Category: 629-30-1

Synthetic Route of 629-30-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 629-30-1, name is 1,7-Heptanediol. This compound has unique chemical properties. The synthetic route is as follows.

7- bromoheptane-l-ol1 (2): Heptane- 1,7-diol (36.0 g, 272 mmol; Alfa Aesar) and aq. 48percent HBr (38 mL, 0.9 equiv.) were heated under reflux in benzene (400 mL) with water removal using a Dean-Stark apparatus. After 16 h, all volatiles were removed in vacuo and the residue was purified by Si02 column chromatography using a gradient of 10-30percent EtOAc/hexanes as eluent to give 7-bromoheptan-l-ol (26.22 g, 62percent) as a colorless oil. TLC: 50percent EtOAc/hexanes, Rf ~ 0.40; NMR (400 MHz, CDC13) delta 3.61 (t, 2H, J = 7.1 Hz), 3.39 (t, 2H, J= 6.8 Hz), 1.80- 1.88 (m, 2H), 1.52-1.58 (m, 2H), 1.30-1.46 (m, 6H).

According to the analysis of related databases, 629-30-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MCW RESEARCH FOUNDATION, INC.; IMIG, John, David; CAMPBELL, William, B.; FALCK, John, Russell; WO2012/138706; (2012); A1;,
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Application of 629-30-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 629-30-1, name is 1,7-Heptanediol. A new synthetic method of this compound is introduced below.

Fe(NO3)3¡¤9H2O (40.4 mg, 10 molpercent) and ABNO (7 mg, 5 molpercent) were used in this order.1,7-heptanediol (132 mg, 1 mmol) was added to a 10 ml reaction tube.Then add 2ml of acetonitrile as a solvent and open the reaction at room temperature.The degree of reaction was then checked by GC-MS. Reaction 15h,After the reaction is over,An internal standard, n-dodecane, was added and the product was quantitatively analyzed by GC.1,7-heptanediol conversion rate of 86percent,Product yield 85percent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,629-30-1, 1,7-Heptanediol, and friends who are interested can also refer to it.

Reference:
Patent; Dalian Institute of Chemical Physics; Gao Shuang; Wang Lianyue; Chen Bo; Lv Ying; (5 pag.)CN106831675; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 629-30-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.629-30-1, name is 1,7-Heptanediol, molecular formula is C7H16O2, molecular weight is 132.2, as common compound, the synthetic route is as follows.

To a solution of 1,7- heptane diol (10.0 g, 75.7 mmol) in THF (100 mL) was added sodium hydride (1.81 g, 60percent dispersion in oil, 75.7 mmol) portion wise at 0 oC under nitrogen atmosphere. Stir the reaction mixture at 0 oC for 15 min. Then TBDPSCl (20.8 g, 75.7 mmol) was added slowly to the reaction mixture followed by addition of TBAI (2.79 g, 7.57 mmol). The stirring was continued for additional 12 h at room temperature. The reaction mixture was quenched at 0 oC by saturated aqueous NH4Cl solution (200 mL). THF was removed under reduced pressure and the product was extracted from aqueous layer with EtOAc (3 x 500 mL).The combined organic layers were washed with brine (2 x 100 mL) and dried over Na2SO4(anhydrous), filtered and concentrated in vacuo. Purification by column chromatography (Silica gel) of crude residue eluting with 30-35percent EtOAc in hexane afforded mono-protected alcohol as a colorless oil. Yield : 25.1 g, 89 percent 1H NMR (400 MHz, CDCl3) : d 7.64-7.61 (m, 4H), 7.38-7.31 (m, 6H), 3.66-3.56 (m, 4H), 1.58-1.48 (m, 3H), 1.41-1.25 (m, 7H), 1.04 (s, 9H).

The chemical industry reduces the impact on the environment during synthesis 629-30-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Kumaraswamy, Gullapalli; Ramakrishna, Gajula; Sridhar, Balasubramanian; Tetrahedron Letters; vol. 52; 15; (2011); p. 1778 – 1782;,
Alcohol – Wikipedia,
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Reference of 629-30-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.629-30-1, name is 1,7-Heptanediol, molecular formula is C7H16O2, molecular weight is 132.2, as common compound, the synthetic route is as follows.

7- bromoheptane-l-ol1 (2): Heptane- 1,7-diol (36.0 g, 272 mmol; Alfa Aesar) and aq. 48% HBr (38 mL, 0.9 equiv.) were heated under reflux in benzene (400 mL) with water removal using a Dean-Stark apparatus. After 16 h, all volatiles were removed in vacuo and the residue was purified by Si02 column chromatography using a gradient of 10-30% EtOAc/hexanes as eluent to give 7-bromoheptan-l-ol (26.22 g, 62%) as a colorless oil. TLC: 50% EtOAc/hexanes, Rf ~ 0.40; NMR (400 MHz, CDC13) delta 3.61 (t, 2H, J = 7.1 Hz), 3.39 (t, 2H, J= 6.8 Hz), 1.80- 1.88 (m, 2H), 1.52-1.58 (m, 2H), 1.30-1.46 (m, 6H).

The chemical industry reduces the impact on the environment during synthesis 629-30-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MCW RESEARCH FOUNDATION, INC.; IMIG, John, David; CAMPBELL, William, B.; FALCK, John, Russell; WO2012/138706; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts