Category: 627-27-0

Application of 627-27-0 ,Some common heterocyclic compound, 627-27-0, molecular formula is C4H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate 38. [0131] NaH (50% in oil, 2.88 g, 0.06 mol) was slowly added to a solution of Intermediate 37 (3 g, 0.041 mol) in 30 mL anhydrous DMF in ice-bath. After stirring for 0.5 h, BnBr (5.38 mL, 0.045 mol) was added to the reaction solution and stirred at r.t. for overnight. The mixture was poured into 80 mL H2O at 0 C., extracted with EtOAc. The combined organic phase was washed with aq. NH4Cl, brine and dried over Na2SO4. After concentration, the residue was dissolved in PE (petroleum ether), and filtered through a pad of silica gel. The filtrate was concentrated to afford the Intermediate 38 as colorless oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,627-27-0, its application will become more common.

Reference:
Patent; MICURX PHARMACEUTICALS, INC.; GORDEEV, Mikhail Fedorovich; LIU, Jinqian; YUAN, Zhengyu; WANG, Xinghai; US2013/165411; (2013); A1;,
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Synthetic Route of 627-27-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.627-27-0, name is But-3-en-1-ol, molecular formula is C4H8O, molecular weight is 72.1057, as common compound, the synthetic route is as follows.

To a suspension of 8.0 g NaH (333.32 mmol, 60 % w/vdispersion in mineral oil, 4.0 eq) in 100 cm3, anhydrousTHF was added drop wise to a solution of 6.0 g 3-buten-1-ol 8 (83.33 mmol, 1.0 eq) at 0 C. To this mixture, 0.150 gTBAI and 11.9 cm3 benzyl bromide (99.99 mmol, 1.2 eq)were added, and stirring was continued for 2 h at the sametemperature and overnight at 25 C. The reaction mixturewas quenched by small crushed ice flakes until a clearsolution (biphasic) had formed. The reaction mixture wasextracted with ether and the extract was washed with water(1 9 100 cm3), brine (1 9 100 cm3) and dried over anhydrousNa2SO4. Evaporation of the solvents followed bycolumn chromatography (silica gel, 60-120 mesh, 5 %EtOAc in pet. ether) afforded the pure product 9 (12.2 g,91 % yield) as a colorless liquid.

Statistics shows that 627-27-0 is playing an increasingly important role. we look forward to future research findings about But-3-en-1-ol.

Reference:
Article; Pratapareddy, Bommareddy; Sreenivasulu, Reddymasu; Hatti, Islavathu; Venkata Basaveswara Rao, Mandava; Raju, Rudraraju Ramesh; Monatshefte fur Chemie; vol. 146; 11; (2015); p. 1921 – 1926;,
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Related Products of 627-27-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 627-27-0, name is But-3-en-1-ol, molecular formula is C4H8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

But-3-en-1-yl methanesulfonate 8 was prepared from 3-buten-1-ol using the protocol described byD. Pei et al.:2 methanesulfonyl chloride (1.10 equiv, 110 mmol, 8.51 mL) was added dropwise to asolution of 3-buten-1-ol (1.00 equiv, 100 mmol, 7.21 g) and triethylamine (1.10 equiv, 110 mmol,15.3 mL) in CH2Cl2 (0.20 L) at 0 C. The mixture became cloudy. After 5 min of stirring, the coldbath was removed and stirring was continued for 1 h. The reaction mixture was then washed withsaturated NaHCO3 aqueous solution (0.10 L) and H2O (0.10 L). The organic layer was dried overMgSO4, filtered and concentrated to afford mesylate 8 (14.3 g, 95.2 mmol, 95%) as a colourless oilthat was used as such, without purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 627-27-0, But-3-en-1-ol.

Reference:
Article; Wolan, Andrzej; Kowalska-Six, Justyna A.; Rajerison, Holisoa; Cesario, Michele; Cordier, Marie; Six, Yvan; Tetrahedron; vol. 74; 38; (2018); p. 5248 – 5257;,
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Electric Literature of 627-27-0, Adding some certain compound to certain chemical reactions, such as: 627-27-0, name is But-3-en-1-ol,molecular formula is C4H8O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-27-0.

PPh3 (95.5 g), phthalimide (56.1 g) and 3 -Buten-l-ol (25.0 g) were suspended in dry THF (250 mL) and cooled to 0 C. Diisopropyl azodicarboxylate (75.1 mL) was then added dropwise over a period of 20 min. The resulting mixture was stirred at 0 C for 30min and then at r.t. over night. Control by LC/MS showed product. THF was removed in vacuo as far as possible. The oily residue was diluted with PE/EtOAc = 9:1 (400 mL) and stirred vigourously until a precipitate occured. The precipitated OPPh3 was filtered off and washed extensively with PE/EtOAc = 9:1. The combined filtrates were filtered through a patch of SiO 2 and then evaporated. The residue was diluted with PE (200 mL), mixed vigourously and placed in an icebath. The precipitated product was then filtered off and washed with PE to afford the product in sufficent purity as pale yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 627-27-0, But-3-en-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; OMEICOS THERAPEUTICS GMBH; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; MAX DELBRUeCK-CENTRUM FUeR MOLEKULARE MEDIZIN; FISCHER, Robert; KONKEL, Anne; WESSER, Tim; WESTPHAL, Philipp; SCHUNK, Wolf-Hagen; WESTPHAL, Christina; FALCK, John Russel; (121 pag.)WO2017/13265; (2017); A1;,
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