Category: 627-27-0

Dong, Jie; Yuan, Xiang-Ai; Yan, Zhongfei; Mu, Liying; Ma, Junyang; Zhu, Chengjian; Xie, Jin published the artcile< Manganese-catalysed divergent silylation of alkenes>, Formula: C4H8O, the main research area is diphosphinoamino diphosphinomethyl manganese carbonyl complex preparation catalyst silylation; crystal structure diphosphinoamino diphosphinomethyl manganese carbonyl complex; mol structure diphosphinoamino diphosphinomethyl manganese carbonyl complex; alkene silylation manganese catalyst; potential energy surface alkene silylation manganese catalyst DFT.

Transition-metal-catalyzed, redox-neutral dehydrosilylation of alkenes is a long-standing challenge in organic synthesis, with current methods suffering from low selectivity and narrow scope. The authors report a general and simple method for the Mn-catalyzed dehydrosilylation and hydrosilylation of alkenes, with Mn2(CO)10 as a catalyst precursor, by using a ligand-tuned metalloradical reactivity strategy. This enables versatility and controllable selectivity with a 1:1 ratio of alkenes and silanes, and the synthetic robustness and practicality of this method are demonstrated using complex alkenes and light olefins. The selectivity of the reaction was studied using d. functional theory calculations, showing the use of an iPrPNP ligand to favor dehydrosilylation, while a JackiePhos ligand favors hydrosilylation. The reaction is redox-neutral and atom-economical, exhibits a broad substrate scope and excellent functional group tolerance, and is suitable for various synthetic applications on a gram scale. [graphic not available: see fulltext].

Nature Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Xiangtai; Chen, Dengfeng; Liu, Rui; Jiang, Ping; Huang, Shenlin published the artcile< Synthesis of 2-(Cyanomethyl)benzoic Esters via Carbon-Carbon Bond Cleavage of Indanones>, Related Products of 627-27-0, the main research area is cyanomethyl benzoic ester preparation; indanone alc bond cleavage.

A novel synthesis of 2-(cyanomethyl)benzoic esters 2-C(R)CN-3-R1-4-R2-5-R3C6HC(O)OR4 (R = H, Me; R1 = H, Br, CN, CF3; R2 = H, Br, OMe, Cl, etc.; R3 = H, Me, OMe, Br; R4 = Me, Bn, furan-2-ylmethyl, 2H-1,3-benzodioxol-5-ylmethyl, etc.) and ethyl2-(3-cyanopropyl)benzoate from indanone derivatives I (R5 = Me, Ph, 4-trifluoromethylphenyl) and [5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-ylidene]amino acetate has been established. This reaction proceeds via a deprotonation of alcs. R4OH with a chem. base, followed by a nucleophilic addition to indanones I and Beckmann fragmentation. In addition, this reaction could also work under electrochem. conditions, and no external chem. bases were needed. This mild method offers a novel strategy for the late-stage functionalization of various natural alcs. such as citronellol, nerol, abietyl alc., etc.

Journal of Organic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Related Products of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Zheqi; Wu, Dong; Ding, Chao; Yin, Guoyin published the artcile< Modular synthesis of diarylalkanes by nickel-catalyzed 1,1-diarylation of unactivated terminal alkenes>, Electric Literature of 627-27-0, the main research area is arylboronic acid terminal alkene bromoarene nickel catalyst regioselective diarylation; diaryl alkane preparation.

A nickel-catalyzed 1,1-diarylation of electronically unbiased alkenes was developed, providing straightforward access to diarylalkanes from readily available materials. Importantly, both the efficiency and the regioselectivity of this transformation were ensured by reaction conditions, rather than the coordinating group of substrates. It was also demonstrated that under balloon pressure, ethylene and propylene was also be utilized as substrates. Preliminary mechanistic experiments suggested that this transformation involves a Ni(0)/Ni(II) catalytic cycle rather than a Ni(I)/Ni(III) cycle.

CCS Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rana, Rohit; Shreya; Upadhyay, Rahul; Maurya, Sushil K. published the artcile< Synthesis of Macrocyclic Lactones and Dilactones Using Olive Oil>, Recommanded Product: But-3-en-1-ol, the main research area is ester olive oil Grubbs second generation macrocyclization catalyst; lactone preparation; dilactone preparation.

Macrocyclic lactones have redolent characteristics of muscones that originate from the rectal musk organs of the musk deer. These lactones are the primary raw material in the flavor and fragrance industry and are also found within the cyclic frameworks of various bioactive mols. Due to great demand, many efforts have been made for their synthesis; however, strategies generating a large number of macrocyclic analogs from renewable resources have not been fully realized and are urgently required. Here, we outline a sustainable, straightforward, and eco-friendly approach to synthesize high-valued macrocyclic lactones utilizing olive oil under greener reaction conditions. The outlined method allows us to turn biomass into valuable 12- to 29-membered lactones and dilactones.

ACS Omega published new progress about Diastereoselective synthesis. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fouad, Farid; Khairuddean, Melati; Twieg, Robert published the artcile< Synthesis and liquid crystalline studies of biphenylyl-1,3,4-thiadiazoles and diphenyl-1,3,4-thiadiazoles: influence of side chain semifluorination and lateral ring fluorination>, Computed Properties of 627-27-0, the main research area is biphenylyl thiadiazole preparation liquid crystal structure property thermal stability; diphenyl thiadiazole preparation liquid crystal structure property thermal stability.

Four series of 1,3,4-thiadiazole based compounds I [R = C2H5, C6H13O; R1 = Me, Et, n-Pr, etc.] II [R2 = R3 = C9H19, F(CF2)4(CH2)3, F(CF2)6(CH2)3, etc.] and III [X = Y = H, F] were synthesized, and their liquid crystalline properties were studied. Series I compounds I [R = C2H5, C6H13O; R1 = Me, Et, n-Pr, etc.] were two tailed biphenylyl-1,3,4-thiadiazoles. Series II II [R2 = R3 = C9H19, F(CF2)4(CH2)3, F(CF2)6(CH2)3, etc.] was a set of new diphenyl-1,3,4-thiadiazoles with perhydrogenated and semifluorinated tails. Series III compounds II [R2 = R3 = F(CF2)4(CH2)3, F(CF2)6(CH2)3, etc.] were sym. semifluorinated diphenyl-1,3,4-thiadiazoles. Two laterally fluorinated diphenyl-1,3,4-thiadiazoles along with their parent nonfluorinated compound III [X = Y = H, F] were also synthesized. In all of the four series SmA and/or SmC phases was observed

Liquid Crystals published new progress about Carboxylic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Computed Properties of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Grabka, Michal; Kula, Przemyslaw; Szala, Mateusz; Jasek, Krzysztof; Czerwinski, Michal published the artcile< Fluorophenol-Containing Hydrogen-Bond Acidic Polysiloxane for Gas Sensing-Synthesis and Characterization>, COA of Formula: C4H8O, the main research area is fluorophenol polysiloxane hydrosilylation gas sensor property; coatings for gravimetric sensors; hydrogen-bond acidic polysiloxane; on-site detection of CWAs; sensor polymer.

In this work, the synthesis of a new polysiloxane, poly {dimethylsiloxane-co-[4-(2,3-difluoro-4-hydroxyphenoxy) butyl] methylsiloxane} (dubbed PMFOS), is presented. This polymer exhibits high hydrogen bond acidity and was designed to be used as a sensor layer in gas sensors. The description of the synthetic route of the PMFOS has been divided into two main stages: the synthesis of the functional substituent 4-(but-3-en-1-yloxy)-2,3-difluorophenol, and the post-polymerization functionalization of the polysiloxane chain (methylhydrosiloxane-dimethylsiloxane copolymer) via hydrosilylation. The synthesized material was subjected to instrumental anal., which confirmed its structure. The performed thermal anal. made it possible to determine some properties important for the sensor application, such as glass transition temperature and decomposition temperature The results showed that PMFOS meets the requirements for materials intended for use in gas sensors based on acoustoelec. transducers.

Polymers (Basel, Switzerland) published new progress about Gas sensors. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, COA of Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hewitt, Kirsten A.; Xie, Pei-Pei; Thane, Taylor A.; Hirbawi, Nadia; Zhang, Shuo-Qing; Matus, Alissa C.; Lucas, Erika L.; Hong, Xin; Jarvo, Elizabeth R. published the artcile< Nickel-Catalyzed Domino Cross-Electrophile Coupling Dicarbofunctionalization Reaction To Afford Vinylcyclopropanes>, SDS of cas: 627-27-0, the main research area is vinylcyclopropane enantioselective diastereoselective preparation DFT; alkynyl tosylpiperidine domino cross electrophile coupling dicarbofunctionalization nickel catalyst.

A nickel-catalyzed domino reaction was established that harnesses sulfonamide, alkyl chloride, and alkyne functionalities in a multistep sequence to afford vinylcyclopropanes I [R = Me, n-hexyl, Ph, etc.] bearing tetrasubstituted olefins. The starting materials were prepared by iron-promoted aza-Prins reactions of ynals. This method provided rapid synthetic access to valuable building blocks with applications in medicinal chem. Exptl. and computational results supported the initiation of the catalytic cycle by the oxidative addition of propargylic sulfonamide, and a key ambiphilic allenylnickel intermediate leads to a bifurcated reaction pathway that generates olefin isomers.

ACS Catalysis published new progress about Alkenes, trans Role: SPN (Synthetic Preparation), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Weil, Tatjana; Kirupakaran, Abbna; Le, My-Hue; Rebmann, Philipp; Mieres-Perez, Joel; Issmail, Leila; Conzelmann, Carina; Mueller, Janis A.; Rauch, Lena; Gilg, Andrea; Wettstein, Lukas; Gross, Ruediger; Read, Clarissa; Bergner, Tim; Palsson, Sandra Axberg; Uhlig, Nadja; Eberlein, Valentina; Woell, Heike; Klaerner, Frank-Gerrit; Stenger, Steffen; Kuemmerer, Beate M.; Streeck, Hendrik; Fois, Giorgio; Frick, Manfred; Braubach, Peter; Spetz, Anna-Lena; Grunwald, Thomas; Shorter, James; Sanchez-Garcia, Elsa; Schrader, Thomas; Muench, Jan published the artcile< Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses>, Application of C4H8O, the main research area is mol tweezer corona virus disease antiviral.

The COVID-19 pandemic caused by SARS-CoV-2 presents a global health emergency. Therapeutic options against SARS-CoV-2 are still very limited but urgently required. Mol. tweezers are supramol. agents that destabilize the envelope of viruses resulting in a loss of viral infectivity. Here, we show that first-generation tweezers, I and II, disrupt the SARS-CoV-2 envelope and abrogate viral infectivity. To increase the antiviral activity, a series of 34 advanced mol. tweezers were synthesized by insertion of aliphatic or aromatic ester groups on the phosphate moieties of the parent mol. I. A structure activity relationship study enabled the identification of tweezers with a markedly enhanced ability to destroy lipid bilayers and to suppress SARS-CoV-2 infection. Selected tweezer derivatives retain activity in airway mucus and inactivate the SARS-CoV-2 wildtype and variants of concern as well as respiratory syncytial, influenza, and measles viruses. Moreover, inhibitory activity of advanced tweezers against respiratory syncytial virus and SARS-CoV-2 was confirmed in mice. Thus, potentiated tweezers are broad-spectrum antiviral agents with great prospects for clin. development to combat highly pathogenic viruses.

JACS Au published new progress about Anticoronaviral agents. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Loro, Camilla; Oble, Julie; Foschi, Francesca; Papis, Marta; Beccalli, Egle M.; Giofre, Sabrina; Poli, Giovanni; Broggini, Gianluigi published the artcile< Acid-mediated decarboxylative C-H coupling between arenes and O-allyl carbamates>, SDS of cas: 627-27-0, the main research area is aryl propanamine preparation; diaryl propane preparation; indane preparation; allyl tosyl carbamate arene decarboxylative coupling acid catalyst.

Treatment of O-allyl N-tosyl carbamates RNHC(O)OC(R1)(R2)(CH2)nCH=CHR3 (R = Ts, o-Ns; R1 = R2 = R3 = H, Me; n = 0, 1) with aromatic compounds ArH (Ar = 2,4,6-trimethylphenyl, 2-methylphenyl, 1,3,5-triethylphenyl, etc.) of Cu(OTf)2 or TMSOTf as promoters affords N-substituted 1-arylpropan-2-amines ArCH2CH(CH3)NHR3, 1,2- or 1,1-diarylpropanes I, or indanes II (R4 = R5 = H, Me), depending on the nature of the promoter and of aryl substrates. A full mechanistic rational allowing appreciation of the outcome of these novel C-H based cascades is proposed. An initial acid promoted decarboxylative/deamidative Friedel-Crafts allylation takes place. After protonation of the allylated arene, evolution of the resulting cation may follow different paths depending on the nature of the arene partner and of the allyl moiety in the carbamate.

Organic Chemistry Frontiers published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Loro, Camilla; Oble, Julie; Foschi, Francesca; Papis, Marta; Beccalli, Egle M.; Giofre, Sabrina; Poli, Giovanni; Broggini, Gianluigi published the artcile< Acid-mediated decarboxylative C-H coupling between arenes and O-allyl carbamates>, SDS of cas: 627-27-0, the main research area is aryl propanamine preparation; diaryl propane preparation; indane preparation; allyl tosyl carbamate arene decarboxylative coupling acid catalyst.

Treatment of O-allyl N-tosyl carbamates RNHC(O)OC(R1)(R2)(CH2)nCH=CHR3 (R = Ts, o-Ns; R1 = R2 = R3 = H, Me; n = 0, 1) with aromatic compounds ArH (Ar = 2,4,6-trimethylphenyl, 2-methylphenyl, 1,3,5-triethylphenyl, etc.) of Cu(OTf)2 or TMSOTf as promoters affords N-substituted 1-arylpropan-2-amines ArCH2CH(CH3)NHR3, 1,2- or 1,1-diarylpropanes I, or indanes II (R4 = R5 = H, Me), depending on the nature of the promoter and of aryl substrates. A full mechanistic rational allowing appreciation of the outcome of these novel C-H based cascades is proposed. An initial acid promoted decarboxylative/deamidative Friedel-Crafts allylation takes place. After protonation of the allylated arene, evolution of the resulting cation may follow different paths depending on the nature of the arene partner and of the allyl moiety in the carbamate.

Organic Chemistry Frontiers published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts