Category: 65-22-5

Synthesis, structural characterization and antioxidant activity of some vanadium(IV), Mo(VI)/(IV) and Ru(II) complexes of pyridoxal Schiff base derivatives was written by Elsayed, Shadia A.;Noufal, Aya M.;El-Hendawy, Ahmed M.. And the article was included in Journal of Molecular Structure in 2017.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

New complexes containing vanadium(IV), Mo(VI)/(IV) and Ru(II) derived from Schiff base of pyridoxal and S-benzyldithiocarbazate (H₂pysb) or p-toluidine (Hpytol) have been prepared The structures of the described compounds were elucidated by elemental analyses, spectroscopic techniques (IR, ¹H NMR, UV-Vis and EPR) magnetism, molar conductivity and thermal anal. measurements. Their redox behaviors were also studied by cyclic voltammetry. The ligand H₂pysb showed coordination to the metal ions in a dibasic tridenate manner through deprotonated phenolate oxygen, azomethine nitrogen and thiolate sulfur, while Hpytol behaved as monobasic bidentate through phenolate oxygen and azomethine nitrogen. The complexes were tested for their antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and the data obtained revealed that the scavenging activity of the complexes towards DPPH is high for the oxovanadium(IV) complexes with lower IC₅₀ values which are comparable to ascorbic acid as a standard antioxidant. The EC₅₀ concentration ratio together with other antioxidant parameters are also reported. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

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Alcohol – Wikipedia,
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Vitamin-B6 Schiff base dioxovanadium(V) complex for targeted visible light-induced anticancer activity was written by Kumar, Arun;Banerjee, Samya;Mukherjee, Sanjoy;Chakravarty, Akhil R.. And the article was included in Indian Journal of Chemistry in 2017.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

A dioxovanadium(V) complex of vitamin-B6 Schiff base [VO2L] (1) (where H2L·HCl is 3-hydroxy-5-(hydroxymethyl)-4-(((2-hydroxyphenyl)imino)methyl)-2-methylpyridin-1-ium chloride) has been prepared and structurally characterized. Its photo-induced cytotoxicity and mechanism of cell death has been studied. Single crystal X-ray structure shows five-coordinate square-pyramidal geometry of the complex having the dianionic O,N,O-donor tridentate vitamin-B6 Schiff base and two cis-oriented oxo ligands bound to V(V). DFT study shows the HOMO located on the amino-phenolic moiety, while the LUMO is on the protonated aromatic unit, i.e., the pyridiniumphenolate moiety. Vitamin-B6 transporting membrane carrier (VTC) pathway seems to be responsible for the higher cellular uptake and activity of the complex into the cervical HeLa and breast cancer MCF-7 cells in preference to the normal embryonic fibroblast 3T3 cells. The complex exhibits reactive oxygen species (ROS) mediated apoptotic photocytotoxicity in visible light of 400-700 nm in the cancer cells (IC50: ∼16μM), while being essentially non-toxic in the dark. Alk. Comet assay shows damage of the nuclear DNA. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Category: alcohols-buliding-blocks).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Category: alcohols-buliding-blocks

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A novel Schiff base derivative of pyridoxal for the optical sensing of Zn²⁺ and cysteine was written by Anand, Thangaraj;Kumar, Ashok S. K.;Sahoo, Suban K.. And the article was included in Photochemical & Photobiological Sciences in 2018.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

An easy to prepare novel vitamin B6 cofactor derivative 3-hydroxy-N’-((3 hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene)-2-naphthohydrazide (NPY) was synthesized by a one pot condensation reaction of pyridoxal with 3-hydroxy-2-naphthoic hydrazide and applied for the optical detection of Zn²⁺ and cysteine in the aqueous DMSO medium. The addition of Zn²⁺ ions leads to a selective blue-shift in the fluorescence emission spectrum of NPY from 530 nm to 475 nm, which allowed ratiometric detection of Zn²⁺ ions down to 8.73 × 10^-7 M without any interference from other tested metal ions. This system was also successfully applied to detect intracellular Zn²⁺ ions in live HeLa cells. Further, when the in situ generated NPY·Zn²⁺ complex was interacted with various amino acids, the addition of cysteine resulted in an instantaneous color change from light yellow to colorless and the absorbance at 435 nm of the complex was quenched selectively. Also, the fluorescence of the NPY·Zn²⁺ complex was quenched, which allowed the detection of cysteine down to 6.63 × 10^-7 M. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

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Alcohol – Wikipedia,
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Efficient Production of γ-GABA Using Recombinant E. coli Expressing Glutamate Decarboxylase (GAD) Derived from Eukaryote Saccharomyces cerevisiae was written by Xiong, Qiang;Xu, Zheng;Xu, Lu;Yao, Zhong;Li, Sha;Xu, Hong. And the article was included in Applied Biochemistry and Biotechnology in 2017.Recommanded Product: 65-22-5 The following contents are mentioned in the article:

γ-Aminobutyric acid (γ-GABA) is a non-proteinogenic amino acid, which acts as a major regulator in the central nervous system. Glutamate decarboxylase (namely GAD, EC 4.1.1.15) is known to be an ideal enzyme for γ-GABA production using L-glutamic acid as substrate. In this study, we cloned and expressed GAD gene from eukaryote Saccharomyces cerevisiae (ScGAD) in E. coli BL21(DE3). This enzyme was further purified and its optimal reaction temperature and pH were 37 °C and pH 4.2, resp. The cofactor of ScGAD was verified to be either pyridoxal 5′-phosphate (PLP) or pyridoxal hydrochloride. The optimal concentration of either cofactor was 50 mg/L. The optimal medium for E. coli-ScGAD cultivation and expression were 10 g/L lactose, 5 g/L glycerol, 20 g/L yeast extract, and 10 g/L sodium chloride, resulting in an activity of 55 U/mL medium, three times higher than that of using Luria-Bertani (LB) medium. The maximal concentration of γ-GABA was 245 g/L whereas L-glutamic acid was near completely converted. These findings provided us a good example for bio-production of γ-GABA using recombinant E. coli expressing a GAD enzyme derived from eukaryote. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Recommanded Product: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 65-22-5

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Alcohol – Wikipedia,
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Enhanced chemical sensing for Cu²⁺ based on composites of ZIF-8 with small molecules was written by Zhang, Jun;Zhao, Xiuyang;Liu, Xuefeng;Dong, Chuan. And the article was included in RSC Advances in 2020.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

Two organic mols., pyridoxal hydrazide (PAH) and salicylaldehyde based Rhodamine B hydrazone (RBS) were integrated into zeolitic imidazolate framework-8 (ZIF-8) to give composites, namely PAH/ZIF-8 and RBS/ZIF-8. The organic mols. and ZIF-8 are proposed to be assembled via hydrogen bonds and π-π stacking in the composites. The mass fraction of PAH and RBS in the composites was calculated to be 21.86% and 29.3%. The fluorescence of PAH/ZIF-8 is quenched regularly by Cu²⁺. The detection limit for Cu²⁺ was calculated to be 1.42 nM for PAH/ZIF-8, which is one order of magnitude lower than that of PAH. The detection limit for Cu²⁺ was determined to be 0.8 μM for RBS/ZIF-8, which is three times lower than that of RBS. The two composites both display high selectivity to Cu²⁺ over competing metal ions. The PAH/ZIF-8 fluorescent sensor was successfully applied to Cu²⁺ determination in environmental water. PAH/ZIF-8 exhibits excellent cell membrane permeability and low cytotoxicity in cellular imaging. The enhanced chem. sensor was designed by introducing small mols. into ZIF-8 for the specific recognition of Cu²⁺. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

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Alcohol – Wikipedia,
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Thiosemicarbazone ligand, nickel(II) and ruthenium(II) complexes based on vitamin B6 vitamer: The synthesis, different coordination behaviors and antioxidant activities was written by Bal-Demirci, Tulay;Guveli, Sukriye;Yesilyurt, Saffet;Ozdemir, Namik;Ulkuseven, Bahri. And the article was included in Inorganica Chimica Acta in 2020.Computed Properties of C8H10ClNO3 The following contents are mentioned in the article:

Mixed ligand nickel(II) and ruthenium(II) complexes were synthesized from pyridoxal-N-allyl-thiosemicarbazone hydrochloride and triphenylphosphine. The structures of the complexes were characterized by elemental anal., IR, ¹H and ³¹P NMR, conductivity, magnetic moment measurements and single-crystal x-ray diffraction technique. Based on x-ray crystallog. studies, a square-planar structure is proposed for the Ni(II) complex, in which the thiosemicarbazone ligand acts as dianionic tridentate ONS ligand. In the case of the Ru(II) complex, the thiosemicarbazone is coordinated to metal atom as a monoanionic bidentate NS donor ligand in an octahedral geometry. Antioxidant activities of the ligand and its metal complexes were calculated as their trolox equivalent antioxidant capacities (TEAC) by CUPRAC method and DPPH assay. Both the ligand and its metal complexes are antioxidant and are much more antioxidant at least 2.1 times than trolox, even, ligand is 3.5 times greater than that of trolox according to CUPRAC. A linear correlation (correlation coefficient R² = 0.9997) appeared between the obtained TEAC values by the two antioxidant assays. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Computed Properties of C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Computed Properties of C8H10ClNO3

Referemce:
Alcohol – Wikipedia,
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Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics was written by Hoegl, Annabelle;Nodwell, Matthew B.;Kirsch, Volker C.;Bach, Nina C.;Pfanzelt, Martin;Stahl, Matthias;Schneider, Sabine;Sieber, Stephan A.. And the article was included in Nature Chemistry in 2018.SDS of cas: 65-22-5 The following contents are mentioned in the article:

Pyridoxal phosphate (PLP) is an enzyme cofactor required for the chem. transformation of biol. amines in many central cellular processes. PLP-dependent enzymes (PLP-DEs) are ubiquitous and evolutionarily diverse, making their classification based on sequence homol. challenging. Here we present a chem. proteomic method for reporting on PLP-DEs using functionalized cofactor probes. We synthesized pyridoxal analogs modified at the 2′-position, which are taken up by cells and metabolized in situ. These pyridoxal analogs are phosphorylated to functional cofactor surrogates by cellular pyridoxal kinases and bind to PLP-DEs via an aldimine bond which can be rendered irreversible by NaBH₄ reduction Conjugation to a reporter tag enables the subsequent identification of PLP-DEs using quant., label-free mass spectrometry. Using these probes we accessed a significant portion of the Staphylococcus aureus PLP-DE proteome (73%) and annotate uncharacterized proteins as novel PLP-DEs. We also show that this approach can be used to study structural tolerance within PLP-DE active sites and to screen for off-targets of the PLP-DE inhibitor D-cycloserine. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5SDS of cas: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 65-22-5

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Alcohol – Wikipedia,
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Tin(IV) Schiff base complexes derived from pyridoxal: Synthesis, spectroscopic properties and cytotoxicity was written by Galvan-Hidalgo, Jose M.;Chans, Guillermo M.;Ramirez-Apan, Teresa;Nieto-Camacho, Antonio;Hernandez-Ortega, Simon;Gomez, Elizabeth. And the article was included in Applied Organometallic Chemistry in 2017.Product Details of 65-22-5 The following contents are mentioned in the article:

The synthesis of monomeric pentacoordinated diorganotin(IV) complexes derived from pyridoxal hydrochloride and 4- or 5-R-substituted ortho-aminophenols is described. The complexes were characterized using UV-visible, IR, mass, ¹H NMR, ¹³C NMR and ¹¹⁹Sn NMR spectral techniques. The mol. structure of three complexes was established using X-ray diffraction: two complexes show a distorted trigonal bipyramidal geometry, in which the basal plane is defined by the Bu groups and the iminic nitrogen atom, whereas the oxygen atoms from the aromatic ring occupy axial positions; in contrast, another complex exhibits a square pyramidal geometry. The cytotoxic activity of all complexes against human cell lines U-251 (glioblastoma), K-562 (chronic myelogenous leukemia), HCT-15 (human colorectal cancer), MCF-7 (human breast cancer) and SKLU-1 (non-small-cell lung cancer) was evaluated, and the inhibitory percentage values indicated higher activity than the reference standard, cisplatin. Acute toxicity studies were performed in vivo for the prepared complexes to determine the lethal medium dose (LD₅₀) after i.p. administration to mice. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Product Details of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Product Details of 65-22-5

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Alcohol – Wikipedia,
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Three-in-one type fluorescent sensor based on a pyrene pyridoxal cascade for the selective detection of Zn(II), hydrogen phosphate and cysteine was written by Upadhyay, Yachana;Anand, Thangaraj;Babu, Lavanya Thilak;Paira, Priyankar;Crisponi, Guido;S K, Ashok Kumar;Kumar, Rajender;Sahoo, Suban K.. And the article was included in Dalton Transactions in 2018.Product Details of 65-22-5 The following contents are mentioned in the article:

A novel fluorescent receptor L was synthesized by Schiff base condensation of 1-pyrenemethylamine with the vitamin B₆ cofactor pyridoxal. The receptor L is highly selective and sensitive towards Zn²⁺ ions among other tested metal ions. Upon interaction with Zn²⁺, the receptor L showed a distinct fluorescence enhancement at 485 nm due to the excimer formation leading to the fluorescent color change from blue to bluish-green. Subsequently, when the in situ generated ZnL₂ complex interacted with various anions and amino acids, the addition of H₂PO₄^– and cysteine reinstated the fluorescence of the receptor L due to the demetalation of Zn²⁺ from the ZnL₂ complex. Accordingly, the receptor L was developed for the highly selective, specific and sensitive detection of three important bioactive analytes, i.e., Zn²⁺, H₂PO₄^– and cysteine with a detection limit down to 2.3 × 10^-6 M, 2.18 × 10^-7 M and 1.59 × 10^-7 M, resp. Addnl., the receptor L was applied to the detection of intracellular Zn²⁺ ions in live HeLa cells. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Product Details of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Product Details of 65-22-5

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Alcohol – Wikipedia,
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A new pyridoxal based fluorescence chemo-sensor for detection of Zn(II) and its application in bio imaging was written by Mandal, Senjuti;Sikdar, Yeasin;Maiti, Dilip K.;Maiti, Guru Prasad;Mandal, Sushil Kumar;Biswas, Jayanta Kumar;Goswami, Sanchita. And the article was included in RSC Advances in 2015.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

This paper describes the activity of a Schiff base ligand, derived from pyridoxal, as a promising fluorescence probe for biol. important Zn(II) ion sensing. A physiol. compatible pyridoxal based chemosensor PydDmen was synthesized and evaluated for its fluorescent response towards metal ions. Chemosensor PydDmen exhibits a selective turn-on type response in the presence of Zn²⁺ in ethanol-water mixture The addition of EDTA quenches the fluorescence of receptor PydDmen-Zn²⁺, making the chemosensor PydDmen reversible. The response is specific for Zn(II) ions, and remains almost unaffected by the presence of alkali and alk. earth metals but is suppressed to varying degrees by transition metal ions. The selectivity mechanism of PydDmen for Zn²⁺ is the combined effects of proton transfer between the prevailing tautomeric forms, C=N isomerization and CHEF. The DFT optimized structure of the complex is compatible with elemental anal., mass spectrometry, FT-IR, electronic and NMR spectra. The exptl. and theor. support in terms of NMR spectroscopy and DFT are provided to establish the existence of Zn²⁺ induced transformation of PydDmen to a 3-pyridone tautomeric form. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts