Category: 623-69-8

Electric Literature of 623-69-8 ,Some common heterocyclic compound, 623-69-8, molecular formula is C5H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To NaH (0.366 g, 9.16 mmol) in THF (12 mL) at 0 °C was added 1 ,3- dimethoxy-2-propanol (1 g, 8.32 mmol) in THF (8 mL) solution. The mixture was warmed to room temperature and stirred for 0.5 hour. To this was added tosyl chloride (1.587 g, 8.32 mmol) in one portion. The white cloudy mixture was stirred at room temperature for 16 hours. LC/MS showed complete conversion. The reaction mixture was poured into water and extracted with EtOAc. The organic extracts were combined, washed with brine, dried with sodium sulfate and concentrated in vacuo to give 2 g of colorless oil. The crude mixture was purified by Analogix system (silica gel column 80 g, gradient: 0 min, 100percentn-heptane; 5-12 min, 20percent EtOAc in Heptane; 12-15 min. 30percent EtOAc in Heptane and hold until 30 min). The pure fractions were combined and concentrated in vacuo to give 1.25 g of product as colorless oil which solidified upon standing.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-69-8, its application will become more common.

Reference:
Patent; NOVARTIS AG; ANTONIOS-MCCREA, William, R.; BARSANTI, Paul, A.; HU, Cheng; JIN, Xianming; MARTIN, Eric, J.; PAN, Yue; PFISTER, Keith, B.; SENDZIK, Martin; SUTTON, James; WAN, Lifeng; WO2012/66070; (2012); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 623-69-8, name is 1,3-Dimethoxypropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H12O3

To a solution of 3-bromophenol (6g, 34.7mmol) and 1,3-dimethoxypropan-2-ol (5.OOg,41.6mmol) in THE (l5OmL) was added triphenylphosphine (13.64g, 52.Ommol) and the reaction mixture cooled to 0C followed by dropwise addition of DIAD (6.74mL, 34.7mmol). The reaction was allowed to warm to room temperature, then stirred for 12h. The reaction mixture was concentratedvacua. The obtained residue was dissolved in EtOAc (SOmL), washed with water (SOmL) and brine(SOmL), dried over Na24, concentrated in vacua and subjected to silica column chromatography(SOg column), eluting with 20% EtOAc in petroleum ether. The relevant fractions were combined andconcentrated in vacua affording the title compound (4.Og, 42%) as a yellow liquid: MS ES+ve m/z275, 277 (M–H).

With the rapid development of chemical substances, we look forward to future research findings about 623-69-8.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ANDERSON, Niall Andrew; CAMPBELL-CRAWFORD, Matthew Howard James; HANCOCK, Ashley Paul; LEMMA, Seble; PRITCHARD, John Martin; PROCOPIOU, Panayiotis Alexandrou; REDMOND, Joanna Mary; SOLLIS, Steven Leslie; (77 pag.)WO2017/162572; (2017); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 623-69-8, name is 1,3-Dimethoxypropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 623-69-8

Synthesis of trans-N 1 -(1 ,3-dimethoxypropan-2-yl)cyclohexane-1 ,4-diamine (IntermediateStep 1 . To NaH (0.366 g, 9.16 mmol) in THF (12 mL) at 0 °C was added 1 ,3- dimethoxy-2-propanol (1 g, 8.32 mmol) in THF (8 mL) solution. The mixture was warmed to ambient temperature and stirred for 0.5 hour. To this was added tosyl chloride (1.587 g, 8.32 mmol) in one portion. The resulting white cloudy mixture then was stirred at ambient temperature for 16 hours. LC/MS showed complete conversion to 1 ,3- dimethoxypropan-2-yl 4-methylbenzenesulfonate. The reaction mixture was poured into water and extracted with EtOAc. The organic extracts were combined, washed with brine, dried with sodium sulfate and concentrated in vacuo to yield 2 g of a colorless oil. The crude mixture was purified by Analogix system (silica gel column 80 g, gradient: 0 min, 100percentn-heptane; 5-12 min, 20percent EtOAc in Heptane; 12-15 min. 30percent EtOAc in Heptane and hold until 30 min). The pure fractions were combined and concentrated in vacuo to yield 1.25 g of the tosylate product 1 ,3-dimethoxypropan-2-yl 4- methylbenzenesulfonate as a colorless oil, which solidified upon standing.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 623-69-8, 1,3-Dimethoxypropan-2-ol.

Reference:
Patent; NOVARTIS AG; ANTONIOS-MCCREA, William R.; BARSANTI, Paul A.; HU, Cheng; JIN, Xianming; LIN, Xiaodong; MARTIN, Eric J.; PAN, Yue; PFISTER, Keith B.; RENHOWE, Paul A.; SENDZIK, Martin; SUTTON, James; WAN, Lifeng; WO2012/101066; (2012); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.623-69-8, name is 1,3-Dimethoxypropan-2-ol, molecular formula is C5H12O3, molecular weight is 120.15, as common compound, the synthetic route is as follows.name: 1,3-Dimethoxypropan-2-ol

To a solution of 1, 3-dimethoxy-2-hydroxypropane (3.84g, 0. 032mol) in DCM (70ml) cooled at 5 C was added triethylamine (Sml, 0. 036mol) followed by slow addition of methanesulphonyl chloride (2. 72ml, 0. 035mol). The mixture was then stirred at ambient temperature for 24 hours. The mixture was then absorbed onto silica gel and purified by flash silica chromatography DCM: isohexane (3: 1) to give the title compound (3.74g, 59percent). NMR 3.15 (s, 3H), 3.28 (s, 6H), 3.52 (d, 4H), 4.78 (q, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,623-69-8, 1,3-Dimethoxypropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2003/76436; (2003); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 623-69-8, name is 1,3-Dimethoxypropan-2-ol, molecular formula is C5H12O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C5H12O3

61c. Methanesulfonic acid 2-methoxy-1-methoxymethyl-ethyl ester 4.3 mL of methanesulfonyl chloride was added dropwise at 5¡ã C. to a stirred solution of 6.0 g of 1,3-dimethoxy-propan-2-ol and 9.0 mL of triethylamine in 60 mL of dichloromethane. Stirring was continued for 72 hours at room temperature, followed by extraction with water. The combined organic extracts were dried (sodium sulfate) and concentrated and the residue purified by silica chromatography (isohexane/ethyl acetate=9/1, 8/2, 7/3, 6/4 v/v) yielding 2.5 g of methanesulfonic acid 2-methoxy-1-methoxymethyl-ethyl ester as an oil. EI-MS: 198 (M+).

With the rapid development of chemical substances, we look forward to future research findings about 623-69-8.

Reference:
Patent; Akzo Nobel N.V.; US6194409; (2001); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 623-69-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.623-69-8, name is 1,3-Dimethoxypropan-2-ol, molecular formula is C5H12O3, molecular weight is 120.15, as common compound, the synthetic route is as follows.

Section 1 step: the epoxychloropropane and methanol under the action of the NaOH, in order to an excess of methanol as a solvent reflux reaction 6 hours, to obtain 1,3-dimethoxy-2-propanol; The mole ratio is that, epoxychloropropane: NaOH= 1 : 1.05; Methanol consumption per mole of epichlohydrin substrate for adding 0.6L of the methanol. Section 2 step: the resulting 1,3-dimethoxy-2-propanol with 4-n-butyl benzoyl chloride in triethylamine under the action of acid, in tetrahydrofuran solvent reflux reaction for 7 hours, shown in formula III obtained ether acid ester composition (i); The mole ratio is that, 1,3-dimethoxy-2-propanol: 4-n-butyl benzoyl chloride: triethylamine = 1:1: 1.5; Tetrahydrofuran according to the amount of per mole of the 1,3-dimethoxy-2-propanol is added to substrate 1.5L tetrahydrofuran

Statistics shows that 623-69-8 is playing an increasingly important role. we look forward to future research findings about 1,3-Dimethoxypropan-2-ol.

Reference:
Patent; China Petroleum and Chemical Corporation; China Petroleum & Chemical Corporation Beijing Research Institute of Chemical; Hu, Jianjun; Liu, Haitao; Gao, Mingzhi; Ma, Jixing; Cai, Xiaoxia; Zhang, Xiaofan; Chen, Jianhua; Ma, jing; Li, Changxiu; Li, Xianzhong; Wang, Jun; (12 pag.)CN103664615; (2016); B;,
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Reference of 623-69-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 623-69-8 as follows.

To NaH (0.366 g, 9.16 mmol) in THF (12 mL) at 0 ¡ãC was added 1 ,3-dimethoxy-2- propanol (1 g, 8.32 mmol) in THF (8 mL) solution. The mixture was warmed to room temperature and stirred for 0.5 hour. To this was added tosyl chloride (1.587 g, 8.32 mmol) in one portion. The white cloudy mixture was stirred at room temperature for 16 hours. LC/MS showed complete conversion. The reaction mixture was poured into water and extracted with EtOAc. The organic extracts were combined, washed with brine, dried with sodium sulfate and concentrated in vacuo to give 2 g of colorless oil. The crude mixture was purified by column chromatography (silica gel column 80 g, gradient: 0 min, 100percentn-heptane; 5-12 min, 20percent EtOAc in Heptane; 12-15 min. 30percent EtOAc in Heptane and hold until 30 min). The pure fractions were combined and concentrated under reduced pressure to give 1.25 g of product as colorless oil which solidified upon standing

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-69-8, its application will become more common.

Reference:
Patent; NOVARTIS AG; ANTONIOS-MCCREA, William R.; BARSANTI, Paul A.; HU, Cheng; JIN, Xianming; LIN, Xiaodong; MARTIN, Eric J.; PAN, Yue; PFISTER, Keith B; RENHOWE, Paul A.; SENDZIK, Martin; SUTTON, James; WAN, Lifeng; WO2012/101065; (2012); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts