Category: 6338-55-2

Reference of 6338-55-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, molecular formula is C6H15NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 16 (2.6 g, 17.4 mmol) was dissolved in a mixture of 10 mL of methanol and 5 mL of water,0.695g sodium hydroxide was dissolved in 10mL of water was added to the above solution,Then a solution of (Boc) 2O (4.167 g, 19.1 mmol) in methanol (5 mL) was added and stirred overnight.After the reaction was completed, the solvent was removed by spin-drying, 15 mL of water was added and extracted with dichloromethane (3 * 20 mL). After drying over anhydrous sodium sulfate, the organic solvent was removed and the residue was eluted with 1: 1 EtOAc / Column chromatography gave 2.15 g of compound 17 in 50% yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol.

Reference:
Patent; Shanghai Jiao Tong University; Shen Yumei; Yang Qinglai; Tan Lianjiang; Li Xinhui; Shao Zhifeng; Gong Bing; Li Xiaowei; Liu Yazhi; Zhang Zhen; (35 pag.)CN104725453; (2017); B;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, molecular formula is C6H15NO3, molecular weight is 149.1882, as common compound, the synthetic route is as follows.Computed Properties of C6H15NO3

S48 (0.45 g, 3.00 mmol), DIPEA (1.6 mL, 9.00 mmol) were added, dissolving in DMF (20 mL) at -12 C for 30 min in N2. Then S5 (in DMF, 5 mL, 0.71 g, 1.00 mmol) was dropped into this mixture, stirring overnight. After this reaction the solvent was removed, the mixture was dissolved in deionized water (25 mL), then the aqueous was washed by DCM (25 mL) three times. This aqueous dialyzed in deionized water 5 times and freeze-dried to get S49 (1.21 g, 67%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Wang, Jue; Qi, Wenjing; Chen, Guosong; Chinese Chemical Letters; vol. 30; 3; (2019); p. 587 – 591;,
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Application of 6338-55-2 ,Some common heterocyclic compound, 6338-55-2, molecular formula is C6H15NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

See FIG. 22 for the synthesis of DBCO-PEG-OH (compound [IV]). To a solution of 2- (2- (2-aminoethoxy) ethoxy) ethan-1-ol (compound [I], 0.267 g, 1.789 mmol) in 2 ml anhydrous DCM at RT was added DBCO- (Compound [II], 0.24 g, 0.596 mmol) in DMF (5 mL) was slowly added.After the addition is complete,The reaction solution was stirred for 2 hours at RT. HPLC showed complete disappearance of the succinimide. The reaction was maintained in the dark at -20 C in the freezer.The next morning,The reaction solution was warmed below RT and diluted with 3 ml DCM.Silica gel (5 g) was added and the slurry was evaporated to dryness on a rotary evaporator.Loading the remaining powder onto the ISCO loading cartridge,Purification by column chromatography (12 g silica gel column, 5-20% methanol / DCM)0.2 g of DBCO-PEG-OH (compound [IV]) was obtained. Yield: 77%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6338-55-2, its application will become more common.

Reference:
Patent; Roseuwel Bio Tekeu Nol Ro Jiseu In Kopo Lei Tideu; Me Ri-meon-bae-ri-el; Ga I-jeo-tim; Mol Ra-pol-deo-beul-yu; Ra I-deu-a-us-de-ril; (101 pag.)KR2019/34320; (2019); A;,
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Application of 6338-55-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

2-(2,6- Dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione (1.0 equiv.), compound 13a/13b/13c (1.5 equiv.) and DIPEA (3.0 equiv.) in 2 mL DMF were stirred at 90 C overnight. Water was added to the reaction mixture and it was extracted with EtOAc. The organic phase was washed with water x1, brine x1, dried over Na2SO4, filtered and evaporated to dryness. The resulting mixture was purified by column chromatography using DCM and MeOH as eluents to afford 14a-c. (0329) [0151] 2-(2,6-Dioxopiperidin-3-yl)-4-((2-(2-(2- hydroxyethoxy)ethoxy)ethyl)amino)isoindoline-1,3-dione (14a): 1H NMR (400 MHz, CDCl3) delta 8.19 (br s, 1H), 7.55-7.44 (m, 1H), 7.10 (d, J = 7.1 Hz, 1H), 6.91 (d, J = 8.5 Hz, 1H), 6.57 (t, J = 5.2 Hz, 1H), 4.91 (dd, J = 12.0, 5.4 Hz, 1H), 3.85-3.65 (m, 8H), 3.64-3.59 (m, 2H), 3.51-3.43 (m, 2H), 2.92-2.68 (m, 3H), 2.57 (br s, 1H), 2.18-2.07 (m, 1H) ppm.

According to the analysis of related databases, 6338-55-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOVENTURES, LLC; ZHENG, Guangrong; ZHOU, Daohong; ZHANG, Xuan; KHAN, Sajid; HE, Yonghan; ZHANG, Peiyi; (151 pag.)WO2019/144117; (2019); A1;,
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Application of 6338-55-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6338-55-2 as follows.

To a 1 L three-necked flask, 23.5 g of a compound BP103a03 (1.0 eq), 68.6 g (Boc)2O (2.0 eq), and a mixture of methanol and triethylamine (9:1) (500 ml) were added, and the mixture was stirred and refluxed for 1 h. After completion of the reaction was monitored by TLC, methanol was evaporated triethylamine, dissolved in water and extracted three times with dichloromethane, and the combined organic layers were washed with water once, dried over anhydrous sodium sulfate, the solvent was distilled off, and dried to give a solid BP103a04 of 34.8g

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6338-55-2, its application will become more common.

Reference:
Patent; Borui Bio-pharmaceutical (Suzhou) Co., Ltd.; Yuan Jiandong; Huang Yangqing; Song Yunsong; (20 pag.)CN109771658; (2019); A;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, molecular formula is C6H15NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C6H15NO3

To a stirring mixture of 2-[2-(2-aminoethoxy)ethoxy]ethanol (S108A, 25.0 g, 167 mmol) and N-methyl morpholine (21.0 mL, 191 mmol) in dioxane (100 mL) was added dropwise a solution of Fmoc-OSu (62.2 g, 184 mmol) in dioxane (50 mL). After stirring overnight, the reaction was concentrated in vacuo to afford a light yellow oil. The crude was re-dissolved in EtOAc and washed with sat. NaHCO3 (aq.) and brine. The organic layer was removed in vacuo to afford an oil, which was purified by SiO2 chromatography to provide the FmocNH-PEG2-OH (S108, 55 g, 88% yield). ESI+ m/z calcd 371.4, found 372.2 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 6338-55-2.

Reference:
Patent; TOLLNINE, INC.; PONS, Jaume; WAN, Hong I.; BRADSHAW, Curt W.; SIM, Bang Janet; KUO, Tracy Chia-Chien; (239 pag.)WO2020/81744; (2020); A1;,
Alcohol – Wikipedia,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, molecular formula is C6H15NO3, molecular weight is 149.1882, as common compound, the synthetic route is as follows.HPLC of Formula: C6H15NO3

A solutionof 2-[2-(2-aminoethoxy)ethoxy]ethanol (0.41 g, 2.75 mmol, 1.1 eq.) and Et3N (660 L, 4.75mmol, 1.9 eq.) in methanol (15 mL) was stirred at 30C for 1 h. NBD-Cl (0.5 g, 2.50 mmol, 1eq.) was added and the reaction was stirred in the dark for 16 h at 30C. Insoluble material wasremoved by filtration, and the filtrate was dried. The resulting solid was dissolved in H2O (5mL) and purified on a sephadex LH-20 column, eluting with H2O to give the product as anorange solid (0.33 g, 1.05 mmol, 42% yield).LRMS (ESI-): m/z calculated 311.10 ([M-H]-), found 311.18 ([M-H]-), (ESI+): m/z calculated335.27 ([M+Na]+), found 335.09 ([M+Na]+); HRMS (ESI+): m/z calculated 335.09621([M+Na]+) for C12H16N4O6Na, found 335.09650 ([M+Na]+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Glenister, Alexandra; Simone, Michela I.; Hambley, Trevor W.; PLoS ONE; vol. 14; 7; (2019);,
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Electric Literature of 6338-55-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 6338-55-2, Name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, SMILES is NCCOCCOCCO, belongs to alcohols-buliding-blocks compound. In a article, author is Hogan, Natasha L., introduce new discover of the category.

Brain-Derived neurotrophic factor Va166Met induces female-specific changes in impulsive behaviour and alcohol self-administration in mice

Substance use disorders are a debilitating neuropsychiatric condition, however it remains unclear why some individuals are at greater risk of substance use disorders than others and what genetic factors determine such individual differences. Impulsivity appears a promising candidate endophenotype to bridge the gap between genetic risk and addiction. Brain-derived neurotrophic factor (BDNF), and in particular the BDNFval66Met polymorphism, has been suggested to be involved in both impulsivity and substance use disorders, however results so far have been inconsistent. To investigate the role of BDNF, and more specifically the BDNFval66Met polymorphism, in both impulsivity and operant alcohol self-administration using the same animal model. Separate cohorts of humanized Val66Met transgenic mice were assessed for either trait impulsivity in the 5-choice serial reaction time (5-CSRT) touchscreen task, or propensity towards obtaining ethanol in an operant paradigm. It was found that female hBDNE(val/val) mice exhibited both greater impulsivity compared to hBDNF(Met/Met) mice of the same sex as shown by a higher number of premature responses at one of three increased inter-trial intervals tested in the 5-CSRT task, and a greater propensity toward stable ethanol self-administration relative to male mice of the same genotype in the operant paradigm. By contrast, male mice showed no difference between genotypes in impulsivity or stable ethanol self-administration. The hBDNF(Met/Met) genotype appears to sex-specifically alter aspects of both impulsive behaviour and addiction propensity. These results suggest that impulse behaviour may be a possible predictor of addiction risk.

Electric Literature of 6338-55-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 6338-55-2.

Reference:
Alcohol – Wikipedia,
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Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.6338-55-2, Name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, SMILES is NCCOCCOCCO, belongs to alcohols-buliding-blocks compound. In a document, author is Doaei, Saeid, introduce the new discover, SDS of cas: 6338-55-2.

Interactions of anthropometric indices, rs9939609 FTO gene polymorphism and breast cancer: A case-control study

Contradictory results were reported on the effect of fat mass- and obesity-associated (FTO) gene and anthropometric measurements on breast cancer (BC). This study aimed to assess the interactions between rs9939609 polymorphism of FTO gene, anthropometric indices and BC risk in Iranian women. This case-control study was performed on 540 women including 180 women with BC and 360 healthy women in Tehran, Iran. Physical activity and dietary intakes were assessed by validated questionnaires. Data on sociodemographic and pathologic factors of the participants as well as their blood samples were collected. The rs9939609 FTO gene polymorphism was genotyped using the tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). No significant association was found between BC and risk allele of FTO rs9939609 polymorphism after adjustments for the confounders. However, there was a significant association between rs9939609 polymorphism risk allele and BC risk in females with overweight, even after adjusting for age, family history of BC, abortion, BMI and the number of pregnancies (P < .05). The association was disappeared after further adjustments for lifestyle factors including smoking, alcohol consumption, calorie and macronutrients intake, and physical activity. The FTO gene polymorphism was associated with the risk of BC in overweight individuals. This association was influenced by environmental factors including diet, alcohol consumption and smoking. Future studies are required to confirm the association between the FTO gene and BC in overweight females and to identify the underlying mechanisms. The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 6338-55-2 is helpful to your research. SDS of cas: 6338-55-2.

Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.6338-55-2, Name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, SMILES is NCCOCCOCCO, belongs to alcohols-buliding-blocks compound. In a document, author is Doaei, Saeid, introduce the new discover, SDS of cas: 6338-55-2.

Interactions of anthropometric indices, rs9939609 FTO gene polymorphism and breast cancer: A case-control study

Contradictory results were reported on the effect of fat mass- and obesity-associated (FTO) gene and anthropometric measurements on breast cancer (BC). This study aimed to assess the interactions between rs9939609 polymorphism of FTO gene, anthropometric indices and BC risk in Iranian women. This case-control study was performed on 540 women including 180 women with BC and 360 healthy women in Tehran, Iran. Physical activity and dietary intakes were assessed by validated questionnaires. Data on sociodemographic and pathologic factors of the participants as well as their blood samples were collected. The rs9939609 FTO gene polymorphism was genotyped using the tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). No significant association was found between BC and risk allele of FTO rs9939609 polymorphism after adjustments for the confounders. However, there was a significant association between rs9939609 polymorphism risk allele and BC risk in females with overweight, even after adjusting for age, family history of BC, abortion, BMI and the number of pregnancies (P < .05). The association was disappeared after further adjustments for lifestyle factors including smoking, alcohol consumption, calorie and macronutrients intake, and physical activity. The FTO gene polymorphism was associated with the risk of BC in overweight individuals. This association was influenced by environmental factors including diet, alcohol consumption and smoking. Future studies are required to confirm the association between the FTO gene and BC in overweight females and to identify the underlying mechanisms. The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 6338-55-2 is helpful to your research. SDS of cas: 6338-55-2.

Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts