Category: 6214-45-5

Gonka, Elzbieta published the artcileExpanded Hexapyrrolohexaazacoronenes. Near-Infrared Absorbing Chromophores with Interrupted Peripheral Conjugation, Category: alcohols-buliding-blocks, the main research area is expanded hexapyrrolohexaazacoronene near IR absorbing chromophore interrupted peripheral conjugation.

A family of azacoronenes containing up to two saturated bridges at the periphery was synthesized from substituted hexapyrrolylbenzenes using a two-step condensation-aromatization procedure. The introduction of peripheral bridges provides access to nonplanar, sterically crowded systems that display complex reactivity patterns, involving stereospecific aromatization of bridges and nucleophile additions Despite the interrupted conjugation on the periphery, the new azacoronenes have easily accessible higher oxidation levels, and a quadruply charged species was chem. generated by reaction with SbCl5. These oxidized species show extensive π-electron conjugation and are efficient UV-vis-NIR absorbers, active up to ca. 2400 nm. Interruption of peripheral conjugation is shown to induce a tendency toward biradicaloid electron configurations in doubly oxidized species.

Journal of the American Chemical Society published new progress about Aromatization. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Johansson, Gary published the artcileMolecular recognition directed self-assembly of tubular liquid crystalline and crystalline supramolecular architectures from Taper Shaped (15-crown-5)methyl 3,4,5-tris(p-alkyloxybenzyloxy)benzoates and (15-crown-5)methyl 3,4,5-tris(p-dodecyloxy)benzoate, Computed Properties of 6214-45-5, the main research area is crown ether hydroxymethyl benzoate derivative; liquid crystalline hydroxymethyl crown benzoate; supramol architecture hydroxymethyl crown benzoate; mol recognition hydroxymethyl crown benzoate.

The syntheses and characterization of title crown ether derivatives I [R = p-Me(CH2)nOC6H4CH2, where n = 3, 5, or 11 (27); R = Me(CH2)11 (28)] are described. Complexation of the crown ether endo-receptor with CF3SO3Na destabilizes the crystalline phase of I and induces for the case of 27 and 28 the self-assembly of a supramol. cylindrical channel-like architecture which displays a thermotropic hexagonal columnar (Φh) mesophase. Most remarkably, in the crystalline phase of the complexes of 27 with CF3SO3Na the cylindrical structure of the Φh mesophase is maintained. Characterization of these supramol. architectures was performed by a combination of differential scanning calorimetry, thermal optical polarized microscopy, X-ray scattering and mol. modeling. A model is proposed in which a stratum of the column is formed by six mols. of 27 and 28 with the crown ether receptors residing in the column center and the alkyl tails radiating toward the column periphery. Endo-Recognition generated via the (15-crown-5)methyl receptor upon complexation, and exo-recognition provided by the tapered 3,4,5-tris(p-dodecyloxybenzyloxy)benzoate and 3,4,5-tris(p-dodecyloxy)benzoate fragments of 27 and 28 provide the driving force for the self-assembly of this cylindrical supramol.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about Liquid crystals. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Computed Properties of 6214-45-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maertens, Christophe published the artcileSynthesis and characterization of end-functionalized oligo(vinylthiophenes) with liquid crystal properties, Computed Properties of 6214-45-5, the main research area is end functionalized vinylthiophene liquid crystal property.

A general scheme for the synthesis of end-functionalized conjugated (E)-vinylthiophene oligomers with liquid crystal and potential 2nd-order nonlinear optical properties is described. These push-pull thiophene-containing aromatic mols. show mesogenic properties over different temperature ranges depending on the chain length and the functional end-groups.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry published new progress about Liquid crystals. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Computed Properties of 6214-45-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Byeong Wook published the artcileStructure-activity relationship (SAR) studies on the mutagenic properties of 2,7-diaminofluorene and 2,7-diaminocarbazole derivatives, Product Details of C11H16O2, the main research area is structure activity relationship mutagenic properties diaminofluorene diaminocarbazole; Ames test; Aromatic amines; HCV NS5A inhibitor.

We discovered that 2,7-diaminofluorene or 2,7-diaminocarbazole moiety can be employed as a core structure of highly effective NS5A inhibitors that are connected through amide bonds to proline-valine-carbamate motifs. Amide bonds can be easily cleaved via various metabolic pathways upon administration into the body, and metabolites containing 2,7-diaminofluorene and 2,7-diaminocarbazole core structures have been known to be strong mutagens. To avoid the mutagenesis issue of these core structures, we examined various functional groups at the C9 or N9 position of 2,7-diaminofluorene or 2,7-diaminocarbazole, resp., through the Ames test in TA98 and TA100 mutants of Salmonella typhimurium LT-2. We discovered that, through proper alkyl substitution at the C9 or N9 position, 2,7-diaminofluorene and 2,7-diaminocarbazole moieties can be successfully employed in drug discovery without necessarily causing mutagenicity problems.

Bioorganic & Medicinal Chemistry Letters published new progress about Ames test. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Barber, Amelia Moreno published the artcileSolid-phase synthesis of novel inhibitors of farnesyl transferase, Safety of (4-Butoxyphenyl)methanol, the main research area is hydroxynitrotrifluorophenyl ether preparation farnesyl transferase inhibitor.

A novel diphosphate mimic, the 2,3,6-trifluoro-5-hydroxy-4-nitrophenoxy group, has been employed as the template in the solid-phase synthesis of novel farnesyl transferase inhibitors using the Mitsunobu reaction. The most potent inhibitor 1-farnesyloxy-5-hydroxy-2,3,6-trifluoro-4-nitrobenzene displayed an IC50 of 6.3 μM vs. farnesyl transferase.

Bioorganic & Medicinal Chemistry Letters published new progress about hydroxynitrotrifluorophenyl ether preparation farnesyl transferase inhibitor. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Safety of (4-Butoxyphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Purohit, Ajay published the artcileSynthesis and Biological Evaluation of Pyridazinone Analogues as Potential Cardiac Positron Emission Tomography Tracers, Category: alcohols-buliding-blocks, the main research area is fluorinated pyridazinone preparation cardiac positron emission tomog tracer SAR; mitochondrial complex 1 inhibitor fluorinated pyridazinone preparation SAR; imaging PET tracer fluorinated pyridazinone preparation structure activity relationship.

A series of fluorinated pyridazinone derivatives, e.g. I [R1 = H, R2 = CH2(CH2)2CH2F, O(CH2)2CH2F, CH2CH2CHFCH3, etc.; R1 = D, R2 = CH2OCD2CD2F], with IC50 values ranging from 8 to 4000 nM for the mitochondrial complex 1 (MC1) have been prepared Structure-activity relationship (SAR) assessment indicated preference of the fluorine label to be incorporated on an alkyl side chain rather than directly on the pyridazinone moiety. Tissue distribution studies of a series of analogs ([18F]I) in Sprague-Dawley (SD) rats identified I (R1= H, R2 = CH2OCH2CH218F) (II) as the most promising radiotracer with high uptake in cardiac tissue (3.41%ID/g; 30 min post injection) in addition to favorable heart to nontarget organ distribution ratios. MicroPET images of SD rats and nonhuman primates after II administration allowed easy assessment of the myocardium through 60 min with minimal lung or liver interference.

Journal of Medicinal Chemistry published new progress about Heart. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Byeong Wook published the artcileStructure-activity relationship (SAR) studies on the mutagenic properties of 2,7-diaminofluorene and 2,7-diaminocarbazole derivatives, Product Details of C11H16O2, the main research area is structure activity relationship mutagenic properties diaminofluorene diaminocarbazole; Ames test; Aromatic amines; HCV NS5A inhibitor.

We discovered that 2,7-diaminofluorene or 2,7-diaminocarbazole moiety can be employed as a core structure of highly effective NS5A inhibitors that are connected through amide bonds to proline-valine-carbamate motifs. Amide bonds can be easily cleaved via various metabolic pathways upon administration into the body, and metabolites containing 2,7-diaminofluorene and 2,7-diaminocarbazole core structures have been known to be strong mutagens. To avoid the mutagenesis issue of these core structures, we examined various functional groups at the C9 or N9 position of 2,7-diaminofluorene or 2,7-diaminocarbazole, resp., through the Ames test in TA98 and TA100 mutants of Salmonella typhimurium LT-2. We discovered that, through proper alkyl substitution at the C9 or N9 position, 2,7-diaminofluorene and 2,7-diaminocarbazole moieties can be successfully employed in drug discovery without necessarily causing mutagenicity problems.

Bioorganic & Medicinal Chemistry Letters published new progress about Ames test. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Manetti, Fabrizio published the artcileParallel Solution-Phase and Microwave-Assisted Synthesis of New S-DABO Derivatives Endowed with Subnanomolar Anti-HIV-1 Activity, Name: (4-Butoxyphenyl)methanol, the main research area is arylthiopyrimidinone preparation HIV 1 transcriptase inhibitor.

A simple and efficient methodol. for the parallel solution-phase synthesis has been set up to obtain a series of thiouracils, in turn selectively S-benzylated under microwave irradiation to give new S-DABOs. Biol. screening led to the identification of compounds with nanomolar activity toward both the highly purified recombinant human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) enzyme (wild-type and mutants) and wild-type (wt) and mutant HIV-1 strains. In particular, I was found to be the most potent S-DABO reported so far (ID50 = 26 nM toward the isolated wt enzyme) with subnanomolar activity toward both the wt and the pluriresistant virus (IRLL98) HIV-1 strain (EC50 < 0.14 nM and EC50 = 0.22 nM, resp.). Mol. modeling calculations were also performed to investigate the binding mode of such compounds onto the non-nucleoside reverse transcriptase inhibitor binding site and to rationalize the relationships between their chem. structure and activity values toward wt RT. Journal of Medicinal Chemistry published new progress about Homo sapiens. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Name: (4-Butoxyphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kapur, S. published the artcileToxicology of benzyl alcohols: a QSAR analysis, Related Products of alcohols-buliding-blocks, the main research area is QSAR benzyl alc toxicity.

There is an evidence that benzyl alcs. may exhibit toxicity via a radical mechanism. To test this possibility, the authors studied the toxicity of para substituted benzyl alcs. on rapidly dividing cancer cells (L1210 leukemia). This system has previously found utility in studying the apparent radical toxicity of a variety of phenols. However, no evidence could be found for an electronic effect and the cellular toxicity was associated primarily with hydrophobicity. Comparison of this quant. structure-activity relationships (QSAR) with others for the reactions of benzyl alcs. in diverse systems provides insight into mechanisms of action. A QSAR for the interaction of benzyl alcs. with protozoa yields an equation that is dependent on both hydrophobicity and acidity of the OH group vs. a mixture of bacteria and fungi, the critical dependence on hydrophobicity prevails with a small dependence on a resonance-stabilized, radical mediated electronic effect. The chloramphenicols provide an instructive example, where the radical mediated electronic effect overshadows the hydrophobic contribution to bacterial toxicity. These various QSAR for benzyl alcs. indicate that mechanisms of growth inhibition in vitro vary depending on cell/organism type, the strength of the bond and lability of the hydrogen, and the strength of the initiating radical reagent.

Chemosphere published new progress about Cytotoxicity. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adib, Mehdi published the artcileTBHP/n-Bu4PBr-Promoted Oxidative Cross-Dehydrogenative Coupling of Aryl Methanols: A Facile Synthesis of Symmetrical Carboxylic Anhydride Derivatives, Category: alcohols-buliding-blocks, the main research area is carboxylic anhydride preparation aryl methanol oxidative dehydrogenative coupling.

A transition-metal-free oxidative cross-dehydrogenative coupling reaction was developed for the preparation of sym. carboxylic anhydrides through self-coupling dual C-O bond formations of aryl methanols. In the presence of a catalytic amount of tetrabutylphosphonium bromide (TBPB) as transfer agent and aqueous tert-Bu hydroperoxide (TBHP) as oxidant and reactant, methylene groups of aryl methanols were efficiently oxidized to C:O and coupled with the peroxide oxygen from TBHP to form a diverse array of sym. carboxylic anhydride derivatives

Synlett published new progress about Anhydrides Role: SPN (Synthetic Preparation), PREP (Preparation). 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts