Category: 620-92-8

USAEME-GC/MS Method for Easy and Sensitive Determination of Nine Bisphenol Analogs in Water and Wastewater was written by Kiejza, Dariusz;Kotowska, Urszula;Polinska, Weronika;Karpinska, Joanna. And the article was included in Molecules in 2022.Electric Literature of C13H12O2 The following contents are mentioned in the article:

A new, simple and sensitive method for isolating nine compounds from the bisphenol group (analogs: A, B, C, E, F, G, Cl₂, Z, AP) based on one-step liquid-liquid microextraction with in situ acylation followed by gas chromatog.-mass spectrometry was developed and validated using influent and effluent wastewaters. The chemometric approach based on the Taguchi method was used to optimize the main conditions of simultaneous extraction and derivatization. The recoveries of the proposed procedure ranged from 85 to 122%, and the repeatability expressed by the coefficient of variation did not exceed 8%. The method’s limits of detection were in the range of 0.4-64 ng/L, and the method’s limits of quantification ranged from 1.3 to 194 ng/L. The developed method was used to determine the presence of the tested compounds in wastewater from a municipal wastewater treatment plant located in northeastern Poland. From this sample, eight analytes were detected. Concentrations of bisphenol A of 400 ng/L in influent and 100 ng/L in effluent were recorded, whereas other bisphenols reached 67 and 50 ng/L for influent and effluent, resp. The removal efficiency of bisphenol analogs in the tested wastewater treatment plant ranged from 7 to approx. 88%. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Electric Literature of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Electric Literature of C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Selective Removal of Phenolic Compounds by Peroxydisulfate Activation: Inherent Role of Hydrophobicity and Interface ROS was written by Liu, Xinru;Liu, Ying;Qin, Hehe;Ye, Ziwei;Wei, Xiaojie;Miao, Wei;Yang, Dianhai;Mao, Shun. And the article was included in Environmental Science & Technology in 2022.Application of 620-92-8 The following contents are mentioned in the article:

Selective removal of organic pollutants by advanced oxidation methods has been receiving increasing attention for environmental remediation. In this study, a novel catalyst, which can selectively oxidize phenolic compounds (PCs) based on their hydrophobicity, composed of metal-organic-framework-derived Fe/Fe₃O₄ and three-dimensional reduced graphene oxide (rGOF) is designed for peroxydisulfate (PDS) activation. This heterogeneous PDS activation system can completely degrade hydrophobic PCs within 30 min. By investigating the hydrophobic properties of eight representative PCs, a pos. correlation between the hydrophobicity of PC and the reaction kinetics is reported for the first time. The selective removal stems from the strong interaction between highly hydrophobic PCs and the catalyst. Moreover, the mechanism investigation shows that the degradation reaction is triggered by interface reactive oxygen species (ROS). Our study reveals that the selective degradation of organic pollutants by PDS activation depends on the hydrophilic and hydrophobic properties of the pollutant and catalyst. The reported results provide new insights into a highly selective and efficient PDS activation system for organic pollutant removal. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Application of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

High throughput screening of bisphenols and their mixtures under conditions of low-intensity adipogenesis of human mesenchymal stem cells (hMSCs) was written by Norgren, Kalle;Tuck, Astrud;Vieira Silva, Antero;Burkhardt, Paula;Oeberg, Mattias;Munic Kos, Vesna. And the article was included in Food and Chemical Toxicology in 2022.Synthetic Route of C13H12O2 The following contents are mentioned in the article:

In vitro models of adipogenesis are phenotypic assays that most closely mimic the increase of adipose tissue in obesity. Current models, however, often lack throughput and sensitivity and even report conflicting data regarding adipogenic potencies of many chems. Here, we describe a ten-day long adipogenesis model using high content anal. readouts for adipocyte number, size, and lipid content on primary human mesenchymal stem cells (MSC) sensitive enough to compare bisphenol A derivatives quant. in a robust and high throughput manner. The number of adipocytes was the most sensitive endpoint capable of detecting changes of 20% and was used to develop a benchmark concentration model (BMC) to quant. compare eight bisphenols (tested at 0.1-100μM). The model was applied to evaluate mixtures of bisphenols obtaining the first exptl. evidence of their additive effect on human MSC adipogenesis. Using the relative potency factors (RPFs), we show how a mixture of bisphenols at their sub-active concentrations induces a significant adipogenic effect due to its additive nature. The final active concentrations of bisphenols in tested mixtures reached below 1μM, which is within the concentration range observed in humans. These results point to the need to consider the toxicity of chem. mixtures This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Synthetic Route of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Towards replacement of animal tests with in vitro assays: a gene expression biomarker predicts in vitro and in vivo estrogen receptor activity was written by Corton, J. Christopher;Liu, Jie;Kleinstreuer, Nicole;Gwinn, Maureen R.;Ryan, Natalia. And the article was included in Chemico-Biological Interactions in 2022.SDS of cas: 620-92-8 The following contents are mentioned in the article:

High-throughput transcriptomics (HTTr) has the potential to support efforts to reduce or replace some animal tests. In past studies, we described a computational approach utilizing a gene expression biomarker consisting of 46 genes to predict estrogen receptor (ER) activity after chem. exposure in ER-pos. human breast cancer cells including the MCF-7 cell line. We hypothesized that the biomarker model could identify ER activities of chems. examined by Endocrine Disruptor Screening Program (EDSP) Tier 1 screening assays in which transcript profiles of the same chems. were examined in MCF-7 cells. For the 62 chems. examined including 5 chems. examined in this study using RNA-Seq, the ER biomarker model accuracy was 1) 97% for in vitro reference chems., 2) 76-85% for guideline uterotrophic assays, and 3) 87-88% for guideline and nonguideline uterotrophic assays. For the same chems., these accuracies were similar or slightly better than those of the ToxCast ER model based on 18 in vitro assays. The performance of the ER biomarker model indicates that HTTr interpreted using the ER biomarker correctly identifies active and inactive ER reference chems. As part of the HTTr screening program the approach could rapidly identify chems. with potential ER bioactivities for addnl. screening and testing. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8SDS of cas: 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Physiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (Danio rerio) Accounting for Variations in Metabolic Rates, Brain Distribution, and Liver Accumulation was written by Chelcea, Ioana;Oern, Stefan;Hamers, Timo;Koekkoek, Jacco;Legradi, Jessica;Vogs, Carolina;Andersson, Patrik L.. And the article was included in Environmental Science & Technology in 2022.Quality Control of 4,4′-Methylenediphenol The following contents are mentioned in the article:

Bisphenol A (BPA) is an industrial chem., which has raised human health and environmental concerns due to its endocrine-disrupting properties. BPA analogs are less well-studied despite their wide use in consumer products. These analogs have been detected in water and aquatic organisms around the world, with some analogs showing toxic effects in various species including fish. Here, we present novel organ-specific time-course distribution data of bisphenol Z (BPZ) in female zebrafish (Danio rerio), including concentrations in the ovaries, liver, and brain, a rarely sampled organ with high toxicol. relevance. Furthermore, fish-specific in vitro biotransformation rates were determined for 11 selected bisphenols. A physiol. based toxicokinetic (PBTK) model was adapted for four of these bisphenols, which was able to predict levels in the gonads, liver, and brain as well as the whole body within a 2-5-fold error with respect to exptl. data, covering several important target organs of toxicity. In particular, predicted liver concentrations improved compared to currently available PBTK models. Predicted data indicate that studied bisphenols mainly distribute to the carcass and gonads and less to the brain. Our model provides a tool to increase our understanding on the distribution and kinetics of a group of emerging pollutants. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Quality Control of 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Quality Control of 4,4′-Methylenediphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The potential mechanism of BPF-induced neurotoxicity in adult zebrafish: Correlation between untargeted metabolomics and gut microbiota was written by Gu, Jie;Zhu, Yuanhui;Guo, Min;Yin, Xiaogang;Liang, Mengyuan;Lou, Xinyu;Chen, Jingrong;Zhou, Linjun;Fan, Deling;Shi, Lili;Hu, Guocheng;Ji, Guixiang. And the article was included in Science of the Total Environment in 2022.Reference of 620-92-8 The following contents are mentioned in the article:

Bisphenol F (BPF) is becoming the main substitute for bisphenol A (BPA) in plastics for food and beverage applications. Previous studies have demonstrated the neurotoxicity of BPF; however, its lifecycle toxicity and the underlying mechanisms remain poorly understood. In the current study, zebrafish were continuously exposed to BPF for four months from the embryo to adult stages in order to assess its neurotoxicity. Locomotor behaviors significantly decreased after BPF exposure, which was accompanied by a decrease in body weight, length, and hatching rate. Addnl., BPF increased the expression of inflammatory genes in the brain and destroyed the zebrafishes intestinal integrity. Meanwhile, the 16S rRNA gene sequence results showed a significantly decreased microbiota abundance and diversity following BPF treatment. Neurotransmitter metabolites were also altered by BPF. Notably, the correlation anal. between microbiota and neurotransmitter metabolism verified that gut microbiota dysbiosis was closely related to the disturbance of neurotransmitter metabolites. Therefore, the present study evaluated the neurotoxicity of lifecycle exposure to BPF and unraveled a novel mechanism involving disturbance of neurotransmitter metabolism and gut dysbiosis, which may provide potential targets for BPF-mediated neurotoxicity. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Reference of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Reference of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mechanical interlocking of SWNTs with N-rich macrocycles for efficient ORR electrocatalysis was written by Zhang, Wanzheng;Guillen-Soler, Melanie;Moreno-Da Silva, Sara;Lopez-Moreno, Alejandro;Gonzalez, Luisa R.;Gimenez-Lopez, Maria del Carmen;Perez, Emilio M.. And the article was included in Chemical Science in 2022.Application In Synthesis of 4,4′-Methylenediphenol The following contents are mentioned in the article:

Substitutional N-doping of single-walled carbon nanotubes is a common strategy to enhance their electrocatalytic properties in the oxygen-reduction reaction (ORR). Here, we explore the encapsulation of SWNTs within N-rich macrocycles as an alternative strategy to display electroactive sites on the surface of SWNTs. We design and synthesize four types of mech. interlocked derivatives of SWNTs (MINTs) by combining two types of macrocycles and two types of SWNT samples. Comprehensive electrochem. characterization of these MINTs and their reference SWNTs allows us to establish structure-activity relationships. First, we show that all MINT samples are superior electrocatalysts compared to pristine SWNTs, which serves as general validation of our strategy. Secondly, we show that macrocycles displaying both N atoms and carbonyl groups perform better than those with N atoms only. Finally, we demonstrate that a tighter fit between macrocycles and SWNTs results in enhanced catalytic activity and stability, most likely due to a more effective charge-transfer between the SWNTs and the macrocycles. These results, focusing on the ORR as a testbed, show the possibility of understanding electrocatalytic performance of SWNTs at the mol. level and thus enable the design of more active and more stable catalysts in the future. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Application In Synthesis of 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application In Synthesis of 4,4′-Methylenediphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Associations between urinary bisphenol A and its analogues and semen quality: A cross-sectional study among Chinese men from an infertility clinic was written by Chen, Pan-Pan;Liu, Chong;Zhang, Min;Miao, Yu;Cui, Fei-Peng;Deng, Yan-Ling;Luo, Qiong;Zeng, Jia-Yue;Shi, Tian;Lu, Ting-Ting;Yin, Wen-Jun;Lu, Wen-Qing;Yi, Gui-Lin;Qiu, Gao-Kung;Zeng, Qiang. And the article was included in Environment International in 2022.Electric Literature of C13H12O2 The following contents are mentioned in the article:

Human studies on association between bisphenol A (BPA) exposure and semen quality, mostly based on single urinary measurement, are inconsistent. There is limited human evidence on BPA analogs such as bisphenol F (BPF) and bisphenol S (BPS), and little is known on potential effects of bisphenol mixtures We aimed to explore whether individual or mixtures of BPA, BPS and BPF assessed in repeated urinary measurements were associated with semen quality among 984 Chinese men from an infertility clinic. We found that higher BPA exposure was associated with increased odds ratios (ORs) of having below-reference sperm concentration, total sperm count, progressive motility and total motility (all P for trends < 0.05). Higher BPS exposure was associated with increased ORs of having below-reference progressive motility and total motility (both P for trends = 0.02); the ORs comparing extreme quartiles were 1.62 (95CI: 1.07, 2.43) and 1.57 (95CI: 1.06, 2.33), resp. Elevated risks for each outcome were also observed when bisphenol mixtures were at ≥ 55th percentiles. For semen quality parameters modeled as continuous outcomes, inverse associations with individual BPA and BPS and bisphenol mixtures were still estimated Our results suggested that higher exposure to individual BPA and BPS and bisphenol mixtures were associated with impaired semen quality. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Electric Literature of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Electric Literature of C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

MOF@COF functionalized cotton fiber as a platform for high performance extraction and removal of bisphenols from water samples was written by Xu, Xianliang;Zhang, Nan;Gao, Yan;Bao, Tao;Wang, Sicen. And the article was included in Journal of Environmental Chemical Engineering in 2022.Recommanded Product: 620-92-8 The following contents are mentioned in the article:

In the present work, a novel composite CCF@UiO-66-NH₂@TpBD (CCF stands for carboxyl cotton fiber) was fabricated for the extraction and removal of BPs from aqueous samples. Both the UiO-66-NH₂ (MOF) and TpBD (COF) were immobilized on CCF through feasible layer-by-layer and Schiff base reaction, and characterized using field emission SEM (FESEM) equipped with energy dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), Fourier transform IR spectroscopy (FT-IR), and XPS techniques. The CCF@UiO-66-NH₂@TpBD was packed in pipet tip as micro-column to investigate the adsorption of BPs using a pipet tip solid-phase extraction (PT-SPE) method. Various parameters (sampling flow rate, sample pH, amount of adsorbent, ionic strength, methanol concentration, and flow rate of eluent) affecting the extraction efficiency were optimized. Based on strong π-π conjugation, hydrogen bonding, and hydrophobic interactions, the adsorbent exhibited good extraction and removal capability. A low limit of detection (0.16-0.75 ng/mL) and a high adsorption (4.3-5.6 mg/g) were obtained. Accordingly, the composite CCF@UiO-66-NH₂@TpBD material was shown to be a suitable adsorbent for the extraction and removal of BPs from aquatic samples due to excellent reusability, reproducibility, and high adsorption capacity. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Recommanded Product: 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Controlled and Predictably Selective Oxidation of Activated and Unactivated C(sp³)-H Bonds Catalyzed by a Molybdenum-Based Metallomicellar Catalyst in Water was written by Thiruvengetam, Prabaharan;Chand, Dillip Kumar. And the article was included in Journal of Organic Chemistry in 2022.Application of 620-92-8 The following contents are mentioned in the article:

The synthesis of carbonyl derivatives from renewable feedstocks, by direct oxidation/functionalization of activated and unactivated C(sp³)-H bonds under a controlled and predictably selective fashion, especially in late stages, remains a formidable challenge. Herein, for the first time, cost-effective and widely applicable protocols for controlled and predictably selective oxidation of petroleum waste and feedstock ingredients like methyl-/alkylarenes to corresponding value-added carbonyls have been developed, using a surfactant-based oxodiperoxo molybdenum catalyst in water. The methodologies use hydrogen peroxide (H₂O₂) as an environmentally benign green oxidant, and the reactions preclude the need of any external base, additive, or cocatalyst and can be operated under mild eco-friendly conditions. The developed protocols show a wide substrate scope and eminent functional group tolerance, especially oxidation-liable and reactive boronic acid groups. Upscaled multigram synthesis of complex steroid mols. by late-stage oxidation proves the robustness and practical utility of the current protocol since it employs an inexpensive recyclable catalyst and an easily available oxidant. A plausible mechanism has been proposed with the help of few controlled experiments and kinetic and computational studies. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Application of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts