Category: 623-04-1

623-04-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 623-04-1, name is (4-Aminophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

p-Aminobenzyl alcohol (PAB-OH) (310 mg, 2.59 mmol) was added to a solution of Fmoc-Leu-OH (830 mg, 2.35 mmol) and /V-ethoxycarbonyl-2-ethoxy-1,2- dihydroquinoline (EEDQ) (630 mg, 2.59 mmol) in anhydrous dichloromethane (DCM) (50 ml_) and the reaction solution was stirred at room temperature overnight. The solvent was then evaporated under reduced pressure and the residue was purified by column chromatography eluting with DCM:MeOH 98:2 to afford 1 (1.00 g, 92%) as a colourless powder

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 623-04-1, (4-Aminophenyl)methanol.

Reference:
Patent; UNIVERSITY OF BRADFORD; LOADMAN, Paul; FALCONER, Robert; GILL, Jason; (57 pag.)WO2017/93719; (2017); A1;,
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623-04-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 623-04-1, name is (4-Aminophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

4-aminobenzyl alcohol (1 g, 8.12 mmol) was dissolved in 5 mL of 5M hydrochloric acid solution,A solution of sodium nitrite (840 mg, 12.18 mmol, dissolved in 20 mL of deionized water) was added dropwise to the solution. The mixture was added dropwise within 30 minutes. The reaction mixture was vigorously stirred in an ice-water bath.Sodium azide (2.1 g, 32.3 mmol) was added portionwise to the reaction system, and the resulting mixture was stirred at room temperature overnight. After the reaction is complete,The residue was poured into saturated NaHCO3 solution and extracted with ethyl acetate. The organic layer was washed with saturated NaCl solution, dried over anhydrous Na2SO4, filtered and concentrated.The crude product was isolated and purified by silica gel column chromatography (EA:PE=1:3, volume ratio) to give 950 mg of a yellow oily liquid in a yield of 78.0%.

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Reference:
Patent; Peking University; Tang Xinjing; Jin Qingqing; (36 pag.)CN107365254; (2017); A;,
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623-04-1, Adding some certain compound to certain chemical reactions, such as: 623-04-1, name is (4-Aminophenyl)methanol,molecular formula is C7H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 623-04-1.

2.15g (17.5mmol) of 4-aminobenzyl alcohol was added to 20mL of 10% HCl aqueous solution at 0C, followed by addition of 1.45g (21.0mmol, 1.2equiv) sodium nitrite dissolved in dry 10mL CH2Cl2. After the mixture was stirred at 0C for 1h, 4mL of sodium azide (1.88g, 28.9mmol) aqueous solution was added drop-wise and stirred overnight. Then, the mixture was quenched with brine and extracted with ethyl acetate (100mL¡Á3). The combined organic layer was dried over anhydrous sodium sulfate and concentrated in vacuum. Finally, the crude product was purified by flash chromatography (petroleum/ethyl acetate=4:1) to give a yellow oil (2.21g, 85%). 1H NMR (400MHz, DMSO): delta=6.95 (d, J=8Hz, 2H), 6.50 (d, J=8Hz, 2H), 4.92 (s, 2H), 4.79 (t, J=8Hz, 1H), 4.28 (d, J=8Hz, 2H) (Fig.S3). 13C NMR (100MHz, DMSO): delta=145.97, 131.13, 128.78, 115.20, 65.16 (Fig.S4)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 623-04-1.

Reference:
Article; Xiang, Kaiqiang; Liu, Yunchang; Li, Changjiang; Tian, Baozhu; Tong, Tianzhong; Zhang, Jinlong; Dyes and Pigments; vol. 123; (2015); p. 78 – 84;,
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623-04-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 623-04-1 as follows.

Step B; 4-Acetamidobenzyl acetateTo a solution of (4-aminophenyl)methanol (2.0 g, 16.2 mmol) from step A and DMAP (0.40 g, 3.2 mmol)in DCM (50 mL) was added dropwise acetic anhydride (7.6 mL, 81.0 mmol) at 0 0C over 30 min. After stirring under nitrogen for 30 min, the solution was concentrated and extracted with DCM twice. The combined extracts were washed with water and brine, dried over Na2SO4 and concentrated. Column chromatography on silica (20% EA in PE) afforded the title compound as white solid (3.35 g, 100%). 1H NMR (CDCl3, 300 MHz): delta 7.51 (d, J = 8.1 Hz, 2H), 7.31 (d, J = 8.1 Hz, 2H), 5.05 (s, 2H), 2.16 (s, 3H), 2.08 (s, 3H). MS (ESI, Pos. 1.5 kV) m/z 230.0 (M+Na)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-04-1, its application will become more common.

Reference:
Patent; SHANGHAI TARGETDRUG CO., LTD.; AVEXA LIMITED; WO2009/89659; (2009); A1;,
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623-04-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 623-04-1 as follows.

Preparation of 4-((tert-butyldimethyIsilyloxy)methyI)aniline; To a solution of (4-aminophenyl)methanol (3 g, 24.36 mmol) in DMF (85 mL) was added DMAP (0.982 g, 8.04 mmol) and triethylamine (4.07 mL, 29.2 mmol). Tertbutylchloro- dimethylsilane (4.04 g, 26.8 mmol) was added. The reaction mixture was stirred at ambient temperature overnight. The reaction mixture was filtered to remove the salt. The filtrate was concentrated to afford 7.9 g of a red solid, which was dissolved in EtOAc (200 mL), washed with water (100 mL), saturated ammonium chloride (2 x 50 mL), water (2 x 50 mL) and brine (50 mL), the organic layer was dried over Na2SO4. Filtration and concentration afforded 4- ((tertbutyldimethylsilyloxy)methyl)aniline (5.66 g, 23.84 mmol, 98% yield) as a red oil. LCMS (Table 1, Method a) R, = 3.10 min, m/z 238.19 (M+H)+; 1H NMR (400 MHz, DMSO-d6) delta ppm 6.94 (d, 2H), 6.51 (d, 2H), 4.95 (s, 2H), 4.49 (s, 2H), 0.87 (s, 9H), 0.03 (s, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-04-1, its application will become more common.

Reference:
Patent; ABBOTT LABORATORIES; WO2009/11850; (2009); A2;,
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Adding a certain compound to certain chemical reactions, such as: 623-04-1, (4-Aminophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 623-04-1, blongs to alcohols-buliding-blocks compound. 623-04-1

a tert-Butyl N-(4-(hydroxymethyl)phenyl)carbamate (4-Aminophenyl)methanol (1.23 g, 10 mmol) and diisopropylethylamine (2.6 mL, 15 mmol) was mixed with di-tert-butyl dicarbonate (2.62 g, 12 mmol) in dichloromethane (50 mL). The mixture was stirred at room temperature overnight. Ethyl acetate was added and the organic layer was washed with water, 1.0N HCl, saturated sodium carbonate, water, brine, dried over MgSO4, filtered and evaporated. The crude product was purified by flash column chromatography with Ethyl acetate/heptane (2:3) to give tert-butyl N-(4-(hydroxymethyl)phenyl)carbamate (2.16 g, 9.67 mmol). 1H NMR (CDCl-d) delta1.52 (s, 9H), 4.63 (s, 2H), 6.47 (bs, 1H), 7.30 (d, 8.5 Hz, 2H), 7.36 (d, 8.5 Hz,2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-04-1, its application will become more common.

Reference:
Patent; Hirst, Gavin C.; Calderwood, David; Munschauer, Rainer; Arnold, Lee D.; Johnston, David N.; Rafferty, Paul; US2003/153752; (2003); A1;,
Alcohol – Wikipedia,
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623-04-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 623-04-1, name is (4-Aminophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Compound 6 was synthesized from the corresponding aminated compound. For this a solution of 4-aminobenzyl alcohol (2.15 g, 17.5 mmol) were dissolved in THF (25 mL) and dropped into a rounded bottom flask cooled at 4 oC containing an aqueous solution of H2SO4 (4.8 mL 98%, in 60 mL of water). -Caution for preparing the H2SO4 solution slowly add concentrated acid into cooled water and not vice versa – Over the obtained acid solution of 4 amino benzyl alcohol in ice bath, a solution of NaNO2 (1.45g, 21 mmol) dissolved in water (10 mL) was added. The mixture was led to react 1 h in ice bath. Passed that time NaN3 (1.8 g, 28.9 mmol) dissolved in 5 mL water was added to the solution. The mixture was led to react overnight. Passed that time 4-azidobenzyl alcohol was collected by three liquid-liquid extraction processes using dichloromethane (100 mL). Fractions were collected dried over anhydrous Na2SO4, concentrated and purified by flash column chromatography (DCM: MetOH 19:1). Yield 84%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 623-04-1, (4-Aminophenyl)methanol.

Reference:
Article; Cao-Milan, Roberto; Castellanos, Laura; Gopalakrishnan, Sanjana; He, Luke D.; Huang, Rui; Landis, Ryan F.; Li, Cheng-Hsuan; Luther, David C.; Makabenta, Jessa Marie V.; Rotello, Vincent M.; Scaletti, Federica; Vachet, Richard W.; Wang, Li-Sheng; Zhang, Xianzhi; Chem; vol. 6; 5; (2020); p. 1113 – 1124;,
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