4-H₂NC₆H₄, etc.] and imidazolidines II [R¹ = Me, Bn] was obtained by reacting the obtained aldehyde with various amines and diamines. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Facile preparation of nanosized yttrium oxide by the thermal decomposition of amorphous Schiff base yttrium complex precursor was written by Pizl, Martin;Jankovsky, Ondrej;Ulbrich, Pavel;Szabo, Norbert;Hoskovcova, Irena;Sedmidubsky, David;Bartunek, Vilem. And the article was included in Journal of Organometallic Chemistry in 2017.Product Details of 65-22-5 The following contents are mentioned in the article:

Nanoparticles of yttrium (III) oxide were synthesized by thermal combustion of previously prepared yttrium complex of pyridoxylidenealanine under air atm. at 750°. Amorphous complex was characterized by x-ray diffraction and IR and NMR spectroscopy. The prepared nanoparticles were characterized by x-ray diffraction and TEM revealing the size of the vast majority of particles ranging from 10 to 30 nm. The synthesis method can be modified by addition of any RE and can be used for many applications especially in the field of non-linear optics or in biomedical applications where use of more fine nanoparticles may be problematic or even dangerous. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Product Details of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Experimental and theoretical study on a new copper(II) complex derived from pyridoxal hydrochloride and 1,2-diaminocyclohexane was written by Mandal, Senjuti;Sikdar, Yeasin;Sanyal, Ria;Goswami, Sanchita. And the article was included in Journal of Molecular Structure in 2017.Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

Guided by a pyridoxal derived Schiff base ligand, H₂PydChda 5-Hydroxymethyl-4-({2-[(5-hydroxymethyl-2-methylpyridin-3-hydroxy-4-ylethylene)amino]cyclohexylimino}-methyl)-2-methylpyridin-3-ol. a new copper(II) complex, [Cu(PydChda-2H⁺)]₂·4ClO₄·2H₂O was constructed and structurally characterized by single crystal x-ray diffraction study. DFT calculations further substantiate the exptl. features. Addnl., experiments were performed to demonstrate the accessibility to any enzymic activity and the complex provides pos. response for phosphatase activity towards 4-NPP substrate. CCDC 1445630. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aluminium(III) sensing by pyridoxal hydrazone utilising the chelation enhanced fluorescence effect was written by Kejik, Zdenek;Kaplanek, Robert;Havlik, Martin;Briza, Tomas;Vavrinova, Danuse;Dolensky, Bohumil;Martasek, Pavel;Kral, Vladimir. And the article was included in Journal of Luminescence in 2016.HPLC of Formula: 65-22-5 The following contents are mentioned in the article:

A chemosensor based on pyridoxal hydrazone was prepared in a two-step synthesis with a high yield. Chemosensor 1 exhibits high sensitivity and anti-disturbance for aluminum(III) ions among other biol. important metal ions. Aluminum(III) ion sensing was accomplished using a chelation enhanced fluorescence (CHEF) effect and photoinduced electron transfer (PET) inhibition. Chemosensor 1 shows a high association constant (1×10⁵ M^-1) towards aluminum(III) ions in DMSO-H₂O (9:1, volume/volume). The detection limit of the fluorescence response of chemosensor 1 for aluminum(III) ions is 6×10^-7 M. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5HPLC of Formula: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.HPLC of Formula: 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Helical water-soluble Ni^II complexes with pyridoxal ligand derivatives: Structural evaluation and interaction with biomacromolecules was written by Mainardi Martins, Francisco;Chaves, Otavio Augusto;Acunha, Thiago V.;Roman, Daiane;Iglesias, Bernardo Almeida;Back, Davi Fernando. And the article was included in Journal of Inorganic Biochemistry in 2021.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

This article deals with the synthesis of Schiff-based bis-azomethine-based ligands derived from pyridoxal and aliphatic dihydrazides (L1-L3) and the synthesis of Ni(II) complexes C1-C4. The synthesized complexes had their structures elucidated by monocrystal x-ray diffraction and were characterized by vibrational and absorption spectroscopy. The synthesized ligands have characteristics that gave self-assembly processes, thus, the flexibility or rigidity of the coordination of organic mols. added to the orbitals of the Ni^II cation gives helical complexes with double helix and a dinuclear Ni(II) complex. Also, compounds was their interactions with CT-DNA and HSA absorption and emission anal. and mol. docking calculations This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts