Category: 620-92-8

Occurrence and Exposure Assessment of Bisphenol Analogs Through Different Types of Drinking Water in Korea was written by Lim, Jae-Eun;Liao, Chunyang;Moon, Hyo-Bang. And the article was included in Exposure and Health.Recommanded Product: 620-92-8 The following contents are mentioned in the article:

Presence of endocrine disruptors in drinking water is a public and global concern. Bisphenol A (BPA) has been primarily used for polycarbonate plastics and epoxy resins. Due to domestic and global regulations on BPA, other bisphenol analogs (BPs) have been introduced as alternatives. Despite this, few studies have been conducted for human health risks of BPA and their alternatives, such as bisphenol F (BPF) and bisphenol S (BPS), through the consumption of drinking water. The present study aimed to determine seven BPs in three types of drinking water (tap water, purified water, and bottled water) to assess the occurrence, regional differences, source tracking, and potential health risks of BPs. BPA and BPF were detectable in almost all drinking water samples. The BPA concentration in tap water was significantly higher than that observed in purified water, whereas the BPF concentration in purified water was higher than those observed in tap water and bottled water. This result provides a wake-up call to improve the safety of purified water for emerging contaminants, such as BPF. The highest BP concentrations were observed for regions with intensive industrial activities and human populations. The concentration ratios of BPF/BPA in all tap water samples were greater than 1, indicating replacement of BPA with BPF in industrial markets. Boiling increased BPA and decreased BPF and BPS concentrations in tap water. The estimated daily intakes of BPA through consumption of drinking water for all age groups and scenarios (0.36-0.72 ng/kg bw/day) were lower than the tolerable daily intake (4.0 μg/kg bw/day) proposed by the European Food Safety Authority, implying a limited health risk. Toddlers were the highest exposure group for all BPs and scenarios. This is the first comprehensive survey of several BPs in different types of drinking water. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Recommanded Product: 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 620-92-8

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A systematic comparison of the developmental vascular toxicity of bisphenol A and its alternatives in vivo and in vitro was written by Ji, Guixiang;Gu, Jie;Guo, Min;Zhou, Linjun;Wang, Zhen;Shi, Lili;Gu, Aihua. And the article was included in Chemosphere in 2022.Application of 620-92-8 The following contents are mentioned in the article:

Due to the potential toxicity of bisphenol A (BPA), several bisphenols (BPs), including bisphenol F (BPF), bisphenol S (BPS) and bisphenol AF (BPAF), have been gradually used as its main substitutes, and the levels of these alternatives in different environmental media have been constantly increasing. Although some previous studies have shown that bisphenol substitutes have similar or greater acute toxicity and estrogenic effects than BPA, comparative studies on the cardiovascular toxicity of BPs have not been evaluated. In this study, the developmental vascular toxicity of BPA and three predominant substitutes (BPF, BPS and BPAF) were evaluated using zebrafish embryos and human vascular endothelial cells (HUVECs). BP exposure at a sublethal concentration of 1/10 96 h median lethal concentration (96 h-LC50) significantly hindered intersegmental vessel (ISV) growth, delayed common cardinal vein (CCV) remodeling and decreased subintestinal vessels (SIVs) in Tg (fli1:EGFP) zebrafish embryos. Meanwhile, the results of the endothelial tube formation assay showed that in vitro angiogenesis was inhibited by BP exposure. Mechanistically, BP exposure increased oxidative stress characterized by a significant decrease in superoxide dismutase (SOD) and catalase (CAT) activity, accompanied by increased levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in both zebrafish and HUVECs. Therefore, the vascular toxicity and oxidative stress potency of the BPs were compared and evaluated, ranking as follows: BPAF > BPF > BPA > BPS. To the best of our knowledge, the present work, for the first time, systematically provides direct evidence for BPA and its alternatives on developmental vascular toxicity in vitro and in vivo. Therefore, these findings will provide insight into the rational and safe application of BPA substitutes. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Application of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 620-92-8

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Alcohol – Wikipedia,
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Optimisation of the conditions of dispersive liquid-liquid microextraction for environmentally friendly determination of bisphenols and benzophenone in complex water matrices by LC-MS/MS was written by Coutinho, Rodrigo;Gomes Vianna, Marco Tadeu;Marques, Marcia. And the article was included in Microchemical Journal in 2022.Name: 4,4′-Methylenediphenol The following contents are mentioned in the article:

Due to well-known risks to human and environmental health, the increasing presence of several micropollutants even in very low concentrations in environmental matrixes requires sustainable and advanced anal. methods to expand monitoring programs, particularly for water quality control. The objective of this study was to optimize the conditions of the dispersive liquid-liquid microextraction (DLLME) for a combined group of emerging micropollutants (bisphenol A, bisphenol S, bisphenol F, bisphenol AF and benzophenone) in complex water matrixes. Ten variables were chosen as the most important for DLLME procedure and the Design of Experiments (DoE) approach was applied to find the most relevant variables and optimize the DLLME procedure. The optimized DLLME was then, applied to real complex water samples including raw and treated wastewaters and surface water in Rio de Janeiro city, Brazil, and the extracted samples were analyzed by ultra-performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS). The variables vortex mixing time (VMT), Dispersive Solvent Volume (DSV) and Extractor Solvent Volume (ESV) are the most important among the variables evaluated. The recovery efficiencies ranged from 60 to 120% after optimization the amounts of target compounds found in the five real aqueous matrixes varied from 0.005 to 150μg L-1. The association of optimized DLLME with the UPLC-MS/MS met the validation requirements adopted and generated anal. results of high quality. The advantages of this extraction technique include reduction of cost per anal.; low volume of samples and low volume of solvent required; no need to use cartridges; reduction of waste generation. The method is, therefore, suitable to process large numbers of samples, particularly in countries with limited budgets for environmental monitoring. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Name: 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Name: 4,4′-Methylenediphenol

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Alcohol – Wikipedia,
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Last piece in the puzzle of bisphenols BPA, BPS and BPF metabolism: Kinetics of the in vitro sulfation reaction was written by Durcik, Martina;Gramec Skledar, Darja;Tomasic, Tihomir;Trontelj, Jurij;Peterlin Masic, Lucija. And the article was included in Chemosphere in 2022.Related Products of 620-92-8 The following contents are mentioned in the article:

Bisphenols are endocrine-disrupting chems. ubiquitously present in the environment, with the consequent exposure to humans. In humans, bisphenols are metabolized to glucuronide and sulfate conjugates. Recent studies indicate that sulfation represents an important bisphenol metabolic pathway for the most vulnerable humans, such as the growing fetus. Our aim was to evaluate sulfation kinetics of commonly detected bisphenols in biol. samples: bisphenol A (BPA), bisphenol S (BPS), and bisphenol F (BPF). Furthermore, we evaluated estrogenic agonist potencies and long-term stability of these bisphenol sulfates. BPS and BPF sulfates were prepared by chem. synthesis. Sulfation kinetics of the selected bisphenols were tested in pooled human liver cytosol, as a source for soluble phase II enzymes, including liver sulfotransferases, with quantification by LC-MS/MS. A validated transactivation assay using the hERα-Hela 9903 cell line was used to determine estrogenic agonist potencies. Moreover, BPA, BPS, and BPF sulfate stabilities were examined under various conditions and during storage. In vitro sulfation of BPA and BPS followed Michaelis-Menten kinetics; BPF sulfation followed a substrate inhibition model. Sulfation rates were comparable for these bisphenols, although their K_M values indicated some large differences in affinities. BPA and BPS sulfates are not hERα agonists. The bisphenol sulfates can be considered stable for at least 2 days under these tested media conditions. These data indicate that bisphenol sulfation is an important route in their biotransformation. Compared to glucuronidation, these bisphenols show slower sulfation rates but similar K_M values. BPA and BPS metabolic biotransformation by sulfation provides their detoxification as they are without estrogenic activities. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Related Products of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 620-92-8

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Alcohol – Wikipedia,
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European interlaboratory comparison investigations (ICI) and external quality assurance schemes (EQUAS) for the analysis of bisphenol A, S and F in human urine: Results from the HBM4EU project was written by Vaccher, Vincent;Lopez, Marta Esteban;Castano, Argelia;Mol, Hans;Haji-Abbas-Zarrabi, Karin;Bury, Daniel;Koch, Holger M.;Dvorakova, Darina;Hajslova, Jana;Nubler, Stefanie;Kaur Sakhi, Amrit;Thomsen, Cathrine;Vorkamp, Katrin;Goen, Thomas;Antignac, Jean-Philippe. And the article was included in Environmental Research in 2022.Synthetic Route of C13H12O2 The following contents are mentioned in the article:

The Human Biomonitoring for Europe initiative (HBM4EU) aims to study the exposure of citizens to chems. and potentially associated health effects. One objective of this project has been to build a network of laboratories able to answer to the requirements of European human biomonitoring studies. Within the HBM4EU quality assurance and quality control scheme (QA/QC), a number of interlaboratory comparison investigations (ICIs) and external quality assurance schemes (EQUASs) were organized to ensure data consistency, comparability and reliability. Bisphenols are among the prioritized substance groups in HBM4EU, including bisphenol A (BPA), bisphenol S (BPS) and bisphenol F (BPF) in human urine. In four rounds of ICI/EQUAS, two target concentration levels were considered, related to around P25 and P95 of the typical exposure distribution observed in the European general population. Special attention was paid to the conjugated phase II metabolites known to be most dominant in samples of environmentally exposed individuals, through the anal. of both native samples and samples fortified with glucuronide forms. For the low level, the average percentage of satisfactory results across the four rounds was 83% for BPA, 71% for BPS and 62% for BPF. For the high level, the percentages of satisfactory results increased to 93% for BPA, 89% for BPS and 86% for BPF. 24 out of 32 participating laboratories (75%) were approved for the analyses of BPA in the HBM4EU project according to the defined criterion of Z-scores for both low and high concentration levels in at least two ICI/EQUAS rounds. For BPS and BPF, the number of qualified laboratories was 18 out of 27 (67%) and 13 out of 28 (46%), resp. These results demonstrate a strong anal. capability for BPA and BPS in Europe, while improvements may be needed for BPF. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Synthetic Route of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Systematic evaluation of the evidence for identification of endocrine disrupting properties of Bisphenol F was written by Wiklund, Linus;Beronius, Anna. And the article was included in Toxicology in 2022.Application of 620-92-8 The following contents are mentioned in the article:

Identification of endocrine disruptors (EDs) is a highly prioritized issue in the EU. However, scientific criteria to identify EDs have so far only been implemented for biocidal and plant protection products. The European Commission is working on developing a horizontal approach to the identification of EDs across legislations, based on these scientific criteria. With this study, our aim was to evaluate evidence on endocrine disrupting properties of Bisphenol F (BPF) by applying the process set out for biocidal and plant protection products in Europe. BPF is not registered under REACH and therefore assumed not to be produced in the EU > 1 ton/yr, yet the substance has been detected in urine, serum, and breast milk in populations from different countries in Europe. BPF is raising concern since it is an analog of the known ED and reproductive toxicant Bisphenol A. Relevant evidence on endocrine disrupting properties of BPF from the open literature was collected using systematic review methodol. Pre-defined inclusion criteria were developed to select relevant studies, and data was extracted The reliability of included studies was evaluated by the Science in Risk Assessment and Policy tool, and results were converted into Klimisch categories to allow for categorization of study reliability. A weight-of-evidence approach was used to analyze the evidence and draw conclusions on endocrine-related activity and/or endocrine adversity. We found that there is sufficient evidence to conclude on an endocrine mechanism, and while evidence for adversity was not considered sufficient, we still conclude that BPF could also cause endocrine-mediated adversity. Two modes of action were postulated based on the collected data for BPF. Challenges of performing the ED assessment for data-poor chems. and the importance of adequate reporting of studies in the open literature, especially for new approach methods, are discussed. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Application of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quantification of differential tissue biomarker responses to microplastic ingestion and plasticizer bioaccumulation in aquaculture reared sea bream Sparus aurata was written by Capo, Xavier;Alomar, Carme;Compa, Monserrat;Sole, Montserrat;Sanahuja, Ignasi;Soliz Rojas, Dulce Lucy;Gonzalez, Gema Paniagua;Garcinuno Martinez, Rosa Maria;Deudero, Salud. And the article was included in Environmental Research in 2022.HPLC of Formula: 620-92-8 The following contents are mentioned in the article:

Marine aquaculture is considered a potential source of microplastics (MPs). MPs can induce oxidative stress and damage in marine species. In this study we evaluated the impact of MPs intake in the com. fish, Sparus aurata, from aquaculture facilities and the antioxidant response associated to this MPs ingestion in caged specimens for 120 days. Sampling was carried out at the beginning of the study (T0), at 60 days (T60) and at 120 days (T120). At each sampling stage, gastrointestinal tract, blood, plasma, liver and muscle samples were obtained to analyze MPs intake (gastrointestinal tract), oxidative stress markers (blood, plasma and liver) and plasticizers bioaccumulation (muscle). Fish sampled at T60 presented the highest MPs intake and plasticizers accumulated in muscle over time, but with a different pattern according to type: bisphenols and phthalates. This indicates MPs ingestion induces a differential tissue response in S. aurata. Similarly, stress biomarkers presented a differential response throughout the study, depending on the analyzed tissue. In the case of oxidative damage markers, for malondialdehyde (MDA) an increase throughout the study was observed both in liver and blood cells but with a progressive decrease in plasma. In the case of phase I detoxifying enzyme activities in liver, 7-ethoxyresorufin O-deethylase (EROD), 7-benzyloxy-4-[trifluoromethyl]-coumarin-O-debenzyloxylase (BFCOD) and carboxylesterases (CE), showed a comparable decrease at T60 with a slight recovery at T120. In contrast, glutathione-S-transferase (GST) activity was significantly enhanced at T60 compared to the other sampling stages. In conclusion, MPs ingestion occurs in aquaculture reared seabream where potentially associated plasticizers accumulate in the muscle and both could be responsible for plasma and liver oxidative stress damage and alterations on detoxifying biomarkers responses. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8HPLC of Formula: 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Urinary concentrations of bisphenol analogues in the south of China population and their contribution to the per capital mass loads in wastewater was written by Wang, Hao;Tang, Shaoyu;Zhou, Xi;Gao, Rui;Liu, Zehua;Song, Xiaofei;Zeng, Feng. And the article was included in Environmental Research in 2022.Electric Literature of C13H12O2 The following contents are mentioned in the article:

Bisphenol analogs (BPs) are heavily used and neg. affect the health of human beings, however, there is little knowledge regarding human exposure to BPs other than BPA. This study aims to assess human exposure to BPs through investigating pooled urine and wastewater samples. Twenty-four pooled urine samples were prepared from 960 specimens (classified by age and gender). Wastewater samples were collected from six major wastewater treatment plants (WWTPs) in Guangzhou, South of China. BPA, BPS, and BPAF were widely detected in urine samples, with a median concentration of 0.96, 0.42, and 0.15μg/L, resp. Median urinary levels of BPA and BPS were higher in males than females (p > 0.05). In addition, BPA and BPS urinary levels in young adults (15-30 years old) were greater than those in children (0-15 years old) (p > 0.05). Nevertheless, most of the BPs were detected in wastewater samples, of which BPA and BPS were predominant BPs, with a median concentration of 1.0 and 0.29μg/L. The average per capital mass loads of ΣBPs on the weekdays of mix typed WWTP was much higher than those of the weekends. Nonetheless, the average loads of ΣBPs on the weekdays of domestic WWTP was slightly lower than those of the weekends. This indicated that important sources of BPs might include industrial wastewater and household cleaning products. Urinary BPA, BPS, and BPAF accounted for less than 5% per capital mass loads in wastewater, suggesting that much of the BPA, BPS, and BPAF in municipal wastewater originate non-human excretion. Hence, the wastewater-based epidemiol. (WBE) approach based on parent compounds is not available for assessing human exposure to BPs, neither for other industrial chems. with diverse sources in municipal wastewater. These results contributes to the development of an efficient surveillance system which can provide insight in the trends of human exposure of BPs. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Electric Literature of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Electric Literature of C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simultaneous determination of bisphenol A and its analogues in foodstuff using UPLC-MS/MS and assessment of their health risk in adult population was written by Shaaban, Heba;Mostafa, Ahmed;Alqarni, Abdulmalik M.;Almohamed, Yasmeen;Abualrahi, Duaa;Hussein, Dania;Alghamdi, Meshal. And the article was included in Journal of Food Composition and Analysis in 2022.Formula: C13H12O2 The following contents are mentioned in the article:

Replacing bisphenol A with its analogs may represent a risk to human health because of their potential synergic effects. In this study, a fast, sensitive and reliable UPLC-MS/MS method for the identification and quantification of bisphenol A, bisphenol F, bisphenol S, D8 and pergafast in foodstuff was developed and validated. Sample preparation and clean up were carried out using ultrasonic extraction followed by solid-phase extraction on Oasis HLB cartridges. The developed method was successfully applied for simultaneous determination of the target analytes in 140 food samples from various categories (including: vegetables, dairy products, seafood products, condiments, beverages, oils & fats and others). The recovery ranged from 80.3% to 103.8% with relative standard deviations not higher than 11.5%. Limits of detection were within the range of 0.003-0.015μg kg-1 under the optimized conditions. Bisphenol A was found in the majority of food samples (83%) with the highest concentration of 110μg kg-1. Canned food contained higher concentrations of total bisphenols (23.8μg kg-1) compared to food samples packed in plastic containers (7.68μg kg-1), paper (3.53μg kg-1) or glass (1.14μg kg-1). The estimated daily intake for the detected bisphenols was also calculated (286.7 and 307.8 ng kg-1 BW day-1) for male and female adults, resp. The dietary exposure to total bisphenols through foodstuffs investigated in this study were found to be higher than the recently updated tolerable daily intake value of BPA (0.04 ng kg-1 BW day-1). Also, the calculated hazard index was found to be higher than 1, indicating that the exposure to the detected bisphenols is more likely to cause risk to consumers through the dietary intake. To the best of our knowledge, this is the first report estimating the health risk associated with dietary exposure to bisphenol A and its analogs in Saudi Arabia. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Formula: C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Identification and quantification of bisphenols in water by dissipation followed by silylation using gas chromatography-mass spectrometry analysis was written by Katari, B. V. Narasimha Raju;Madhu, Vemula;Nowduri, Annapurna;Kaliyaperumal, Muralidharan;Rumalla, Chidananda Swamy. And the article was included in Asian Journal of Chemistry in 2022.Product Details of 620-92-8 The following contents are mentioned in the article:

Bisphenols are important endocrine disruptors, which were widely used in the variety of food packing and storage materials which often come into contact with various food products packed in them. The presence of bisphenols in water is harmful for the health of humans as well as aquatic animals and also, they accumulate over a period of time. Hence, the present work aimed to develop a simple and accurate GCMS-SIM method for the quantification of bisphenols in packaged drinking water as well as the water samples collected in river and lakes in Andhra Pradesh state of India. Bisphenols were extracted by simple solvent extraction with acetonitrile and silylated by N,O-bis(trimethylsilyl)trifluoro acetamide and analyzed by GC-MS. Various parameters that affect the recovery of the analytes were carefully optimized and the developed method was validated. The recoveries of the analytes were in the range of 80-120 % with quantification limit of 1 ng/L. The calibration curve was linear in the concentration range of 5 ng/L to 10 μg/L. The method was applied for the quantification of bisphenols in packaged drinking water at room temperature and at 50 °C at various time intervals. The results proved that the water sample kept at room temperature doesn′t shows peaks corresponding to bisphenols. The water sample exposed to 50 °C for 30 days bisphenols content 10, 12, 22 and 8 ng/L resp. for bisphenol G (BPG), bisphenol F (BPF), bisphenol E, (BPE) and bisphenol A (BPA) whereas the same sample at 180 days of exposer shows 60, 51, 61 and 22 ng/L resp. confirms that the leaching of plastic due to temperature increases the bisphenols level. Among the real time samples studied, the bisphenols level was observed to be very high in Kolleru Lake and it is having 17, 14, 8 and 12 ng/L of BPG, BPF, BPE and BPA, resp. confirms that due to high plastic pollution the bisphenols level was high in these samples. Hence, it can be concluded that the method can be suitable for the anal. of bisphenols in drinking water as well as in wastewater samples. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Product Details of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts