Category: 6338-55-2

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows. 6338-55-2

4-Ethynylaniline (170.4 mg, 1.5 mmol) was added to a solution of 4-nitrophenyl chloroformate (289.3 mg, 1.4mmol) in tetrahydrofuran (6.8 mL), stirred at room temperature for 3 hours, and then the solvent was distilled away undera reduced pressure. To a solution of the resulting crude product in dichloromethane (4 mL), a solution of 2-[2-(2-aminoethoxy)ethoxy]ethanol (239 mg, 1.6 mmol) in dichloromethane (4 mL) and triethylamine (303 mL, 2.2 mmol) wereadded, stirred at room temperature overnight, and then the solvent was distilled away under a reduced pressure. Theresidue was purified by silica gel column chromatography (ethyl acetate/methanol (v/v) = 100/0 ? 90/10) to obtain thetitle compound (325.4 mg, 77%) as a pale yellow oily matter.1H NMR (400 MHz, CDCl3) delta 8.30 (1H, br s), 7.32 (4H, m), 6.22 (1H, br t, J = 4.4 Hz), 4.37 (1H, br s), 3.72 (2H, br t, J= 4.4 Hz), 3.55-3.53 (6H, m), 3.49 (2H, t, J = 4.4 Hz), 3.36-3.34 (2H, m), 3.05 (1H, s)

Statistics shows that 6338-55-2 is playing an increasingly important role. we look forward to future research findings about 2-(2-(2-Aminoethoxy)ethoxy)ethanol.

Reference:
Patent; Senju Pharmaceutical Co., Ltd.; TAKEDA, Norihiko; MIYABE, Tomoyo; MACHIDA, Shinnosuke; MACHIDA, Mamiko; NAKAJIMA, Takeshi; (94 pag.)EP3127900; (2017); A1;,
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A common compound: 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol,molecular formula is C6H15NO3, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 6338-55-2

General procedure: The desired aminoalcohol (17 mmol, 2-(2-aminoethoxy)ethanol or 2-[2-(2-aminoethoxy)ethoxy]ethanol) was dissolved in CH3OH (10 mL) and TEA (5.45 mL, 39.2 mmol) was added. To this solution, stirred at room temperature, was added dropwise a solution of benzyloxycarbonyl chloride (ZCl, 3.2 g, 18.77 mmol) in CH3OH (5 mL). After the addition was complete the reaction mixture was stirred at room temperature for 20 h, protected from moisture with a CaCl2 drying tube. The solvent was then evaporated and the crude was dissolved in CH2Cl2 (150 mL) and washed first with a 5% aqueous solution of KHSO4 (2 ¡Á 50 mL) and then with water (2 ¡Á 50 mL). The evaporation of the dried solvent (Na2SO4) afforded the product as a clear oil pure enough to be used in the following steps.

With the rapid development of chemical substances, we look forward to future research findings about 6338-55-2.

Reference:
Article; Sissi, Claudia; Dovigo, Luca; Greco, Maria Laura; Ciancetta, Antonella; Moro, Stefano; Trzci?ski, Jakub W.; Mancin, Fabrizio; Rossi, Paola; Spalluto, Giampiero; Tecilla, Paolo; Tetrahedron; vol. 73; 21; (2017); p. 3014 – 3024;,
Alcohol – Wikipedia,
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Adding some certain compound to certain chemical reactions, such as: 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6338-55-2. 6338-55-2

A mixed solution of 23.5 g of the compound BP103a03 (1.0 eq), 68.6 g of (Boc) 2O (2.0 eq) and 500 ml of methanol: triethylamine (9: 1) was added to a 1 L three-necked flask, After the completion of the reaction, methanol triethylamine was distilled off, water was added to dissolve, and the mixture was extracted three times with dichloromethane. The organic layer was combined and washed once with water , Dried over anhydrous sodium sulfate, the solvent was distilled off,34.8 g of solid BP103a04 was obtained.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6338-55-2.

Reference:
Patent; Beu Light Je Ne Bio-me D Keol Tekeunolroji Ko ., L Tidi .; W An-ji-yen-dung; Hwang -yang-ching; Sung -wn-sung; W An-pang; (164 pag.)KR2019/7483; (2019); A;,
Alcohol – Wikipedia,
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6338-55-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of SL_0498 (120 mg, 177 mumol) in MeCN (15 mL) was added 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (26 mg, 177 mumol) followed by NEt3 (74 muL, 531 mumol). The resulting yellow solution was left at 22 C. for 16 hours, at which point TLC analysis indicated complete consumption of starting material. Solvent was removed in vacuo, and crude residue was purified by silica gel chromatography (0?10% MeOH/DCM) to provide 106 mg (87% yield) of SL_0503 as a clear oil. 1H NMR (300 MHz, DMSO-d6) delta 7.22-7.12 (m, 3H), 5.79 (m, 2H), 4.55 (t, J=5.5, 1H), 4.47-4.43 (m, 4H), 4.04 (t, J=4.8 Hz, 2H), 3.62 (t, J=6.6 Hz, 2H), 3.55 (t, J=4.8 Hz, 2H), 3.52-3.45 (m, 14H), 3.44-3.36 (m, 10H), 3.16-3.06 (m, 6H), 1.70 (p, J=6.7 Hz, 2H), 1.49 (p, J=6.9 Hz, 2H), 1.42-1.25 (m, 4H). MS (ESI+) calc’d for C29H55ClN3O13+ [M+H]+ 688.34, found 688.3

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol.

Reference:
Patent; Promega Corporation; Levin, Sergiy; Ohana, Rachel Friedman; Kirkland, Thomas; Wood, Keith V.; (117 pag.)US2016/355523; (2016); A1;,
Alcohol – Wikipedia,
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6338-55-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, molecular formula is C6H15NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of SL_0160 (269 mg, 732 mumol) in MeCN (10 mL) was added 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (109 mg, 732 mumol) followed by NEt3 (200 muL, 145 mumol). The resulting yellow solution was left at 22 C. for 24 hours, at which point TLC analysis indicated complete consumption of starting material. Solvent was removed in vacuo, and crude residue was purified by silica gel chromatography (0?100% EtOAc/hexanes) to provide 220 mg (80% yield) of SL_0483 as a clear oil. 1H NMR (300 MHz, DMSO-d6) delta 7.15 (t, J=5.4 Hz, 1H), 5.62 (dt, J=11.4, 5.7 Hz, 1H), 5.49 (dt, J=11.4, 6.5 Hz, 1H), 4.57-4.51 (m, 3H), 4.24 (d, J=5.7 Hz, 2H) 3.51-3.46 (m, 6H), 3.42-3.37 (m, 4H), 3.11 (q, J=5.9 Hz, 2H), 0.87 (s, 9H), 0.05 (s, 6H). MS (ESI+) calc’d for C17H35NaNO6Si+ [M+H]+ 400.21, found 400.2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Promega Corporation; Levin, Sergiy; Ohana, Rachel Friedman; Kirkland, Thomas; Wood, Keith V.; (117 pag.)US2016/355523; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows. 6338-55-2

A solution of the amino alcohol (620) (313.6 g, 2.1mol) in THF (3.5 L) was treated, portion- wise, with N-(Benzyloxycarbonyloxy)succinimide (621) (550 g, 2.21mol). Once the reaction was complete (18 h) the THF was removed under reduced pressure and the residue dissolved in CH2Cl2 (2.5 L), then washed with an equal volume of HCl (1 M), NaHCO3 (Sat. Aq.), H2O and brine. The organic extract was dried (MgSO4), filtered and concentrated. The crude material (600g) was subjected to chromatography (4kg silica; 1-12% CH3OH-CH2Cl2) to yield HO- Trig-NHZ (622) (468g, 78%) as a clear-yellow viscous oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; GENEVANT SCIENCES GMBH; HEYES, James; HOLLAND, Richard J.; JUDGE, Adam; LAM, Kieu Mong; (0 pag.)WO2020/93061; (2020); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts