Category: 627-18-9

《Syntheses of diselenide-containing dynamic polymers and their application in polymer alloys》 was written by Liu, Jia; Ma, Xiaoning; Tong, Yanping; Lang, Meidong. Recommanded Product: 627-18-9This research focused ontrimethylenecarbonate polycarbonate diselenidediol initiated blend mech property; caprolactone polyester diselenidediol initiated blend mech property. The article conveys some information:

The diselenide-containing polycarbonate ((PTMCSe)2) and diselenide-containing poly(ε-caprolactone) ((PCLSe)2) were synthesized by the ring opening polymerization using a new compound of di-(1-hydroxypropyl) diselenide ((HOC3H6Se)2) as initiator. The dynamic properties of these diselenide-containing polymers were revealed by diselenide exchange reactions, which could be realized under visible irradiation at room temperature As the result of the diselenide exchange between (PTMCSe)2 and (PCLSe)2, a di-block polymer (PCLSeSePTMC) was formed in (PTMCSe)2/(PCLSe)2 alloy. Taking advantage of the diselenide exchange, the compatibility and miscibility of (PTMCSe)2/(PCLSe)2 alloy was significantly improved by the exchange product (PCLSeSePTMC) which acted as polymeric compatibilizer. This novel concept may be applied in other polymer alloys containing dynamic covalent polymers. In the part of experimental materials, we found many familiar compounds, such as 3-Bromopropan-1-ol(cas: 627-18-9Recommanded Product: 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Recommanded Product: 627-18-9

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of C3H7BrOIn 2019 ,《Diblock copolymers consisting of a redox polymer block based on a stable radical linked to an electrically conducting polymer block as cathode materials for organic radical batteries》 appeared in Polymer Chemistry. The author of the article were Hergue, Noemie; Ernould, Bruno; Minoia, Andrea; De Winter, Julien; Gerbaux, Pascal; Lazzaroni, Roberto; Gohy, Jean-Francois; Dubois, Philippe; Coulembier, Olivier. The article conveys some information:

End-functionalized poly(3-hexylthiophene) (P3HT) and poly(2,2,6,6-tetramethylpiperidinyloxy-4-yl methacrylate) (PTMA) were synthesized using controlled polymerization techniques and linked together to lead to a diblock copolymer structure via click cycloaddition These diblock copolymers were further blended with carbon nanotubes (CNTs) to be used as cathodes in organic radical batteries. The performances of these batteries were studied during charge/discharge cycling at constant and variable current densities (C rate). In order to shed light on the importance of the diblock copolymer architecture, the results were compared to the capacities measured on electrodes made of blends of P3HT and PTMA homopolymers. Theor. simulations were finally used to corroborate the good electrochem. properties of the synthesized diblock copolymers. The results came from multiple reactions, including the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Electric Literature of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Electric Literature of C3H7BrO

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Alcohol – Wikipedia,
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Zeng, Yuan; Liu, Guoqiang; Lv, Tong; He, Xianzhe; Wei, Yen; Pan, Ruihao; Yang, Lei; Tao, Lei published an article in 2022. The article was titled 《Antioxidant Polymers via the Ugi Reaction for In Vivo Protection of UV-Induced Oxidative Stress》, and you may find the article in Chemistry of Materials.HPLC of Formula: 627-18-9 The information in the text is summarized as follows:

Small-mol. antioxidants perform poorly in vivo in combating oxidative stress because of their low bioavailability. Water-soluble polymeric antioxidants can overcome the limitations of small mol. antioxidants (instability, poor water solubility, fast metabolism, etc.), but there are only a few efficient synthesis methods to prepare safe and effective polymeric antioxidants. In this study, we develop a series of antioxidant polymers containing ferrocene and/or indole moieties through the Ugi four-component reaction and simple free radical polymerization These polymers are screened using different criteria to find a biocompatible antioxidative polymer that effectively inhibits the lethal and teratogenic effects of UV-induced oxidative damage on zebrafish embryos. This study identifies a strategy to use antioxidative polymers in vivo, demonstrates the value of multicomponent reactions in interdisciplinary areas, and provides the underlying insights to guide the design of antioxidant polymeric biomaterials. In the experimental materials used by the author, we found 3-Bromopropan-1-ol(cas: 627-18-9HPLC of Formula: 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.HPLC of Formula: 627-18-9

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Alcohol – Wikipedia,
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Related Products of 627-18-9In 2020 ,《Multi pH-sensitive polymer-drug conjugate mixed micelles for efficient co-delivery of doxorubicin and curcumin to synergistically suppress tumor metastasis》 appeared in Biomaterials Science. The author of the article were Zhou, Yuanhang; Zhou, Chuhang; Zou, Yang; Jin, Yao; Han, Shidi; Liu, Qi; Hu, Xinping; Wang, Leqi; Ma, Yining; Liu, Yan. The article conveys some information:

Combination therapy has been proved to be an effective strategy to inhibit metastasis, however, its efficacy is always compromised by the poor delivery efficiency of drugs. In this study, multi pH-sensitive polymer-drug conjugate mixed micelles were fabricated by the self-assembly of PEOz-PLA-ace-Cur, a conjugate of curcumin (Cur) with poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) (PEOz-PLA) through the linkage of the pH-cleavable acetal bond, and PEOz-PLA-imi-DOX, a conjugate of doxorubicin (DOX) with PEOz-PLA through the linkage of the pH-cleavable benzoic imine bond. The mixed conjugate micelles (PP-Cur/PP-DOX-Mix-PMs) with accurately and conveniently controlled mass ratio of the two drugs were demonstrated to have a small particle size (40-128 nm), high drug loading capacity and pH-dependent drug release behavior. Notably, PP-Cur5/PP-DOX1-Mix-PMs exhibited slower DOX release under physiol. conditions compared with PEOz-PLA-imi-DOX micelles, resulting in deeply reduced side effects in vivo. Furthermore, the mixed conjugate micelles showed synergistically enhanced inhibition of MDA-MB-231 cell growth and metastasis evidenced by the results of in vitro anti-invasion, wound healing and anti-migration assessment, and in vivo bioluminescence imaging in nude mice, and significant reduction of the side effects of DOX compared with dual drug phys. loaded polymeric micelles. Mechanistic studies demonstrated that the possible inhibitory mechanism of PP-Cur5/PP-DOX1-Mix-PMs on tumor metastasis could be assigned to their inhibition of the invasion, migration, intravasation and extravasation of tumor cells. In conclusion, the multi pH-sensitive polymer-drug conjugate mixed micelles with synergistically enhanced anti-tumor and anti-metastasis activity are potential candidates for safe and effective cancer combination therapy.3-Bromopropan-1-ol(cas: 627-18-9Related Products of 627-18-9) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Related Products of 627-18-9

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Dong, Min; Zheng, Guili; Gao, Feng; Li, Min; Zhong, Chen published an article in Frontiers in Pharmacology. The title of the article was 《Three-carbon linked dihydroartemisinin-isatin hybrids: design, synthesis and their antiproliferative anticancer activity》.Recommanded Product: 3-Bromopropan-1-ol The author mentioned the following in the article:

Fifteen dihydroartemisinin-isatin hybrids (5a-e and 6a-j) linked with three-carbon were designed, synthesized. The antiproliferative activity against lung cancer cell lines including drug-sensitive A549, doxorubicin-resistant A549 (A549/DOX) and cisplatin-resistant A549 (A549/DDP) lung cancer cell lines was tested. The cytotocivity towards normal lung epithelial BEAS-2B cell line was also investigated. From the structure-activity relationship (SAR), it was found that hydrogen bond donors (especially hydroxime and thiosemicarbazide) at C-3 position and electron-withdrawing groups (fluoro and chloro) at C-5 position of isatin moiety were beneficial for the activity. A significant part of them (half maximal inhibitory concentration/IC50: 5.72-55.52 μM) demonstrated considerable antiproliferative activity, and the activity was superior to that of dihydroartemisinin (IC50: 69.42-88.03 μM) and artemisinin (IC50: >100 μM). In particular, two hybrids 6a, e (IC50: 5.72-9.84 μM) were not inferior to doxorubicin (IC50: 4.06 μM) and cisplatin (IC50: 9.38 μM) against drug-sensitive A549 cells and were more potent than doxorubicin (IC50: 54.32 and 15.10 μM) and cisplatin (IC50: 19.74 and 66.89 μM) against multidrug-resistant A549/DOX and A549/DDP lung cancer cell lines. In addition, hybrids 6a, e (IC50: >100 μM) showed no toxicity towards BEAS-2B cells, proving their excellent selectivity profile. Furthermore, hybrid 6a also possessed good stability in mouse and human microsomes, as well as excellent pharmacokinetic properties. Accordingly, hybrid 6a could serve as a promising anti-lung cancer chemotherapeutic candidate for further preclin. evaluations. In the part of experimental materials, we found many familiar compounds, such as 3-Bromopropan-1-ol(cas: 627-18-9Recommanded Product: 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Recommanded Product: 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Synthesis and Aggregation of a Porphyrin-Cored Hyperbranched Polyglycidol and Its Application as a Macromolecular Photosensitizer for Photodynamic Therapy》 were Kadhim, Alaa; McKenzie, Luke K.; Bryant, Helen E.; Twyman, Lance James. And the article was published in Molecular Pharmaceutics in 2019. COA of Formula: C3H7BrO The author mentioned the following in the article:

Macromols. are potentially useful delivery systems for cancer drugs, as their size allows them to utilize the enhanced permeability and retention effect (EPR), which facilitates selective delivery to (and retention within) tumors. In addition, macromol. delivery systems can prolong circulation times as well as protect and solubilize toxic and hydrophobic drug moieties. Overall, these properties and abilities can result in an enhanced therapeutic effect. Photodynamic therapy (PDT) combines the use of oxygen and a photosensitizer (PS), which become toxic upon light irradiation We proposed that a PS encapsulated within a water-soluble macromol. could exploit the EPR effect and safely and selectively deliver the PS to a tumor. In this paper, we describe the synthesis of a porphyrin-cored hyperbranched polymer that aggregated into larger micellar structures. DLS and TEM indicated that these aggregated structures had diameters of 45 and 20 nm for the solvated and nonsolvated species, resp. The porphyrin-cored HBP (PC-HBP), along with the nonencapsulated porphyrin (THPP), were screened against EJ bladder carcinoma cells in the dark and light. Both THPP and PC-HBP displayed good toxicity in the light, with LD50 concentrations of 0.5 and 1.7μM, resp. However, in the dark, the nonincorporated porphyrin (THPP) displayed significant toxicity, generating an LD50 of 4μM. On the other hand, no dark toxicity was observed for the polymer system (PC-HBP) at concentrations of 100μM or less. As such, incorporation within the large polymer aggregate serves to eliminate dark toxicity while maintaining excellent toxicity when irradiated. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9COA of Formula: C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.COA of Formula: C3H7BrO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Redox-responsive ferrocene-containing poly(ionic liquid)s for antibacterial applications》 were Zhang, Tikai; Guo, Jiangna; Ding, Yingying; Mao, Hailei; Yan, Feng. And the article was published in Science China: Chemistry in 2019. Recommanded Product: 3-Bromopropan-1-ol The author mentioned the following in the article:

Ferrocene (Fc)-containing imidazolium type ionic liquids (ILs) and corresponding poly(ionic liquid) (PIL) membranes with tunable antibacterial activity based on electrochem. redox reaction and host-guest chem. were developed. The effect of Fc moiety on the antimicrobial activities against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) was studied by min. inhibitory concentration (MIC). The presence of Fc groups highly enhanced the antibacterial efficiency of Fccontaining ILs because of the generation of reactive oxygen species (ROS). The electrochem. oxidation of Fc to Fc+ and the formation of inclusion complexes between Fc and β-CD via host-guest interactions decreased the antibacterial activities of ILs and PIL membranes. The antibacterial activities may be recovered in some extent upon the electrochem. reduction of Fc+ to Fc or the exclusion of the Fc out of the cavity of β-CD. Furthermore, all the Fc-containing PIL membranes showed relatively low hemolysis activities and none cytotoxicity toward human cells, indicating clin. feasibility in topical applications. The experimental part of the paper was very detailed, including the reaction process of 3-Bromopropan-1-ol(cas: 627-18-9Recommanded Product: 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Recommanded Product: 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Glucose- and pH-Responsive Supramolecular Polymer Vesicles Based on Host-Guest Interaction for Transcutaneous Delivery of Insulin》 was written by Lin, Yonghui; Hu, Wei; Bai, Xiaowen; Ju, Yanshan; Cao, Cong; Zou, Shufen; Tong, Zaizai; Cen, Chao; Jiang, Guohua; Kong, Xiangdong. Related Products of 627-18-9 And the article was included in ACS Applied Bio Materials in 2020. The article conveys some information:

Smart insulin delivery platforms having the ability of mimicking pancreatic cells are highly expected for diabetes treatment. Herein, a smart glucose-sensitive insulin delivery platform on the basis of transcutaneous microneedles has been designed. The as-prepared microneedles are composed of glucose- and pH-responsive supramol. polymer vesicles (PVs) as the drug storage and water soluble polymers as the matrix. The well-defined PVs are constructed from the host-guest inclusion complex between water-soluble pillar[5]arene (WP5) with pH-responsiveness and paraquat-ended poly(phenylboronic acid) (PPBA-G) with glucose-sensitivity. The drug-loaded PVs, including insulin and glucose oxidase (GOx) can quickly respond to elevated glucose level, accompanied by the disassocn. of PVs and fast release of encapsulated insulin. Moreover, the insulin release rate is further accelerated by GOx, which generates gluconic acid at high glucose levels, thus decreasing the local pH. Therefore, the host-guest interaction between WP5 and PPBA-G is destroyed and a total structure disassocn. of PVs takes place, contributing to a fast release of encapsulated insulin. The in vivo insulin delivery to diabetic rats displays a quick response to hyperglycemic levels and then can fast regulate the blood glucose concentrations to normal levels, which demonstrates that the obtained smart insulin device has a highly potential application in the treatment of diabetes. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Related Products of 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Related Products of 627-18-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker》 was published in Molecular Pharmaceutics in 2020. These research results belong to Prag, Hiran A.; Kula-Alwar, Duvaraka; Pala, Laura; Caldwell, Stuart T.; Beach, Timothy E.; James, Andrew M.; Saeb-Parsy, Kourosh; Krieg, Thomas; Hartley, Richard C.; Murphy, Michael P.. Computed Properties of C3H7BrO The article mentions the following:

Many mitochondrial metabolites and bioactive mols. contain two carboxylic acid moieties that make them unable to cross biol. membranes. Hence, there is considerable interest in facilitating the uptake of these mols. into cells and mitochondria to modify or report on their function. Conjugation to the triphenylphosphonium (TPP) lipophilic cation is widely used to deliver mols. selectively to mitochondria in response to the membrane potential. However, permanent attachment to the cation can disrupt the biol. function of small dicarboxylates. Here, we have developed a strategy using TPP to release dicarboxylates selectively within mitochondria. For this, the dicarboxylate is attached to a TPP compound via a single ester bond, which is then cleaved by intramitochondrial esterase activity, releasing the dicarboxylate within the organelle. Leaving the second carboxylic acid free also means mitochondrial uptake is dependent on the pH gradient across the inner membrane. To assess this strategy, we synthesized a range of TPP monoesters of the model dicarboxylate, malonate. We then tested their mitochondrial accumulation and ability to deliver malonate to isolated mitochondria and to cells, in vitro and in vivo. A TPP-malonate monoester compound, TPP11-malonate, in which the dicarboxylate group was attached to the TPP compound via a hydrophobic undecyl link, was most effective at releasing malonate within mitochondria in cells and in vivo. Therefore, we have developed a TPP-monoester platform that enables the selective release of bioactive dicarboxylates within mitochondria. In addition to this study using 3-Bromopropan-1-ol, there are many other studies that have used 3-Bromopropan-1-ol(cas: 627-18-9Computed Properties of C3H7BrO) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Computed Properties of C3H7BrO

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Alcohol – Wikipedia,
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The author of 《Metal free synthesis of ethylene and propylene carbonate from alkylene halohydrin and CO2 at room temperature》 were Khokarale, Santosh Govind; Mikkola, Jyri-Pekka. And the article was published in RSC Advances in 2019. Related Products of 627-18-9 The author mentioned the following in the article:

Herein we describe a metal free and one-pot pathway for the synthesis of industrially important cyclic carbonates such as ethylene carbonate and propylene carbonates from mol. CO2 under mild reaction conditions. In the actual synthesis, the alkylene halohydrins such as alkylene chloro- or bromo or iodohydrin and organic superbase, 1,8-diazabicyclo-[5.4.0]-undec-7-ene (DBU) reacted equivalently with CO2 at room temperature The syntheses of cyclic carbonates were performed in DMSO as a solvent. Both 1,2 and 1,3 halohydrin precursors were converted into cyclic carbonates except 2-bromo- and iodoethanol, which were reacted equivalently with DBU through n-alkylation and formed corresponding n-alkylated DBU salts instead of forming cyclic carbonates. NMR anal. was used to identify the reaction components in the reaction mixture whereas this technique was also helpful in terms of understanding the reaction mechanism of cyclic carbonate formation. The mechanistic study based on the NMR anal. studies confirmed that prior to the formation of cyclic carbonate, a switchable ionic liquid formed in situ from alkylene chlorohydrin, DBU and CO2. As a representative study, the synthesis of cyclic carbonates from 1,2 chlorohydrins was demonstrated where the synthesis was carried out using chlorohydrin as a solvent as well as a reagent. In this case, alkylene chlorohydrin as a solvent not only replaced DMSO in the synthesis but also facilitated an efficient separation of the reaction components from the reaction mixture The EC or PC, [DBUH][Cl] as well as an excess of the alkylene chlorhydrin were separated from each other following solvent extraction and distillation approaches. In this process, with the applied reaction conditions, >90% yields of EC and PC were achieved. Meanwhile, DBU was recovered from in situ formed [DBUH][Cl] by using NaCl saturated alk. solution Most importantly here, we developed a metal free, industrially feasible CO2 capture and utilization approach to obtain EC and PC under mild reaction conditions. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Related Products of 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Related Products of 627-18-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts