Category: 65-22-5

Effect of double substitution in cationic chitosan derivatives on dna transfection efficiency was written by Badazhkova, Veronika D.;Raik, Sergei V.;Polyakov, Dmitry S.;Poshina, Daria N.;Skorik, Yury A.. And the article was included in Polymers (Basel, Switzerland) in 2020.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

In this work, chitosan was chem. modified by a reaction with 4-formyl-N,N,N-trimethylanilinium iodide and pyridoxal hydrochloride and subsequent reduction of the imine bond with NaBH4. This reaction yielded three novel derivatives, N-[4-(N ‘,N’,N’-trimethylammonium)benzyl]chitosan chloride (TMAB-CS), N-[(3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridine)methyl]chitosan chloride (Pyr-CS), and N-[4-(N’,N’,N”-trimethylammonium)benzyl]-N-[(3-hydroxy-5-(hydroxymethyl)-2-methyl-4- pyridine)methyl]chitosan chloride (PyrTMAB-CS). Their structures and degrees of substitution were established by 1H NMR spectroscopy as DS1 = 0.22 for TMAB-CS, DS2 = 0.28 for Pyr-CS, and DS1 = 0.21, DS2 = 0.22 for PyrTMAB-CS. Dynamic light scattering measurements revealed that the new polymers formed stable polyplexes with plasmid DNA encoding the green fluorescent protein (pEGFP-N3) and that the particles had the smallest size (110-165 nm) when the polymer:DNA mass ratio was higher than 5:1. Transfection experiments carried out in the HEK293 cell line using the polymer:DNA polyplexes demonstrated that Pyr-CS was a rather poor transfection agent at polymer:DNA mass ratios less than 10:1, but it was still more effective than the TMAB-CS and PyrTMAB-CS derivatives that contained a quaternary ammonium group. Overall, the results show the possibility of combining substituent effects in a single carrier, thereby increasing its efficacy. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

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Alcohol – Wikipedia,
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Selective blocking of primary amines in branched polyethylenimine with biocompatible ligand alleviates cytotoxicity and augments gene delivery efficacy in mammalian cells was written by Tripathi, Sushil K.;Gupta, Niharika;Mahato, Manohar;Gupta, Kailash C.;Kumar, Pradeep. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2014.Reference of 65-22-5 The following contents are mentioned in the article:

Recently, polyethylenimines (PEIs) have emerged as efficient vectors for nucleic acids delivery. However, inherent cytotoxicity has limited their in vivo applications. To address this concern as well as to incorporate hydrophobic domains for improving interactions with the lipid bilayers in the cell membranes, we have tethered varying amounts of amphiphilic pyridoxyl moieties onto bPEI to generate a small series of pyridoxyl-PEI (PyP) polymers. Spectroscopic characterization confirms the formation of PyP polymers, which subsequently form stable complexes with pDNA in nanometric range with pos. surface charge. The projected modification not only accounts for a decrease in the d. of 1° amines but also allows formation of relatively loose complexes with pDNA (cf. bPEI). Alleviation of the cytotoxicity, efficient interaction with cell membranes and easy disassembly of the pDNA complexes have led to the remarkable enhancement in the transfection efficiency of PyP/pDNA complexes in mammalian cells with one of the formulations, PyP-3/pDNA complex, showing transfection in ∼68% cells compared to ∼16% cells by Lipofectamine/pDNA complex. Further, the efficacy of PyP-3 vector has been established by delivering GFP-specific siRNA resulting in ∼88% suppression of the target gene expression. These results demonstrate the efficacy of the projected carriers that can be used in future gene therapy applications. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Reference of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Reference of 65-22-5

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cu(II) complexes of a bio-compatible aminoguanidine Schiff base: Histidine sensing and DNA-binding studies was written by Chakraborty, Moumita;Mohanty, Monalisa;Dinda, Rupam;Sengupta, Swaraj;Kumar Chattopadhyay, Shyamal. And the article was included in Polyhedron in 2022.Application of 65-22-5 The following contents are mentioned in the article:

Two Cu(II) complexes of pyridoxal-aminoguanidine Schiff base ligand with formula [Cu(HL)Cl]₂(OAc)₂·4H₂O (1) and [Cu(HL)Cl(NCS)].H₂O (2) are reported. The ligand and the complexes were characterized by their elemental analyses, ESI-MS, Uv-Vis, IR spectroscopy and cyclic voltammetric measurements. Single crystal structures of complex 1 and 2 were solved by X-ray diffraction. In both the Cu(II) complexes Cu(II) ions are in a square pyramidal geometry having geometry index (τ) value of 0.11 for complex 1 and 0.15 for complex 2. Both the complexes bind to calf-thymus DNA with binding constant comparable to ethidium bromide. CD studies revealed an intercalative mode of binding for both the complexes. In addition, the complexes also show promising cleavage of pUC19 supercoiled plasmid DNA with 1 showing the highest cleavage activity of ∼ 99%. In addition, both the complexes selectively recognize L-histidine amino acid. The low detection limit values (0.085μM and 0.19μM for complexes 1 and 2, resp.) ascertain the making of an efficient L-histidine biosensor. The absorption, emission and mass spectral results establish the formation of Cu(His)₂ complex, with liberation of the fluorescent free ligand as the mechanism of sensing. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application of 65-22-5

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Alcohol – Wikipedia,
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Design, synthesis and biological evaluation of novel thiosemicarbazone-indole derivatives targeting prostate cancer cells was written by He, Zhang-Xu;Huo, Jin-Ling;Gong, Yun-Peng;An, Qi;Zhang, Xin;Qiao, Hui;Yang, Fei-Fei;Zhang, Xin-Hui;Jiao, Le-Min;Liu, Hong-Min;Ma, Li-Ying;Zhao, Wen. And the article was included in European Journal of Medicinal Chemistry in 2021.Electric Literature of C8H10ClNO3 The following contents are mentioned in the article:

To discover novel anticancer agents with potent and low toxicity, a range of new thiosemicarbazone-indole analogs I [R = H, Me, Cl, OMe; R¹ = H, Me, R² = H, Me, OH, etc.; R³ = H, Me; X = N, C] based on lead compound II were designed and synthesized previously. Most compounds displayed moderate to high anticancer activities against five tested tumor cells (PC3, EC109, DU-145, MGC803, MCF-7). Specifically, the represented compound I [R = H, R¹ = Me; R² = Me, R³ = H] (III) possessed strong antiproliferative potency and high selectivity toward PC3 cells with the IC₅₀ value of 0.054μM, compared with normal WPMY-1 cells with the IC₅₀ value of 19.470μM. Preliminary mechanism research indicated that compound (III) could significantly suppress prostate cancer cells (PC3, DU-145) growth and colony formation in a dose-dependent manner. Besides, derivative (III) induced G1/S cycle arrest and apoptosis, which may be related to ROS accumulation due to the activation of MAPK signaling pathway. Furthermore, mol. (III) could effectively inhibit tumor growth through a xenograft model bearing PC3 cells and had no evident toxicity in vivo. Overall, based on the biol. activity evaluation, analog (III) can be viewed as a potential lead compound for further development of novel anti-prostate cancer drug. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Electric Literature of C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Electric Literature of C8H10ClNO3

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis, characterization and antimicrobial activity of copper(II) complexes with hydrazone derived from 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde was written by Mezey, Reka-Stefana;Mathe, Istvan;Shova, Sergiu;Grecu, Maria-Nicoleta;Rosu, Tudor. And the article was included in Polyhedron in 2015.Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

Pyridoxal isonicotinoyl hydrazone (HL) and its copper(II) complexes: [CuLCl(H₂O)₂] (1), [CuL(OAc)](H₂O) (2), [CuL(OAcac)] (3), [CuL(NO₃)](H₂O) (4), [CuL₂](H₂O) (5) were synthesized and characterized. The ligand was obtained by condensation of 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde (pyridoxal) hydrochloride with isonicotinoyl hydrazide. The characterization of the formed compounds was done by ¹H NMR, ¹³C NMR, UV-visible, IR and EPR spectroscopy as well by thermal studies and elemental anal. The crystal structure of HL was determined by single crystal x-ray diffraction studies. The microbiol. effect of the ligand and all five complexes against both Gram-pos. and Gram-neg. strains, Staphylococcus aureus ATTC 6538, Bacillus cereus ATCC 14579, Escherichia coli W3110 and Pseudomonas aeruginosa ATCC 9027 was tested. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Novel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer’s disease was written by Palanimuthu, Duraippandi;Wu, Zhixuan;Jansson, Patric J.;Braidy, Nady;Bernhardt, Paul V.;Richardson, Des R.;Kalinowski, Danuta S.. And the article was included in Dalton Transactions in 2018.COA of Formula: C8H10ClNO3 The following contents are mentioned in the article:

Alzheimer’s disease (AD) is characterized by multiple pathol. hallmarks, including β-amyloid aggregation, oxidative stress, and metal dys-homeostasis. In the absence of treatments addressing its multi-factorial pathol., the authors designed novel multifunctional adamantane-based semicarbazones and hydrazones (1-12) targeting AD hallmarks. Of these, 2-pyridinecarboxaldehyde (N-adamantan-1-yl)benzoyl-4-amidohydrazone (10) was identified as the lead compound, which demonstrated: pronounced iron chelation efficacy; attenuation of Cu^II-mediated β-amyloid aggregation; low cytotoxicity; inhibition of oxidative stress; and favorable characteristics for effective blood-brain barrier permeation. Structure-activity relationships revealed that pyridine-derived hydrazones represent a promising pharmacophore for future design strategies due to their ability to bind critical Fe^II pools. Collectively, the unique multifunctional activity of these agents provides a novel therapeutic strategy for AD treatment. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5COA of Formula: C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C8H10ClNO3

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pyridoxal derivatized copper(II) complexes: Evaluation of antioxidant, catecholase, and DNA cleavage activity was written by Pereira, Mateus Brum;Fontana, Liniquer Andre;Siqueira, Josieli Demetrio;Auras, Bruna L.;da Silva, Marcos P.;Neves, Ademir;Gabriel, Philipe;Terenzi, Hernan;Iglesias, Bernardo Almeida;Back, Davi Fernando. And the article was included in Inorganica Chimica Acta in 2018.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

This manuscript describes the synthesis, characterization and structural anal. of Cu(II) complexes with pyridoxal-type bidentate ligands, obtained from the condensation between pyridoxal and ortho-halogenated substituted anilines (C1–C5). Complexes C1, C2 and C5 were measured by x-ray single crystal anal. which showed classic and trifurcated H bonds and interaction as a sigma-hole between the O atoms of the iodine ligand derivative in the C5. All compounds were tested as mimetics of superoxide dismutase (SOD), through NBT photoreduction method in aqueous solution of pH 7.8, but the complex C5 showed an expressive IC₅₀ of 0.4 μM. Catecholase-like activity of C1–C5 in the presence of substrate 3,5-di-tert-butylcatechol and cleavage of plasmid DNA were also evaluated. Again, the best results were associated with the complex C5 containing I in the ortho position. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

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Alcohol – Wikipedia,
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Kinetics and Mechanism of the Interaction and Transaldimination of Products of Condensation of Pyridoxal Hydrochloride with L-α-, D-α-, and β-Alanines was written by Pishchugin, F. V.;Tuleberdiev, I. T.. And the article was included in Russian Journal of Physical Chemistry A in 2021.Recommanded Product: 65-22-5 The following contents are mentioned in the article:

The kinetics and mechanism of the condensation and transaldimination of products of pyridoxal condensation with L-α-, D-α-, and β-alanines are studied via UV spectroscopy and polarimetry. It is found that pyridoxal hydrochloride interacts stereospecifically with L-α- and D-α-alanines, accompanied by the formation of intermediate products with a strictly defined structure that promote the elimination of hydrogen atoms (with L-α-alanine) or CO2 (with D-α-alanine) and the subsequent formation of a quinoid structure whose hydrolysis yields the final products. The reactions of transaldimination between pyridoxalidene-β-alanine, pyridoxalidene-L-α-, pyridoxalidene-D-α-alanines, and L-α- and D-α-alanines are studied. It is shown that transaldimination proceeds in two stages: the addition of L-α- and D-α-amino acids to Schiff bases with the formation of N-acetals of a strictly defined structure, and the cleavage of one of the amino acids with the formation of new Schiff bases. Schemes are proposed for the mechanisms of the studied reactions. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Recommanded Product: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis, characterization and phosphatase inhibitory activity of dioxidovanadium(V) complexes with Schiff base ligands derived from pyridoxal and resorcinol was written by Siqueira, Josieli D.;Menegatti, Angela C. O.;Terenzi, Hernan;Pereira, Mateus B.;Roman, Daiane;Rosso, Eduardo F.;Piquini, Paulo C.;Iglesias, Bernardo A.;Back, Davi F.. And the article was included in Polyhedron in 2017.Reference of 65-22-5 The following contents are mentioned in the article:

In this manuscript, we report the synthesis of dioxidovanadium(V) complexes, their identification by spectroscopic and electrochem. methods, the structural characterization by X-ray diffraction and d. functional theory calculations, as well as their in vitro inhibitory activity of protein tyrosine phosphatases (PTPs). The structural anal. revealed the formation of dianionic complexes with [VO₂]²⁺ species in compounds 1, [VO₂(L¹)]₂[Et₃NH]₂ and 2, [VO₂]₂(L²)[(DBU-H)]₂ (H₂L¹ = 2,4-(dihydroxyphenyl)ethylidene)benzohydrazide and H₄L² = bis[(3-hydroxy-5-(hydroxymethyl)-2methylpyridin-4-yl)methylene]oxalohydrazide. The mol. frontier orbitals of dioxidovanadium(V) complexes are characterized and compared. Furthermore, the enzymic experiments revealed that complex 1 inhibited at least two of the PTPs evaluated with potent activity (IC₅₀ = 1.5 μM). This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Reference of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Spectrophotometric, potentiometric, and conductometric studies of binary complex formation between copper(II) and three forms of vitamin B₆ in aqueous solutions was written by Chylewska, Agnieszka;Ogryzek, Malgorzata;Chmurzynski, Lech;Makowski, Mariusz. And the article was included in Journal of Coordination Chemistry in 2015.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

This article reports the detailed study concerning the mode of binding of three forms of vitamin B₆, pyridoxamine (pm), pyridoxine (pn), and pyridoxal (pl), with Cu(II) in aqueous solutions using three independent methods: potentiometry, conductometry, and UV-vis spectroscopy. The stability constants of complexes formed between copper(II) and vitamin B₆ were investigated by potentiometric titration in 0.1 M KNO₃ ionic medium at 25 °C. While drawing the relations between molar conductance and the ratio of metal to ligand concentrations, different types of lines were obtained indicating the formation of 1:1 and 1:2 stoichiometric compounds The stability constants have been determined using EQUID and CVEQUID computer programs and the obtained results were in agreement. The relatively high values of stability constants of Cu(II)-vitamin B₆ complexes obtained from three independent methods in comparison to those with other competing cations suggest that the complexes studied are relatively stable in aqueous solutions This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts