Category: 6282-88-8

Electric Literature of 6282-88-8 ,Some common heterocyclic compound, 6282-88-8, molecular formula is C9H11ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 3- (4-chlorophenyl) propanol (17.1 g, 0.1 mol) was addedTo DMF (170 ml)Slowly added at 0 C60% NaH (3 g, 0.1 mol),Stir for 30 minutes,Then joinN- (3-bromopropyl) piperidine (22.6 g, 0.11 mol) inDMF (30 mL).The mixture was stirred at 0 & lt; 0 & gt; C2 hours,And then reacted at 20 C for 8 hours.Then diluted with 400 ml of water,Extracted twice with 400 ml of ethyl acetate,Combine organic phase,Washed twice with 2N sodium hydroxide and brine,Dried over magnesium sulfate,filter,Room temperature into the HCl gas,Stir the solid,filter,dry,To obtain 30.7 g of a pale yellow solid product,Yield 92.5%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6282-88-8, its application will become more common.

Reference:
Patent; Reyoung Pharmaceutical Co.,Ltd; Hu, qingwen; Cai, lianhui; Cao, Yan; Yu, zhibo; (7 pag.)CN104447620; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 6282-88-8 ,Some common heterocyclic compound, 6282-88-8, molecular formula is C9H11ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 502-[3-(4-chlorophenyl)propyl]-N-hydroxy-1-oxo-1,2-dihydroisoquinoline-7-carboxamide Compound I-131 Step 1: 1-(3-bromopropyl)-4-chlorobenzeneTo a solution of 3-(4-chlorophenyl)propan-1-ol (0.25 g, 1.46 mmol) in dichloromethane (5.5 mL) cooled at 0 C. was added triphenylphosphine (0.42 g, 1.6 mmol) and carbon tetrabromide (0.51 g, 1.5 mmol) and the reaction was stirred at rt overnight. The reaction was quenched with water and extracted with DCM (2¡Á). The combined organic phases were then washed with water, and brine, dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by flash silica gel chromatography (0% to 70% EtOAc/hexanes) to afford 1-(3-bromopropyl)-4-chlorobenzene (0.34 g, quant.). LC-MS: (FA) ES+234.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6282-88-8, 3-(4-Chlorophenyl)propan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Millennium Pharmaceuticals, Inc.; US2012/94997; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 6282-88-8 ,Some common heterocyclic compound, 6282-88-8, molecular formula is C9H11ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(f) 135 ml of pyridine are added dropwise to 150 g of 3-(4-chlorophenyl)-propan-1-ol and 206.6 g of p-toluenesulphonyl chloride in 300 ml of chloroform at 0. After the addition, the mixture is stirred at room temperature for 3 hours and the solution is poured into a mixture of 400 ml of water and 120 ml of concentrated hydrochloric acid. The organic phase is separated off, washed 3 times with water, dried over sodium sulphate and concentrated to a yellowish viscous oil in vacuo, yield: 285 g of p-toluenesulphonic acid 3-(4-chlorophenyl)-propyl ester.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6282-88-8, 3-(4-Chlorophenyl)propan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Byk Gulden Lomberg Chemische Fabrik Gesellschaft; US4334089; (1982); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6282-88-8, name is 3-(4-Chlorophenyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. name: 3-(4-Chlorophenyl)propan-1-ol

3- (4-chlorophenyl) propanol (17.1g, 0.1mol) was added to DMF (150ml) added successively N- (3- chloropropyl) piperidine (17.8g, 0.11mol), potassium carbonate (6.9g, 0.05mol), potassium iodide 1g, was heated to 95 , the reaction was stirred for 12 hours.The mixture was cooled to room temperature, then diluted with 300ml water, extracted twice with 400ml of ethyl acetate, the combined organic phases, 2N sodium hydroxide and twice with brine, dried over magnesium sulfate, filtered, and HCl at room temperature gas, stirring the precipitated solid was filtered and dried to give light yellow solid solution of 29.8 g, yield 89.7%, HPLC: 99.6%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6282-88-8, 3-(4-Chlorophenyl)propan-1-ol.

Reference:
Patent; Reyoung Pharmaceutical Co.,Ltd; Hu, qingwen; Cai, lianhui; Cao, Yan; Yu, zhibo; (7 pag.)CN104447620; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 6282-88-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6282-88-8, name is 3-(4-Chlorophenyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

(26-1) Synthesis of 1-(3-bromopropyl)-4-chlorobenzene (compound 26-1) [Show Image] 3-(4-Chlorophenyl)-1-propanol (1.00 g) was dissolved in methylene chloride (30 ml), triphenylphosphine (1.66 g) and N-bromosuccinimide (1.11 g) were added under ice-cooling, and the mixture was stirred under ice-cooling for 6 hr. The reaction mixture was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. Diethyl ether (50 ml) was added, and the precipitated triphenylphosphine oxide was filtered off. The concentrate of the filtrate was purified by silica gel column chromatography (hexane alone) to give the object product (1.30 g) as a colorless oil. 1H-NMR(CDCl3) delta (ppm): 2.10-2.18(2H, m), 2.76(2H, t, J=7.3Hz), 3.38(2H, t, J=6.5Hz), 7.13(2H, d, J=8.3Hz), 7.31-7.35(2H, m).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6282-88-8, 3-(4-Chlorophenyl)propan-1-ol.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2168944; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts