Category: 6346-09-4

Deldaele, Christopher published the artcileRoom-Temperature Practical Copper-Catalyzed Amination of Aryl Iodides, Formula: C8H19NO2, the publication is ChemCatChem (2016), 8(7), 1319-1328, database is CAplus.

An efficient and highly practical procedure was reported for the Ullmann-Goldberg-type copper-catalyzed amination of aryl iodides. By using a combination of copper iodide and proline in the presence of an excess of an amine, a wide range of aryl iodides were readily aminated at room temperature The reaction proceeded well regardless of the electronic properties of the starting aryl iodide and the amination products were obtained without the need for purification by column chromatog. in most cases. Owing to its efficiency and the mildness of the reaction conditions, this amination was extended to the amination of complex aryl iodides at room temperature

ChemCatChem published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Omran, Anahid published the artcileSynthesis of 3-(3-hydroxyphenyl)pyrrolidine dopamine D₃ receptor ligands with extended functionality for probing the secondary binding pocket, Category: alcohols-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(10), 1897-1902, database is CAplus and MEDLINE.

A series of 3-(3-hydroxyphenyl)pyrrolidine analogs which incorporate N-alkyl groups and N-butylamide-linked benzamide functionality were synthesized and their in vitro binding affinities at human dopamine receptors were evaluated. The authors’ ligand design strategy was to take the 3-(3-hydroxyphenyl)pyrrolidine scaffold and extend functionality from the orthosteric binding site to the secondary binding pocket for enhancing affinity and selectivity for the D₃ receptor. The N-alkyl analogs constitute a homologous series from N-pentyl to N-decyl to probe the length/bulk tolerance of the secondary binding pocket of the D₃ receptor. Enantiomeric 3-(3-hydroxyphenyl)pyrrolidine analogs were also prepared to test the chirality preference of the orthosteric binding site for this scaffold. Benzamide analogs were prepared to enhance affinity and/or selectivity based upon the results of the homologous series.

Bioorganic & Medicinal Chemistry Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tai, Benjamin C. U. published the artcileSynthetic Poly(Vinylalcohol)-Based Membranes for Cartilage Surgery and Repair, Quality Control of 6346-09-4, the publication is Biotechnology Journal (2017), 12(12), n/a, database is CAplus and MEDLINE.

Cell-based therapies for cartilage repair are continually being developed to treat osteoarthritis. The cells are either introduced directly by intra-articular injection or via a cell-seeded matrix scaffold. Here, poly(vinylalc.)-based membranes are developed to be used for mesenchymal stem cell implantation in cartilage repair procedures, having controllable physicochem. properties such as porosity, mech. strength, and permeability, and a unique self-sealing property. The membranes possess a bilayer structure with a less porous layer providing mech. strength and selective permeability, exhibit an elastic modulus of between 0.3 and 0.9 MPa, and are permeable to mols. <40 kDa, which is in the range of cartilage permeability. Three different peptide ligands with the sequences Ac-GCGYGRGDSPG, Ac-GCG(OPG)4REGOFG(OPG)4, and Ac-GCG(OPG)7, resp., are conjugated to the membranes and subject to in vitro cell adhesion and differentiation assays. Col I/Col II gene expression ratios indicated that the collagen-mimetic peptide, Ac-GCG(OPG)7, best supported mesenchymal stem cell differentiation into the chondrogenic lineage. Although low retention of the membrane is observed in vivo in a rabbit knee model, results suggest that the membrane was able to facilitate mesenchymal stem cell implantation and differentiation to chondrocytes. These PVA-based membranes provide a feasible, synthetic, off-the-shelf material for the delivery of stem cells, and can be modified for other surgical applications.

Biotechnology Journal published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C19H21N3O3S, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Xiaoping published the artcileOn the chemistry of 1-pyrroline in solution and in the gas phase, HPLC of Formula: 6346-09-4, the publication is Scientific Reports (2017), 7(1), 1-8, database is CAplus and MEDLINE.

1-Pyrroline has a highly characteristic odor, which is employed by living organisms for chem. signaling and other purposes, but the mechanism whereby this odor is formed remains poorly understood. Here we used a combination of ambient mass spectrometry (AMS) and NMR (NMR) spectroscopy to exptl. address the mechanistic aspects of 1-pyrroline volatility and other controversies regarding the chem. of this compound Our results indicate that in solution the volatility of the monomer species is significantly higher than that of the trimer species, and 1-pyrroline is evaporated mainly in its monomer state. Neat 1-pyrroline is essentially the pure trimer and displays ca. 100-fold lower evaporation rate than the monomer state in solution In the gas-phase the trimer species is irreversibly decomposed into monomer species. Under equilibrium conditions the vapor of 1-pyrroline entirely consists of monomer species. The evaporation rate of 1-pyrroline in water has a step-wise dependence on the solution pH, the abrupt increase in volatility (>1,000-fold) occurring around the pKa value of 1-pyrroline (6.8). The pronounced step-wise dependence of 1-pyrroline volatility around neutral pH may also be an important evolutionary factor allowing living systems to regulate the odor strength from very weak to very strong with minimal efforts.

Scientific Reports published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C7H5ClN2S, HPLC of Formula: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Wenbo published the artcileSynthesis of Multisubstituted Pyrroles from Enolizable Aldehydes and Primary Amines Promoted by Iodine, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Journal of Organic Chemistry (2019), 84(9), 5655-5666, database is CAplus and MEDLINE.

1,2,4-Trisubstituted pyrroles were synthesized from enolizable aliphatic aldehydes and primary aliphatic amines by using iodine as the dual Lewis acid/mild oxidant. In the presence of 3.0 equiv of TBHP, enolizable α,β-unsaturated aldehyde, for example, cocal reacted with aromatic primary amines to form C2-iodized N-arylpyrroles. An acetal-containing pyrrole was successfully prepared from 4-aminobutyraldehyde di-Et acetal, which can be converted easily to 5,6,7,8-tetrahydroindolizine derivatives

Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, A. V. published the artcileReaction of 4-Chloro-6-[1-(vinylsulfonyl)pyrrolidin-2-yl]benzene-1,3-diol with Some Amines, Computed Properties of 6346-09-4, the publication is Russian Journal of General Chemistry (2018), 88(1), 131-135, database is CAplus.

4-Chloro-6-[1-(vinylsulfonyl)pyrrolidin-2-yl]benzene-1,3-diol prepared by the reaction of 2-ethoxypyrrolidine with 4-chlororesorcinol was introduced into the aza-Michael reaction with various amines which led to the formation of new 1-sulfonyl-2-arylpyrrolidines.

Russian Journal of General Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C7H6Cl2, Computed Properties of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, A. V. published the artcileSynthesis of 1-(arylsulfonyl)pyrrolidines from aryl alcohols and 1-[(4-chlorophenyl)sulfonyl]-2-ethoxypyrrolidine, Formula: C8H19NO2, the publication is Russian Journal of Organic Chemistry (2017), 53(2), 199-202, database is CAplus.

Acid-catalyzed reaction of 1-[(4-chlorophenyl)sulfonyl]-2-ethoxypyrrolidine with aryl alcs. led to the formation of new 1-(arylsulfonyl)pyrrolidines. The reaction proceeded under mild conditions and might be used as a convenient method for the synthesis of pyrrolidine-1-sulfonylarene derivatives containing a phenol fragment in the position 2.

Russian Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C9H10O4, Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vagapova, L. I. published the artcileSynthesis and structure of new phosphorylated β- and γ-amino acetals containing a sterically hindered phenol group, Category: alcohols-buliding-blocks, the publication is Russian Journal of Organic Chemistry (2015), 51(9), 1268-1271, database is CAplus.

α-Phosphorylated 3,5-di-tert-butyl-4-methylidenecyclohexa-2,5-dien-1-ones reacted with 3,3-diethoxypropan-1-amine and 4,4-diethoxybutan-1-amine to afford new α-amino phosphonates containing sterically hindered phenol and acetal groups.

Russian Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C50H65O4P, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vagapova, L. I. published the artcileβ- and γ-amino acetals containing phosphine oxide groups. Synthesis and reactions with resorcinol derivatives, Safety of 4,4-Diethoxybutan-1-amine, the publication is Russian Journal of Organic Chemistry (2014), 50(6), 778-782, database is CAplus.

New β- and γ-amino acetals containing phosphine oxide groups were synthesized by the Kabachnik-Fields reaction of β- and γ-amino acetals with paraformaldehyde and dialkylphosphine oxides. Heating of the resulting β- and γ-amino acetals with 2-methylresorcinol and pyrogallol in boiling trifluoroacetic acid afforded (dialkylphosphoryl)(ω,ω-diarylalkyl)ammonium trifluoracetates.

Russian Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H6ClN, Safety of 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tripathi, Shashank published the artcileConstruction of Highly Functionalized Piperazinones via Post-Ugi Cyclization and Diastereoselective Nucleophilic Addition, Formula: C8H19NO2, the publication is Journal of Organic Chemistry (2020), 85(11), 6910-6923, database is CAplus and MEDLINE.

Aminals were prepared by Ugi multicomponent cyclocondensation reactions of 2-aminoacetaldehyde di-Me acetal, aldehydes or ketones such as 3-indolecarboxaldehyde, carboxylic acids such as benzoic acid, and isocyanides such as benzyl isocyanide. In the presence of BF₃·Et₂O in CH₂Cl₂, the aminals underwent (diastereoselective) substitution reactions with nucleophiles such as Me₃SiR [R = H₂C:CHCH₂, NC, N₃, OCPh(:CH₂)], triethylsilane, or N-methylindole to yield piperazinones such as I (X = Y = O). Ugi reactions with aminoaldehyde acetals with longer carbon chains yielded only acyclic products. I (X = Y = H₂) was prepared as a dragmacidin C analog, while two piperazinones were used to prepare praziquantel analogs.

Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H10S, Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts