Category: 6346-09-4

Truax, Valarie M. published the artcileDiscovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists, Synthetic Route of 6346-09-4, the publication is ACS Medicinal Chemistry Letters (2013), 4(11), 1025-1030, database is CAplus and MEDLINE.

A de novo hit-to-lead effort involving the redesign of benzimidazole-containing antagonists of the CXCR4 receptor resulted in the discovery of a novel series of 1,2,3,4-tetrahydroisoquinoline (TIQ) analogs. In general, this series of compounds show good potencies (3-650 nM) in assays involving CXCR4 function, including both inhibition of attachment of X4 HIV-1_IIIB virus in MAGI-CCR5/CXCR4 cells and inhibition of calcium release in Chem-1 cells. Series profiling permitted the identification of TIQ-(R)-stereoisomer I as a potent and selective CXCR4 antagonist lead candidate with a promising in vitro profile. The drug-like properties of I were determined in ADME in vitro studies, revealing low metabolic liability potential. Further in vivo evaluations included pharmacokinetic experiments in rats and mice, where I was shown to have oral bioavailability (F = 63%) and resulted in the mobilization of white blood cells (WBCs) in a dose-dependent manner.

ACS Medicinal Chemistry Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C7H6Cl2O, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Martin-Montero, Raul published the artcileNi-catalyzed Reductive Deaminative Arylation at sp³ Carbon Centers, Category: alcohols-buliding-blocks, the publication is Organic Letters (2019), 21(8), 2947-2951, database is CAplus and MEDLINE.

A Ni-catalyzed reductive deaminative arylation at unactivated sp³ carbon centers is described. This operationally simple and user-friendly protocol exhibits excellent chemoselectivity profile and broad substrate scope, thus complementing existing metal-catalyzed cross-coupling reactions to forge sp³ C-C linkages. These virtues have been assessed in the context of late-stage functionalization, hence providing a strategic advantage to reliably generate structure diversity with amine-containing drugs.

Organic Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, Andrey V. published the artcileSynthesis of novel macrocyclic and heterocyclic taurine derivatives based on the reaction of sodium 2-[(4,4-diethoxybutyl)amino]ethanesulfonate with phenols, Application of 4,4-Diethoxybutan-1-amine, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2020), 56(7), 888-891, database is CAplus.

An approach to the synthesis of novel macrocyclic and heterocyclic taurine derivatives I and II (R = H, Me, OH) based on the reaction of sodium 2-[(4,4-diethoxybutyl)amino]ethanesulfonate with phenols 2-R-3-OHC₆H₃OH in the presence of trifluoroacetic acid has been developed.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C14H12N2S, Application of 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ghoshal, Anirban published the artcile[3 + 2]-Dipolar Cycloaddition of Aldehyde-Tethered Alkynamides and Trimethylsilyl Amino Esters: A Gateway to Uniquely Functionalized Polycyclic N-Heterocycles via Post-Ugi Functionalization, COA of Formula: C8H19NO2, the publication is Journal of Organic Chemistry (2020), 85(23), 14890-14904, database is CAplus and MEDLINE.

An efficient method for the generation of uniquely functionalized pyrrolo-pyrrolizinones, pyrido-pyrrolizinones, and azepino-pyrrolizinones via [3 + 2]-dipolar cycloaddition is described. The method involves the synthesis of tethered alkynamides using Ugi condensation and oxidation that were subsequently subjected to a dipolar cycloaddition reaction with trimethylsilyl amino esters. Further transformations to demonstrate the utility of these scaffolds were also investigated.

Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, COA of Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wan, Ruiying published the artcileConstruction of ion conducting channels by embedding hydrophilic oligomers in piperidine functionalized poly(2,6-dimethyl-1,4-phenylene oxide) membranes, SDS of cas: 6346-09-4, the publication is European Polymer Journal (2021), 110150, database is CAplus.

A suitable microphase separation morphol. has been demonstrated to be an efficient strategy to achieve high ionic conductivity with reasonable durability to anion exchange membranes (AEMs). Herein, hydrophilic oligomers of polyethylene glycols (PEGs) with different mol. weights were blended, sep., with poly(2,6-dimethyl-1,4-phenylene oxide) modified by 4,4-diethoxybutan-1-amine and 1-methylpiperidine (20PDM). The presence of hydrophilic PEGs facilitates the formation of the interconnected nano-channels in the AEMs for ion conduction according to the anal. results by both transmission electron microscopy (TEM) and small angle X-ray scattering (SAXS). The membrane containing 2 wt% PEGs with a mol. weight of 2 kDa reaches a hydroxide conductivity of 97.2 mS cm^-1 at 80°C, which is 25 mS cm^-1 higher than that the pristine 20PDM membrane possessing the same ion exchange capacity. A peak power d. of 328 mW cm^-2 is attained at 60°C by the proposed membrane based single fuel cell fueling with humidified H₂ and O₂ with 0.1 MPa of back pressure. The chem. structure, water uptake and swelling as well as resistance to hot alkali solutions of the prepared membranes were investigated.

European Polymer Journal published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C15H14Cl2S2, SDS of cas: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bremner, John B. published the artcileAnnulation of Eight- to Ten-Membered Oxaza Rings to the Benzo[b]thiophene System by Intramolecular Nucleophilic Displacement, COA of Formula: C8H19NO2, the publication is Australian Journal of Chemistry (2014), 67(8 & 9), 1217-1221, database is CAplus.

Concise synthetic routes to 2H-benzo[b]thieno[3,2-b][1,5]oxazocin-6(3H)-one, and the new benzo[b]thieno[3,2-b][1,5]oxazonin-7(2H)-one and 2H-benzo[b]thieno[3,2-b][1,5]oxazecin-8(3H)-one systems, have been developed based on intramol. nucleophilic displacement in the key ring forming step.

Australian Journal of Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, COA of Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Patel, Bhavesh H. published the artcileCommon origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism, Synthetic Route of 6346-09-4, the publication is Nature Chemistry (2015), 7(4), 301-307, database is CAplus and MEDLINE.

A minimal cell can be thought of as comprising informational, compartment-forming and metabolic subsystems. To imagine the abiotic assembly of such an overall system, however, places great demands on hypothetical prebiotic chem. The perceived differences and incompatibilities between these subsystems have led to the widely held assumption that one or other subsystem must have preceded the others. Here we exptl. investigate the validity of this assumption by examining the assembly of various biomol. building blocks from prebiotically plausible intermediates and one-carbon feedstock mols. We show that precursors of ribonucleotides, amino acids and lipids can all be derived by the reductive homologation of hydrogen cyanide and some of its derivatives, and thus that all the cellular subsystems could have arisen simultaneously through common chem. The key reaction steps are driven by UV light, use hydrogen sulfide as the reductant and can be accelerated by Cu(I)-Cu(II) photoredox cycling.

Nature Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Frankowski, Kevin J. published the artcileDiscovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis, Application of 4,4-Diethoxybutan-1-amine, the publication is Journal of Medicinal Chemistry (2022), 65(12), 8303-8331, database is CAplus and MEDLINE.

A high-throughput, high-content assay was developed to identify novel small mols. that selectively reduce PNC prevalence in cancer cells. The pyrrolopyrimidine series able to reduce PNC prevalence in PC3M cancer cells at submicromolar concentrations without affecting cell viability was identified and further optimized. Structure-activity relationship exploration of the structural elements necessary for activity resulted in the discovery of several potent compounds Anal. of in vitro drug-like properties led to the discovery of the bioavailable analog, metarrestin, which has shown potent antimetastatic activity with improved survival in rodent models and is currently being evaluated in a first-in-human phase 1 clin. trial.

Journal of Medicinal Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Application of 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bobrova, Angelina Yu. published the artcile(2-Fluoroallyl)pyridinium tetrafluoroborates: novel fluorinated electrophiles for Pd-catalyzed allylic substitution, Application In Synthesis of 6346-09-4, the publication is Organic & Biomolecular Chemistry (2021), 19(21), 4678-4684, database is CAplus and MEDLINE.

An efficient two-step approach to 2-fluoroallyl amines was developed that involves the synthesis of (2-fluoroallyl)pyridinium tetrafluoroborates from readily available gem-bromofluorocyclopropanes and the application of the former as novel and stable 2-fluoroallyl electrophiles for Pd-catalyzed allylic substitution.

Organic & Biomolecular Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Application In Synthesis of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Feng published the artcileSynthetic studies towards atkamine, Product Details of C8H19NO2, the publication is Chinese Chemical Letters (2021), 32(2), 668-671, database is CAplus.

Atkamine (I) is a complex marine pyrroloiminoquinone alkaloid that comprises a heptacyclic scaffold bearing five different heterocycles and four contiguous stereocenters, and therefore it is a highly challenging target for synthetic chemists. We herein reported a modular synthetic strategy toward this alkaloid, featuring a formal [5 + 2] annulation and an asym. Michael addition The efficient synthesis of the long-chain aliphatic aldehyde and chiral amino acetal fragments have been achieved. A simplified tetracyclic intermediate bearing the core structure of atkamine has been successfully constructed through the formal [5 + 2] annulation.

Chinese Chemical Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H8O2, Product Details of C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts