Category: 6346/9/4

Jeppesen, Troels E. published the artcileOxime Coupling of Active Site Inhibited Factor Seven with a Nonvolatile, Water-Soluble Fluorine-18 Labeled Aldehyde, Category: alcohols-buliding-blocks, the publication is Bioconjugate Chemistry (2019), 30(3), 775-784, database is CAplus and MEDLINE.

A nonvolatile fluorine-18 aldehyde prosthetic group was developed from [¹⁸F]SFB, and used for site-specific labeling of active site inhibited factor VII (FVIIai). FVIIai has a high affinity for tissue factor (TF), a transmembrane protein involved in angiogenesis, proliferation, cell migration, and survival of cancer cells. A hydroxylamine N-glycan modified FVIIai (FVIIai-ONH₂) was used for oxime coupling with the aldehyde [¹⁸F]2 under mild and optimized conditions in an isolated RCY of 4.7 ± 0.9%, and a synthesis time of 267 ± 5 min (from EOB). Retained binding and specificity of the resulting [¹⁸F]FVIIai to TF was shown in vitro. TF-expression imaging capability was evaluated by in vivo PET/CT imaging in a pancreatic human xenograft cancer mouse model. The conjugate showed exceptional stability in plasma (>95% at 4 h) and a binding fraction of 90%. In vivo PET/CT imaging showed a mean tumor uptake of 3.8 ± 0.2% ID/g at 4 h post-injection, a comparable uptake in liver and kidneys, and low uptake in normal tissues. In conclusion, FVIIai was labeled with fluorine-18 at the N-glycan chain without affecting TF binding. In vitro specificity and a good in vivo imaging contrast at 4 h postinjection was demonstrated.

Bioconjugate Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Jing published the artcileEnantioselective synthesis of an octahydroindolizine (indolizidine) alcohol using an enzymatic resolution, Synthetic Route of 6346-09-4, the publication is Organic & Biomolecular Chemistry (2017), 15(14), 2953-2961, database is CAplus and MEDLINE.

A homo-chiral synthesis of (7R,8aS)-octahydro-5,5-dimethylindolizin-7-amine 8 and (7S, 8aS)-octahydro-5,5-dimethylindolizin-7-ol 9, amine building blocks which have found applications within the pharmaceutical industry, is presented. The approach uses a Novozym 435-mediated kinetic resolution of racemic octahydroindolizine (indolizidine) alc. 13 as a key step (up to 100 g scale).

Organic & Biomolecular Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H5F3O2S, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kwon, Yongseok published the artcilePlatinum-Catalyzed Synthesis of Substituted Phenanthrenes from Biphenyl Propargyl Alcohols via a Carbene Intermediate, COA of Formula: C8H19NO2, the publication is Organic Letters (2014), 16(18), 4936-4939, database is CAplus and MEDLINE.

An efficient synthesis for phenanthrenes via a Pt-carbene intermediate is described. Using Pt as a catalyst, the readily accessible biphenyl propargyl alc. substrate can be transformed to the vinylphenanthrene system through a cascade involving electrophilic cyclization, dehydration, and 1,2-H migration. The synthetic utility and efficiency of this protocol were demonstrated via the concise total synthesis of antofine.

Organic Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, COA of Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, Almir S. published the artcileFacile synthesis of 2-(2-arylpyrrolidin-1-yl)pyrimidines via acid-catalyzed reaction of N-(4,4-diethoxybutyl)pyrimidin-2-amine with phenols, Category: alcohols-buliding-blocks, the publication is Monatshefte fuer Chemie (2015), 146(11), 1845-1849, database is CAplus.

N-(4,4-diethoxybutyl)pyrimidin-2-amine undergoes acid-catalyzed intramol. cyclization in the presence of phenols leading to the formation of 2-(2-arylpyrrolidin-1-yl)pyrimidine derivatives Target compounds were obtained with moderate to good yields by operationally simple one-step procedure.

Monatshefte fuer Chemie published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, A. S. published the artcileSynthesis of new polyphenols containing sym-triazine fragment, SDS of cas: 6346-09-4, the publication is Russian Journal of General Chemistry (2016), 86(3), 761-763, database is CAplus.

Synthesis of 2-[4,4-bis(3-methyl-2,4-dihydroxyphenyl)alkylamino]-4,6-dimorpholino-1,3,5-trazines by the condensation of a sym-triazine acetals and 2-methylresocinol and the effect of the length of the methylene spacer between the acetal group and sym-triazine moiety on the reaction were presented.

Russian Journal of General Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, SDS of cas: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, Mukattis B. published the artcileO, o-Dialkyl-S-(1,1-dimethyl-2-oxoethyl)dithiophosphates: Synthesis and Reactions with N-Nucleophiles, Category: alcohols-buliding-blocks, the publication is Heteroatom Chemistry (2015), 26(6), 436-440, database is CAplus.

Hydrolysis of the new types of iminium salts was used to synthesize O,O-dialkyl-S-(1,1-dimethyl-2-oxoethyl)dithiophosphates or 2-dialkoxythiophosphorylthio-substituted aldehydes with C isochain. Reactions of aldehydes with N-, N,N-, and O,N-nucleophiles gave new phosphorylated imines containing an acetal group at different positions, perhydro-1,3-diazol and oxazol with the diisopropoxythiophosphorylthio group in a side chain, and hydrazone of this aldehyde and diphenylphosphinylacetic acid hydrazide.

Heteroatom Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kennedy, Sean published the artcileSuperacid-promoted synthesis of indolizidine derivatives, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Tetrahedron Letters (2018), 59(20), 1932-1935, database is CAplus.

A series of amido-acetals were reacted with the Bronsted superacid, CF₃SO₃H, to provides indolizidine derives by a cyclization cascade. A mechanism is proposed involving formation of a vinylogous enol which undergoes a 6π-electrocyclization reaction with an adjacent N-acyl iminium ion group. With aryl substituents, there is a strong tendency for the N-acyl iminium ion group to undergo Friedel-Crafts type cyclizations with the aryl group. The synthetic methodol. was used to prepare the alkaloid natural product, ipalbidine.

Tetrahedron Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mero, Anna published the artcileHyaluronic Acid as a Protein Polymeric Carrier: An Overview and a Report on Human Growth Hormone, Application In Synthesis of 6346-09-4, the publication is Current Drug Targets (2015), 16(13), 1503-1511, database is CAplus and MEDLINE.

Hyaluronic acid (HA) is a natural polysaccharide primarily present in the vitreous humor and in cartilages where it plays a key structural role in organizing the cartilage extracellular matrix. HA is used in a wide range of applications including treatment of arthritis (as a viscosupplementation agent for joints) and in a variety of cosmetic injectable products. Its safety profile is thus well established. Thanks to its high biocompatibility and targeting properties, HA has also been investigated for use as a carrier of anticancer drugs and, recently, also of proteins. Its role in the last case is a particularly challenging one as dedicated coupling chemistries are required to preserve the protein′s conformation and activity. This study focuses on the state of the art on protein HAylation. New data from our laboratory on the local delivery of specific biologics to joints will also be outlined.

Current Drug Targets published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Application In Synthesis of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al Sulaiman, Dana published the artcileChemically Modified Hydrogel-Filled Nanopores: A Tunable Platform for Single-Molecule Sensing, Application In Synthesis of 6346-09-4, the publication is Nano Letters (2018), 18(9), 6084-6093, database is CAplus and MEDLINE.

Label-free, single-mol. sensing is an ideal candidate for biomedical applications that rely on the detection of low copy numbers in small volumes and potentially complex biofluids. Among them, solid-state nanopores can be engineered to detect single mols. of charged analytes when they are elec. driven through the nanometer-sized aperture. When successfully applied to nucleic acid sensing, fast transport in the range of 10-100 nucleotides per ns often precludes the use of standard nanopores for the detection of the smallest fragments. Herein, hydrogel-filled nanopores (HFN) are reported that combine quartz nanopipettes with biocompatible chem. poly(vinyl) alc. hydrogels engineered inhouse. Hydrogels were modified phys. or chem. to finely tune, in a predictable manner, the transport of specific mols. Controlling the hydrogel mesh size and chem. composition allowed us to slow DNA transport by 4 orders of magnitude and to detect fragments as small as 100 base pairs (bp) with nanopores larger than 20 nm at an ionic strength comparable to physiol. conditions. Considering the emergence of cell-free nucleic acids as blood biomarkers for cancer diagnostics or prenatal testing, the successful sensing and size profiling of DNA fragments ranging from 100 bp to >1 kbp long under physiol. conditions demonstrates the potential of HFNs as a new generation of powerful and easily tunable mol. diagnostics tools.

Nano Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Application In Synthesis of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Loska, Rafal published the artcileA three-component synthesis of aryl(heteroaryl)acylamides, Safety of 4,4-Diethoxybutan-1-amine, the publication is Organic & Biomolecular Chemistry (2015), 13(38), 9872-9882, database is CAplus and MEDLINE.

A three-component reaction of azole or azine N-oxides, 1,1-difluorostyrenes and amines gives amides of α-aryl-α-heteroarylacetic or propionic acids. The key step is 1,3-dipolar cycloaddition between N-oxide and difluorostyrene leading to the acyl fluoride intermediate, which has been identified and characterized by NMR spectroscopy. The whole process is an example of selective functionalization of C-H bonds in both 5- and 6-membered heterocyclic systems.

Organic & Biomolecular Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Safety of 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts