Category: 6346-09-4

Gundogdu-Hizliates, Cevher’s team published research in Bioorganic Chemistry in 52 | CAS: 6346-09-4

Bioorganic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Quality Control of 6346-09-4.

Gundogdu-Hizliates, Cevher published the artcileSynthesis of new ibuprofen derivatives with their in silico and in vitro cyclooxygenase-2 inhibitions, Quality Control of 6346-09-4, the publication is Bioorganic Chemistry (2014), 8-15, database is CAplus and MEDLINE.

Cyclooxygenase-2 (COX-2) is one of the important targets for treatment of inflammation related diseases. In the literature, most of drug candidates are first synthesized and then their COX-2 inhibitory activities are tested by in vitro and in vivo experiments However, synthesis of dozens of drug analogs without any interpretations on their inhibitory activity can result in loss of time and chems. Therefore, synthetic drug designs with mol. modeling are of importance to synthesize selective drug candidates against inflammatory diseases. The synthesis of the novel ibuprofen derivatives through their in silico and in vitro COX-2 inhibitory activities were investigated in the present study. Starting from ibuprofen, ibuprofen amide and ibuprofen acyl hydrazone derivatives were synthesized. According to the results of the in silico mol. docking and in vitro enzyme inhibition studies, the synthesized novel ibuprofen derivatives have selective COX-2 inhibition, and mol. 3a and 3c were showed higher inhibition compared to ibuprofen. In conclusion, the newly synthesized ibuprofen derivatives can be used in model in vivo studies.

Bioorganic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Storz, Michael P.’s team published research in Organic & Biomolecular Chemistry in 12 | CAS: 6346-09-4

Organic & Biomolecular Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C10H18O, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Storz, Michael P. published the artcileFrom in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Organic & Biomolecular Chemistry (2014), 12(32), 6094-6104, database is CAplus and MEDLINE.

Recent studies have shown that compounds based on a (2-nitrophenyl)methanol scaffold are promising inhibitors of PqsD, a key enzyme of signal mol. biosynthesis in the cell-to-cell communication of Pseudomonas aeruginosa. The most promising mol. displayed anti-biofilm activity and a tight-binding mode of action. Herein, the authors report on the convenient synthesis and biochem. evaluation of a comprehensive series of (2-nitrophenyl)methanol derivatives The in vitro potency of these inhibitors against recombinant PqsD as well as the effect of selected compounds on the production of the signal mols. HHQ and PQS in P. aeruginosa were examined The gathered data allowed the establishment of a structure-activity relationship, which was used to design fluorescent inhibitors, and finally, led to the discovery of (2-nitrophenyl)methanol derivatives with improved in cellulo efficacy providing new perspectives towards the application of PqsD inhibitors as anti-infectives.

Organic & Biomolecular Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C10H18O, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vagapova, L. I.’s team published research in Russian Journal of General Chemistry in 88 | CAS: 6346-09-4

Russian Journal of General Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C11H8O3, Quality Control of 6346-09-4.

Vagapova, L. I. published the artcileKabachnik-Fields Reaction in the Synthesis of New Acetal-Containing Aminophosphine Oxides, Quality Control of 6346-09-4, the publication is Russian Journal of General Chemistry (2018), 88(9), 1912-1914, database is CAplus.

The Kabachnik-Fields reaction in a ternary system of 4,4-diethoxybutylamine-dialkyl(tolyl)-phosphine acid-3,5-di-tert-butyl-4-hydroxybenzaldehyde (or paraformaldehyde) afforded new aminophosphine oxides containing 3,5-di-tert-butyl-4-hydroxyphenol moiety and an acetal group.

Russian Journal of General Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C11H8O3, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Jiajia’s team published research in Chem in 2019 | CAS: 6346-09-4

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Product Details of 6346-09-4

Product Details of 6346-09-4On November 14, 2019 ,《Direct Dearomatization of Pyridines via an Energy-Transfer-Catalyzed Intramolecular [4+2] Cycloaddition》 appeared in Chem. The author of the article were Ma, Jiajia; Strieth-Kalthoff, Felix; Dalton, Toryn; Freitag, Matthias; Schwarz, J. Luca; Bergander, Klaus; Daniliuc, Constantin; Glorius, Frank. The article conveys some information:

A catalytic, dearomative cycloaddition reaction with pyridines, e.g., I using photoinduced energy transfer catalysis has been reported, thereby advancing dearomatization methodol. and increasing the topol. of pyridine dearomatization products, e.g., II. This unprecedented method features high yields, broad substrate scope, excellent functional group tolerance, and facile scalability. Furthermore, a recyclable and sustainable polymer immobilized photocatalyst was employed. Computational and exptl. investigations support a mechanism in which a cinnamyl moiety is promoted to its corresponding excited triplet state through visible-light-mediated energy transfer catalysis, followed by a regioselective and dearomative [4+2] cycloaddition to pyridines. This work demonstrates the contribution of visible light catalysis toward enabling thermally challenging organic transformations. In the part of experimental materials, we found many familiar compounds, such as 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Product Details of 6346-09-4)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Product Details of 6346-09-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yue, Huifeng’s team published research in Chemical Science in 2019 | CAS: 6346-09-4

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Application In Synthesis of 4,4-Diethoxybutan-1-amine

The author of 《Nickel-catalyzed C-N bond activation: activated primary amines as alkylating reagents in reductive cross-coupling》 were Yue, Huifeng; Zhu, Chen; Shen, Li; Geng, Qiuyang; Hock, Katharina J.; Yuan, Tingting; Cavallo, Luigi; Rueping, Magnus. And the article was published in Chemical Science in 2019. Application In Synthesis of 4,4-Diethoxybutan-1-amine The author mentioned the following in the article:

Nickel-catalyzed reductive cross coupling of activated primary amines with aryl halides under mild reaction conditions has been achieved for the first time. Due to the avoidance of stoichiometric organometallic reagents and external bases, the scope regarding both coupling partners is broad. Thus, a wide range of substrates, natural products and drugs with diverse functional groups are tolerated. Moreover, exptl. mechanistic investigations and d. functional theory (DFT) calculations in combination with wavefunction anal. have been performed to understand the catalytic cycle in more detail. The results came from multiple reactions, including the reaction of 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Application In Synthesis of 4,4-Diethoxybutan-1-amine)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Application In Synthesis of 4,4-Diethoxybutan-1-amine

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Smolobochkin, Andrey V.’s team published research in Tetrahedron in 2020 | CAS: 6346-09-4

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: 6346-09-4

Smolobochkin, Andrey V.; Turmanov, Rakhymzhan A.; Gazizov, Almir S.; Voloshina, Alexandra D.; Voronina, Julia K.; Sapunova, Anastasiia S.; Burilov, Alexander R.; Pudovik, Michail A. published their research in Tetrahedron on August 14 ,2020. The article was titled 《One-pot imination / Arbuzov reaction of 4-aminobutanal derivatives: Synthesis of 2-phosphorylpyrrolidines and evaluation of anticancer activity》.Recommanded Product: 6346-09-4 The article contains the following contents:

A novel one-pot method for the preparation of N-substituted 2-phopshorylpyrrolidines, e.g. I, from readily available 4,4-diethoxybutan-1-amine derivatives and P (III) acid chlorides is described. The presented method benefits from simple reaction and work-up procedures, mild reaction conditions, avoids protecting group introduction-removal stages and provides a straightforward access to target compounds In vitro cytotoxicity studies indicate that obtained 2-phopshorylpyrrolidines inhibit selectively M-Hela tumor cells growth. The activity of some derivatives towards M-Hela and MCF-7 tumor cells is comparable to that of reference drug Tamoxifen. In contrast to Tamoxifen and Doxorubicin tested compounds have no cytotoxic effects on normal cells. After reading the article, we found that the author used 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Recommanded Product: 6346-09-4)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: 6346-09-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Martin-Montero, Raul’s team published research in Organic Letters in 2019 | CAS: 6346-09-4

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Formula: C8H19NO2

《Ni-catalyzed Reductive Deaminative Arylation at sp3 Carbon Centers》 was written by Martin-Montero, Raul; Yatham, Veera Reddy; Yin, Hongfei; Davies, Jacob; Martin, Ruben. Formula: C8H19NO2 And the article was included in Organic Letters on April 19 ,2019. The article conveys some information:

A Ni-catalyzed reductive deaminative arylation at unactivated sp3 carbon centers is described. This operationally simple and user-friendly protocol exhibits excellent chemoselectivity profile and broad substrate scope, thus complementing existing metal-catalyzed cross-coupling reactions to forge sp3 C-C linkages. These virtues have been assessed in the context of late-stage functionalization, hence providing a strategic advantage to reliably generate structure diversity with amine-containing drugs. The results came from multiple reactions, including the reaction of 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Formula: C8H19NO2)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Formula: C8H19NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Feng’s team published research in Chinese Chemical Letters in 2021 | CAS: 6346-09-4

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Application In Synthesis of 4,4-Diethoxybutan-1-amine

Zhang, Feng; Niu, Yujie; Hong, Dacheng; Ye, Yilin; Hua, Yuhui; Ding, Shihao; Zhang, Yandong published an article on February 28 ,2021. The article was titled 《Synthetic studies towards atkamine》, and you may find the article in Chinese Chemical Letters.Application In Synthesis of 4,4-Diethoxybutan-1-amine The information in the text is summarized as follows:

Atkamine (I) is a complex marine pyrroloiminoquinone alkaloid that comprises a heptacyclic scaffold bearing five different heterocycles and four contiguous stereocenters, and therefore it is a highly challenging target for synthetic chemists. We herein reported a modular synthetic strategy toward this alkaloid, featuring a formal [5 + 2] annulation and an asym. Michael addition The efficient synthesis of the long-chain aliphatic aldehyde and chiral amino acetal fragments have been achieved. A simplified tetracyclic intermediate bearing the core structure of atkamine has been successfully constructed through the formal [5 + 2] annulation. In the experiment, the researchers used 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Application In Synthesis of 4,4-Diethoxybutan-1-amine)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Application In Synthesis of 4,4-Diethoxybutan-1-amine

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wan, Ruiying’s team published research in European Polymer Journal in 2021 | CAS: 6346-09-4

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.COA of Formula: C8H19NO2

Wan, Ruiying; Xu, Shicheng; Wang, Jin; Yang, Yunfei; Zhang, Dengji; He, Ronghuan published an article on January 5 ,2021. The article was titled 《Construction of ion conducting channels by embedding hydrophilic oligomers in piperidine functionalized poly(2,6-dimethyl-1,4-phenylene oxide) membranes》, and you may find the article in European Polymer Journal.COA of Formula: C8H19NO2 The information in the text is summarized as follows:

A suitable microphase separation morphol. has been demonstrated to be an efficient strategy to achieve high ionic conductivity with reasonable durability to anion exchange membranes (AEMs). Herein, hydrophilic oligomers of polyethylene glycols (PEGs) with different mol. weights were blended, sep., with poly(2,6-dimethyl-1,4-phenylene oxide) modified by 4,4-diethoxybutan-1-amine and 1-methylpiperidine (20PDM). The presence of hydrophilic PEGs facilitates the formation of the interconnected nano-channels in the AEMs for ion conduction according to the anal. results by both transmission electron microscopy (TEM) and small angle X-ray scattering (SAXS). The membrane containing 2 wt% PEGs with a mol. weight of 2 kDa reaches a hydroxide conductivity of 97.2 mS cm-1 at 80°C, which is 25 mS cm-1 higher than that the pristine 20PDM membrane possessing the same ion exchange capacity. A peak power d. of 328 mW cm-2 is attained at 60°C by the proposed membrane based single fuel cell fueling with humidified H2 and O2 with 0.1 MPa of back pressure. The chem. structure, water uptake and swelling as well as resistance to hot alkali solutions of the prepared membranes were investigated. In the experiment, the researchers used many compounds, for example, 4,4-Diethoxybutan-1-amine(cas: 6346-09-4COA of Formula: C8H19NO2)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.COA of Formula: C8H19NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Irie, Raku’s team published research in Journal of Natural Products in 2021 | CAS: 6346-09-4

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Computed Properties of C8H19NO2

《Structure Revision of Protoaculeine B, a Post-translationally Modified N-Terminal Residue in the Peptide Toxin Aculeine B》 was written by Irie, Raku; Miyako, Kei; Matsunaga, Satoko; Sakai, Ryuichi; Oikawa, Masato. Computed Properties of C8H19NO2 And the article was included in Journal of Natural Products on April 23 ,2021. The article conveys some information:

The structure of protoaculeine B, the N-terminal residue of the marine peptide toxin aculeine B, is revised to the cis-1,3-disubstituted tetrahydro-β-carboline framework. We prepared two truncated model compounds that lack a long-chain polyamine using the one-step Pictet-Spengler reaction of tryptophan and compared their NMR, mass spectra, and chem. reactivity with those of the natural protoaculeine B. The synthetic models reproduced the profiles of the natural product well, which confirmed the appropriateness of the structure revision. After reading the article, we found that the author used 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Computed Properties of C8H19NO2)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Computed Properties of C8H19NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts