Category: 621-37-4

Fernandez-Jalao, Irene; Balderas, Claudia; Calvo, Maria V.; Fontecha, Javier; Sanchez-Moreno, Concepcion; De Ancos, Begona published an article in 2021, the title of the article was Impact of high-pressure processed onion on colonic metabolism using a dynamic gastrointestinal digestion simulator.Computed Properties of 621-37-4 And the article contains the following content:

Onions are the main dietary source of flavonols that have been associated with important health-promoting properties. Onion treated by high-pressure processing (HPP-treated onion) was subjected to a dynamic gastrointestinal digestion and colon fermentation simulator (DGID-CF) to study the effect on the gut microbiota metabolism in the three colon regions (ascending-AC, transverse-TC, and descending-DC) by means of chronic feeding with 27 g/day for 14 days. HPP-treated onion presented a high content of the flavonols quercetin-3,4-diglucoside and quercetin-4-glucoside, and a large percentage of them reached the AC without change. TC and DC progressively increased the total phenolic metabolites 2.5 times resp. to day 2, mainly 3-hydroxyphenylacetic, 4-hydroxyphenylacetic, 3-(4-hydroxyphenyl)-propionic, and 3,4-dihydroxyphenylpropionic acids. In addition, the chronic feeding increased the beneficial colon bacteria Bifidobacterium spp. and Lactobacillus spp. and the production of total SCFAs (acetic, propionic, and butyric acids) 9 times (AC), 2.2 times (TC), and 4.4 times (DC) resp. to day 1. A multivariate anal. (principal component anal., PCA) showed a clear separation between the three colon regions based on their phenolic composition (precursors and metabolites). These results showed that HPP-treated onion modulated the human gut microbiotas metabolism and the DGID-CF is a good system to study these changes. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Computed Properties of 621-37-4

The Article related to colon metabolism gastrointestine digestion allium, gastrointestinal digestion-colon fermentation model, gut microbiota, high-pressure processing, onion, quercetin glycosides metabolites, short-chain fatty acids and other aspects.Computed Properties of 621-37-4

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Alcohol – Wikipedia,
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On October 25, 2021, Rimnacova, Lucie; Moos, Martin; Opekar, Stanislav; Vodrazka, Petr; Pejchal, Vladimir; Mraz, Jaroslav; Simek, Petr published an article.Related Products of 621-37-4 The title of the article was Ethyl chloroformate mediated gas chromatographic-mass spectrometric biomonitoring of acidic biomarkers of occupational exposure and endogenous metabolites in human urine. And the article contained the following:

Numerous industrial organic pollutants such as aromates, alkoxyalcs., other organic solvents and monomers are absorbed, metabolized, and finally excreted in urine mostly as carboxylic acids that are determined as biomarkers of exposure. For a number of these xenometabolites, biol. limits (levels of biomarkers in biol. material) have been established to prevent damage to human health. Till now, most of the anal. procedures used have been optimized for one or a few analytes. Here, we report a more comprehensive approach enabling rapid GC-MS screening of sixteen acidic biomarkers in urine that are metabolized in the human body from several important industrial chems.; benzene, toluene, styrene, xylenes, alkoxyalcs., carbon disulfide, furfural and N,N-dimethylformamide. The new method involves immediate in situ derivatization – liquid liquid microextraction of urine by an Et chloroformate-ethanol-chloroform-pyridine medium and GC-MS anal. of the derivatized analytes in the lower organic phase. The xenometabolite set represents diverse chem. structures and some of hippuric and mercapturic acids also provided unusual derivatives that were unambiguously elucidated by means of new Et chloroformates labeled with stable isotopes and by synthesis of the missing reference standards In the next step, an automated routine was developed for GC-MS/MS anal. using a MetaboAuto sample preparation workstation and the new method was validated for fourteen metabolites over the relevant concentration range of each analyte in the spiked pooled human urine. It shows good linearity (R2 ≥ 0.982), accuracy (from 85% to 120%), precision (from 0.7% to 20%) and recovery (from 89% to 120%). The method performance was further successfully proved by GC-MS/MS anal. of the certified IP45 and RM6009 reference urines. Moreover, we show that the new method opens up the possibility for biomonitoring of combined and cumulative occupational exposures as well as for urinary metabolite profiling of persons exposed to harmful industrial chems. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Related Products of 621-37-4

The Article related to ethyl chloroformate gcms occupational exposure acidic biomarker metabolite urine, biomarker of occupational exposure, endogenous metabolites, ethyl chloroformate mediated derivatization, urine, xenometabolite and other aspects.Related Products of 621-37-4

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Alcohol – Wikipedia,
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On April 16, 2022, Wang, Yixuan; Li, Hui; Li, Xiaozhen; Wang, Chenxi; Li, Qianhong; Xu, Meng; Guan, Xiangluo; Lan, Zhenghui; Ni, Yongqing; Zhang, Yan published an article.Synthetic Route of 621-37-4 The title of the article was Widely targeted metabolomics analysis of enriched secondary metabolites and determination of their corresponding antioxidant activities in Elaeagnus angustifolia var. orientalis (L.)Kuntze fruit juice enhanced by Bifidobacterium animalis subsp. Lactis HN-3 fermentation. And the article contained the following:

Elaeagnus angustifolia var. orientalis (L.)Kuntze fruit contains a large number of naturally occurring mols. present as glycoside, methylated, and Me ester conjugates, which should be hydolyzed or transformed to become bioactive forms. For this purpose, Bifidobacterium animalis subsp. lactis HN-3 was selected to ferment Elaeagnus angustifolia var. orientalis (L.)Kuntze fruit juice (EOJ). After fermentation, the total phenolic content (TPC) and antioxidant capacity of the EOJ increased significantly compared to the non-fermented EOJ. Using widely-targeted metabolomics anal., polyphenolic compounds involved in the flavonoid biosynthetic pathway were determined to be up-regulated in the fermented EOJ. In addition, the metabolites generated by 8 deglycosidation, 5 demethylation, 5 hydrogenation, and 28 other reactions were detected in higher concentrations in the fermented EOJ compared to the non-fermented EOJ. Interestingly, these up-regulated metabolites have higher antioxidant and other biol. activities than their metabolic precursors, which provide a theor. basis for the development of Bifidobacterium-fermented plant products with stronger functional activities. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Synthetic Route of 621-37-4

The Article related to elaeagnus bifidobacterium fruit juice antioxidant secondary metabolites metabolomics, antioxidant activity, elaeagnus angustifolia var. orientalis(l.)kuntze, material transformation, widely-targeted metabolomic analysis and other aspects.Synthetic Route of 621-37-4

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Alcohol – Wikipedia,
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On May 15, 2022, Yan, Jun; Chen, Qi; Tian, Lei; Li, Kang; Lai, Wenqing; Bian, Liping; Han, Jie; Jia, Rui; Liu, Xiaohua; Xi, Zhuge published an article.Safety of 3-Hydroxyphenylacetic acid The title of the article was Intestinal toxicity of micro- and nano-particles of foodborne titanium dioxide in juvenile mice: Disorders of gut microbiota-host co-metabolites and intestinal barrier damage. And the article contained the following:

The wide use of TiO2 particles in food and the high exposure risk to children have prompted research into the health risks of TiO2. We used the microbiome and targeted metabolomics to explore the potential mechanism of intestinal toxicity of foodborne TiO2 micro-/nanoparticles after oral exposure for 28 days in juvenile mice. Results showed that the gut microbiota-including the abundance of Bacteroides, Bifidobacterium, Lactobacillus, and Prevotella-changed dynamically during exposure. The organic inflammatory response was activated, and lipopolysaccharide levels increased. Intestinal toxicity manifested as increased mucosal permeability, impaired intestinal barrier, immune damage, and pathol. changes. The expression of antimicrobial peptides, occludin, and ZO-1 significantly reduced, while that of JNK2 and Src/pSrc increased. Compared with micro-TiO2 particles, the nano-TiO2 particles had strong toxicity. Fecal microbiota transplant confirmed the key role of gut microbiota in intestinal toxicity. The levels of gut microbiota-host co-metabolites, including pyroglutamic acid, L-glutamic acid, phenylacetic acid, and 3-hydroxyphenylacetic acid, changed significantly. Significant changes were observed in the glutathione and propanoate metabolic pathways. There was a significant correlation between the changes in gut microbiota, metabolites, and intestinal cytokine levels. These, together with the intestinal barrier damage signaling pathway, constitute the network mechanism of the intestinal toxicity of TiO2 particles. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Safety of 3-Hydroxyphenylacetic acid

The Article related to gut microbiota disorder intestinal barrier damage toxicity microparticle nanoparticle, titanium dioxide pyroglutamic phenylacetic acid juvenile, biomarker, correlation, fecal transplant, gut microbiome, tio(2) microparticle, tio(2) nanoparticle and other aspects.Safety of 3-Hydroxyphenylacetic acid

Referemce:
Alcohol – Wikipedia,
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On April 30, 2020, Zabela, Volha; Sampath, Chethan; Oufir, Mouhssin; Butterweck, Veronika; Hamburger, Matthias published an article.SDS of cas: 621-37-4 The title of the article was Single dose pharmacokinetics of intravenous 3,4-dihydroxyphenylacetic acid and 3-hydroxyphenylacetic acid in rats. And the article contained the following:

3,4-Dihydroxyphenylacetic acid (DOPAC) and 3-hydroxyphenylacetic acid (3-HPAA) are intestinal metabolites of the dietary flavonoid quercetin. DOPAC reportedly showed anxiolytic activity after i.p. administration in rats. The fate of these metabolites after consumption, and the pharmacol. properties of 3-HPAA in the body are largely unknown. The aim of the current study was to characterize pharmacokinetic properties of DOPAC and 3-HPAA after i.v. bolus application in rats. UHPLC-MS/MS methods for quantification of DOPAC and 3-HPAA levels in lithium heparin Sprague Dawley rat plasma were developed and validated according to international regulatory guidelines. Non-compartmental and compartmental analyses were performed. Pharmacokinetic profiles of DOPAC and 3-HPAA followed a two-compartment body model, with a fast distribution into peripheral tissues (half-lives of 3.27-5.26 min) and rapid elimination from the body (half-lives of 18.4-33.3 min). The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4

The Article related to pharmacokinetics dihydroxyphenylacetic hydroxyphenylacetic acid uhplc msms, 3,4-dihydroxyphenylacetic acid (pubchem cid: 547), 3-hpaa, 3-hydroxyphenylacetic acid (pubchem cid: 12122)., dopac, pharmacokinetics, uhplc-ms/ms, validation and other aspects.SDS of cas: 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On August 1, 2020, Yan, Yan; Fu, Cai; Cui, Xiaofang; Pei, Xiangping; Li, Aiping; Qin, Xuemei; Du, Chenhui; Du, Huizhi published an article.Application of 621-37-4 The title of the article was Metabolic profile and underlying antioxidant improvement of Ziziphi Spinosae Folium by human intestinal bacteria. And the article contained the following:

Ziziphi Spinosae Folium, the leaf of Ziziphus jujuba Mill. Var. spinosa (Bunge) Hu ex H. F. Chou (LZJS), is currently used as a healthy tea in China. This study evaluated the chem. components and antioxidant activities of LZJS flavonoid (LZJSF) and fermented LZJSF (FLZJSF) using human intestinal bacteria (HIB) through dynamic fermentation Eighteen flavonoids were simultaneously identified in LZJSF using UHPLC-Q-Orbitrap-MS method, nine of which were targeted for a HIB metabolism study. Seven small phenolic acids were identified in FLZJSF. Not only at chem. level but also at PC12 cell level, FLZJSF samples fermented for 4 and 6 h showed significant pos. correlation between their activities and flavonoid aglycons, which were transformed from LZJSF. However, FLZJSF samples (8 h and longer time) mainly contained phenolic acids and indicated weak activities. Thus, LZJSF was found to result in increased antioxidant activity and could be com. utilized as a novel functional food. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application of 621-37-4

The Article related to ziziphi spinosae folium tea metabolic profile antioxidant intestine bacteria, 3, 4-dihydroxyphenylacetic acid, antioxidant, flavonoids, human intestinal bacteria, kaempferol, kaempferol-3-o-rutinoside, quercetin, quercetin-3-o-robinobioside, quercetin-3-o-rutinoside, quercetin-3-o-β-d-galactose and other aspects.Application of 621-37-4

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Alcohol – Wikipedia,
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Williams, Alexander F.; White, Andrew J. P.; Spivey, Alan C.; Cordier, Christopher J. published an article in 2020, the title of the article was meta-Selective C-H functionalisation of aryl boronic acids directed by a MIDA-derived boronate ester.SDS of cas: 621-37-4 And the article contains the following content:

N-Methyliminodiacetic acid (MIDA) boronates are boronic acid derivatives which are stable to reduction, oxidation and transmetalation. This has led to their widespread use as boronic acid protecting groups (PGs) and in iterative cross-couplings. authors describe herein the development of a novel MIDA derivative that acts in a dual manner, as a protecting group and a directing group (DG) for meta C(sp2)-H functionalisation of arylboronic acids. Palladium catalyzed C-H alkenylations, acetoxylations and arylations are possible, at room temperature and under aerobic conditions. Deprotection to reveal the functionalized boronic acids is rapid and allows for full recovery of the DG. The technique allows the facile diversification of aryl boronic acids and their subsequent use in a range of reactions or in iterative processes. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4

The Article related to methyliminodiacetic acid boronate preparation cross coupling, selective carbon hydrogen functionalization methyliminodiacetic acid boronate ester, palladium catalyzed alkenylation acetoxylation arylation protecting directing group, crystal mol structure methyliminodiacetic acid boronate ester and other aspects.SDS of cas: 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On January 30, 2022, Tamargo, Alba; Cueva, Carolina; Taladrid, Diego; Khoo, Christina; Moreno-Arribas, M. Victoria; Bartolome, Begona; Gonzalez de Llano, Dolores published an article.Safety of 3-Hydroxyphenylacetic acid The title of the article was Simulated gastrointestinal digestion of cranberry polyphenols under dynamic conditions and its impact on antiadhesive activity against uropathogenic bacteria. And the article contained the following:

This study is the first dynamic simulation of gastrointestinal digestion of cranberry polyphenols [1 g cranberry extract per day (206.2 mg polyphenols) for 18 days]. Samples from the simulated ascending, transverse, and descending colon of the dynamic gastrointestinal simulator simgi were analyzed. Results showed that 67% of the total cranberry polyphenols were recovered after simulated gastrointestinal digestion. Specifically, benzoic acids, hydroxycinnamic acids, phenylpropionic acids, phenylacetic acids, and simple phenols were identified. Cranberry feeding modified colonic microbiota composition of Enterococcaceae population significantly. However, increments in microbial-derived short-chain fatty acids, particularly in butyric acid, were observed Finally, the simgi effluent during cranberry feeding showed significant antiadhesive activity against uropathogenic Escherichia coli (13.7 ± 1.59% of inhibition). Understanding the role that gut microbiota plays in cranberry metabolism could help to elucidate its interaction with the human body and explain cranberry protective effects against urinary tract infections. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Safety of 3-Hydroxyphenylacetic acid

The Article related to cranberry polyphenol metabolite antioxidant renoprotectant urinary tract infection, antiadhesive activity, cranberry, gut microbiota, metabolism, phenolic metabolites, polyphenols, short chain fatty acids (scfas), simgi® model, urinary tract infections (utis), uropathogenic escherichia coli and other aspects.Safety of 3-Hydroxyphenylacetic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On November 15, 2022, Shi, Yali; Zhu, Yin; Ma, Wanjun; Shi, Jiang; Peng, Qunhua; Lin, Zhi; Lv, Haipeng published an article.Safety of 3-Hydroxyphenylacetic acid The title of the article was Comprehensive investigation on non-volatile and volatile metabolites in four types of green teas obtained from the same tea cultivar of Longjing 43 (Camellia sinensis var. sinensis) using the widely targeted metabolomics. And the article contained the following:

In this study, we produced roasted, baked, steamed, and sun-dried green tea products using the same batch of fresh tea leaves (FTL) of Longjing 43 (Camellia sinensis var. sinensis), and explored processing effects on the metabolic profiles of four types of green teas (FGTs) using the widely targeted metabolomics. Results showed that 146 differential metabolites including flavonoids, amino acids, lipids, and phenolic acids were screened among 1034 non-volatiles. In addition, nineteen differential metabolites were screened among 79 volatiles. Most of non-volatiles and volatiles metabolites changed notably in different manufacturing processes, whereas there were no significant differences (p>0.05) in the levels of total catechins between FGTs and FTL. The transformation of metabolites was the dominant trend during green tea processing. The results contribute to a better understanding of how the manufacturing process influences green tea quality, and provide useful information for the enrichment of tea biochem. theory. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Safety of 3-Hydroxyphenylacetic acid

The Article related to volatile nonvolatile metabolite green teas longjing metabolomic, differential metabolite, epigallocatechin gallate, geraniol, green tea, kaempferol, linalool, methyl salicylate, non-volatile metabolite, phenylethyl alcohol, process technology, quercetin, theanine, volatiles, widely targeted metabolomics, l-phenylalanine, α-linolenic acid and other aspects.Safety of 3-Hydroxyphenylacetic acid

Referemce:
Alcohol – Wikipedia,
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On March 5, 2022, Fang, Yuying; Tan, Qingyun; Zhou, Huihao; Gu, Qiong; Xu, Jun published an article.Application In Synthesis of 3-Hydroxyphenylacetic acid The title of the article was Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents. And the article contained the following:

Herein, with phenotypic assays, a new diphenylbutene derivative ferroptosis inhibitor, DPT was discovered. Based on this hit, new diphenylbutene derivatives I [R1 = H, 2-OMe, 3-OH, etc.; R2 = H, 3-OH, 4-OH, etc.] synthesized via condensation of (piperazinyl)pyrimidine and (phenyl)-phenylpentadienoic acids II and evaluated their ferroptosis inhibitory activities in HT22 mouse hippocampal neuronal cells and found that three compounds exhibited improved inhibitory activities compared with DPT. Among these active compounds, compound I [R1 = 3-OMe-4-HOC6H4, R2 = H] displayed the most potent anti-ferroptosis activity (EC50 = 1.7μM). Further studies demonstrated that compound I [R1 = 3-OMe-4-HOC6H4, R2 = H] was a specific ferroptosis inhibitor. It was revealed that different than the classic ferroptosis inhibitors, compound I [R1 = 3-OMe-4-HOC6H4, R2 = H] blocked ferroptosis by increasing FSP1 protein level. Compound I [R1 = 3-OMe-4-HOC6H4, R2 = H] could penetrate blood-brain barrier (BBB). In a rat model of ischemic stroke, compound I [R1 = 3-OMe-4-HOC6H4, R2 = H] effectively mitigated cerebral ischemic injury. Therefore, it was confirmed that compound I [R1 = 3-OMe-4-HOC6H4, R2 = H] as a novel ferroptosis inhibitor with a new scaffold, was promising for further development as an agent against neurol. diseases. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application In Synthesis of 3-Hydroxyphenylacetic acid

The Article related to phenyl pyrimidinyl piperazinyl pentadienone diastereoselective preparation ferroptosis inhibitor dpt, piperazinyl pentadienone phenyl pyrimidinyl diastereoselective preparation adme human, phenylpentadienoic phenyl acid preparation piperazinyl pyrimidine condensation, cinnamaldehyde phenylacetic acid perkin, diphenylbutene, fsp1 and other aspects.Application In Synthesis of 3-Hydroxyphenylacetic acid

Referemce:
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