Category: 647-42-7

Related Products of 647-42-7 , The common heterocyclic compound, 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a stirred solution of the corresponding thiazoline 4a-c (2.0 mmol) in dry CH2Cl2 (8 mL) under N2 atmosphere at room temperature, were added subsequently the corresponding alcohol (2.0 mmol) EDCI (2.0 mmol) and catalytic amount of DMAP. After 16 h, the organic phase was transferred to an extraction funnel, washed with saturated NaHCO3 (2 × 10 mL), water (2 × 10 mL) and the organic layer was dried with Na2SO4. The solvent was evaporated and the remaining product was purified by chromatography (hexanes/AcOEt = 80:20).

The synthetic route of 647-42-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Schneider, Juliana M. F. M.; Sales, Eric S.; Livotto, Paolo R.; Schneider, Paulo H.; Merlo, Aloir A.; Journal of the Brazilian Chemical Society; vol. 25; 8; (2014); p. 1493 – 1503;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, molecular weight is 364.1, as common compound, the synthetic route is as follows.HPLC of Formula: C8H5F13O

Weigh 2.2 g of succinic anhydride in a 250 ml dry anhydrous three-necked flask.After filling with nitrogen for 10 min, the air in the flask and a small amount of water in the reaction system were replaced.80 ml of anhydrous ethylene glycol dimethyl ether was added to the reaction system.After pyridine 0.15ml, the temperature was raised to 75 C, 7.28 g of trifluoro-n-octanol and 40 ml of ethylene glycol dimethyl ether were gradually added dropwise to the reaction system, and the addition process was carried out to ensure that the temperature of the reaction system was controlled at 65-75 C, and the addition was completed. Rear,The reaction was maintained at 75 C for 18 h, and the reaction was stopped after 18 h.After the reaction, a certain amount of saturated NaHCO3 was added to the reaction system, and the succinic acid monoester acid was converted into a sodium salt dissolved in water. Then, a certain amount of ethyl acetate is poured into the reaction system, and unreacted fluoroalcohol, succinic anhydride and the reaction to form a succinic acid diester are dissolved in the organic phase, and the monoester acid is dissolved in the aqueous phase, and the aqueous phase is separated.The obtained aqueous phase is placed in an ice water bath, acidified with concentrated hydrochloric acid, and extracted with a certain amount of ethyl acetate, and the extract is dried with a certain amount of anhydrous magnesium sulfate.Distillation under reduced pressure gave a purer succinic acid monoester acid. The synthetic route is as follows:

At the same time, in my other blogs, there are other synthetic methods of this type of compound,647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Han Tuo Optical Materials Co., Ltd.; Fu Zhiwei; Song Hongbo; Dai Junyan; Ran Ruicheng; Mao Guoping; (23 pag.)CN108997182; (2018); A;,
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Reference of 647-42-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctane-1-ol (20 g,55 mmol) and triphenylphosphine (15.7 g, 60 mmol) were dissolved in 110 ml of anhydrous acetonitrile and deoxygenated with argon. The mixture was heated at 60 C and bromine (9.6 g,60 mmol) was added dropwise. The mixture was stirred for 5 h at this temperature. After cooling down to room temperature, the reaction mixture was extracted with diethyl ether and the ether layers were washed with brine. After drying with Na2SO4, the ether was evaporated and the crude product was dissolved in 100 ml of dichloromethane. This solution was stirred with 50 g of silica gel for 2 h and then filtered and evaporated. The crude product was distilled at reduced pressure.

According to the analysis of related databases, 647-42-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Luka?, Milo?; Garajova, Maria; Mrva, Martin; Devinsky, Ferdinand; Ondriska, Franti?ek; Kubincova, Janka; Journal of Fluorine Chemistry; vol. 164; (2014); p. 10 – 17;,
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Synthetic Route of 647-42-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

C6F13-CH2CH2-O-CH2CH=CH2197.11g (488mmol) was dropped in 2 hours. It agitated at 110 degrees C after the end of dropping for 2 hours. Then, it lowered to 70 degrees C. NaOH solution 25.07g was added 0.1%, and it stirred for 2 hours. drying in 60 degrees C / 5KPa — after the end of drying, and the temperature — cull — bora — fin 3(made in Japanese Emba Illo Kem Carzou)2.51g was added, and it stirred for 2 hours. It filtered with the 0.1micrometer PTFE membrane filter, steam distillation of the filtrate was carried out using 100 degrees C / 5KPa, and the water 62.5g, and 206.3 g of object compounds (compound B1) were obtained (89% of yield).

According to the analysis of related databases, 647-42-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KAO CORPORATION; WATARAI, ETSUKO; IGARASHI, TAKANORI; YAGO, YUKO; UEHARA, KOICHI; (20 pag.)JP2017/25048; (2017); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks

To a mixture, kept under stirring, of C6F13CH2CH2OH(252 g, 0.692 moles), tetrahydrofurane (350 ml) and cyclohexane (300 ml) at 250C, an aqueous solution ofNaOH (400 ml, 50%) was added drop-wise. After stirring for 2 hours, benzyltriethyl ammonium chloride (25 g, 0.11 moles) as phase transfer catalyst, and then 1- bromopentane (209 g, 1.38 moles) were added. The reaction mixture was kept under stirring at 400C for 40 hours, then at 700C for 8 hours. The resulting mixture was poured into water and the organic phase thus ob- tained was washed two times with water. After removing the fraction having a low boiling point, the raw product was subjected to distillation at reduced pressure, thus obtaining 215 g of C6F13CH2CH2O (CH2) 4CH3 (yield 72%, boiling point 110C/6 mbar, n 1.3385) . Spectrographic data confirm the obtained structure: GC/MS m/z at 435 (M+H)+, 377 (M-CH2CH2CH2CH3) +, 71 (- CH2CH2CH2CH2CH3) + ; for NMR data see Tables 1-2.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol.

Reference:
Patent; ALChiMI.A. S.r.l.; WO2009/133575; (2009); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, molecular weight is 364.1, as common compound, the synthetic route is as follows.Computed Properties of C8H5F13O

The same fluoroalkyloxy alkanes as in Examples 1- 4 were prepared following an alternative procedure. A mixture comprising 0.1 moles of fluorinated alcohol, 60 ml of N-methyl-2-pyrrolidone, 0.2 moles of 1- bromoalkane, and 60 ml of a 45% aqueous solution of KOH was heated under stirring for 5 hours at 500C, then at 700C for 2 hours so as to complete the reac- tion. The raw reaction mixture was filtered so as to remove the formed KBr, and then diluted in 20 ml of water; the organic phase thus obtained comprised the desired fluoroalkyloxy alkane (yield: 80%) .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; ALChiMI.A. S.r.l.; WO2009/133575; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol

(3) In a 4-liter reactor equipped with electromagnetic stirring, a rectification column, a thermometer, a constant pressure dropping funnel, a separator, a condenser, etc., 2500 g of an intermediate product obtained by (2) (6.05 mol of a fluorine-containing alcohol) is added. 20 g of p-toluenesulfonic acid and 13 g of hydroquinone. StirThe temperature was raised to 90 C, and 413 g (5.74 mol) of acrylic acid was added dropwise thereto for 2 hours.At the end of the reaction, no significant water droplets were produced after 5 hours of continuous reaction.The fluorine-containing olefin and the unreacted fluoroalcohol are distilled off.Refining 2133 g of perfluorohexylethyl acrylate, the purity is 99.02%,The yield was 88.8%.

With the rapid development of chemical substances, we look forward to future research findings about 647-42-7.

Reference:
Patent; Jinan Qifu New Materials Co., Ltd.; Shandong Chemical Institute; Li Haijing; Zhang Liting; (6 pag.)CN108911983; (2018); A;,
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Electric Literature of 647-42-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, molecular weight is 364.1, as common compound, the synthetic route is as follows.

Toluene (2 L), 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctane-1-ol (2.18 kg, 6.0 mol), 2-methyl-2-propenic acid (methacrylic acid) (567 g, 6.6 mol) and 1,4-dihydroxybenzene (hydroquinone) (6.59 g, 60 mmol) were added and then p-toluenesulfonic acid monohydrate (148.06 g, 0.78 mol) was added thereto. The obtained solution was heated and subjected to reflux dehydration at 115 C. for 5 hours. After reflux dehydration, the obtained reaction solution was cooled to around room temperature and added with triethylamine (151.5 g, 1.50 mol) was added thereto, stirred for 0.5 hours and then added with 150 g of silica gel. After stirring for 0.5 hours, the silica gel was filtered off and the obtained filtrate was added with 1,4-dihydroxybenzene (hydroquinone) (1.32 g, 12.0 mmol), and the solvent was removed in vacuum distillation and then was purified in distillation to obtain 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctane 2-methyl-2-propenic acid ester (2.44 kg, 94%).

The chemical industry reduces the impact on the environment during synthesis 647-42-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; WAKO PURE CHEMICAL INDUSTRIES, LTD.; US2010/324314; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol. A new synthetic method of this compound is introduced below., Safety of 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol

To a solution of the perfluoroalkyl alcohol (10 mmol) in 10 mLof dry THF, was added sodium hydride (60% 1.4 equiv. dissolved in 2 mL of dry THF in oil) at 0 C under nitrogen atmosphere. The mixture was stirred for 30 min. Then 1.35 g (10 mmol) of henylisothiocyanate was added. The reaction mixture was allowed to warm to room temperature and stirred for 3 h. The mixture was quenched with saturated aqueous ammonium chloride. The aqueous layer was washed with diethyl ether and the combined organic layers were dried over Na2SO4. The solvent was removed by vacuum evaporation and the crude products were purified with column chromatography on silica gel (70-230 meshes) using petroleum ether/diethyl ether (8:2) as eluent or recrystallized in cyclohexane to give the corresponding O-perfluoroalkyl thiocarbamate.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol.

Reference:
Article; Chniti, Ines; Sanhoury; Chehidi; Journal of Fluorine Chemistry; vol. 156; (2013); p. 101 – 105;,
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Electric Literature of 647-42-7, Adding some certain compound to certain chemical reactions, such as: 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol,molecular formula is C8H5F13O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 647-42-7.

To a mixture of 2-(perfluorohexyl)ethanol (33.3 g, 46 mmol) and succinic anhydride (9.7 g, 49 mmol) and 10ml tetrahydrofuranand stirred at 100C And allowed to react for 60 minutes.Thereafter, the mixture was cooled to 30 DEG C, 100 mL of water was added, and the mixture was further cooled to 15 DEG C, and the precipitated crystals were collected by filtration to obtain carboxylic acid (1-2a). (39.7 g, 94%).

According to the analysis of related databases, 647-42-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Fuji Photo Film Co., Ltd.; Kato, Syunya; Yoshikawa, Masaru; (58 pag.)KR101634475; (2016); B1;,
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