Category: 62640-03-3

On March 29, 1954, Zima, Otto; von Werder, Fritz published a patent.Category: alcohols-buliding-blocks The title of the patent was Choline derivatives. And the patent contained the following:

The compatibility of compounds ROCH2CH2NR12CH2SMe+X- is improved by oxidation of the thio to the sulfoxide group. To a solution of 30 g. dimethyl(尾-hydroxyethyl)(methylthiomethyl)ammonium chloride in 45 cc. water is added 22 g. 30% aqueous H2O2. The yield of dimethyl(尾-hydroxyethyl)(methylsulfinylmethyl)ammonium chloride is 28 g., m. 96掳, also prepared by oxidation of chloromethyl sulfide with H2O2 and condensation with dimethylaminoethanol. In a similar manner is prepared diethyl(尾-hydroxyethyl)(methylsulfinylmethyl)ammonium chloride, m. 126掳. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Category: alcohols-buliding-blocks

2-(Methylamino)ethan-1-ol hydrochloride(cas:62640-03-3) belongs to alcohols. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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On August 30, 1956, Abe, Kyuji published a patent.Electric Literature of 62640-03-3 The title of the patent was Monoalkylaminoethanols. And the patent contained the following:

Hydroxyethylsaccharin (11.3 g.) is boiled with 25 cc. 20% NaOH solution 10 min., 16.5 g. Me2SO4 added, and warmed at 50-60掳 1 hr. to afford sirupy N-methyl-N-(hydroxyethyl)-慰-carboxybenzenesulfonamide (I). I is boiled with NaOH solution prepared from 4.4 g. NaOH, 13 cc. H2O, and 20 cc. alc. 1 hr., slightly acidified by dilute HCl, the alc. evaporated in vacuo, heated with 20 cc. 10% HCl 2 hrs., cooled, made alk. by NaOH, distilled with steam, the product caught in dilute HCl, evaporated, and dried to afford 72% monomethylaminoethanol hydrochloride, hygroscopic crystals; picrate, m. 146-7掳. Similarly were prepared monoethylaminoethanol hydrochloride, hygroscopic crystals (picrate, m. 125-6掳); and monomethylaminoethyl Ph ether hydrochloride, m. 174-5掳. These are useful as starting materials for antihistaminic drugs. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Electric Literature of 62640-03-3

2-(Methylamino)ethan-1-ol hydrochloride(cas:62640-03-3) belongs to alcohols. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Electric Literature of 62640-03-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On February 28, 1997, Sakuma, Masayuki; Fukami, Hiroshi; Kuwahara, Yasumasa published an article.Electric Literature of 62640-03-3 The title of the article was Attractiveness of alkylamines and aminoalcohols related to the aggregation attractant pheromone of the German cockroach, Blattella germanica (L.) (Dictyoptera: Blattellidae). And the article contained the following:

Alkylamines, aminoalcs., and alcs. related to the aggregation attractant pheromone of the German cockroach were examined for their attractiveness to nymphs by using a linear track olfactometer. Free amines and aminoalcs., which were too volatile to be retained on a dispenser, were continuously applied as aqueous solution onto the air-intake of the olfactometer, and amine hydrochlorides were dispensed on metal disks as dry material to simulate the natural condition where the attractant amines occur as salt. All the examined C1-C6 alkylamines including primary, secondary and tertiary amines represented both chemotaxis and anemotaxis, potencies of which were evaluated as ED50 by probit anal. The potencies of free amines were almost the same: chemotaxis ranged from 0.56 nmol/min of trimethylamine to 4.1 nmol/min of pyrrolidine, whereas those of hydrochlorides were separated into moderately active primary and more active secondary and tertiary amine hydrochlorides. In the aminoalcs. structurally related to the principal pheromonal component 1-dimethylamino-2-methyl-2-propanol, 1-dimethylamino-2-propanol was the most potent at 0.098 nmol/min. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Electric Literature of 62640-03-3

The Article related to attractiveness alkylamine aminoalc pheromone cockroach nymph, Nonmammalian Biochemistry: Other and other aspects.Electric Literature of 62640-03-3

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On December 25, 1991, Nakada, Masanori; Inoue, Shintaro; Tonomura, Mikio published a patent.Computed Properties of 62640-03-3 The title of the patent was Ethanolamine derivatives for treatment of diseases accompanied by excessive collagen accumulation. And the patent contained the following:

R1NR2CHR3CH2OH (R1, R2 = H, Me; R3 = H, Me, Et; R1 = R2 = R3 ≠ H) or their pharmacol. acceptable salts are useful for treatment of diseases, such as hepatic fibrosis (including cirrhosis and chronic hepatitis), pulmonary fibrosis, keloid, scleroderma, etc. An aqueous 600 μM N-methylethanolamine (I) solution (2 mL) was added to a 2 mL a medium containing human HT-P11 fibrosarcoma cells to show 224% promotion of procollagenase production by the cells. Rats with hepatic fibrosis were administered p.o. with an aqueous 66.6 mg I/mL solution at 3 mL/kg/day for 7 wk to show serum levels of glutamic-pyruvic transaminase 436, glutamic-oxaloacetic transaminase 1250, and γ-glutamyl transpeptidase 7.0 U/L, vs. 948, 2170, and 17.6 U/L, resp., for controls without administration of I. I also lowered the serum levels of total bilirubin, alk. phosphatase, thymol turbidity, and ZnSO4 turbidity. I at 2 g/kg p.o. showed no mortality in mice. Tablets (200 mg each) containing I.HCl 50, lactose 10, corn starch 30, crystalline cellulose 8, hydroxypropyl cellulose 1, and Mg stearate 1 g were formulated. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Computed Properties of 62640-03-3

The Article related to liver lung fibrosis treatment ethanolamine, cirrhosis hepatitis treatment ethanolamine, scleroderma treatment procollagenase production ethanolamine, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 62640-03-3

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Cabani, S.; Mollica, V.; Lepori, L.; Lobo, S. T. published an article in 1977, the title of the article was Volume changes in the proton ionization of amines in water. 2. Amino alcohols, amino ethers, and diamines.Formula: C3H10ClNO And the article contains the following content:

From d. measurements (25°) of aqueous solutions at various concentrations of solute, apparent molar volumes of some open-chain bifunctional primary, secondary and tertiary amines were determined; the compounds studied were X(CH2)nNH2 (X = HO, MeO, H2N; n = 2,3) and 2-XCH2CH2OH (X = MeNH, EtNH, Me2N, Et2N) and their mono- and dihydrochlorides, for which ΔV1° and ΔV2° for the 1st and 2nd steps of proton ionization were calculated from the limiting partial molar volumes Values ΔV1° for the above bifunctional amines are compared with the corresponding values for monofunctional amines, and the difference in ΔV1° caused by the introduction of the 2nd hydrophilic center is discussed. The volumes and entropies of ionization of the amines and carboxylic acids are compared, and the deviations of these functions from predictions based on simple electrostatic theories are considered. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Formula: C3H10ClNO

The Article related to amine ionization molar volume, Physical Organic Chemistry: Structure Effects and other aspects.Formula: C3H10ClNO

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On September 18, 2013, Chen, Longdi published a patent.Synthetic Route of 62640-03-3 The title of the patent was Synergistic hair conditioner containing Camellia sinensis leaf oil. And the patent contained the following:

The invention discloses a hair conditioner containing (by weight) Camellia sinensis leaf oil 0.2-0.6%, dihydrogenated tallowamidoethyl hydroxyethylmoniumchloride 2-5%, cetearyl phosphate 3-6%, L-glucitol 1-3%, and water in balance. The hair conditioner also contains zinc pyrithione, eugenol and ammothamnine. The hair conditioner has antifungal effect and anti-dandruff effect, and improves hair loss and tinea capitis. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Synthetic Route of 62640-03-3

The Article related to synergistic hair conditioner camellia leaf oil fungicide tinea capitis, Essential Oils and Cosmetics: Hair Preparations and other aspects.Synthetic Route of 62640-03-3

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On July 28, 1998, Hikima, Toshio published a patent.COA of Formula: C3H10ClNO The title of the patent was skin cosmetics containing biphenyl compounds. And the patent contained the following:

Skin cosmetics showing excellent skin-lightening, antiaging and rough skin-preventing effects contain: [A] ascorbic acid or derivatives and/or fibroblast collagen formation promoters and [B] biphenyl compounds(I)[R1 = Me, Et, Pr, CH2OH, C3H6OH, CH2CH:CH2] or (II) [R2 = H, C1-8 hydrocarbons]. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).COA of Formula: C3H10ClNO

The Article related to skin cosmetic biphenyl compound, ascorbate collagen formation promoter skin cosmetic, Essential Oils and Cosmetics: Skin Preparations and other aspects.COA of Formula: C3H10ClNO

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On June 28, 2018, Din Belle, David; Makela, Mikko; Passiniemi, Mikko; Pietikainen, Pekka; Rummakko, Petteri; Tiainen, Eija; Vaismaa, Matti; Wohlfahrt, Gerd published a patent.Safety of 2-(Methylamino)ethan-1-ol hydrochloride The title of the patent was Preparation of the pyran derivatives as cyp11a1 (cytochrome p450 monooxygenase 11a1) inhibitors. And the patent contained the following:

The invention is related to the preparation of the pyran derivatives as cyp11a1 (cytochrome P 450 monooxygenase 11a1) inhibitors I. The invention compounds I , wherein ring B is a 4-10 membered monocyclic or bicyclic ring containing 0-4 heteroatoms independently selected form N, O or S; A is 2-tetrahydroindenyl, 2-tetrahydroisoquinolinyl, etc; L is absent, CH2, CH2CH2, etc.; R1 is hydrogen, C1-7 alkyl, C1-7 alkoxy, etc.; R2 is H, halo, OH, etc.; R3 is H, halo, NO2, etc.; R4 is H, halo, OH, etc.; R5 is H, halo, C1-7 alkyl; R23 is H or oxo; R24 is H or C1-7 alkyl; and their pharmaceutically acceptable salts are claimed. Compound I was prepared by multi-step procedure (procedure given). The compounds of formula I possess utility as cytochrome P 450 monooxygenase 11A1(CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroidreceptor, particularly androgen receptor,dependent diseases and conditions, such asprostate cancer. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Safety of 2-(Methylamino)ethan-1-ol hydrochloride

The Article related to preparation pyran cyp11a1 cytochrome p450 monooxygenase inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyrans and other aspects.Safety of 2-(Methylamino)ethan-1-ol hydrochloride

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On June 25, 2006, Yang, Dehong; Yang, Benyong; Li, Hui published an article.Category: alcohols-buliding-blocks The title of the article was Synthesis of 2-(methyl-2-pyridinylamino)ethanol. And the article contained the following:

The title compound [i.e., 2-[methyl(2-pyridinyl)amino]ethanol] is a key intermediate in the synthesis of rosiglitazone. A reaction of 2-chloropyridine with two equivalent 2-(methylamino)ethanol gave the target compound and 2-(methylamino)ethanol hydrochloride. To enhance the reaction yield, appropriately increasing reaction temperature and changing post-treatment can shorten reaction time to 7-8 h, simplify the operation and significantly improve the yield to 95%. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Category: alcohols-buliding-blocks

The Article related to rosiglitazone methylpyridinylamino ethanol preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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On April 22, 2004, Lowe, John A.; Volkmann, Robert A. published a patent.Formula: C3H10ClNO The title of the patent was Preparation of 2-amino-6-(2,4,5-substituted-phenyl)pyridines as nitrous oxide synthase (NOS) inhibitors. And the patent contained the following:

Title compounds I [R1 = Me, Et, Pr, etc.; R2 = H, Me, Et, Pr, etc.; m = 1-3; R3-4 = Ph, 5-6-membered heteroaryl containing from 1 to 4 heteroatoms, etc.] are prepared For instance, 4-benzyloxy-5-ethyl-2-methoxyphenylboronic acid (preparation given) is reacted with 2-bromo-6-(2,5-dimethylpyrrol-1-yl)pyridine (EtOHaq, Na2CO3, (PPh3)4Pd, reflux, 64 h) and the resulting adduct debenzylated (MeOH, NH4O2CH, Pd(OH)2, reflux, 45 min), the amino residue unmasked (EtOHaq, NH2OH, reflux, 16 h), alkylated with 3-((methanesulfonyl)oxy)azetidine-1-carboxylic acid tert-Bu ester (DMSO, t-BuOK) and finally converted to II (THF, LAH). Example compounds exhibit IC50 < 1 μM for inhibition of NOS. I are useful for the treatment of treatment and prevention of central nervous system and other disorders. I are also used for inhibiting neurol. damage caused by impairment of glucose and/or oxygen to the brain; in one embodiment, the NOS inhibitor is administered to the mammal prior to surgery, e.g., prior to cardiac surgery, angioplasty, or angiog. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Formula: C3H10ClNO

The Article related to amino phenyl pyridine nitric oxide synthase inhibitor preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C3H10ClNO

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Alcohol – Wikipedia,
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