Category: 6346-09-4

Smolobochkin, A. V. published the artcileCyclization of 1-(4,4-diethoxybutyl)-3-aryl(thio)ureas to 2-arylpyrrolidines and 2,3′-bipyrrole derivatives, Quality Control of 6346-09-4, the publication is Russian Chemical Bulletin (2016), 65(3), 731-734, database is CAplus.

A reaction of 1-(4,4-diethoxybutyl)-3-phenylthiourea with resorcinol, 2-methylresorcinol, pyrogallol and hydroquinone in chloroform in the presence of trifluoroacetic acid leading to 2-aryl-1-(N-phenylcarbamothioyl)pyrrolidines I [R = H, Me, OH] and II has been described. The compounds such as 1-(4,4-diethoxybutyl)-3-aryl(thio)ureas R¹NHC(X)NH(CH₂)₃CH(OC₂H₅)₂ [R¹ = C₆H₅, 4-H₃COC₆H₄, 4-BrC₆H₄; X = O, S] in the presence of an acid catalyst undergo intramol. cyclization and dimerization with the formation of 1,1′-bis(N-arylcarbamo(thio)yl)-2,3′-bipyrrole derivatives III.

Russian Chemical Bulletin published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C18H26ClN3O, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, A. V. published the artcileSynthesis of functionalized diarylbutane derivatives by the reaction of 2-methylresorcinol with γ-ureidoacetals, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Russian Journal of General Chemistry (2015), 85(7), 1779-1782, database is CAplus.

The synthesis of the target compounds was achieved by a reaction of N-(4,4-diethoxybutyl)urea derivatives (urea acetals) with 2-methyl-1,3-benzenediol (methylresorcinol, phenol derivative). The title compounds thus formed included N-[4-bis(2,4-dihydroxy-3-methylphenyl)butyl]urea derivatives A reaction of N-(4,4-diethoxybutyl)-N’,N’-dimethylurea with 2-naphthalenol (phenol analog) gave N,N-dimethyl-N’-[3-(14H-dibenzo[a,j]xanthen-14-yl)propyl]urea.

Russian Journal of General Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C17H14F3N3O2S, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, A. V. published the artcileInteraction of 1,1′-(hexane-1,6-diyl)bis[3-(4,4-diethoxybutyl)urea] with resorcinol derivatives. Synthesis of bisarylpyrrolidines, Quality Control of 6346-09-4, the publication is Russian Journal of General Chemistry (2015), 85(2), 517-519, database is CAplus.

In this letter to the editor, the synthesis of 2-aryl-pyrrolidines from 1,1′-(hexane-1,6-diyl)bis[3-(4,4-diethoxybutyl)urea] with resorcinol derivatives is presented. Of note, when chloroform, benzene or acetone solvents were used with trifluoroacetic acid catalyst, complex mixtures of polymers were formed. However, using water in diluted sulfuric acid presented the desired products.

Russian Journal of General Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C4H3Cl2N3, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, A. V. published the artcileSynthesis of (E)-4-(4-chlorobenzylidene)-3,4-dihydro-2H-pyrrole-based pyrrolinium salts, Synthetic Route of 6346-09-4, the publication is Russian Chemical Bulletin (2020), 69(2), 382-385, database is CAplus.

Pyrrolinium salts containing 3-arylidene fragment were obtained. Their synthesis is based on the reaction of (E)-4-(4-chlorobenzylidene)-3,4-dihydro-2H-pyrrole with various bromo-alkanes. Structures of the obtained compounds were confirmed by a set of physico-chem. anal. methods.

Russian Chemical Bulletin published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C9H9ClO4, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, Andrey published the artcileSynthesis of novel 2-(het)arylpyrrolidine derivatives and evaluation of their anticancer and anti-biofilm activity, Quality Control of 6346-09-4, the publication is Molecules (2019), 24(17), 3086pp., database is CAplus and MEDLINE.

A library of novel 2-(het)arylpyrrolidine-1-carboxamides I [R = H, n-hexyl, 4-MeOC₆H₄, etc.; Ar = 4-hydroxy-6-methyl-pyran-2-one-3-yl, 4-hydroxycoumarin-3-yl, 1,3-benzodioxol-5-ol-6-yl, 6-chloro-4-((4-yl-3-hydroxyphenyl)amino)-5-nitrobenzo[c][1,2,5]oxadiazole 1-oxide] was obtained via a modular approach based on the intramol. cyclization/Mannich-type reaction of N-(4,4-diethoxybutyl)ureas. Their anti-cancer activities both in vitro and in vivo were tested. The in vitro activity of some compounds toward M-Hela tumor cell lines was twice that of reference drug tamoxifen, whereas cytotoxicity toward normal Chang liver cell did not exceed tamoxifen toxicity. In vivo studies showed that the number of surviving animals on day 60 of observation was up to 83% and increased life span (ILS) was up to 447%. Addnl., some pyrrolidine-1-carboxamides possessing a benzofuroxan moiety obtained were found to effectively suppress bacterial biofilm growth. Thus, these compounds were promising candidates for further development both as anti-cancer and anti-bacterial agents.

Molecules published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C21H37BO, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, Andrey V. published the artcileCyclization of 1-(4,4-diethoxybutyl)-3-arylureas: a case study, Synthetic Route of 6346-09-4, the publication is Monatshefte fuer Chemie (2018), 149(3), 535-541, database is CAplus.

The study on the reaction of (4,4-diethoxybutyl)ureas with nucleophilic aromatics was reported herein. It was found that the structure of the products mainly depends on the strength of the acid used as catalyst as well as aromatic nucleophile nature and its concentration Either 2-arylpyrrolidines e.g., (R,S)-2,2′-(4,6-Dihydroxy-5-methyl-1,3-phenylene)bis[N-(naphthalen-1-yl)pyrrolidine-1-carboxamide], diarylbutanes, 1-[4,4-Bis(5-chloro-2,4-dihydroxyphenyl)butyl]-3-(naphthalen-1-yl)urea, bispyrrole derivatives, N-(Naphthalen-1-yl)-4-[1-(naphthalen-1-ylcarbamoyl)pyrrolidin-2-yl]-2,3-dihydro-1H-pyrrole-1-carboxamide, or pyrrolidinequinazolinones can be synthesized via variation of these factors. The proposed mechanism of the reaction is discussed.

Monatshefte fuer Chemie published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C10H11NO4, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, Andrey V. published the artcileAcid-catalyzed reaction of phenols with N-(4,4-diethoxybutyl)sulfonamides – a new method for the synthesis of 2-aryl-1-sulfonylpyrrolidines, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2017), 53(2), 161-166, database is CAplus.

A new method for the synthesis of 2-aryl-1-sulfonylpyrrolidines I (R = Me, Et, Ph, p-tolyl; R¹ = 5-chloro-2,4-dihydroxyphenyl, 2-hydroxynaphthalen-1-yl, 2,7-dihydroxynaphthalen-1-yl) on the basis of reactions between various phenols ArH and N-(4,4-diethoxybutyl)sulfonamides RS(O)₂NH(CH₂)₃CH(OEt)₂ in the presence of trifluoroacetic acid has been developed.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C10H16O2, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Khairullin, R. A. published the artcileSynthesis of O,O-Dialkyl S-(1,1-dimethyl-2-oxoethyl) dithiophosphates and their reactions with N-nucleophiles, Related Products of alcohols-buliding-blocks, the publication is Doklady Chemistry (2016), 467(2), 131-135, database is CAplus.

O,O-Dialkyl S-(1,1-dimethyl-2-oxoethyl) dithiophosphates, 2-(dialkoxythiophosphorylthio)-substituted aldehydes with branched carbon groups, were obtained by hydrolysis of phosphoryl-containing iminium salts. The reaction with primary amines results in imines containing acetal group in different positions. Tri- and tetra-substituted perhydro-1,3-diazoles and oxazoles containing a phosphorus atom in the side chain were prepared by reacting the aldehydes with O,Nand N,N-dinucleophiles.

Doklady Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Akondi, Srirama Murthy published the artcileAerobic, Diselenide-Catalyzed Redox Dehydration: Amides and Peptides, Name: 4,4-Diethoxybutan-1-amine, the publication is Organic Letters (2018), 20(3), 538-541, database is CAplus and MEDLINE.

At 2.5 mol % loadings using reaction temperatures between 30-55 °C, ortho-functionalized diaryl diselenides are highly effective organocatalytic oxidants for aerobic redox dehydrative amidic and peptidic bond formation using tri-Et phosphite as a simple terminal reductant. This simple-to-perform organocatalytic reaction relies on the ability of selenols to react directly with dioxygen in air without recourse to metal catalysts. It represents an important step toward the development of a general, economical, and benign catalytic redox dehydration protocol.

Organic Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Name: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Afanasyev, Oleg I. published the artcileDirect Reductive Amination of Camphor Using Iron Pentacarbonyl as Stoichiometric Reducing Agent: Features and Limitations, HPLC of Formula: 6346-09-4, the publication is European Journal of Organic Chemistry (2020), 2020(39), 6289-6294, database is CAplus.

The method of direct reductive amination of camphor and fenchone was proposed. The most effective reducing agent is iron pentacarbonyl. No ligands or solvents are needed. The stereochem. of the corresponding products was determined by HMBC, HSQC, and NOESY spectra. The limitations of the method were shown. The reaction of camphor with primary amines led to exclusively exo product, while the reaction of fenchone led to exclusively endo product. The reaction of camphor with cyclic secondary amines led to the mixture of endo and exo isomers.

European Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, HPLC of Formula: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts