Category: 627-18-9

Electric Literature of 627-18-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-18-9, name is 3-Bromopropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 3,4-Dihydropyran (DHP, 15 mmol) was added slowly to a stirred solution of bromohydrin (10 mmol) and p-toluenesulfonic acid (1 mmol) in dichloromethane (20 mL) on ice bath. After stirring at room temperature overnight, the reaction mixture was diluted with water and extracted with dichloromethane. The organic layer was washed with brine and dried over anhydrous Na2SO4. The solvent was evaporated under reduced pressure, and the residue was purified by flash column chromatography to afford 1-5 as a light yellow oil. 2-(3-Bromopropoxy)tetrahydro-2H-pyran (1). Yield 94.2%. 1H NMR spectrum, delta, ppm: 1.37-1.55 m (4H), 1.57-1.65 m (1H), 1.70-1.78 m (1H), 2.01-2.10 m (2H), 3.37-3.49 m (4H), 3.73-3.83 m (2H), 4.49-4.55 m (1H). 13C NMR spectrum, deltaC, ppm: 19.4, 25.4, 30.5, 30.6, 32.8, 62.1, 64.8, 98.7.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 627-18-9, 3-Bromopropan-1-ol.

Reference:
Article; Zhang; Dong; Meng; Huang; Li; Russian Journal of General Chemistry; vol. 88; 11; (2018); p. 2388 – 2393; Zh. Obshch. Khim.;,
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627-18-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-18-9, name is 3-Bromopropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Take a 500 mL three-necked flask dried in an oven, equipped with a mechanical stirrer and a thermometer. Add 98% sulfuric acid (50.0 g, 0.5 mol), dichloromethane 60 mL, and cool to -5 to 5 C in an ice salt bath. Fuming nitric acid (33.5g, 0.5mol) was slowly added. Then, 3-bromo-1-propanol (46 g, 0.33 mol) was added dropwise to the mixture, and the reaction medium was stirred at -5 to 5 C for 4 to 5 hours. The mixture was poured into cold water (350 g) maintaining the temperature between -5 and 5 C. After pouring, the organic phase was taken, 80 mL of dichloromethane was added to the aqueous phase, the organic phase was combined, the combined organic phases were washed with water, adjusted to pH = 6-7 by adding 8% sodium hydroxide, washed with brine, organic phase Dry with magnesium sulfate. Dichloromethane was evaporated under reduced pressure to give 3-bromopropyl nitrate (yield compound of formula M) (53.5 g, 88.1%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 627-18-9, 3-Bromopropan-1-ol.

Reference:
Patent; Chongqing Weipeng Pharmaceutical Co., Ltd.; Li Nenggang; Liu Zeyan; Lin Song; Chen Xiaopeng; Zhou Xingguo; Yao Hequan; (18 pag.)CN108892624; (2018); A;,
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627-18-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 627-18-9, name is 3-Bromopropan-1-ol, molecular formula is C3H7BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesis of Compound (1b):At less than 0 C,Dihydroartemisinin (840 mg, 3.0 mmol) and 3-bromo-1-propanol (0.42 mL, 4.6 mmol)Dissolved in CH2Cl2 (20 mL), BF3¡¤Et2O (0.63 mL, 5.0 mmol) was added dropwise.After the dropwise addition, stirring was continued for 5 min at the same temperature, and then transferred to an ice water bath.Stirring was continued for about 50 minutes. After the reaction is over,Wash with saturated NaHCO3 solution, water and saturated brine.The organic layer was collected and dried over anhydrous sodium sulfate.Concentrate to a pale yellow oily crude product.The crude product was chromatographed on silica gel (ethyl acetate: petroleum ether = 3:97)A colorless solid (471 mg, 39%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 627-18-9, 3-Bromopropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangzhou University Of Traditional Chinese Medicine (Guangzhou Traditional Chinese Medicine Institute); He Xixin; Pi Rongbiao; Li Mingtao; Zhong Xiaolin; Luo Huijuan; Wang Jiamin; (12 pag.)CN108586480; (2018); A;,
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627-18-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-18-9, name is 3-Bromopropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

In a 500 mL round-bottom flask, 3-bromopropan-1-ol (12.4 g, 89.2 mmol, 1 eq.) was dissolved in acetone (200 mL). A solution of sodium azide (29.0 g, 466 mmol, 5.2 e.) in deionized water (120 mL) was added while stirring. A catalytic amount of Kl (approximately 2 mg) was added. This solution was stirred at room temperature for 48 hours. After extraction with diethyl ether (3 x 80 mL), the combined organic layers were dryed over K2CO3. The drying agent was filtered off and the solvent evaporated in vacuo to give 3-azidopropan-1-ol as a highly viscous colourless oil (8.09 g, 80.0 mmol, 90 %). HRMS ESI(+) (MeOH) calculated for [M+Na]+: 124.04813, found: 124.04790.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 627-18-9, 3-Bromopropan-1-ol.

Reference:
Patent; Universitaet Zuerich; GADEMANN, Karl; BERG, Regina; MEIER, Andrea; (43 pag.)EP3508492; (2019); A1;,
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