Category: 629-41-4

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 629-41-4, name is 1,8-Octanediol, the common compound, a new synthetic route is introduced below. Computed Properties of C8H18O2

A new series of tris-malonate tethers that possess an open structure and bear alkyl groups as spacers were tested. The synthesis of one such tether that worked well with C60 is described in FIG. 6. PPTS: Pyridinium toluene-4-sulfonate. The intermediates of the synthesis of FIG. 6 were purified by flash column chromatography as follows, and were fully characterized by 13C-, 1H-NMR and mass spectrometry (FAB-MS). 1: SiO2, Hexane/EtOAc=1/1, Colorless oil. 2: SiO2, Hexane/EtOAc=7/3, Colorless oil. 3: SiO2, Hexane/EtOAc=3/2, Colorless oil. 4: SiO2, Hexane/EtOAc=1/1, Colorless oil. The yield of the first step of the synthesis was 39% because the bis-protected diol was also formed. The reason is that 1,8-octane-diol was not well soluble in CH2Cl2 and consequently, the mono-protected diol (soluble in CH2Cl2) was subjected to a rapid second reaction. We expect the use of larger amounts of solvent will improve the yield of the first step of the synthesis. Yields about 85% have been reported for similar diols according to the experimental procedure we followed. For details see: H. M. S. Kumar, B. V. S. Reddy, E. J. Reddy, J. S. Yadav, Chemistry Letters, 1999, 857-858.

The synthetic route of 629-41-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hirsch, Andreas; Beuerle, Florian; Chronakis, Nikos; US2006/47167; (2006); A1;,
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Application of 629-41-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 629-41-4, name is 1,8-Octanediol, molecular formula is C8H18O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The compound 2-1-1 (octanediol) (1.01 g, 6.91 mmol) was dissolved in 20 ml of toluene, and 40% HBr (aq) (1.12 ml, 7.81 mmol) was added to the reaction system at room temperature, bath reflux.72h after TLC monitoring, there is still the remaining raw materials, add 40% HBr (aq) (0.5ml, 3.49mmol), continue to return 24h.The system was cooled to room temperature, diluted with ether, saturated sodium bicarbonate solution, saturated sodium chloride solution, washed once, sodium sulfate dried about half an hour after the filter, steamed ether.The residue was purified by column chromatography on silica gel, eluting with petroleum ether: ethyl acetate = 6: 1 to give an oily product, 1.21 g, in 84.3% yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 629-41-4, 1,8-Octanediol.

Reference:
Patent; PEKING UNIVERSITY; YE, XINSHAN; HOU, JINGFEI; (25 pag.)CN103373955; (2016); B;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.629-41-4, name is 1,8-Octanediol, molecular formula is C8H18O2, molecular weight is 146.23, as common compound, the synthetic route is as follows.Safety of 1,8-Octanediol

General procedure: A mixture of 1,n-diols 1a-d (1.0 mmol), DHP-hexane 3% (v/v) (1.96 mmol) and aqueous 5 M NaHSO4 (01 mL) was prepared. To 1,10-decanediol 1c and 1,12-dodecanediol 1d, 0.2 mL of DMSO were also added to the mixture at the beginning of the reaction. This mixture was stirred at 40 C for 16 h and then extracted with hexane (3 × 20 mL). The combined organic phases were dried (Na2SO4), filtered and then evaporated under reduced pressure. The residue obtained was chromatographed using silica gel using hexane/EtOAc (8:2) to yield pure Compounds 2a-d.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,629-41-4, 1,8-Octanediol, and friends who are interested can also refer to it.

Reference:
Article; Gonalves, Alessandra Mirtes Marques Neves; De Lima, Aline Brito; Da Silva Barbosa, Maria Cristina; De Camargos, Luiz Fernando; De Oliveira, Jlia Teixeira; De Souza Barbosa, Camila; Villar, Jos Augusto Ferreira Perez; Costa, Andr Carvalho; Da Silva, Isabella Viana Gomes; Silva, Luciana Maria; De Pilla Varotti, Fernando; Dos Santos, Fabio Vieira; Viana, Gustavo Henrique Ribeiro; Marine Drugs; vol. 12; 8; (2014); p. 4361 – 4378;,
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Application of 629-41-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 629-41-4 as follows.

In a 2 L three-opening bottle into the 1, 8 – octandiol (250 g, 1.712 muM), toluene (1000 ml), 48% hydrogen bromide (231 ml, 2 . 054 muM, 1.2 eq), heating to 110 C reflux 30 hours. Added 48% hydrogen bromide (84 ml, 0 . 753 muM, 0 . 44 eq), heating reflux for 20 hours, GC detection with a small amount of residues of raw materials. Cooling to the room temperature plus 500 ml petroleum ether dilution, liquid […] bromic acid, organic phase are saturated sodium bicarbonate (400 ml × 2) and saturated brine (400 ml × 2) cleaning, dried with anhydrous sodium sulfate. Turns on lathe does 8 – bromine propyl butyl-carbinol 318 g, yield 83%, direct throws down the step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,629-41-4, its application will become more common.

Reference:
Patent; Changzhou University; He Jiayi; Xia Ran; Wu Linsheng; Hu Xiwen; Jin Xinyu; Chen Ke; Li Yuan; Qiu Lin; Chen Xin; (8 pag.)CN109796336; (2019); A;,
Alcohol – Wikipedia,
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Application of 629-41-4 ,Some common heterocyclic compound, 629-41-4, molecular formula is C8H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: DHP (3.46 ml, 37.9 mmol) and a catalytic amount of PPTS were added to a solution of 1,8-octanediol (Compound 7, 5.85 g, 40.0 mmol) in CHCl3 (100 ml) in a stream of argon at room temperature, and the mixture was stirred for 16 hours. The reaction solution was stirred for 5 minutes after addition of H2O. The organic layer was separated, and the aqueous layer was extracted with EtOAc. The combined organic layer was washed with a saturated aqueous NaHCO3 solution then with a saturated aqueous NaCl solution, and was dried over Na2SO4. After evaporation of the solvent, the residue was purified by column chromatography on silica gel (Hexane:EtOAc = 3:1 to 2:1) to yield the corresponding THP ether (4.95 g, 54%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,629-41-4, its application will become more common.

Reference:
Patent; aRigen Pharmaceuticals, Inc.; SAIMOTO, Hiroyuki; KITA, Kiyoshi; YABU, Yoshisada; YAMAMOTO, Masaichi; EP2636663; (2013); A1;,
Alcohol – Wikipedia,
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Electric Literature of 629-41-4 , The common heterocyclic compound, 629-41-4, name is 1,8-Octanediol, molecular formula is C8H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 4 The following example describes the synthesis of (E,Z)-8,10-pentadecadien-1-ol acetate. 8-[(Tetrahydro-2H-pyran-2-yl)oxy]-1-octanol. 1,8-Octanediol (16.8 g) (115 mmol) and 4.83 g of dihydropyran (57.5 mmol) in 1400 ml of dichloromethane containing 5 drops of concentrated HCl were stirred for 2 hours. Then 10 g of NaHCO3 were stirred in and the solution was filtered. Dichloromethane was removed with a rotary evaporator, and the resulting residue was triturated with pentane; the undissolved solid was 1,8-octanediol. The solid was filtered from the pentane solution, and the pentane was removed with a rotary evaporator to give 13.2 g (99.8%) of crude product oil.

The synthetic route of 629-41-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The United States of America as represented by the Secretary of Agriculture; US5607670; (1997); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts