Category: 65-22-5

A 1,8-naphthalimide-pyridoxal conjugate as a supramolecular gelator for colorimetric read out of F^– ions in solution, gel and solid states was written by Pati, Chiranjit;Ghosh, Kumaresh. And the article was included in New Journal of Chemistry in 2019.HPLC of Formula: 65-22-5 The following contents are mentioned in the article:

A naphthalimide-pyridoxal conjugate 1 has been designed and synthesized, to form a stable greenish yellow colored gel in DMSO : H₂O (8 : 1 volume/volume). Rheol. study reveals that the gel is mech. strong (G’> G”) over a wide range of applied strains. The morphol. of the gel as determined by FESEM shows a highly cross-linked fibrous network. The gel is anion-responsive and is selectively transformed into a sol with a color change from greenish yellow to deep blue only in the presence of F^– among other anions. In CH₃CN, the composition was also sensitive to basic anions such as F^– and AcO^– ions. In solution, F^– was differentiated from AcO^– through a color change. While the yellow colored solution in acetonitrile was changed into deep blue in the presence of F^–, AcO^– ions gave a faint blue coloration. A similar colorimetric differentiation of F^– from AcO^– has been possible in CH₃CN by a reusable Schiff base-linked Merrifield resin 1a or 1b. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5HPLC of Formula: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 65-22-5

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Eco-friendly and efficient synthesis, characterisation and antibacterial studies of unsymmetrical bidentate Schiff bases and their Zn(II) complexes was written by Srivastava, K. P.;Singh, Anuradha;Singh, Suresh Kumar. And the article was included in Oriental Journal of Chemistry in 2014.SDS of cas: 65-22-5 The following contents are mentioned in the article:

A rapid, efficient, clean and environmentally benign exclusive synthesis of Schiff bases as new ligands and their complexes with Zn(II) were developed using condensation of pyridoxal with amoxicillin, cephalexin, sulfamethoxazole and trimethoprim efficiently in an alc. suspension medium using alkali catalyst with excellent yields under microwaves irradiation This method provides several advantages such as environmental friendliness, simple work-up procedure, short reaction times, nonhazardous and excellent yield of products. The results are compared with conventional methods for their yield and reaction time. The Schiff base ligands and the complexes were characterized by micro-anal., thermo-gravimetric, magnetic and spectroscopic studies. All the Schiff bases were bidentate (NO donor) ligands. All complexes are six coordinate dihydrates and with 1:2 metal:ligand ratio. The complexes are colored and stable in air. All the complexes under study possess antibacterial activity. The antibacterial activity showed the following trend:. Zn(II)-complexes > Schiff base ligands > Parent drugs. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5SDS of cas: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.SDS of cas: 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Development of a chemically defined medium for studying foodborne bacterial-fungal interactions was written by Aunsbjerg, S. D.;Honore, A. H.;Vogensen, F. K.;Knoechel, S.. And the article was included in International Dairy Journal in 2015.Related Products of 65-22-5 The following contents are mentioned in the article:

There is a growing interest for using natural preservatives in the food and dairy industries including the application of bacterial cultures to inhibit fungal spoilage. Several antifungal metabolites from bacteria have been identified, but their relative importance has been difficult to establish. In dynamic systems such as fermented milk products, the complexity of the food matrix affects detection, identification and quantification of antifungal metabolites, and thereby the understanding of the bacterial-fungal interactions. To ease the identification and quantification of bacterial metabolites (as judged by ultra-performance liquid chromatog./mass spectrometry) a chem. defined interaction medium (CDIM) was developed. The medium supported growth of antifungal cultures such as Lactobacillus paracasei and Propionibacterium freudenreichii, as well as spoilage molds and yeasts isolated from fermented milk products. Both strong and weak antifungal interactions observed in milk could be reproduced in CDIM. The medium seems suitable for studying antifungal activity of bacterial cultures. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Related Products of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 65-22-5

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Experimental and Computational Investigations of 4-((E)-(2-Amino-5- Nitrophenylimino)Methyl)-5- (Hydroxymethyl)-2-Methylpyridin-3-Ol Schiff Base Derived from Vitamin B₆ was written by Beyramabadi, S. A.;Khashi, M.;Morsali, A.;Gharib, A.;Chegini, H.. And the article was included in Journal of Structural Chemistry in 2018.COA of Formula: C8H10ClNO3 The following contents are mentioned in the article:

An unsym. tridentate Schiff base 4-((E)-(2-amino-5-nitrophenylimino)methyl)-5-(hydroxymethyl)- 2-methylpyridin-3-ol is newly synthesized and characterized exptl. Its geometrical parameters, the assignment of IR bands and NMR chem. shifts are also computed by the d. functional theory method. In addition, the atoms in mols. (AIM) anal. is employed to investigate its geometry. Only one of the diamine-NH₂ groups undergoes the condensation reaction. In the structure of the synthesized Schiff base, the remaining amino group lies in the para position with respect to the nitro group (isomer 1). In both gas and solution phases, isomer 1 is more stable than isomer 2 with the meta orientation of the amino and nitro groups. The NMR chem. shifts and the AIM anal. show that isomer 1 is a more favorite structure for the synthesized Schiff base. It has no planar structure. The phenolic proton is engaged in the intramol. hydrogen bond with the azomethine nitrogen atom. The exptl. results are in good agreement with the theor. ones, confirming the validity of the optimized geometry. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5COA of Formula: C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C8H10ClNO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pyridoxal-based low molecular weight progelator as a new chemosensor for the recognition of Ag⁺ and Hg²⁺ under different conditions was written by Roy, Saswati Ghosh;Kumar, Abhishek;Misra, Neeraj;Ghosh, Kumaresh. And the article was included in Materials Advances in 2022.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

Pyridoxal-based low mol. weight progelator 1 has been designed and synthesized for the selective visual detection of Ag⁺ ions through sol-to-gel conversion. Compound 1 shows excellent gelation property with desired gel stiffness only in the presence of Ag⁺ ions over a series of other metal ions in 1 : 1 (volume/volume) aqueous solvent system miscible with organic solvents such as DMSO, DMF, and dioxane, and validates the visual detection of Ag⁺ ions. The gel properties were studied by FTIR, UV-Vis, SEM (SEM), and rheol. measurements. Min. gelation concentration was found to be 3 mg mL^-1. While Ag⁺-induced metallogel in DMSO/H₂O is thermally reversible, it is irreversible in the DMF/H₂O system. The model compound 2, devoid of hydroxyl groups, did not show gelation under identical conditions and established the role of pyridoxal moiety in 1. In addition, compound 1 exhibits the selective sensing of Hg²⁺ ions over a series of metal ions in the solution phase, as established by UV-Vis, fluorescence, and ¹H NMR studies. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis, x-ray crystal structures, spectroscopic and electrochemical studies of Zn(II), Cd(II), Ni(II) and Mn(II) complexes of N¹,N⁴-bis(pyridoxylidene)triethylenetetramine was written by Mondal, Satyajit;Adak, Piyali;Das, Chandrima;Naskar, Sumita;Pakhira, Bholanath;Rheingold, Arnold L.;Sinn, Ekkehard;Eribal, Carla Sue;Chattopadhyay, Shyamal Kumar. And the article was included in Polyhedron in 2014.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

Zn(II), Cd(II), Ni(II) and Mn(II) complexes of a new hexadentate ligand N¹,N⁴-bis(pyridoxylidene)triethylenetetramine were synthesized. X-ray crystal structures show that in all the complexes the metal:ligand stoichiometry is 1:1 and the ligand coordinates in a di-deprotonated hexadentate manner through two phenolate oxygens, two imine nitrogens and two secondary amine N atoms. Fluorescence spectroscopy shows that the ligand centered emission undergoes 3-fold enhancement of intensity on complexation with Zn(II) ion, whereas it is quenched or remains unaffected in presence of various biol. relevant divalent metal ions. The Zn(II) specific fluorescence enhancement indicates that the ligand may be used as a fluorogenic sensor for Zn(II) in biol. systems, with a sensitivity of detection of 10^-8 M. The electronic structures of the ligand as well as the complexes and their UV-visible absorption spectra are explained on the basis of DFT and TD-DFT calculations, resp. Covalence of the metal ligand bond follows the order Ni(II) >>> Mn(II) > Zn(II) ≈ Cd(II). This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis, structure and SOD activity of Mn complexes with symmetric Schiff base ligands derived from pyridoxal was written by Signorella, Sandra;Daier, Veronica;Ledesma, Gabriela;Palopoli, Claudia;Back, Davi Fernando;Lang, Ernesto S.;Kopp, Cristieli Rossini;Ebani, Patricia;Pereira, Mateus Brum;Giacomelli, Cristiano;Piquini, Paulo Cesar. And the article was included in Polyhedron in 2015.Synthetic Route of C8H10ClNO3 The following contents are mentioned in the article:

This study describes the synthesis, crystal structure and antioxidant activity of Mn(III) complexes with Schiff-base ligands obtained from condensation of pyridoxal with alkyl diamines: [Mn(pyr₂en)(H₂O)₂]Cl·4H₂O, [Mn(pyr₂en)(H₂O)(MeOH)]Cl, [Mn(pyr₂pn)(H₂O)₂]ClO₄ and [Mn₂(pyr₂bn)₃]·4H₂O, where H₂pyr₂en = 1,2-bis(pyridoxylidenamino)ethane, H₂pyr₂pn = 1,3-bis(pyridoxylidenamino)propane and H₂pyr₂bn = 1,4-bis(pyridoxylidenamino)butane. The four complexes catalyze the dismutation of superoxide efficiently with IC₅₀ values at 1.22-2.15 μM, evaluated through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. The length of the alkyl spacer in the diamine fragment plays a key role in the antioxidant activity of these complexes, with [Mn(pyr₂pn)(H₂O)₂]ClO₄ showing the lowest IC₅₀ value. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Synthetic Route of C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C8H10ClNO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cobalt complexes containing salen-type pyridoxal ligand and DMSO for cycloaddition of carbon dioxide to propylene oxide was written by Hwang, Saem;Ryu, Ji Yeon;Jung, Sung Hoo;Park, Hyoung-Ryun;Lee, Junseong. And the article was included in Polyhedron in 2020.Formula: C8H10ClNO3 The following contents are mentioned in the article:

Cobalt complexes containing a salen-type pyridoxal ligand with pyridine were synthesized as a new Co(III) catalytic system for the cycloaddition of carbon dioxide. Two cobalt(III) complexes possessing a salen-type pyridoxyl ligand were synthesized by the reaction of pyridoxal ligands (pyr₂en = (N,N’-bis(pyridoxylideneiminato)ethylene) and pyr₂cy = (N,N’-bis(pyridoxylideneiminato)cyclohexane)) and Co(OAc)₂ and characterized by various anal. methods, including IR spectroscopy and high-resolution mass anal. Single-crystal X-ray crystallog. anal. confirmed that the cobalt pyr₂en complex had a distorted octahedral structure: the tetradentate Schiff base ligand binds the cobalt metal in one plane, and the metal center adopts an octahedral geometry by the addnl. coordination of acetate and DMSO. The synthesized complexes were used as catalysts in the cycloaddition of carbon dioxide (CO₂) to propylene oxide. The catalysts showed high activity for cycloaddition between CO₂ and epoxides, even at a low loading (0.5 mol%), in the presence of various cocatalysts. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Formula: C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C8H10ClNO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Peroxidase activity of new mixed-valence cobalt complexes with ligands derived from pyridoxal was written by Fontana, Liniquer Andre;Siqueira, Josieli Demetrio;Ceolin, Joice;Iglesias, Bernardo Almeida;Piquini, Paulo Cesar;Neves, Ademir;Back, Davi Fernando. And the article was included in Applied Organometallic Chemistry in 2019.Computed Properties of C8H10ClNO3 The following contents are mentioned in the article:

New mixed-valence cobalt complexes with ligands derived from pyridoxal were synthesized and characterized, and their application as mimetics of the peroxidase enzyme was investigated. Single-crystal x-ray diffraction was used to analyze all complex structures in the solid state and their electrochem. behavior was investigated. A reactivity pattern was observed in the complex synthesis regarding the cobalt compounds from which analogous zwitterionic derivatives were obtained. The importance of these compounds lies in understanding their behavior in an oxidizing environment and evaluating whether they can activate hydrogen peroxide to oxidize phenolic compounds In nature, enzymes called peroxidases, which efficiently oxidize phenolic compounds, trigger many reactions involving the activation of hydrogen peroxide to oxidize organic substrates. However, these enzymes present several disadvantages, including denaturation and elevated costs. Therefore, these limitations can be overcome by expanding research into the study of synthetic catalysts for the oxidation of phenolic compounds using hydrogen peroxide, which is a highly relevant field of bioinorganic chem. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Computed Properties of C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Computed Properties of C8H10ClNO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Organotin(IV) complexes with ONS donor Schiff base ligand: synthesis, characterization and antimicrobial evaluation was written by Batra, Nisha;Malhotra, Nidhi;Assija, Sonika. And the article was included in Journal of Chemical and Pharmaceutical Research in 2014.Related Products of 65-22-5 The following contents are mentioned in the article:

Organotin(IV) complexes [R₂SnL¹, R₂SnL²; R = Me, Et, Bu and Ph] have been synthesized by reaction of diorganodichlorotin(IV) with biol. potent Schiff base ligands 5-hydroxymethyl-4-[2-mercapto-phenylimino-methyl]-2-methyl-pyridin-3-ol H₂L¹, 4-[5-chloro-2-mercapto-phenylimino-methyl]-5-hydroxymethyl-2-methylpyridin-3-ol H₂L² derived from pyridoxal hydrochloride with 2-aminothiophenol and 2-amino-4-chlorothiophenol resp. The geometry of these compounds has been proposed on basis of elemental analyses, molar conductance and spectroscopic techniques IR, electronic, ¹H, ¹³C and ¹¹⁹Sn NMR. On the basis of these studies it revealed that Schiff base ligands acted as ONS donor system and coordinated to tin atom in tridentate fashion with trigonal pyramidal geometry around tin atom. To compare the biopotency of these complexes, Schiff base ligands and their complexes were also tested for in vitro antimicrobial evaluation against some pathogenic fungi and bacteria. Enrichment was observed in biol. activity of ligands on coordination with tin atom. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Related Products of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts