Category: 627-30-5

Electric Literature of 627-30-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-30-5, name is 3-Chloropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

IMB105 (1.0g, 2.5mmol), 2-bromoethanol (0.22mL, 3.0mmol) or 3-chloropropanol (0.25mL, 3.0mmol), and PPh3 (1.3g, 5.0mmol) were added to dried THF (20mL) under Ar2. The obtained solution was cooled on an ice-water bath. DEAD (2.0mL, 4.25mmol, 40% in tulene) was added to the solution, and the reaction mixture was then allowed to warm to room temperature and stirred for 12h. The solvent was removed in vacuo, and the obtained residue was extracted into ethyl acetate (100mL). The organic layer was washed consecutively with water (50mL), brine (50mL), dried over MgSO4, filtered, and concentrated in vacuo. The residue was purified on silica gel using Petroleumether (60-90C)/ethyl acetate in different proportions to afford 5 or 6.

According to the analysis of related databases, 627-30-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Gu, Yuxi; Hu, Laixing; Liu, Yonghua; Sun, lianqi; Wu, Yanbin; European Journal of Medicinal Chemistry; vol. 191; (2020);,
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Electric Literature of 627-30-5 ,Some common heterocyclic compound, 627-30-5, molecular formula is C3H7ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 10 2-(3-Chloropropoxy)tetrahydropyran To a solution of 3-chloropropanol (20.00 g, 0.212 mol) in dichloromethane (100 mL) 3,4-dihydro-2H-pyran (16.02 g, 0.190 mol) diluted in dichloromethane (17 mL) is added dropwise at 0-5C. The mixture is stirred for 30 minutes and the reaction (checked by TLC analysis) is quenched by washing with saturated sodium bicarbonate (100 mL). After separation the organic layer is washed with water (50 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure at 30C (34.32 g). The title compound is isolated by column chromatography on silica gel eluding with n-hexane:ethyl acetate) (31.28 g, 0.175 mol, 91%). 1H-NMR {300 MHz, CDCl3, delta (ppm)}: 1.2-2.0 (6H); 2.09 (m, 2H, CH2); 3.56 (m, 2H, Cl-CH2); 3.70 (m, 2H, O-CH2); 3.92 (m, 2H, O-CH2); 4.65 (m, 1 H, O-CH-O). GC-MS (El): [M-H]+ = 177; [M-ClCH2CH2CH2O]+ = 85

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,627-30-5, its application will become more common.

Reference:
Patent; Newchem S.p.A.; EP2019114; (2009); A1;,
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Electric Literature of 627-30-5, Adding some certain compound to certain chemical reactions, such as: 627-30-5, name is 3-Chloropropan-1-ol,molecular formula is C3H7ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-30-5.

Example 5: Production of polymer particles by treating a mixture of azide-modified PAA and alkyne-modified PAA with acid; Synthesis of 3-azidopropanol: In a 100 ml_ round bottom flask, liquid 3- chloropropanol (10.0 g, 1.0 equiv), solid sodium azide (17.19 g, 2.5 equiv) were reacted in DMF for 40 hours at 100 0C. The reaction mixture was cooled to room temperature, poured into a reparatory funnel and extracted with diethyl ether (300 ml_) and brine solution (500 ml_). The organic layer was separated and dried over MgSO4. Rotary evaporation removed the diethyl ether solvent at room temperature and yielded crude 3-azidopropanol (12.5 g). 1H-NMR (delta, ppm) CDCI3: 3.76 – 3.73 (t, 2H, HOCH2CH2CH2N3), 3.46 – 3.43 (t, 2H, HOCH2CH2CH2N3), 2.09 (br-s, 1 H, OH), 1.86 – 1.80 (m, 2H, HOCH2CH2CH2N3). IR neat (cm”1): 2100 (N=N=N).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 627-30-5, 3-Chloropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VIVE NANO, INC.; LI, Fugang; PHAM, Hung; ANDERSON, Darren, J.; WO2010/35118; (2010); A1;,
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627-30-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-30-5, name is 3-Chloropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

In a flask, 10.0 g (0.058 mol) of the compound represented by the formula (I-1a), 7.10 g (0.075 mol) of 3-chloropropanol, potassium carbonate 11.99 g (0.087 mol), and 100 mL of ethanol were added and heated under reflux for 5 days. After filtration, the solvent was distilled off and redissolved in toluene. After washing with brine, purification by column chromatography (silica gel) gave 10.7 g (0.046 mol) of the compound represented by the formula (I-11a).

Statistics shows that 627-30-5 is playing an increasingly important role. we look forward to future research findings about 3-Chloropropan-1-ol.

Reference:
Patent; DIC CORPORATION; HORIGUCHI, MASAHIRO; HAYASHI, MASANAO; KUSUMOTO, TETSUO; (90 pag.)JP6102423; (2017); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts