Category: 621-37-4

Liu, Yujia; Myojin, Takumi; Li, Kexin; Kurita, Ayuki; Seto, Masayuki; Motoyama, Ayano; Liu, Xiaoyang; Satoh, Ayano; Munemasa, Shintaro; Murata, Yoshiyuki; Nakamura, Toshiyuki; Nakamura, Yoshimasa published an article in 2022, the title of the article was A Major Intestinal Catabolite of Quercetin Glycosides, 3-Hydroxyphenylacetic Acid, Protects the Hepatocytes from the Acetaldehyde-Induced Cytotoxicity through the Enhancement of the Total Aldehyde Dehydrogenase Activity.Computed Properties of 621-37-4 And the article contains the following content:

Aldehyde dehydrogenases (ALDHs) are the major enzyme superfamily for the aldehyde metabolism Since the ALDH polymorphism leads to the accumulation of acetaldehyde, we considered that the enhancement of the liver ALDH activity by certain food ingredients could help prevent alc.-induced chronic diseases. Here, we evaluated the modulating effects of 3-hydroxyphenylacetic acid (OPAC), the major metabolite of quercetin glycosides, on the ALDH activity and acetaldehyde-induced cytotoxicity in the cultured cell models. OPAC significantly enhanced the total ALDH activity not only in mouse hepatoma Hepa1c1c7 cells, but also in human hepatoma HepG2 cells. OPAC significantly increased not only the nuclear level of aryl hydrocarbon receptor (AhR), but also the AhR-dependent reporter gene expression, though not the nuclear factor erythroid-2-related factor 2 (Nrf2)-dependent one. The pretreatment of OPAC at the concentration required for the ALDH upregulation completely inhibited the acetaldehyde-induced cytotoxicity. Silencing AhR impaired the resistant effect of OPAC against acetaldehyde. These results strongly suggested that OPAC protects the cells from the acetaldehyde-induced cytotoxicity, mainly through the AhR-dependent and Nrf2-independent enhancement of the total ALDH activity. Our findings suggest that OPAC has a protective potential in hepatocyte models and could offer a new preventive possibility of quercetin glycosides for targeting alc.-induced chronic diseases. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Computed Properties of 621-37-4

The Article related to hepatocyte cytotoxicity 3hydroxyphenylacetic acid aldehyde dehydrogenase, 3-hydroxyphenylacetic acid, acetaldehyde, aldehyde dehydrogenase, aryl hydrocarbon receptor, quercetin metabolites and other aspects.Computed Properties of 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 31, 2020, Kim, Hanseol; Kim, Sinyeon; Kim, Dohyeon; Yoon, Sung Ho published an article.Application In Synthesis of 3-Hydroxyphenylacetic acid The title of the article was A single amino acid substitution in aromatic hydroxylase (HpaB) of Escherichia coli alters substrate specificity of the structural isomers of hydroxyphenylacetate. And the article contained the following:

A broad range of aromatic compounds can be degraded by enteric bacteria, and hydroxyphenylacetic acid (HPA) degrading bacteria are the most widespread. Majority of Escherichia coli strains can use both the structural isomers of HPA, 3HPA and 4HPA, as the sole carbon source, which are catabolized by the same pathway whose associated enzymes are encoded by hpa gene cluster. Previously, we observed that E. coli B REL606 grew only on 4HPA, while E. coli B BL21(DE3) grew on 3HPA as well as 4HPA. In this study, we report that a single amino acid in 4-hydroxyphenylacetate 3-hydroxylase (HpaB) of E. coli determines the substrate specificity of HPA isomers. Alignment of protein sequences encoded in hpa gene clusters of BL21(DE3) and REL606 showed that there was a difference of only one amino acid (position 379 in HpaB) between the two, viz., Arg in BL21(DE3) and Cys in REL606. REL606 cells expressing HpaB having Arg379 could grow on 3HPA, whereas those expressing HpaB with Gly379 or Ser379 could not. Structural anal. suggested that the amino acid residue at position 379 of HpaB is located not in the active site, but in the vicinity of the 4HPA binding site, and that it plays an important role in mediating the entrance and stable binding of substrates to the active site. The arginine residue at position 379 of HpaB is critical for 3HPA recognition. Information regarding the effect of amino acid residues on the substrate specificity of structural isomers can facilitate in designing hydoxylases with high catalytic efficiency and versatility. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application In Synthesis of 3-Hydroxyphenylacetic acid

The Article related to escherichia coli aromatic hydroxylase hydroxyphenylacetate amino acid substitution, 4-hydroxyphenylacetate 3-hydroxylase, hydroxyphenylacetic acid, structural isomer, substrate specificity and other aspects.Application In Synthesis of 3-Hydroxyphenylacetic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On August 18, 2021, Huarte, Estibaliz; Serra, Gessica; Monteagudo-Mera, Andrea; Spencer, Jeremy; Cid, Concepcion; de Pena, Maria-Paz published an article.Quality Control of 3-Hydroxyphenylacetic acid The title of the article was Raw and sous-vide-cooked red cardoon stalks (Cynara cardunculus L. var. altilis DC): (Poly)phenol bioaccessibility, anti-inflammatory activity in the gastrointestinal tract, and prebiotic activity. And the article contained the following:

The in vitro anti-inflammatory and prebiotic activity and the content and profile of bioaccessible (poly)phenols and catabolites of raw and sous-vide-cooked red cardoon (Cynara cardunculus L. var. altilis DC) were investigated during gastrointestinal (GI) digestion. Raw cardoon after in vitro GI digestion had 0.7% bioaccessible (poly)phenols, which protected against lipopolysaccharide-induced inflammation by counteracting IL-8, IL-6, TNF-α, and IL-10 secretions in differentiated Caco-2 cells. Contrarily, GI-digested sous vide cardoon showed higher (poly)phenol bioaccessibility (59.8%) and exerted proinflammatory effects in Caco-2 cells. (Poly)phenols were highly metabolized during the first 8 h of in vitro fermentation, and nine catabolites were produced during 48 h of fermentation Colonic-fermented raw and sous-vide-cooked cardoon did not show anti-inflammatory activity in HT-29 cells but presented potential prebiotic activity, comparable to the com. prebiotic FOS, by stimulating health-promoting bacteria such as Bifidobacterium spp. and Lactobacillus/Enterococcus spp. and by increasing the production of total SCFAs, especially acetate. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Quality Control of 3-Hydroxyphenylacetic acid

The Article related to sous vide cooking cynara polyphenol bioaccessibility antiinflammatory digestibility prebiotic, (poly)phenols, cynara, cytokines, gastrointestinal digestion, gut microbiota, heat treatment and other aspects.Quality Control of 3-Hydroxyphenylacetic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 31, 2020, Ulaszewska, Maria M.; Koutsos, Athanasios; Trost, Kajetan; Stanstrup, Jan; Garcia-Aloy, Mar; Scholz, Matthias; Fava, Francesca; Natella, Fausta; Scaccini, Cristina; Vrhovsek, Urska; Tuohy, Kieran; Lovegrove, Julie; Mattivi, Fulvio published an article.Electric Literature of 621-37-4 The title of the article was Two apples a day modulate human:microbiome co-metabolic processing of polyphenols, tyrosine and tryptophan.. And the article contained the following:

Methods: Using an untargeted metabolomics approach, we aimed to identify biomarkers of long-term apple intake and explore how apples impact on the human plasma and urine metabolite profiles. Forty mildly hypercholesterolemic volunteers consumed two whole apples or a sugar and energy-matched control beverage, daily for 8 wk in a randomized, controlled, crossover intervention study. The metabolome in plasma and urine samples was analyzed via untargeted metabolomics. Results: We found 61 urine and 9 plasma metabolites being statistically significant after the whole apple intake compared to the control beverage, including several polyphenol metabolites that could be used as BFIs. Furthermore, we identified several endogenous indole and phenylacetyl-glutamine microbial metabolites significantly increasing in urine after apple consumption. The multiomic dataset allowed exploration of the correlations between metabolites modulated significantly by the dietary intervention and fecal microbiota species at genus level, showing interesting interactions between Granulicatella genus and phenyl-acetic acid metabolites. Phloretin glucuronide and phloretin glucuronide sulfate appeared promising biomarkers of apple intake; however, robustness, reliability and stability data are needed for full BFI validation. Conclusion: The identified apple BFIs can be used in future studies to assess compliance and to explore their health effects after apple intake. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Electric Literature of 621-37-4

The Article related to apple biomarker polyphenol tyrosine tryptophan microbiome metabolic process, apples, biomarker of food intake, orbitrap, polyphenols, tryptophan, tyrosine, untargeted metabolomics, validation and other aspects.Electric Literature of 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dias, Patricia; Pourova, Jana; Voprsalova, Marie; Nejmanova, Iveta; Mladenka, Premysl published an article in 2022, the title of the article was 3-Hydroxyphenylacetic Acid: A Blood Pressure-Reducing Flavonoid Metabolite.Category: alcohols-buliding-blocks And the article contains the following content:

Regular intake of polyphenol-rich food has been associated with a wide variety of beneficial health effects, including the prevention of cardiovascular diseases. However, the parent flavonoids have mostly low bioavailability and, hence, their metabolites have been hypothesized to be bioactive. One of these metabolites, 3-hydroxyphenylacetic acid (3-HPAA), formed by the gut microbiota, was previously reported to exert vasorelaxant effects ex vivo. The aim of this study was to shed more light on this effect in vivo, and to elucidate the mechanism of action. 3-HPAA gave rise to a dose-dependent decrease in arterial blood pressure when administered i.v. both as a bolus and infusion to spontaneously hypertensive rats. In contrast, no significant changes in heart rate were observed In ex vivo experiments, where porcine hearts from a slaughterhouse were used to decrease the need for laboratory animals, 3-HPAA relaxed precontracted porcine coronary artery segments via a mechanism partially dependent on endothelium integrity. This relaxation was significantly impaired after endothelial nitric oxide synthase inhibition. In contrast, the blockade of SKCa or IKCa channels, or muscarinic receptors, did not affect 3-HPAA relaxation. Similarly, no effects of 3-HPAA on cyclooxygenase nor L-type calcium channels were observed Thus, 3-HPAA decreases blood pressure in vivo via vessel relaxation, and this mechanism might be based on the release of nitric oxide by the endothelial layer. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Category: alcohols-buliding-blocks

The Article related to blood pressure flavonoid metabolite 3hydroxyphenylacetic acid, 3-hydroxyphenylacetic acid, artery, blood pressure, coronary, flavonoids, gut microbiota, metabolite, pig, rat, vasorelaxation and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 25, 2020, Zhang, Zhihao; Yang, Ming; Yin, Ailing; Chen, Minmin; Tan, Ninghua; Wang, Majie; Zhang, Yanke; Ye, Hesong; Zhang, Xuefeng; Zhou, Wei published an article.Electric Literature of 621-37-4 The title of the article was Serum metabolomics reveals the effect of electroacupuncture on urinary leakage in women with stress urinary incontinence. And the article contained the following:

Stress urinary incontinence (SUI), which is defined as an involuntary loss of urine upon phys. exertion coughing, sneezing or laughing, has a significant neg. impact on the quality of life of many women. Multi-center, large-scale and randomized clin. trials have illustrated that non-invasive electroacupuncture is an effective treatment for SUI, but its therapeutic mechanism in treating SUI remains unknown. Here, gas chromatog.-mass spectrometry based serum metabolomics was performed to reveal metabolic profiles and diagnostic biomarkers from recruitment of 25 patients and 25 healthy women before and after electroacupuncture. We identified 10 differentially abundant metabolites, including butantriol, 3,4-dihydroxybutanoic acid, succinic acid, 1-deoxypentitol, psicose, citric acid, 3-hydroxybutyric acid, hydracrylic acid, 3-hydroxyphenylacetic acid and D-mannitol, from patients between before and after electroacupuncture. The electroacupuncture therapy altered propanoate metabolism, butanoate metabolism and the tricarboxylic acid cycle. A panel of 8 biomarkers (butantriol, 3,4-dihydroxybutanoic acid, succinic acid, 1-deoxypentitol, psicose, citric acid, 3-hydroxybutyric acid and hydracrylic acid) was evaluated to determine the effect of electroacupuncture on SUI and differentiated well between before and after treatment. The area under the receiver operating characteristic curve was 0.962. The sensitivity, specificity and coincidence rate were 92%, 92% and 96%, resp., at a 95% confidence interval ranging from 0.9053 to 1. Furthermore, the levels of these diagnostic biomarkers were not significantly altered in healthy subjects after sham electroacupuncture. It was indicated that an 8-biomarker panel might be constructed for the therapeutic evaluation of electroacupuncture treatment for SUI. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Electric Literature of 621-37-4

The Article related to metabolomics electroacupuncture urine leakage stress incontinence human woman, electroacupuncture, gas chromatography-mass spectrometry, metabolomics, stress urinary incontinence, therapeutic evaluation and other aspects.Electric Literature of 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 31, 2020, Li, Zhuo; Wang, Bing; Zhang, Bingbing; Cui, Guoyi; Zhang, Fenyan; Xu, Long; Jiao, Linyu; Pang, Lingyan; Ma, Xiaoxun published an article.Computed Properties of 621-37-4 The title of the article was Synthesis, Characterization and Optoelectronic Property of Axial-Substituted Subphthalocyanines. And the article contained the following:

Two novel substituted subphthalocyanines have been prepared introducing m-hydroxybenzoic acid and m-hydroxyphenylacetic acid into the axial position of bromo-subphthalocyanine. The compounds have been characterized by Fourier transform IR (FT-IR), NMR (NMR) and single-crystal X-rays diffraction (XRD) methods. Their photophys. properties show that the axial substitution results into a relatively higher fluorescence quantum efficiency (FF = 5.74 for m-hydroxybenzoic acid and 9.09% for m-hydroxyphenylacetic acid) in comparison with that of the prototype compound, despite the almost negligible influence on the maximum absorption or the emission position. Moreover, the electrochem. behaviors show that the axial-substituted subphthalocyanines also exhibit enhanced specific capacitances of 395 F/g (m-hydroxybenzoic acid) and 362 F/g (m-hydroxyphenylacetic acid) compared with 342 F/g (the prototype) to the largest capacitance at the scan rate of 5 mV/s, and the significantly larger capacitance retentions of 83.6% and 82.1% vs. 37.3% upon d. up to 3 A/g. These results show the potential of these axial-substituted subphthalocyanines in the use as organic photovoltaics and supercapacitors. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Computed Properties of 621-37-4

The Article related to subphthalocyanine organic photovoltaic supercapacitor optoelectronic property, axial-substitution, electrochemical properties, organic optoelectronics, photophysical properties, subphthalocyanines and other aspects.Computed Properties of 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On February 19, 2020, Gonzalez-Dominguez, Raul; Urpi-Sarda, Mireia; Jauregui, Olga; Needs, Paul W.; Kroon, Paul A.; Andres-Lacueva, Cristina published an article.Reference of 3-Hydroxyphenylacetic acid The title of the article was Quantitative Dietary Fingerprinting (QDF)-A Novel Tool for Comprehensive Dietary Assessment Based on Urinary Nutrimetabolomics. And the article contained the following:

Accurate dietary assessment is a challenge in nutritional research, needing powerful and robust tools for reliable measurement of food intake biomarkers. In this work, we have developed a novel quant. dietary fingerprinting (QDF) approach, which enables for the first time the simultaneous quantitation of about 350 urinary food-derived metabolites, including (poly)phenolic aglycons, phase II metabolites, and microbial-transformed compounds, as well as other compounds (e.g., glucosinolates, amino acid derivatives, methylxanthines, alkaloids, and markers of alc. and tobacco consumption). This method was fully validated for 220 metabolites, yielding good linearity, high sensitivity and precision, accurate recovery rates, and negligible matrix effects. Furthermore, 127 addnl. phase II metabolites were also included in this method after identification in urines collected from acute dietary interventions with various foods. Thus, this metabolomic approach represents one-step further toward precision nutrition and the objective of improving the accurateness and comprehensiveness in the assessment of dietary patterns and lifestyles. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Reference of 3-Hydroxyphenylacetic acid

The Article related to quant dietary fingerprinting urine nutrimetabolomics, dietary assessment, quantitative dietary fingerprinting (qdf), targeted metabolomics, ultra-high-performance liquid chromatography−tandem mass spectrometry, urine and other aspects.Reference of 3-Hydroxyphenylacetic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On November 20, 2020, Pereira-Caro, Gema; Clifford, Michael N.; Polyviou, Thelma; Ludwig, Iziar A.; Alfheeaid, Hani; Moreno-Rojas, Jose Manuel; Garcia, Ada L.; Malkova, Dalia; Crozier, Alan published an article.Application of 621-37-4 The title of the article was Plasma pharmacokinetics of (poly)phenol metabolites and catabolites after ingestion of orange juice by endurance trained men. And the article contained the following:

The health benefits of orange juice (OJ) consumption are attributed in part to the circulating flavanone phase II metabolites and their microbial-derived ring fission phenolic catabolites. The present study investigated these compounds in the bloodstream after acute intake of 500 mL of OJ. Plasma samples obtained at 0, 1, 2, 3, 4, 5, 6, 7, 8 and 24 h after OJ intake were analyzed by HPLC-HR-MS. Eleven flavanone metabolites and 36 phenolic catabolites were identified and quantified in plasma. The main metabolites were hesperetin-3-sulfate with a peak plasma concentration (Cmax) of 80 nmol/L, followed by hesperetin-7-glucuronide (Cmax 24 nmol/L), hesperetin-3-glucuronide (Cmax 18 nmol/L) and naringenin-7-glucuronide (Cmax 21 nmol/L). Among the main phenolic catabolites to increase in plasma after OJ consumption were 3-methoxycinnamic acid-4-sulfate (Cmax 19 nmol/L), 3-hydroxy-3-(3-hydroxy-4-methoxyphenyl)propanoic acid (Cmax 20 nmol/L), 3-(3-hydroxy-4-methoxyphenyl)propanoic acid (Cmax 19 nmol/L), 3-(4-hydroxyphenyl)propanoic acid (Cmax 25 nmol/L), and 3-(phenyl)propanoic acid (Cmax 19 nmol/L), as well as substantial amounts of phenylacetic and hippuric acids. The comprehensive plasma pharmacokinetic profiles that were obtained are of value to the design of future ex vivo cell studies, aimed at elucidating the mechanisms underlying the potential health benefits of OJ consumption. This trial was registered at clinicaltrials.gov as NCT02627547. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application of 621-37-4

The Article related to polyphenol metabolite catabolite ingestion orange juice plasma pharmacokinetics, 3-hydroxy-3-(phenyl)propanoic acids, absorption, metabolites, microbial catabolites, orange juice (poly)phenols, potential bioactivity and other aspects.Application of 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Seguido, Miguel Angel; Tarradas, Rosa Maria; Gonzalez-Ramila, Susana; Garcia-Cordero, Joaquin; Sarria, Beatriz; Bravo-Clemente, Laura; Mateos, Raquel published an article in 2022, the title of the article was Sustained Consumption of a Decaffeinated Green Coffee Nutraceutical Has Limited Effects on Phenolic Metabolism and Bioavailability in Overweight/Obese Subjects.Related Products of 621-37-4 And the article contains the following content:

Knowledge on the bioavailability of coffee (poly)phenols mostly come from single dose postprandial studies. This study aimed at investigating the effects of regularly consuming a green coffee phenolic extract (GCPE) on the bioavailability and metabolism of (poly)phenols. Volunteers with overweight/obesity consumed a decaffeinated GCPE nutraceutical containing 300 mg hydroxycinnamates twice daily for two months. Plasma and urinary pharmacokinetics, and fecal excretion of phenolic metabolites were characterized by LC-MS-QToF at weeks 0 and 8. Fifty-four metabolites were identified in biol. fluids. Regular consumption of the nutraceutical produced certain changes: reduced forms of caffeic, ferulic and coumaric acids in urine or 3-(3′-hydroxypenyl)propanoic, and 3,4-dihydroxybenzoic acids in feces significantly increased (p < 0.05) after 8 wk; in contrast, coumaroylquinic and dihydrocoumaroylquinic acids in urine decreased (p < 0.05) compared to baseline excretion. The sum of intestinal and colonic metabolites increased after sustained consumption of GCPE, without reaching statistical significance, suggesting a small overall effect on (poly)phenols′ bioavailability. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Related Products of 621-37-4

The Article related to green coffee nutraceutical consumption phenolic metabolism bioavailability overweight obesity, bioavailability, biotransformation pathways, green coffee, hydroxycinnamates, microbial catabolites, pharmacokinetics and other aspects.Related Products of 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts