Category: 6214-45-5

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6214-45-5, name is (4-Butoxyphenyl)methanol, molecular formula is C11H16O2, molecular weight is 180.24, as common compound, the synthetic route is as follows.HPLC of Formula: C11H16O2

(4-butoxyphenyl)methanol (0.48 mmol, 91.3 mg) was dissolved in tetrahydrofuran (2.0 ml) and NaH (0.96 mmol, 60 %, 38.4 mg) was added in one portion. After gas evolution ceased the suspension was added to a solution of 4-nitrophenyl N-[(2,4- difluorophenyl)methyl]-N-(l-methylpiperidin-4-yl)carbamate (130 mg, 0.32 mmol) dissolved in tetrahydrofuran (2.0 ml). The mixture was stirred for 4 hours, the mixture was partitioned between diethyl ether and 0.2 M NaOH, the organic phase was collected, dried, and the crude was purified by column chromatography using silicon dioxide gel, eluting with 10-25 % methanol in ethyl acetate to afford the title compound (86 mg, yield 60 %): NMR (400 MHz, Chloroform-^) delta 7.42 – 6.97 (m, 3H), 6.97 – 6.63 (m, 4H), 5.25 – 4.96 (m, 2H), 4.58 – 4.33 (m, 2H), 4.23 – 3.72 (m, 1H), 3.96 (t, 2H), 2.85 (d, 2H), 2.25 (s, 3H), 2.13 – 1.86 (m, 2H), 1.84 – 1.41 (m, 8H), 0.98 (t, 3H); LC-MS : 447.3 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6214-45-5, (4-Butoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; ACADIA PHARMACEUTICALS INC.; BURSTEIN, Ethan, S.; OLSSON, Roger; JANSSON, Karl, Erik; SKOeLD, Niklas, Patrik; WAHLSTROeM, Larisa, Yudina; BORGSTROeM, Bjoern, Gustav; VON WACHENFELDT, Henrik; BERGNER, Magnus Gustav, Wilhelm; (146 pag.)WO2019/40104; (2019); A2;,
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Synthetic Route of 6214-45-5 ,Some common heterocyclic compound, 6214-45-5, molecular formula is C11H16O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: In a 5 mL sealed tube, TBPB(30 mol%, 0.041 g), and TBHP (70 wt% in H2O, 1.0 mmol, 0.131 g) was added to a solution ofbenzyl alcohol 1a (0.4 mmol, 0.043 g) in chlorobenzene (1 mL). The resultant mixture washeated at 80 C for 2.5 h. After completion of the reaction as was indicated by TLC monitoring,the reaction mixture was cooled to ambient temperature and saturated NaHCO3 (2 mL) wasadded. The product was extracted with ethyl acetate (2 × 3 mL). The combined organic phasewas dried over Na2SO4. The solvent was removed under the reduced pressure. The residue waspurified by column chromatography using n-hexane-EtOAc (15:1) as eluent to afford pureproduct 2a as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6214-45-5, its application will become more common.

Reference:
Article; Adib, Mehdi; Pashazadeh, Rahim; Synlett; vol. 29; 1; (2018); p. 136 – 140;,
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Synthetic Route of 6214-45-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6214-45-5, name is (4-Butoxyphenyl)methanol, molecular formula is C11H16O2, molecular weight is 180.24, as common compound, the synthetic route is as follows.

Example 8 4-[(4-Butoxyphenyl)methyl]-1,2-dihydro-5-methyl-3 H -pyrazol-3-one The title compound was prepared in a similar manner to that described in Example 1 using 4-butoxybenzyl alcohol instead of 4-isopropoxybenzyl alcohol. 1H-NMR (500MHz, DMSO-d6) delta ppm: 0.91 (3H, t, J=7.4Hz), 1.30-1.50 (2H, m), 1.55-1.75 (2H, m), 1.98 (3H, s), 3.46 (2H, s), 3.80-3.95 (2H, m), 6.70-6.85 (2H, m), 6.95-7.10 (2H, m)

Statistics shows that 6214-45-5 is playing an increasingly important role. we look forward to future research findings about (4-Butoxyphenyl)methanol.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP1213296; (2002); A1;,
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Synthetic Route of 6214-45-5, Adding some certain compound to certain chemical reactions, such as: 6214-45-5, name is (4-Butoxyphenyl)methanol,molecular formula is C11H16O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6214-45-5.

To a solution of different benzyl alcohols (7.82 mmol) in acetonitrile (27 mL), chlorotrimethylsilane (8.73 mmol) was added and then sodium iodide (8.05 mmol) was slowly added. This mixture was allowed to reflux with constant stirring at 90 C for 2 h, under nitrogen.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6214-45-5, (4-Butoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lopez, Jhon J.; Perez, Edwin G.; Synthetic Communications; vol. 49; 5; (2019); p. 715 – 723;,
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Related Products of 6214-45-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6214-45-5, name is (4-Butoxyphenyl)methanol, molecular formula is C11H16O2, molecular weight is 180.24, as common compound, the synthetic route is as follows.

Was synthesized following the same general procedure as that for the preparation of 4-ethoxybenzyl chloride; thionyl chloride (7.42 g, 69.2 mmol), 4-butoxybenzyl alcohol (9.45 g, 52.4 mmol), CH2Cl2 (145 mL). Oil, 10.4 g (99%). 1H NMR (300 MHz, CDCl3) delta=7.28 (d, 2H, J=6.6 Hz), 6.86 (d, 2H, J=6.6 Hz), 4.56 (s, 2H), 3.95 (t, 2H, J=6.6 Hz), 1.76 (m, 2H), 1.48 (m, 2H), 0.97 (t, 3H, J=7.5 Hz). 13C NMR (75 MHz, CDCl3) delta=159.5, 130.2, 129.7, 114.9, 67.9, 46.6, 31.5, 19.4, 14.0.

Statistics shows that 6214-45-5 is playing an increasingly important role. we look forward to future research findings about (4-Butoxyphenyl)methanol.

Reference:
Patent; Percec, Virgil; US2006/88499; (2006); A1;,
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Synthetic Route of 6214-45-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6214-45-5, name is (4-Butoxyphenyl)methanol, molecular formula is C11H16O2, molecular weight is 180.24, as common compound, the synthetic route is as follows.

To a mixture of the compound of Example 58 (200 mg, 1.0 mmol) and pyridine (177 mul, 2.2 mmol) in anhydrous acetonitrile (3 ml), at 0 C. and under nitrogen, was added diphosgene (132 mul, 1.1 mmol). The mixture was allowed to warm to room temperature and stirred for 10 min, before addition to (4-butoxyphenyl)methanol (198 mg, 1.1 mmol) via syringe. The reaction mixture was stirred at room temperature for 30 min and filtered.The filtrate was purified by automated preparative liquid chromatography (Gilson system, 150 mm×22.4 mm LUNA C18(2) 10 mum column, 24 ml/min) using an acetonitrile:water gradient [15:85 (3 min) to 98:2 (16 min)]. The appropriate fractions were combined and concentrated to give the title compound (6 mg).Experimental MH+ 364.0; expected 363.2 (compound de-carboxylates)1H-NMR (d6-Acetone): 0.92-0.98 (3H), 1.43-1.55 (5H), 1.69-1.78 (2H), 2.24-2.30 (6H), 3.97-4.01 (2H), 5.04-5.09 (1H), 5.17-5.18 (2H), 6.48-6.50 (1H), 6.83-6.88 (3H), 6.95-6.98 (2H), 7.10-7.13 (2H), 7.44-7.45 (1H)Rhip. Funct. ED100 mg/cm2=0.03

The chemical industry reduces the impact on the environment during synthesis 6214-45-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER INC.; US2007/167506; (2007); A1;,
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