Category: 63012-03-3

Ramanujam, V. M. Sadagopa’s team published research in Australian Journal of Chemistry in 1977 | CAS: 63012-03-3

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.SDS of cas: 63012-03-3 Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

《Chromic acid oxidation of benzhydrols – kinetics and mechanism》 was published in Australian Journal of Chemistry in 1977. These research results belong to Ramanujam, V. M. Sadagopa; Venkatasubramanian, N.; Sundaram, S.. SDS of cas: 63012-03-3 The article mentions the following:

The kinetics of the oxidation of Ph2CHOH and several derivatives by chromium(VI) oxide in aqueous AcOH were studied. The rate of oxidation is expressed as: υ = k3[ArAr’CHOH][CrVI][H+]2. The effect of ring substituents on the rate gives a ρ+ value of -0.546 (r = 0.959) pointing to the development of an electron-deficient centre in the transition state. The oxidation of Ph2CDOH proceeds 6.5 times slower than that of its H analog at 55°C. From the Arrhenius plots, activation parameters were evaluated and the isokinetic relationship was analyzed. The results are discussed in terms of a mechanism involving a rate-determining loss of hydride ion from the α-carbon of benzhydroxy chromate ester. In addition to this study using (3-Chlorophenyl)(phenyl)methanol, there are many other studies that have used (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3SDS of cas: 63012-03-3) was used in this study.

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.SDS of cas: 63012-03-3 Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

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Pajouhesh, Hassan’s team published research in Bioorganic & Medicinal Chemistry Letters in 2010 | CAS: 63012-03-3

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Application In Synthesis of (3-Chlorophenyl)(phenyl)methanol

Pajouhesh, Hassan; Feng, Zhong-Ping; Ding, Yanbing; Zhang, Lingyun; Pajouhesh, Hossein; Morrison, Jerrie-Lynn; Belardetti, Francesco; Tringham, Elizabeth; Simonson, Eric; Vanderah, Todd W.; Porreca, Frank; Zamponi, Gerald W.; Mitscher, Lester A.; Snutch, Terrance P. published an article on February 15 ,2010. The article was titled 《Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Application In Synthesis of (3-Chlorophenyl)(phenyl)methanol The information in the text is summarized as follows:

A novel series of compounds derived from the previously reported N-type calcium channel blocker NP118809 (1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one) is described. Extensive SAR studies resulted in compounds with IC50 values in the range of 10-150 nM and selectivity over the L-type channels up to nearly 1200-fold. Orally administered compounds 5 and 21 (I) exhibited both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain. The results came from multiple reactions, including the reaction of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Application In Synthesis of (3-Chlorophenyl)(phenyl)methanol)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Application In Synthesis of (3-Chlorophenyl)(phenyl)methanol

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Singh, Pallavi’s team published research in Journal of Chemical Sciences (Berlin, Germany) in 2022 | CAS: 63012-03-3

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Product Details of 63012-03-3

Singh, Pallavi; Peddinti, Rama Krishna published an article in Journal of Chemical Sciences (Berlin, Germany). The title of the article was 《In situ generated superacid BF3-H2O catalyzed alkylation of p-quinols with diaryl carbinols leading to triarylmethanes》.Product Details of 63012-03-3 The author mentioned the following in the article:

In this paper, a highly efficient and sustainable synthesis of triarylmethanes 4-R-3,6-(OH)2C6H2CH(4-R2C6H4)(4-R1C6H4) (R = Me, Et, i-Pr, Ph; R1 = H, F, Cl, Me; R2 = H, F, Cl, Me, Br) through the dehydrative coupling of p-quinols I with diaryl carbinols 4-R1C6H4CH(OH)(4-R2C6H4) is presented. The catalyst involved in this protocol is in situ generated superacid BF3-H2O from BF3-OEt2. Therefore, moisture has been used as an efficient initiator in this reaction system. A variety of diaryl carbinols and p-quinols have been investigated and found to be compatible to give the triarylmethanes in yields up to 96%.(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Product Details of 63012-03-3) was used in this study.

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Product Details of 63012-03-3

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Nagarajan, K.’s team published research in Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical in 1979 | CAS: 63012-03-3

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Application In Synthesis of (3-Chlorophenyl)(phenyl)methanol

Application In Synthesis of (3-Chlorophenyl)(phenyl)methanolOn October 31, 1979 ,《Oxidation of secondary alcohols by chromium(VI) in presence of oxalic acid》 appeared in Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical. The author of the article were Nagarajan, K.; Sundaram, S.; Venkatasubramanian, N.. The article conveys some information:

The substituent effects on the oxidation kinetics of secondary alcs. (e.g., Ph2CHOH, PhCHMeOH) by Cr(VI) are examined A comparison of the reactivities of secondary alcs. towards oxidation by Cr(VI) in the presence of oxalic acid is also made. The increased reactivity is explained on the basis of the formation of a ternary complex of oxalic acid-Cr(VI)-alcs. with a rate-determining decomposition of the complex involving a direct transition from Cr(VI) to Cr(III). The reduced selectivity in the magnitude of the subsequent effects agrees with this mechanism. The results came from multiple reactions, including the reaction of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Application In Synthesis of (3-Chlorophenyl)(phenyl)methanol)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Application In Synthesis of (3-Chlorophenyl)(phenyl)methanol

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Brief introduction of 63012-03-3

At the same time, in my other blogs, there are other synthetic methods of this type of compound,63012-03-3, (3-Chlorophenyl)(phenyl)methanol, and friends who are interested can also refer to it.

Synthetic Route of 63012-03-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 63012-03-3, name is (3-Chlorophenyl)(phenyl)methanol. A new synthetic method of this compound is introduced below.

To the mixture of (3-chlorophenyl)(phenyl)methanol (42.6 mg, 0.195 mmol), (cyanomethyl)trimethylphosphonium iodide (63.2 mg, 0.26 mmol) and 8-((2S,5R)-2,5- dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile, TFA (44.6 mg, 60 %wt, 0.065 mmol) in propanenitrile (0.3 mL) was added Hunig?s base (0.114 mL, 0.65 mmol). The reaction mixture was stirred at 110 C for 5 hours. The crude material was purified via preparative LC/MS with the following conditions: (1934) Column: XBridge C18, 200 mm x 19 mm, 5 mm particles; Mobile Phase A: 5:95 acetonitrile: water with 10 mM ammonium acetate; Mobile Phase B: 95:5 acetonitrile: water with 10 mM ammonium acetate; Gradient: a 0 minute hold at 50 % B, 50-90 % B over 20 minutes, then a 4 minute hold at 100 % B; Flow Rate: 20 mL/min; Column Temperature: 25 C. Fraction collection was triggered by MS and UV signals. Fractions containing the product were combined and dried via centrifugal evaporation. The yield of diastereomeric product was 7.4 mg. Calculated molecular weight 498.03. Analytical LC/MS was used to determine the final purity. Injection 1 conditions: Column: Waters XBridge C18, 2.1 mm x 50 mm, 1.7 mm particles; Mobile Phase A: 5:95 (1935) acetonitrile:water with 10 mM ammonium acetate; Mobile Phase B: 95:5 (1936) acetonitrile:water with 10 mM ammonium acetate; Temperature: 50 C; Gradient: 0 %B to 100 %B over 3 min, then a 0.50 min hold at 100 %B; Flow: 1 mL/min; Detection: MS and UV (220 nm). Injection 1 results: Purity: 99.4 %; Observed Mass: 498.12; Retention Time: 2.74 min. Injection 2 conditions: Column: Waters XBridge C18, 2.1 mm x 50 mm, 1.7 mm particles; Mobile Phase A: 5:95 acetonitrile:water with 0.1 % trifluoroacetic acid; Mobile Phase B: 95:5 acetonitrile:water with 0.1% trifluoroacetic acid; Temperature: 50 C; Gradient: 0 %B to 100 %B over 3 min, then a 0.50 min hold at 100 %B; Flow: 1 mL/min; Detection: MS and UV (220 nm). Injection 2 results: Purity: 98.1 %; Observed Mass: 498.13; Retention Time: 1.83 min

At the same time, in my other blogs, there are other synthetic methods of this type of compound,63012-03-3, (3-Chlorophenyl)(phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; VELAPARTHI, Upender; CHUPAK, Louis S.; DARNE, Chetan Padmakar; DING, Min; GENTLES, Robert G.; HUANG, Yazhong; KAMBLE, Manjunatha Narayana Rao; MARTIN, Scott W.; MANNOORI, Raju; MCDONALD, Ivar M.; OLSON, Richard E.; RAHAMAN, Hasibur; JALAGAM, Prasada Rao; ROY, Saumya; TONUKUNURU, Gopikishan; VELAIAH, Sivasudar; WARRIER, Jayakumar Sankara; ZHENG, Xiaofan; TOKARSKI, John S.; DASGUPTA, Bireshwar; REDDY, Kotha Rathnakar; RAJA, Thiruvenkadam; (0 pag.)WO2020/6018; (2020); A1;,
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New learning discoveries about category: alcohols-buliding-blocks

At the same time, in my other blogs, there are other synthetic methods of this type of compound,63012-03-3, (3-Chlorophenyl)(phenyl)methanol, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63012-03-3, name is (3-Chlorophenyl)(phenyl)methanol, molecular formula is C13H11ClO, molecular weight is 218.68, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks

General procedure: To a solution of thiol 1 (0.5 mmol) in anhyd CH2Cl2 (2 mL) was added diaryl carbinol 2 (0.6 mmol) and BF3*OEt2 (5 mol% solution in CH2Cl2; 1 mL). The reaction mixture was stirred vigorously for <1 min. After completion of the reaction as checked by TLC, the solvent was removed under reduced pressure, and the residue was subjected to silica gel column chromatography by using 5-10% EtOAc in hexanes to afford the desired symmetrical and unsymmetrical diarylmethyl thioether in good to quantitative yield. At the same time, in my other blogs, there are other synthetic methods of this type of compound,63012-03-3, (3-Chlorophenyl)(phenyl)methanol, and friends who are interested can also refer to it. Reference:
Article; Singh, Pallavi; Peddinti, Rama Krishna; Synthesis; vol. 49; 16; (2017); p. 3633 – 3642;,
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