Category: 627-18-9

《An Artemisinin-Derivative-(NHC)Gold(I) Hybrid with Enhanced Cytotoxicity through Inhibition of NRF2 Transcriptional Activity》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Zhang, Chen; Fortin, Pierre-Yves; Barnoin, Guillaume; Qin, Xue; Wang, Xing; Fernandez Alvarez, Alvaro; Bijani, Christian; Maddelein, Marie-Lise; Hemmert, Catherine; Cuvillier, Olivier; Gornitzka, Heinz. Reference of 3-Bromopropan-1-ol The article mentions the following:

A family of hybrid complexes combining two biol. active motifs, an artemisinin derivative and a cationic bis(NHC)-gold(I) unit, has been synthesized. One of these complexes, 2 a, has been analyzed by single-crystal X-ray diffraction. 2 a shows strong anticancer activities on a large panel of human cancer cell models (prostate, breast, lung, liver, bladder, bone, acute and chronic myeloid leukemias) with GI50 values in the nm range, together with a high selectivity. An original and distinctive mechanism of action, i.e., through inhibition of the redox antioxidant NRF2 transcription factor (strongly associated with aggressiveness and resistance to cancer therapies) has been evidenced. 2 a could remarkably sensitize to sorafenib in HepG2 liver cells, in which dysregulated NRF2 signaling is linked to primary and acquired drug resistance. 2 a also inhibited NF-κB and HIF transcriptional activities, which are also associated with progression and resistance in cancer. Our findings provide evidence that hybrid (NHC)gold(I) compounds represent a new class of organometallic hybrid mols. that may yield new therapeutic agents. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Reference of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Reference of 3-Bromopropan-1-ol

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Name: 3-Bromopropan-1-olIn 2019 ,《Surface Modification Based on Diselenide Dynamic Chemistry: Towards Liquid Motion and Surface Bioconjugation》 was published in Angewandte Chemie, International Edition. The article was written by Xia, Jiahao; Zhao, Peng; Zheng, Ke; Lu, Chenjie; Yin, Shouchun; Xu, Huaping. The article contains the following contents:

Surface modification is an important technique in fields, such as, self-cleaning, surface patterning, sensing, and detection. The diselenide bond is a dynamic covalent bond that can undergo a diselenide metathesis reaction simply under visible light irradiation Herein the authors develop this diselenide dynamic chem. into a versatile surface modification method with a fast response and reversibility. The diselenide bond could be modified onto various substrates, such as, PDMS, quartz, and ITO conductive film glass. Different functional diselenide mols. could then be immobilized onto the surface via diselenide metathesis reaction. By using this modification method the authors could achieve liquid motion in a capillary tube under light illumination. Also this approach has the potential to serve as an efficient modification method for surface bioconjugation, which has practical applications in clin. usage.3-Bromopropan-1-ol(cas: 627-18-9Name: 3-Bromopropan-1-ol) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Name: 3-Bromopropan-1-ol

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《New complexes of liquid crystal discotic triphenylenes: induction of the double gyroid phase》 was written by Otmakhova, O. A.; Piryazev, A. A.; Bondarenko, G. N.; Shandryuk, G. A.; Maryasevskaya, A. V.; Merekalov, A. S.; Ivanov, D. A.; Talroze, R. V.. Electric Literature of C3H7BrOThis research focused ontriphenylene discotic liquid crystal preparation phase transition self assembly. The article conveys some information:

Electron donor-acceptor liquid crystals have been attracting considerable attention due to possible applications in optoelectronics and photonics. The creation of such charge transfer complexes is a powerful and flexible instrument for modifying the structures and properties compared to those of the initial components. In the present work, such an approach is exemplified on new complexes formed via non-covalent interactions of triphenylene discotics, namely, 2,3,6,7,10,11-hexakis(pentyloxy) triphenylene (H5T) and 2-(acryloyloxypropyloxy)-3,6,7,10,11-pentapentylox-triphenylene (TPh-3A), with an electron acceptor, β-(2,4,7-trinitro-9-fluorenylideneaminooxy) propionic acid (TNF-carb). The structure of thin supported films of H5T, TPh-3A and their blends with TNF-carb was investigated by grazing-incidence wide-angle X-ray scattering using a synchrotron source. At room temperature, the pristine discotics crystallize in orthorhombic unit cells whereas the self-assembly of H5T and TPh-3A with TNF-carb results in a double gyroid and hexagonal phases, resp. Formation of the double gyroid phase with the lattice parameter of 36.5 Å is driven by phase separation between the aromatic and alkyl regions of the system. It is supposed that the TNF-carb mols. of the complex are positioned in the nodes of the structure while the H5T mols. are located in the struts adjoining the nodes via triple junctions. For the hexagonal crystal of the TPh-3A/TNF-carb complex, the acceptor mols. are likely located in the interstices between the neighboring supramol. columns of TPh-3A. The mol. structures of the blends were also explored by means of FTIR spectroscopy. A detailed FTIR spectra anal. illustrates fine changes in inter-mol. bonds. For example, the initially dimerized acceptor mols. totally disappear in the complex structures whereas in TPh-3A/TNF-carb addnl. H-bonds between the carboxylate group in TNF-carb and the ester group of TPh-3A form. The exptl. data allows putting forward possible mol. models of the complex structures. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Electric Literature of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Electric Literature of C3H7BrO

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The author of 《Mitochondrial-targeted Hsp90 C-terminal inhibitors manifest anti-proliferative activity》 were Zhang, Zheng; Banerjee, Monimoy; Davis, Rachel E.; Blagg, Brian S. J.. And the article was published in Bioorganic & Medicinal Chemistry Letters in 2019. Application In Synthesis of 3-Bromopropan-1-ol The author mentioned the following in the article:

The development of C-terminal heat shock protein 90 kDa (Hsp90) inhibitors has emerged as a potential treatment for cancer. Similarly, small mols. that target the mitochondria have proven to be efficacious towards cancer, as the reprogramming of mitochondrial function is often associated with oncogenic transformation. Herein, we report the development of triphenylphosphonium (TPP)-conjugated Hsp90 C-terminal inhibitors, their anti-proliferative activity, and accumulation in the mitochondria. In general, TPP-conjugated Hsp90 C-terminal inhibitors were found to manifest increased activity against various cancer cell lines when compared to the parent compounds In the experimental materials used by the author, we found 3-Bromopropan-1-ol(cas: 627-18-9Application In Synthesis of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Application In Synthesis of 3-Bromopropan-1-ol

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In 2019,Angewandte Chemie, International Edition included an article by Zhang, Dapeng; Fan, Yujiao; Chen, Hui; Trepout, Sylvain; Li, Min-Hui. COA of Formula: C3H7BrO. The article was titled 《CO2-Activated Reversible Transition between Polymersomes and Micelles with AIE Fluorescence》. The information in the text is summarized as follows:

Fluorescent polymersomes with both aggregation-induced emission (AIE) and CO2-responsive properties were developed from amphiphilic block copolymer PEG-b-P(DEAEMA-co-TPEMA) in which the hydrophobic block was a copolymer made of tetraphenylethene functionalized methacrylate (TPEMA) and 2-(diethylamino)ethyl methacrylate (DEAEMA) with unspecified sequence arrangement. Four block copolymers with different DEAEMA/TPEMA and hydrophilic/hydrophobic ratios were synthesized, and bright AIE polymersomes were prepared by nanopptn. in THF/water and dioxane/water systems. Polymersomes of PEG45-b-P(DEAEMA36-co-TPEMA6) were chosen to study the CO2-responsive property. Upon CO2 bubbling vesicles transformed to small spherical micelles, and upon Ar bubbling micelles returned to vesicles with the presence of a few intermediate morphologies. These polymersomes might have promising applications as sensors, nanoreactors, or controlled release systems. In addition to this study using 3-Bromopropan-1-ol, there are many other studies that have used 3-Bromopropan-1-ol(cas: 627-18-9COA of Formula: C3H7BrO) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.COA of Formula: C3H7BrO

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The author of 《Hydrophobic Side Chains Impart Anion Exchange Membranes with High Monovalent-Divalent Anion Selectivity in Electrodialysis》 were Irfan, Muhammad; Ge, Liang; Wang, Yaoming; Yang, Zhengjin; Xu, Tongwen. And the article was published in ACS Sustainable Chemistry & Engineering in 2019. Related Products of 627-18-9 The author mentioned the following in the article:

Developing anion exchange membranes that have high anion selectivity and can avoid membrane swelling is a critical, but challenging, target for electrodialysis, which has witnessed great success in a wide range of applications including saline wastewater treatment and resource recovery. We found in this work that by tuning the hydrophobicity of alkyl spacers which connect the pos. charged ammonium groups and polymeric backbones of the anion exchange membrane, high anion selectivity, and low membrane swelling of anion exchange membrane can be achieved. The membranes developed here are capable of discriminating monovalent and divalent anions, with a selectivity for Cl-/SO42- reaching up to 13.07, and our results suggest the chain length of the spacers determines the anion selectivity of membrane. We attribute such phenomenon to the change in side chain hydrophobicity. This is a particularly interesting finding that could facilitate the development of advanced anion exchange membranes for electrodialysis. The experimental part of the paper was very detailed, including the reaction process of 3-Bromopropan-1-ol(cas: 627-18-9Related Products of 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Related Products of 627-18-9

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Ling, Huiping; Li, Hong; Chen, Meijun; Lai, Baolong; Zhou, Haiming; Gao, Hui; Zhang, Jiangye; Huang, Yan; Tao, Yiwen published an article in 2021. The article was titled 《Discovery of a Highly Potent and Novel Gambogic Acid Derivative as an Anticancer Drug Candidate》, and you may find the article in Anti-Cancer Agents in Medicinal Chemistry.SDS of cas: 627-18-9 The information in the text is summarized as follows:

Gambogic Acid (GA), a promising anti-cancer agent isolated from the resin of Garcinia species in Southeast Asia, exhibits high potency in inhibiting a wide variety of cancer cells growth. Moreover, the fact that it is amenable to chem. modification makes GA an attractive mol. for the development of anti-cancer agents. Gambogic acid-3-(4-pyrimidinyloxy) Pr ester (compound 4) was derived from the reaction between 4-hydroxypropoxy pyrimidine and GA. Its structure was elucidated by comprehensive anal. of ESIMS, HRESIMS, 1 D NMR data. Anti-tumor activities of compound 4 and GA in vitro against HepG-2, A549 and MCF-7 cells were investigated by MTT assay. FITC/PI dye was used to test apoptosis. The binding affinity difference of compound 4 and GA binding to IKKΒ was studied by using Discovery Studio 2016. Compound 4 was successfully synthesized and showed strong inhibitory effects on HepG-2, A549 and MCF-7 cells lines with an IC<> 50 value of 1.49±0.11, 1.37±0.06 and 0.64±0.16μM, resp. Mol. docking study demonstrated that four more hydrogen bonds were established between IKKΒ and compound 4, compared with GA. Our results suggested that compound 4 showed significant effects in inducing apoptosis. Further mol. docking study indicated that the introduction of pyrimidine could improve GAs binding affinity to IKKbeta. Compound 4 may serve as a potential lead compound for the development of new anti-cancer drugs. In the experiment, the researchers used 3-Bromopropan-1-ol(cas: 627-18-9SDS of cas: 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.SDS of cas: 627-18-9

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In 2019,Angewandte Chemie, International Edition included an article by Garreau, Marion; Le Vaillant, Franck; Waser, Jerome. Reference of 3-Bromopropan-1-ol. The article was titled 《C-Terminal bioconjugation of peptides through photoredox catalyzed decarboxylative alkynylation》. The information in the text is summarized as follows:

We report the first decarboxylative alkynylation of the C-terminus of peptides starting from free carboxylic acids. The reaction is fast, metal-free, and proceeds cleanly to afford alkynylated peptides with a broad tolerance for the C-terminal amino acid. By the use of hypervalent iodine reagents, the introduction of a broad range of functional groups was successful. C-terminal selectivity was achieved by differentiation of the oxidation potentials of the carboxylic acids based on the use of fine-tuned organic dyes. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Reference of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Reference of 3-Bromopropan-1-ol

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In 2019,European Journal of Medicinal Chemistry included an article by Pisani, Leonardo; Iacobazzi, Rosa Maria; Catto, Marco; Rullo, Mariagrazia; Farina, Roberta; Denora, Nunzio; Cellamare, Saverio; Altomare, Cosimo Damiano. Formula: C3H7BrO. The article was titled 《Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors》. The information in the text is summarized as follows:

Herein we envisaged the possibility of exploiting alkyl nitrates as precursors of alc.-bearing dual inhibitors targeting acetylcholinesterase (AChE) and monoamine oxidase B (MAO B), key enzymes in neurodegenerative syndromes such as Alzheimer’s disease (AD), through biotransformation unmasking an alc. function upon nitric oxide (NO) release. The cooperation to neuroprotection of low fluxes of NO and target enzymes’ inhibition by the alc. metabolites might return a multitargeting effect. The in vitro screening towards ChEs and MAOs of a collection of 21 primary alcs. disclosed a subset of dual inhibitors, among which three diverse chemotypes were selected to study the corresponding nitrates. Nitrate 14 proved to be a brain permeant, potent AChE-MAO B inhibitor by itself. Moreover, it protected human SH-SY5Y lines against rotenone and hydrogen peroxide with a poor inherent cytotoxicity and showed a slow conversion profile to its alc. metabolite 9d that still behaved as bimodal and neuroprotective mol. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Formula: C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Formula: C3H7BrO

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In 2022,Bondarenko, G. N.; Legkov, S. A.; Merekalov, A. S.; Otmakhova, O. A.; Talroze, R. V. published an article in Russian Journal of Physical Chemistry A. The title of the article was 《Molecular Structure and Donor-Acceptor Properties of β-(2,4,7-Trinitro-9-fluorenylideneaminooxy)propionic Acid Complexes with Triphenylene-Containing Systems》.Related Products of 627-18-9 The author mentioned the following in the article:

Quantum chem. calculations and FTIR spectroscopic studies show that β-(2,4,7-trinitro-9-fluorenylideneiminooxy)propionic acid (TNF-carb) can act as an electron acceptor. It stabilizes charge transfer complexes with discotic triphenylene-containing mols. Complexes TNF-carb/discotic may have different compositions (up to 1/4) and stabilize their structure via π-π interaction, but with the complementary hydrogen bonding as well. The results came from multiple reactions, including the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Related Products of 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Related Products of 627-18-9

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