Category: 626-95-9

Adding a certain compound to certain chemical reactions, such as: 626-95-9, 1,4-Pentanediol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

To a solution of (rac)-pentane-l,4-diol (5.00 g) in DMF (53 mL) at 0 C was sequentially added imidazole (3.92 g) and feri-butyl(chloro)diphenylsilane (12 mL) and the mixture was stirred at room temperature for 22 h. The reaction was stopped by the addition of water and the mixture was extracted with hexanes. The combined organic layers were washed with saturated aqueous sodium chloride solution, dried and concentrated to yield the title compound (12.9 g). NMR (400 MHz, DMSO-i/6, 295 K) delta/ppm = 0.97 – 1.04 (m, 12H), 1.31 – 1.43 (m, 2H), 1.46 – 1.66 (m, 2H), 3.51 – 3.60 (m, 1H), 3.60 – 3.67 (m, 2H), 4.31 – 4.38 (m, 1H), 7.40 – 7.48 (m, 6H), 7.58 – 7.64 (m, 4H).

The synthetic route of 626-95-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; LUeCKING, Ulrich; HOG, Daniel; CHRIST, Clara; SACK, Ulrike; SIEGEL, Franziska; LIENAU, Philip; WERBECK, Nicolas; (170 pag.)WO2018/177889; (2018); A1;,
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Adding a certain compound to certain chemical reactions, such as: 626-95-9, 1,4-Pentanediol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 626-95-9, blongs to alcohols-buliding-blocks compound. SDS of cas: 626-95-9

General procedure: An aqueous solution containing 1,4-butanediol (0.5 mmol),cyclohexene (5 mmol, 0.506 mL, 10 equiv), KOH (25 mol%,0.007 g, 0.125 mmol), and 1 or 2 (10 mol%, 0.0506 g or 0.051 g,0.05 mmol) was heated to 100 C for 48 h in a sealed vessel. Oncompletion of the reaction, the products were extracted withDCM and injected into gas chromatography. gamma-Butyrolactonewith 73% and 84% yields was observed with the formation ofcyclohexane with 22% and 24% yields.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,626-95-9, 1,4-Pentanediol, and friends who are interested can also refer to it.

Reference:
Article; Bhatia, Anita; Kannan, Muthukumar; Muthaiah, Senthilkumar; Synlett; vol. 30; 6; (2019); p. 721 – 725;,
Alcohol – Wikipedia,
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Application of 626-95-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 626-95-9, name is 1,4-Pentanediol. A new synthetic method of this compound is introduced below.

Referential Example 2: 4-(t-Butyldiphenylsilyloxy)-1-methyl-1-butanol In N,N-dimethylformamide (200 ml) were dissolved 1,4-pentanediol (10.0 g, 96.0 mmol) and imidazole (6.6 g, 96.9 mmol).. Under ice cooling, t-butyl chlorodiphenylsilane (25.2 ml, 96.4 mmol) was added dropwise.. After completion of the dropwise addition, the reaction mixture was stirred at room temperature for 2 days.. To the reaction mixture was added diethyl ether, followed by washing with water.. The organic layer was dried over anhydrous magnesium sulfate.. After filtration, the residue obtained by concentrating the filtrate under reduced pressure was purified by silica gel chromatography (hexane:ethyl acetate=5:1), whereby the title compound (32.0 g, 97%) was obtained as a colorless oil. IR (ATR) nu: 3350, 2929, 2856, 1427, 1105, 822, 739, 698, 609, 501 cm-1.1H-NMR (400MHz, CDCl3) delta: 1.05(9H,S), 1.19(3H,d,J=6.3Hz), 1.46-1.72(4H,m), 2.02-2.08(1H,m), 3.69(2H,t,J=6.0Hz), 3.78-3.90(1H,m), 7.30-7.50(6H,m), 7.62-7.88(4H,m). MS (m/z): 343 (M++H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,626-95-9, 1,4-Pentanediol, and friends who are interested can also refer to it.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1466898; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 626-95-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 626-95-9, name is 1,4-Pentanediol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: In a typical experiment, a round bottom flask containing 4-6mL of acetonitrile/water mixture (1:1) was charged with 0.5-1.0mmol of the diol, 5mol% of TetMe-IA, and oxone (2equiv). The resulting mixture was stirred at rt for benzylic diols and at 45C for aliphatic diols. At the end of the reaction, as judged from TLC analysis, little water was added to dissolve the inorganic salts, and the organic matter was extracted with EtOAc at least two times. The combined extract was dried over anhydrous Na2SO4, concentrated in vacuo to obtain the crude product, which was subjected to silica-gel column chromatography using ethyl acetate/pet ether to isolate the pure product.

According to the analysis of related databases, 626-95-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Jhulki, Samik; Seth, Saona; Mondal, Manas; Moorthy, Jarugu Narasimha; Tetrahedron; vol. 70; 13; (2014); p. 2286 – 2293;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts