Category: 63012-03-3

Product Details of 63012-03-3On November 30, 2021 ,《Regio- and Stereoselective Synthesis of (Z)- 3-Ylidenephthalides via H3PMo12O40-Catalyzed Cyclization of 2-Acylbenzoic Acids with Benzylic Alcohols》 appeared in Chinese Journal of Chemistry. The author of the article were Yang, Guoping; Li, Ke; Lin, Xiaoling; Li, Yijin; Cui, Chengxing; Li, Shixiong; Cheng, Yuanyuan; Liu, Yufeng. The article conveys some information:

Author report an exclusively tandem C-O and C-C bond forming beyond the esterification and cyclization reaction of 2-acylbenzoic acids with alcs. to regio- and stereoselective synthesis of the (Z)-3-ylidenephthalides. The reaction uses the nontoxic, inexpensive H3PMo12O40 as catalyst and produces water as the sole byproduct, making the reaction environmentally benign and sustainable. Moreover, this reaction features an eco-friendly reaction condition, facile scalability, and easy derivatization of the products to drugs and bioactive compounds The mechanism studies and d. functional theory calculations reveal that the appropriate acid catalyst is the key to the selectivity of this transformation. The experimental part of the paper was very detailed, including the reaction process of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Product Details of 63012-03-3)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Product Details of 63012-03-3

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Alcohol – Wikipedia,
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HPLC of Formula: 63012-03-3On November 5, 2004 ,《The effects of aromatic substituents on the chromatographic enantioseparation of diarylmethyl esters with the Whelk-O1 chiral stationary phase》 appeared in Journal of Chromatography A. The author of the article were Job, Gabriel E.; Shvets, Alex; Pirkle, William H.; Kuwahara, Shunsuke; Kosaka, Masashi; Kasai, Yusuke; Taji, Hiromi; Fujita, Kaori; Watanabe, Masataka; Harada, Nobuyuki. The article conveys some information:

Members of diarylmethanols, diarylmethyl pivalates, and diarylmethyl acetates were enantioresolved with the (S,S)-Whelk-O1 chiral stationary phase (CSP). An analog of the (S,S)-Whelk-O1 selector was combined with enantioenriched samples of the various diarylmethyl pivalates and thereby used as a chiral solvating agent (CSA) for high field 1H NMR studies. The absolute configurations of a number of chiral diarylmethyl pivalates were assigned using this approach, and hydrolysis of the pivalates allowed assignment of the absolute configurations of the corresponding diarylmethanols. Chromatog., 1H NMR, and x-ray evidence are given in support of a chiral recognition model for the enantioresoln. of diarylmethyl esters on this CSP. In the experimental materials used by the author, we found (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3HPLC of Formula: 63012-03-3)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.HPLC of Formula: 63012-03-3

Referemce:
Alcohol – Wikipedia,
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Stavber, Stojan; Kosir, Iztok; Zupan, Marko published an article in Journal of Organic Chemistry. The title of the article was 《Reactions of Alcohols with Cesium Fluoroxysulfate》.SDS of cas: 63012-03-3 The author mentioned the following in the article:

The reactions of alcs. with cesium fluoroxysulfate (CsSO4F) in MeCN suspension were studied, and the role of the structure of the alc. and the reaction conditions on the course of reaction was determined Secondary benzyl alcs. bearing a nonactivating aromatic ring were selectively oxidized to the corresponding ketones, while the CsSO4F-mediated reaction of phenyl-1-naphthylmethanol resulted in the formation of 1-fluoronaphthalene and benzaldehyde. Cyclic and noncyclic secondary alcs. were readily converted to ketones, as well as 1-hydroxybenzocyclanes to benzocyclanones-1, without any further fluorination or oxidation under the reaction conditions. On the other hand, reactions of primary alcs. with CsSO4F resulted in the formation of acid fluorides derived from further fluorination of aldehydes. Another type of transformation was observed in the case of alcs. bearing a benzyl functional group attached geminal to a hydroxy group, where decarbonylation of reactive intermediates resulting in the formation of benzyl fluoride derivatives became the main process. 2-Phenylethanol was so converted to benzyl fluoride and phenylacetyl fluoride in a 3:1 relative ratio, while 2-phenyl-1-propanol was selectively transformed to 1-phenyl-1-fluoroethane. The presence of the radical inhibitor nitrobenzene in the reaction mixture considerably inhibited conversion of the starting material. The same effect was observed by lowering the solvent polarity. Hammett correlation anal. of the effect of substituents on the reaction rates of oxidation of a set of substituted 1-phenyl-1-ethanols to acetophenones gave the reaction constant ρ+ = -0.32, while anal. of analogous data for the transformations of benzyl alcs. to benzoyl fluorides gave the value of -0.54. A mechanism including radical intermediates was proposed for the transformation of alcs. by CsSO4F. In the part of experimental materials, we found many familiar compounds, such as (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3SDS of cas: 63012-03-3)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.SDS of cas: 63012-03-3 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Solvolytic Reactivity of Heptafluorobutyrates and Trifluoroacetates》 was written by Denegri, Bernard; Kronja, Olga. Name: (3-Chlorophenyl)(phenyl)methanol And the article was included in Journal of Organic Chemistry on August 21 ,2009. The article conveys some information:

X,Y-substituted benzhydryl heptafluorobutyrates and trifluoroacetates were subjected to solvolysis in various methanol/water, ethanol/water, and acetone/water mixtures at 25 °C. The LFER equation log k = sf(Ef + Nf) was used to derive the nucleofuge-specific parameters (Nf and sf) for SN1-type reaction. In comparison with TFA, the HFB leaving group is a better nucleofuge for <0.5 unit of Nf. X,Y-Substituted benzhydryl trifluoroacetates solvolyze by way of SN1 reactions unless electron-withdrawing groups are attached to aromatic rings. In such cases the substrates solvolyze faster than predicted for the SN1 route because of the change in mechanism. X,Y-Substituted benzhydryl heptafluorobutyrates examined here (Ef ≥ -7.7) solvolyze according to the SN1 pathway. The almost parallel log k vs. Ef lines in various solvents for HFBs and TFAs, and the corresponding slope parameters (sf are in the range of 0.91 and 0.83), indicate early TS with moderately advanced charge separation NBO charges of HFB and TFA anions and the affinities obtained, all calculated at the PCM-B3LYP/6-311+G(2d,p)//PCM-B3LYP/6-311+G(2d,p) level, revealed that the HFB anion slightly better delocalizes the developing neg. charge than TFA, and that the affinity of the benzhydrylium ion is slightly larger toward TFA than toward the HFB anion, which is in accordance with the greater solvolytic reactivity of HFB.(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Name: (3-Chlorophenyl)(phenyl)methanol) was used in this study.

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Name: (3-Chlorophenyl)(phenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stavber, Stojan; Planinsek, Zdenka; Kosir, Iztok; Zupan, Marko published their research in Journal of Fluorine Chemistry on December 31 ,1992. The article was titled 《Substituent modulation of mild fluorination of aromatic molecules with cesium fluoroxysulfate》.Formula: C13H11ClO The article contains the following contents:

Functionalization of mono- and disubstituted benzene derivative with CsSO4F has been modulated by substituents on the benzene ring. α-Hydroxyalkylbenzenes, with a deactivated ring, were oxidized to phenones, while fluorodealkylation was achieved in high yield when electron-donating groups were present in a para position. Electron-withdrawing substituents favored chain fluorofunctionalization in alkylbenzenes, while ring fluorination was found exclusively in acylamino-derivatized alkylbenzenes; fluoro-addition products were formed in the case of p-alkoxy-substituted alkylbenzene derivatives In the experiment, the researchers used (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Formula: C13H11ClO)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Formula: C13H11ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Bio-inspired asymmetric aldehyde arylations catalyzed by rhodium-cyclodextrin self-inclusion complexes》 was published in Organic & Biomolecular Chemistry in 2022. These research results belong to Tsuda, Susumu; Asahi, Kaoru; Takahashi, Ryota; Yamauchi, Hiroki; Ueda, Ryoji; Iwasaki, Takanori; Fujiwara, Shin-ichi; Kambe, Nobuaki. Safety of (3-Chlorophenyl)(phenyl)methanol The article mentions the following:

Chiral aralkyl alcs. RCH(OH)Ar1 were prepared by asym. arylation of aldehydes RCHO (R = substituted Ph, 2-naphthyl, 2-furyl, Bu) with arylboronic acids Ar1B(OH)2 (Ar1 = substituted P, 2-naphthyl, benzodioxolyl) catalyzed by in situ-formed rhodium self-inclusion NHC-cyclodextrin conjugated complexes. Reaction of 6-O-tosyl-substituted α- and γ-cyclodextrins with 1-Me and 1-mesityl-substituted imidazoles afforded imidazolium proligands Im-CD (L1-L4), which, upon reaction with Rh2(OAc)4 catalyze asym. arylation of the aldehydes RCHO. Transition-metal catalysts are powerful tools for carbon-carbon bond-forming reactions that are difficult to achieve using native enzymes. Enzymes that exhibit inherent selectivities and reactivities through host-guest interactions have inspired widespread interest in incorporating enzymic behavior into transition-metal catalytic systems that highly efficiently produce enantiopure compounds Nevertheless, bio-inspired transition-metal catalysts that are highly enantioselective and reactive have rarely been reported. In this study, we applied γ-cyclodextrin-imidazolium salts to the rhodium-catalyzed asym. arylations of aldehydes. The method exhibits wide substrate scope and the corresponding arylcarbinols are obtained in excellent yields under optimized conditions, with enantiomeric excesses of up to 96% observed Kinetic and competition experiments revealed that self-inclusion of the Rh complex contributes to the high enantioselectivity and reactivity achieved by this catalytic system. Thus, this bio-inspired self-inclusion strategy is promising for the development of highly enantioselective and reactive transition-metal catalysts for asym. carbon-carbon bond formation. The experimental process involved the reaction of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Safety of (3-Chlorophenyl)(phenyl)methanol)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Safety of (3-Chlorophenyl)(phenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthesis, Biological Evaluation, and Binding Mode of Novel 1-[2-(Diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles Targeted at the HIV-1 Reverse Transcriptase》 was written by Silvestri, Romano; Artico, Marino; De Martino, Gabriella; Ragno, Rino; Massa, Silvio; Loddo, Roberta; Murgioni, Chiara; Loi, Anna Giulia; La Colla, Paolo; Pani, Alessandra. Quality Control of (3-Chlorophenyl)(phenyl)methanol And the article was included in Journal of Medicinal Chemistry on April 11 ,2002. The article conveys some information:

A novel series of 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazole (DAMNI) analogs were synthesized and tested in cell-based assays and in enzyme assays against HIV-1 recombinant reverse transcriptase (RT). Preparation of the new derivatives was performed by reacting the appropriate benzhydrols or the corresponding bromides with 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole or the 3-hydroxypropyl homolog. Several compounds showed anti-HIV-1 activity in the submicromolar range. Structure-activity relationship studies suggested that meta substitution at one Ph ring of the diarylmethane moiety strongly influences the antiviral activity. 3,5-Disubstitution at the same Ph ring led to less potent derivatives Mol. modeling and docking studies within the RT non-nucleoside binding site confirmed that DAMNIs, similar to other NNRTIs such as TNK-651 and delavirdine (BHAP U90152), assume a butterfly-like conformation that appears to be halfway between that of classical NNRTIs, such as nevirapine, HEPT, TBZ, TIBO, and DABOs, and the conformation of BHAPs. In particular, the diphenylmethane moiety mimics the wings whereas the 1-(2-methyl-5-nitroimidazolyl)ethane portion resembles the BHAP 5-methanesulfonamidoindole-2-carbonylpiperazine portion. In the experiment, the researchers used many compounds, for example, (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Quality Control of (3-Chlorophenyl)(phenyl)methanol)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Quality Control of (3-Chlorophenyl)(phenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

COA of Formula: C13H11ClOOn March 14, 1997, Kline, Richard H.; Izenwasser, Sari; Katz, Jonathan L.; Joseph, David B.; Bowen, Wayne D.; Newman, Amy Hauck published an article in Journal of Medicinal Chemistry. The article was 《3′-Chloro-3α-(diphenylmethoxy)tropane But Not 4′-Chloro-3α-(diphenylmethoxy)tropane Produces a Cocaine-like Behavioral Profile》. The article mentions the following:

A series of 2′- and 3′-substituted and 3′,3”-disubstituted 3α-(diphenylmethoxy)tropane analogs were designed and synthesized as novel probes for the dopamine transporter. All the analogs were evaluated for displacement of [3H]WIN 35,428 binding at the dopamine transporter and for inhibition of [3H]dopamine uptake in rat caudate putamen. Compounds were observed to monophasically displace [3H]WIN 35,428 binding to the dopamine transporter with affinities of 21.6-1836 nM (Ki). Generally, meta-substituted compounds were more potent than benztropine and equipotent to or slightly less potent than their previously reported para-substituted homologs in inhibiting [3H]WIN 35,428 binding. However, these same meta-substituted analogs were typically less potent than the 4′-substituted analogs in inhibiting [3H]dopamine uptake. Ortho-substituted analogs were generally less potent in both binding and inhibition of uptake at the dopamine transporter than either benztropine or other aryl-substituted homologs. The analogs were also tested for binding at norepinephrine and serotonin transporters as well as muscarinic M1 receptors. None of the compounds in the present study bound with high affinity to either the norepinephrine or serotonin transporters, but all bound to muscarinic M1 receptors with high affinity (Ki = 0.41-2.52 nM). Interestingly, 3′-chloro-3α-(diphenylmethoxy)tropane produced effects like cocaine in animals trained to discriminate 10 mg/kg cocaine from saline, unlike its 4′-Cl homolog and all of the previously evaluated benztropine analogs. Further evaluation of 3′-chloro-3-(diphenylmethoxy)tropane and the other benztropine analogs will undoubtedly prove useful in the elucidation of the role of the dopamine transporter in the reinforcing effects of cocaine and the ultimate identification of a cocaine-abuse treatment. In the experimental materials used by the author, we found (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3COA of Formula: C13H11ClO)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.COA of Formula: C13H11ClO

Referemce:
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Alcohols – Chemistry LibreTexts

Fu, Zhengsheng; Sun, Liping; Cai, Jun; Wang, Xiaoxiong; Wang, Xiaofeng; Zheng, Shangzhen; Shen, Xuwei published an article in Journal of Chromatographic Science. The title of the article was 《Paper chromatographic separation of racemic diphenylmethyl alcohols using only pure water surfactant micellar mobile phase and host-guest chromatography》.Computed Properties of C13H11ClO The author mentioned the following in the article:

This paper reports the separation of nine pairs of racemic diphenylmethyl alcs. with paper chromatog. using hexadecyltrimethylammonium bromide pure H2O micellar solution as the mobile phase. The resulting resolution is excellent. The authors use a novel theory, host-guest chromatog., to describe the main driving force of chromatog. on micellar paper and to discuss the retention behavior. The mechanism of micellar paper chromatog. conforms to the Armstrong equation. The results came from multiple reactions, including the reaction of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Computed Properties of C13H11ClO)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Computed Properties of C13H11ClO Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Palladium-Catalyzed Regiodivergent Substitution of Propargylic Carbonates》 was published in Chemistry – A European Journal in 2016. These research results belong to Locascio, Theresa M.; Tunge, Jon A.. Product Details of 63012-03-3 The article mentions the following:

The palladium(0)-catalyzed, ligand-controlled, regioselective addition of diaryl acetonitrile pronucleophiles to propargylic carbonates is reported. Selective formation of either terminal 1,3-dienyl or propargylated products is proposed to arise from a change in reaction mechanism controlled by the denticity of the coordinating ligand. After reading the article, we found that the author used (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Product Details of 63012-03-3)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Product Details of 63012-03-3 Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts