Category: 62640-03-3

On December 24, 2003, Polla, Magnus published a patent.Safety of 2-(Methylamino)ethan-1-ol hydrochloride The title of the patent was Preparation of 2,5-disubstituted 3-mercaptopentanoic acids as carboxypeptidase U inhibitors. And the patent contained the following:

The title compounds R1(CH2)2CH(SH)CH(CO2H)CH2R2 [I; R1 = (un)substituted Ph, naphthyl, pyridinyl, etc.; R2 = aminopyridinyl, aminothiazolyl, 3-azabicyclo[3.2.1]octyl] which inhibit carboxypeptidase U and thus can be used in the prevention and treatment of diseases where inhibition of carboxypeptidase U is beneficial, were prepared E.g., a 4-step synthesis of 2-[(6-aminopyridin-3-yl)methyl]-5-(1,1′-biphenyl-3-yl)-3-mercaptopentanoic acid (starting from 3-iodo-1,1′-biphenyl), was given. Biol. data was given for 13 exemplified compounds I. In further aspects, the invention relates to pharmaceutical compositions containing at least one compound I. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Safety of 2-(Methylamino)ethan-1-ol hydrochloride

The Article related to mercaptopentanoate aminopyridinylmethyl preparation carboxypeptidase u inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of 2-(Methylamino)ethan-1-ol hydrochloride

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On December 20, 1995, Nishinaka, Koutaro; Kawaguchi, Yasuyoshi published a patent.Recommanded Product: 2-(Methylamino)ethan-1-ol hydrochloride The title of the patent was Rubber compositions for mold cleaning and method therewith. And the patent contained the following:

Title compositions comprise natural and/or synthetic rubbers, amino-alc. salts 2-30 (based on amino alc.), glycols 5-50, adsorbents 30-90, and organic peroxides 0.5-10 phr. A composition containing natural rubber 100, SiO2 (adsorbent) 60, dipropylene glycol 15, Perhexa V 2, monoethanolamine 10, and adipic acid 12 phr showed no NH3 odor at room temperature or 100°, and good cleaning ability initially and after 1 mo at room temperature The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Recommanded Product: 2-(Methylamino)ethan-1-ol hydrochloride

The Article related to mold cleaner aminoalc salt containing rubber, storage stability rubber mold cleaner, Synthetic Elastomers and Natural Rubber: Other Uses and other aspects.Recommanded Product: 2-(Methylamino)ethan-1-ol hydrochloride

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On July 4, 2013, Xiao, Dengming; Zhu, Li; Hu, Yuandong; Yu, Rong; Hu, Wei; Zhao, Na; Peng, Yong; Luo, Hong; Han, Yongxin published a patent.Recommanded Product: 2-(Methylamino)ethan-1-ol hydrochloride The title of the patent was Preparation of ethylene derivatives as selective estrogen receptor regulators. And the patent contained the following:

The invention relates to ethylene derivatives I [wherein R0 and R1 = independently H, halo, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl; A and B = independently aryl or heteroaryl; R2 and R3 = independently halo, hydroxy, amino, cyano, mercapto, carboxyl, alkyl, alkenyl, alkynyl, etc.; m and n = independently 0-3], pharmaceutically acceptable salts, stereoisomers, solvates, polymorphs, tautomers, or prodrugs thereof as selective estrogen receptor modulators (SERMs) for treating atrophic vaginitis, endometriosis, female sex dysfunction, mammary cancer, depression, diabetes mellitus, osteoporosis, etc. For example, II was prepared in a multi-step synthesis. II showed inhibitory activity with IC50 < 100 nM against MCF-7 human breast cancer cell lines. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Recommanded Product: 2-(Methylamino)ethan-1-ol hydrochloride

The Article related to preparation pyridine pyrimidine selective estrogen receptor regulator human, treatment vaginitis endometriosis mammary cancer depression diabetes osteoporosis, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 2-(Methylamino)ethan-1-ol hydrochloride

Referemce:
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On July 18, 2012, Xiao, Dengming; Zhu, Li; Hu, Yuandong; Yu, Rong; Hu, Wei; Zhao, Na; Peng, Yong; Luo, Hong; Han, Yongxin published a patent.Formula: C3H10ClNO The title of the patent was Preparation of ethylene derivatives as selective estrogen receptor regulators. And the patent contained the following:

The invention relates to ethylene derivatives I [wherein R0 and R1 = independently H, halo, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl; A and B = independently aryl or heteroaryl; R2 and R3 = independently halo, hydroxy, amino, cyano, mercapto, carboxyl, alkyl, alkenyl, alkynyl, etc.; m and n = independently 0-3], pharmaceutically acceptable salts, stereoisomers, solvates, polymorphs, tautomers, or prodrugs thereof as selective estrogen receptor regulators for treating atrophic vaginitis, endometriosis, female sex dysfunction, mammary cancer, depression, diabetes mellitus, osteoporosis, etc. For example, II was prepared in a multi-step synthesis. II showed inhibitory activity with IC50 < 100 nM against MCF-7 human breast cancer cell lines. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Formula: C3H10ClNO

The Article related to preparation pyridine pyrimidine selective estrogen receptor regulator human, treatment vaginitis endometriosis mammary cancer depression diabetes osteoporosis, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C3H10ClNO

Referemce:
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On September 7, 2012, James, Kenneth Duke, Jr.; Laudeman, Christopher Patrick; Malkar, Navdeep Balkrishna; Radhakrishnan, Balasingham published a patent.Product Details of 62640-03-3 The title of the patent was Antifungal agents and uses thereof. And the patent contained the following:

The invention features echinocandin class compounds The compounds can be useful for the treatment of fungal infections. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Product Details of 62640-03-3

The Article related to antifungal anidulafungin derivative preparation fungal infection therapy, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Product Details of 62640-03-3

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On February 20, 2014, Barr, Kenneth Jay; MacLean, John; Zhang, Hongjun; Beresis, Richard Thomas; Zhang, Dongshan published a patent.Product Details of 62640-03-3 The title of the patent was 3-Cyclohexenyl and cyclohexyl-substituted indole and indazole compounds as ROR-gamma-T inhibitors and their preparation. And the patent contained the following:

The invention relates to compounds of formula I, and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of ROR-gamma-T-mediated diseases or conditions. Compounds of formula I wherein dashed bond is single and double bond; X is CH2, CO and CRb; Y is CH, CRa and N; n is 0, 1, 2, 3, and 4; A4 is CR5 and N; A5 is CR5 and N; A6 is CR6 and N; A7 is CR7 and N; with the proviso that no more than two of A4 – A7 are N; Ra and Rb are independently C1-4 alkyl; R1 is (un)substituted C3-12 carbocyclyl and (un)substituted 4- to 12-membered heterocyclyl; R2 is hydroxycarbonyl, hydroxycarbonyl-C1-10 alkyl, and carbamoyl; R3 is H, halo, CN, NO2, etc.; R4 – R7 are independently H, halo, amino, CN, OH, etc.; and pharmaceutically acceptable salts and solvates thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their RORγ-T inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of 18 nM. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Product Details of 62640-03-3

The Article related to indole indazole preparation rorgammat inhibitors, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Product Details of 62640-03-3

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Alcohol – Wikipedia,
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On February 24, 2022, Murray, Martin Wayne; Irwin, Mark Robert; Whiting, Andrew; Morelli, Melinda published a patent.Product Details of 62640-03-3 The title of the patent was Vinyl disulfone compound, polymer obtainable by copolymerizing such compound, aqueous polymer dispersion and coating composition comprising such polymer. And the patent contained the following:

The invention relates to a vinyl disulfone compound of general formula CH3-SO2-C(=CH2)-SO2-N(R)-X-Y, wherein R is an alkyl radical comprising in the range of from 1 to 10 carbon atoms; X is an organic moiety comprising in the range of from 1 to 16 carbon atoms; and Y is a vinyl-functional polymerizable group selected from the group consisting of an acryloyl group, a methacryloyl group, a vinyl ester group, a vinyl ether group, a styrene group, an acrylamide group, and a methacrylamide group. The invention further relates to a polymer obtainable by copolymerizing a monomer mixture comprising such vinyl disulfone compound and further ethylenically unsaturated monomers, to an aqueous polymer dispersion or coating composition comprising polymer particles comprising such polymer, and to a coated substrate. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Product Details of 62640-03-3

The Article related to vinyl disulfone acrylate styrene core shell copolymer dispersion coating, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.Product Details of 62640-03-3

Referemce:
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On September 18, 2014, Desroy, Nicolas; Heckmann, Bertrand; Brys, Reginald Christophe Xavier; Joncour, Agnes; Peixoto, Christophe; Bock, Xavier published a patent.Application In Synthesis of 2-(Methylamino)ethan-1-ol hydrochloride The title of the patent was Preparation of imidazo[1,2-a]pyridine derivatives for treatment of inflammatory disorders. And the patent contained the following:

Disclosed are the title imidazo[1,2-a]pyridine derivatives I [R1a = H, halo, C1-C4 alkyl; R1b = halo, halo-(un)substituted C1-C4 alkyl, halo-(un)substituted C1-C4 alkoxy; X = S, O, N:CH, CH:CH; W = N, CR3; R4 = C1-C4 alkyl; R5 = (un)substituted C1-C4 alkyl with CN, OH, halo, C(:O)NH2; one of R6a or R6b = H, Me, halo, and the other is H; Cy = C4-C10 cycloalkyl, 41̃0 membered mono.bicyclic heterocycloalkyl, 47̃ membered heterocycloalkenyl; R7 = independently OH, oxo, halo, etc.; subscript a = 0, 1, 2; R8 = (L1-W1)m-L2-G1 wherein L1 = absent, O, C(:O), SO2, etc.; W1 = C1-C4 alkylene; subscript m = 0, 1; L2 = absent, O, C(:O), OC(:O), etc.; G1 = H, CN, (un)substituted C1-C4 alkyl, etc.; a pharmaceutically acceptable salt, or a solvate, or a pharmaceutically acceptable salt of a solvate thereof; or a biol. active metabolite thereof] for treatment of inflammatory disorders. For example, II was prepared in a multistep synthesis. The present invention relates to compounds I inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions, and methods of treatment using I, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatol. disorders, and/or abnormal angiogenesis associated diseases by administering I. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Application In Synthesis of 2-(Methylamino)ethan-1-ol hydrochloride

The Article related to preparation imidazopyridine treatment inflammatory disorder, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application In Synthesis of 2-(Methylamino)ethan-1-ol hydrochloride

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On October 31, 1979, Ferrari, G.; Casagrande, C. published an article.Category: alcohols-buliding-blocks The title of the article was Synthesis and chemical properties of N- and O-phosphorylated derivatives of creatinol. And the article contained the following:

Treatment of HOCH2CH2NMeC(:NH)NH2.HBr (I.HBr) with POCl3 gave, after hydrolysis, HOCH2CH2NMeC(:NH)NHP(O)(OH)2 (II), from which the di-Na, Ca and Ba salts were prepared II was also prepared by treating I.HBr with H3PO4 and heating the resultant I.H3PO4 to 165° under 5 min pressure. Treatment of Na+ [(4-O2NC6H4CH2O)2P(O)NCN]- with MeNHCH2CH2OH.HCl followed by hydrogenolysis gave HOCH2CH2NMeC(:NH)NHP(O)(OH)2, which rearranged to II upon heating at 155° for 1 h. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Category: alcohols-buliding-blocks

The Article related to phosphorylated creatinol, Aliphatic Compounds: Alcohol and Thiol Esters With Inorganic Acids and other aspects.Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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On July 4, 2012, Xiao, Dengming; Zhu, Li; Hu, Yuandong; Yu, Rong; Hu, Wei; Zhao, Na; Peng, Yong; Luo, Hong; Han, Yongxin published a patent.Application of 62640-03-3 The title of the patent was Preparation of heterocycles as estrogen receptor modulators. And the patent contained the following:

The invention relates to estrogen receptor modulators (e.g., I), processes for preparing them, pharmaceutical preparations comprising them, and their use for treating menopausal or postmenopausal disease, female sexual dysfunction, or breast cancer, etc. For instance, the invention compound I was prepared and gave a MCF-7 inhibition IC50 value of <100 nM. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Application of 62640-03-3

The Article related to heterocycle preparation estrogen receptor modulator, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Application of 62640-03-3

Referemce:
Alcohol – Wikipedia,
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