Category: 622-40-2

Mosallanejad, Arash published the artcileApplication of Tsunoda reagent to the convenient synthesis of drug-like pyrazoles, Quality Control of 622-40-2, the publication is Tetrahedron Letters (2018), 59(18), 1708-1710, database is CAplus.

The versatility of the under-utilized (cyanomethylene)tributylphosphorane (CMBP, Tsunoda reagent) was demonstrated on two occasions in a drug discovery context. Firstly, the high reactivity of the phosphorane allowed the alkylation of a weakly acidic pyrazole when standard Mitsunobu conditions were unsuccessful. Secondly, the clean reaction profile generally obtained using CMBP allowed the direct use of the crude mixture in a subsequent Suzuki cross coupling. This reagent was utilized when isolation of the Mitsunobu reaction product (e.g. containing a boronate) was not desirable.

Tetrahedron Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Quality Control of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nikolic, Vladimir published the artcileBiodegradation of copolymer obtained by grafting reaction between methacrylic acid and starch, Synthetic Route of 622-40-2, the publication is Polymer Bulletin (Heidelberg, Germany) (2019), 76(5), 2197-2213, database is CAplus.

Biodegradation of methacrylic acid and starch graft copolymers was investigated for the first time in this manuscript. Synthesized copolymer was characterized by ¹H NMR spectroscopy (NMR), Fourier transformed IR spectroscopy (FTIR), SEM (SEM) and elemental anal. Copolymers with different percentage of grafting, G (%), were buried in three different types of soil. Biodegradation was monitored by measuring mass loss of the samples and using FTIR and SEM. The highest weight loss was in soil for the orchid growth (all samples had biodegradation higher than 89%), followed by soil for the cactus growth (mass loss higher than 70%) and soil rich in humus where some of the samples had biodegradation rate near or less than 50%. The correlation between G (%) and percent of weight loss after biodegradation was not significant in any types of soil. FTIR and SEM showed that after biodegradation, samples still contained both building components. Respiration test showed higher O₂ consumption and CO₂ production comparing to polystyrene which confirmed biodegradability of the accessible starch in copolymer. Based on the obtained results, degradation mechanism is proposed. First step is biodegradation of easily accessible starch followed by dissolution of the poly(methacrylic acid). This mechanism confirmed that biodegradation depends not only on the percentage of grafting, but also on mol. packaging, chains arrangement and the number and types of microorganisms present in the specific types of soils.

Polymer Bulletin (Heidelberg, Germany) published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Synthetic Route of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ye, Danfeng published the artcileCesium Carbonate Catalyzed Esterification of N-Benzyl-N-Boc-amides under Ambient Conditions, Related Products of alcohols-buliding-blocks, the publication is Organic Letters (2019), 21(17), 6888-6892, database is CAplus and MEDLINE.

A general activated amide to ester transformation catalyzed by Cs₂CO₃, is reported. Using this approach, esterification proceeds under relatively mild conditions and without the need for a transition metal catalyst. This method exhibits broad substrate scope and represents a practical alternative to existing esterification strategies. The synthetic utility of this protocol is demonstrated via the facile synthesis of crown ether derivatives and the late-stage modification of a representative natural product and several sugars in reasonable yields.

Organic Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C11H21BO2Si, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Cheng published the artcileHighly efficient CO₂ fixation into cyclic carbonate by hydroxyl-functionalized protic ionic liquids at atmospheric pressure, Recommanded Product: 2-Morpholinoethanol, the publication is Molecular Catalysis (2021), 111756, database is CAplus.

We report an efficient strategy for CO₂ fixation into cyclic carbonates catalyzed by hydroxyl-functionalized protic ionic liquids (PILs) without any solvent and additive. Excellent yields of cyclic carbonates are obtained for the varied substrates under mild conditions (1 bar and 60°C). Mechanism studies have shown that hydroxyl promoted the activation of epoxide mols. through hydrogen bonding interaction, so that CO₂ can be easily converted into the desired product of cyclic carbonates. In addition, the hydroxyl-functionalized PILs can also be recycled repeatedly. This hydroxyl-functionalized PILs-catalyzed process is proved to be a promising scheme for the chem. conversion of CO₂.

Molecular Catalysis published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tian, Wei published the artcileNovel Anthraquinone Compounds Induce Cancer Cell Death through Paraptosis, Synthetic Route of 622-40-2, the publication is ACS Medicinal Chemistry Letters (2019), 10(5), 732-736, database is CAplus and MEDLINE.

Novel anthraquinone compounds that induce ER stress and paraptosis-like cell death were designed and synthesized. Compound I is the first organic micromol. to kill tumor cells by only paraptosis, and its mechanism of action has been further explored. Paraptosis does not appear to involve either phosphatidylserine translocation associated with apoptosis or cell cycle arrest. The bisbenzyloxy and N-(2-hydroxyethyl)formamide structures may be two critical pharmacophores for paraptosis. Bisbenzyloxy can induce ER stress, and the N-(2-hydroxyethyl)formamide structure can increase the ratio of LC3II/I and cytoplasmic vacuolization and facilitates paraptosis. Some antitumor drugs fail to eradicate malignant cell lines with impaired apoptotic pathways; paraptosis may be a route to kill such cells and provides a new potential strategy for cancer chemotherapy.

ACS Medicinal Chemistry Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C14H14, Synthetic Route of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cheng, Can published the artcileThe absorption of SO₂ by morpholine cyclic amines with sulfolane as the solvent for flue gas, Formula: C6H13NO2, the publication is Journal of Hazardous Materials (2021), 124462, database is CAplus and MEDLINE.

The absorption properties of N-(2-hydroxyethyl) morpholine (HEM), morpholine (MP) and N-(2-aminoethyl) morpholine (AEM) for SO₂ were studied using sulfolane (SUL) as solvent in this work. Among these solvent combinations, HEM/SUL shows the best cyclic absorption performance, and the capacity of HEM-SUL-40 (40 wt% of HEM and 60 wt% of SUL) to absorb 8580 mg/m³ SO₂ (the remainder is N₂) is 192.18 mg/g at 293.15 K. The absorption capacity of the second cycle is 97.5% of the first absorption cycle, which is higher than 70% of the Cansolv amine solution in a com. application with similar exptl. conditions. However, MP/SUL is difficult to desorb at high temperature, and the absorption capacity of AEM/SUL is much lower than HEM/SUL and MP/SUL. According to the FTIR, ¹H NMR and ¹³C NMR, all three cyclic amines have charge transfer effects with SO₂. The structure of HEM/SUL can be recovered after heating, but MP cannot be recovered. Δ_rG_m° in the reaction against HEM with SO₂ increases significantly with increasing temperature The Δ_rG_m° of HEM-SO₂ and MP-SO₂ at 353.15 K is -12.56 kJ/mol and -16.29 kJ/mol, resp., which further explains the easy desorption of HEM-SO₂ and the difficult desorption of MP-SO₂ at high temperaturesulfur dioxide morpholine cyclic amine sulfolane solvent flue gas.

Journal of Hazardous Materials published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Formula: C6H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Pan published the artcileDiscovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin, Related Products of alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (2020), 63(9), 4685-4700, database is CAplus and MEDLINE.

Apcin is one of the few compounds that have been previously reported as a Cdc20 specific inhibitor, although Cdc20 is a very promising drug target. We reported here the design, synthesis, and biol. evaluations of 2,2,2-trichloro-1-aryl carbamate derivatives as Cdc20 inhibitors. Among these derivatives, compound 9f(I) was much more efficient than the pos. compound apcin in inhibiting cancer cell growth, but it had approx. the same binding affinity with apcin in SPR assays. It is possible that another mechanism of action might exist. Further evidence demonstrated that compound 9f also inhibited tubulin polymerization, disorganized the microtubule network, and blocked the cell cycle at the M phase with changes in the expression of cyclins. Thus, it induced apoptosis through the activation of caspase-3 and PARP. In addition, compound 9f inhibited cell migration and invasion in a concentration-dependent manner. These results provide guidance for developing the current series as potential new anticancer therapeutics.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Leshina, M. N. published the artcileSpecific Features of N-Morpholinoethyl Methacrylate Synthesis, Application of 2-Morpholinoethanol, the publication is Russian Journal of Applied Chemistry (2018), 91(7), 1118-1122, database is CAplus.

Methods for synthesis of N-morpholinoethyl methacrylate were compared. It was shown that the monomer produced by acylation of N-morpholinoethanol with methacrylic acid anhydride or methacryloyl chloride spontaneously polymerizes in storage. The possible reasons for the spontaneous polymerization of N-morpholinoethyl methacrylate produced by the acylation method were considered. The conditions in which a stable-in-storage monomer can be obtained in 86-88% yield by the method of re-esterification of Me methacrylate with N-morpholinoethanol were determined

Russian Journal of Applied Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Application of 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Pan published the artcileDiscovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin, Related Products of alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (2020), 63(9), 4685-4700, database is CAplus and MEDLINE.

Apcin is one of the few compounds that have been previously reported as a Cdc20 specific inhibitor, although Cdc20 is a very promising drug target. We reported here the design, synthesis, and biol. evaluations of 2,2,2-trichloro-1-aryl carbamate derivatives as Cdc20 inhibitors. Among these derivatives, compound 9f(I) was much more efficient than the pos. compound apcin in inhibiting cancer cell growth, but it had approx. the same binding affinity with apcin in SPR assays. It is possible that another mechanism of action might exist. Further evidence demonstrated that compound 9f also inhibited tubulin polymerization, disorganized the microtubule network, and blocked the cell cycle at the M phase with changes in the expression of cyclins. Thus, it induced apoptosis through the activation of caspase-3 and PARP. In addition, compound 9f inhibited cell migration and invasion in a concentration-dependent manner. These results provide guidance for developing the current series as potential new anticancer therapeutics.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Leshina, M. N. published the artcileSpecific Features of N-Morpholinoethyl Methacrylate Synthesis, Application of 2-Morpholinoethanol, the publication is Russian Journal of Applied Chemistry (2018), 91(7), 1118-1122, database is CAplus.

Methods for synthesis of N-morpholinoethyl methacrylate were compared. It was shown that the monomer produced by acylation of N-morpholinoethanol with methacrylic acid anhydride or methacryloyl chloride spontaneously polymerizes in storage. The possible reasons for the spontaneous polymerization of N-morpholinoethyl methacrylate produced by the acylation method were considered. The conditions in which a stable-in-storage monomer can be obtained in 86-88% yield by the method of re-esterification of Me methacrylate with N-morpholinoethanol were determined

Russian Journal of Applied Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Application of 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts