Category: 620-92-8

Comparative evaluation of the effects of bisphenol derivatives on oxidative stress parameters in HepG2 cells was written by Ozyurt, Busra;Ozkemahli, Gizem;Yirun, Anil;Ozyurt, Aylin Balci;Bacanli, Merve;Basaran, Nursen;Kocer-Gumusel, Belma;Erkekoglu, Pinar. And the article was included in Drug and Chemical Toxicology (1977).SDS of cas: 620-92-8 The following contents are mentioned in the article:

Bisphenol A (BPA) BPA is an endocrine-disrupting chem. that has a wide range of uses. Exposure to BPA can be by oral, inhalation, and parenteral routes. Although its use in several products is limited, there is still concern on its adverse health effects, particularly for susceptible populations like children. Alternative bisphenols, such as bisphenol S (BPS) and bisphenol F (BPF), are now being used instead of BPA, although there is little information on the toxicity of these bisphenols. BPF is used as a plasticizer in the production of several industrial materials as well as in the coating of drinks and food cans. BPS is used in curing fast-drying epoxy glues, as a corrosion inhibitor and as a reactant in polymer reactions. In this study, the possible toxic effects of BPA, BPS, and BPF in HepG2 cells were evaluated comparatively. For this purpose, their effects on cytotoxicity, production of intracellular reactive oxygen species (ROS), oxidant/antioxidant parameters, and DNA damage have been examined The cytotoxicity potentials of different bisphenols were found to be as BPS > BPF > BPA. All bisphenol derivatives caused increases in intracellular ROS production We observed that all bisphenol derivatives cause an imbalance in some oxidant/antioxidant parameters. Bisphenols also caused significant DNA damage in order of BPF > BPA > BPS. We can suggest that both of the bisphenol derivatives used as alternatives to BPA also showed similar toxicities and may not be considered as safe alternatives. Mechanistic studies are needed to elucidate this issue. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8SDS of cas: 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.SDS of cas: 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An efficient mixed-mode strong anion-exchange adsorbent based on functionalized polyethyleneimine for simultaneous solid phase extraction and purification of bisphenol analogues and monoalkyl phthalate esters in human urine was written by Huang, Chaonan;Yang, Jiajia;Ma, Jiping;Tan, Weiqiang;Wu, Lingxia;Shan, Bin;Wang, Shasha;Chen, Jiping;Li, Yun. And the article was included in Microchemical Journal in 2022.SDS of cas: 620-92-8 The following contents are mentioned in the article:

In this study, a mixed-mode strong anion-exchange (MAX) adsorbent was developed based on amine-functionalized poly(divinylbenzene) (PDVB) functionalized with polyethyleneimine (PEI) followed by quaternization with glycidyl Ph ether (named as PDVB-QPEI). Fourier Transform IR spectroscopy and nitrogen adsorption-desorption experiments indicated that the PDVB-QPEI was successfully synthesized with a BET sp. surface area (SBET) of 118.5 m² g-1, pore volume of 0.37 cm3 g-1, and pore size of 16.41 nm. High ion-exchange capacity (IEC) of 0.57 mmol g-1 was achieved. The important parameters influencing SPE efficiency were optimized, including adsorbent mass, pH of the sample, type and volume of washing solvent and eluent. The practical capability of this novel PDVB-QPEI MAX adsorbent was tested for solid phase extraction and purification of bisphenol analogs and monoalkyl phthalate esters (MPEs) in urine samples. Outstanding extraction and cleanup efficiency were achieved simultaneously for urine samples due to high selectivity of the PDVB-QPEI adsorbent for bisphenol analogs and MPEs. Recovery values ranged from 80.1% to 102.4% with precision (relative standard devition, n = 3) below 6% for these blank urine samples spiked at different levels. The limit of detections (LODs) obtained by HPLC-DAD were in the range of 3-9 ng mL-1. The PDVB-QPEI is superior to com. adsorbents (Oasis HLB, C18 and Oasis MAX). These results demonstrated the great potential application of the PDVB-QPEI adsorbent in routine anal. of bisphenol analogs and MPEs in complex samples. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8SDS of cas: 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.SDS of cas: 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Multifunctional Molecularly Imprinted Receptor-Based Polymeric Membrane Potentiometric Sensor for Sensitive Detection of Bisphenol A was written by Wang, Chan;Qi, Longbin;Liang, Rongning;Qin, Wei. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2022.SDS of cas: 620-92-8 The following contents are mentioned in the article:

Molecularly imprinted polymer (MIP)-based polymeric membrane potentiometric sensors have become an attractive tool for detection of organic species. However, the MIP receptors in potentiometric sensors developed so far are usually prepared by only using single functional monomers. This may lead to low affinities of the MIP receptors due to the lack of diversity of the functional groups, thus resulting in low detection sensitivity of the potentiometric sensors. Addnl., these classical MIP receptors are nonconductive polymers, which are undesirable for the fabrication of an electrochem. sensor. Herein, we describe a novel multifunctional MIP receptor-based potentiometric sensor. The multifunctional MIP receptor is prepared by using two functional monomers, methacrylic acid, and 3-vinylaniline with a dual functionality of both recognition and conduction properties. The poly(aniline) groups are introduced into the methacrylic acid-based MIP by postoxidn. of the aniline monomer. Such poly(aniline) groups not only serve as the addnl. functional groups for selective recognition, but also work as a conducting polymer. The obtained multifunctional MIP receptor shows a high binding capacity and an excellent electron-transfer ability. By using bisphenol A as a model, the proposed multifunctional MIP sensor exhibits a largely improved sensitivity and low noise levels compared to the conventional MIP sensor. We believe that the proposed MIP-based sensing strategy provides a general and facile way to fabricate sensitive and selective MIP-based electrochem. sensors. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8SDS of cas: 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 620-92-8

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mixtures modeling identifies heavy metals and pyrethroid insecticide metabolites associated with obesity was written by Nguyen, Hai Duc;Oh, Hojin;Jo, Won Hee;Hoang, Ngoc Hong Minh;Kim, Min-Sun. And the article was included in Environmental Science and Pollution Research in 2022.Name: 4,4′-Methylenediphenol The following contents are mentioned in the article:

We aim to examine the association between chem. mixtures and obesity. Blood and urinary levels of tween-six chems. were measured in adults who participated in the KoNEHS. We identified the associations of chems. with obesity using linear regression models. Weighted quantile sum (WQS) regression, quantile g-computation (qgcomp), and Bayesian kernel machine regression (BKMR) were conducted as secondary analyses. Of the 3,692 participants included in the anal., 18.0% had obesity. In the logistic regression model, mercury (Hg), lead (Pb), and 3PBA levels were associated with obesity, and significant trends were observed for these chem. tertiles (p < 0.001). Hg, Pb, and 3PBA levels were also associated with BMI. The WQS index was significantly associated with both obesity (OR = 2.15, 95% CI: 2.11-2.20) and BMI (β = 0.39, 95% CI: 0.37-0.51). The qgcomp index also found a significant association between chems. and both obesity (OR = 1.70, 95% CI: 1.56-1.85) and BMI (β = 0.40, 95% CI: 0.39-0.41). Hg, Pb, and 3PBA were the most heavily weighed chems. in these models. In BKMR anal., the overall effect of the mixture was significantly associated with obesity. Hg, Pb, and 3PBA showed pos. trends and were observed as the most important factors associated with obesity. Given increasing exposure to chems., there is a need to investigate the associations between chem. exposures, either sep. or together, and incident obesity risk factors in well-characterized cohorts of different populations, and to identify potential approaches to chem. exposure prevention. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Name: 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: 4,4′-Methylenediphenol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Peanut shells-derived biochars as adsorbents for the pipette-tip solid-phase extraction of endocrine-disrupting phenols in water, milk and beverage was written by Sun, Ruiting;Lu, Fuwei;Yu, Chunmei;Yang, Yanan;Qiao, Lizhen;Liu, Anmin. And the article was included in Journal of Chromatography A in 2022.Recommanded Product: 620-92-8 The following contents are mentioned in the article:

In the present work, a type of biochar materials derived from carbonizing peanut shells were obtained and employed as the adsorbents of pipet-tip solid-phase extraction (PT-SPE) for the enrichment and determination of six endocrine-disrupting phenols (EDPs) in combination with high-performance liquid chromatog. equipped with UV detector (HPLC-UV). Abundant aliphatic and aromatic carbon structures and functional groups from polar heteroatoms (N, O, S) were distributed in the low-cost and eco-friendly peanut shells-derived biochar materials and were favorable for the enrichment of target EDPs. Moreover, the theor. calculation based on d. functional theory (DFT) proved that the effective enrichment of EDPs in aqueous samples benefited from the effective adsorption on the peanut shells-derived biochar materials. The exptl. factors influencing the extraction efficiency were investigated, including adsorbent amount, aspirating/dispensing cycles, the type of elution solvent and elution times, salt addition, sample solution pH and type and volume of washing solvent. Under the optimal conditions, the proposed PT-SPE method exhibited good linear relationship (R2 > 0.993) in the range of 0.5-400μg/L and low limits of detections (LODs) from 0.25 to 2.5μg/L, as well as good precision and accuracy with relative standard deviations (RSDs) of 0.3%-13.2% and recoveries of 83.5%-117.1%. Finally, the biochars-based miniaturized pretreatment method was employed for the determination of six EDPs in bottled water, milk, tea beverage and disposal plastic bag soaked solution with recoveries from 77.5% to 116.5%. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Recommanded Product: 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bisphenol F suppresses insulin-stimulated glucose metabolism in adipocytes by inhibiting IRS-1/PI3K/AKT pathway was written by Chen, Huiling;Li, Jiangbin;Zhang, Yanchao;Zhang, Wei;Li, Xing;Tang, Huanwen;Liu, Yungang;Li, Tianlan;He, Haoqi;Du, Bohai;Li, Li;Shi, Ming. And the article was included in Ecotoxicology and Environmental Safety in 2022.Formula: C13H12O2 The following contents are mentioned in the article:

Obesity is one of the risk factors of metabolic diseases. Decreased sensitivity to insulin or impairment of the insulin signaling pathway may affect the metabolism of adipose tissue. Bisphenol F (BPF) has been widely used in various products as a substitute for bisphenol A (BPA). BPA has been defined as “obesogen”. However, knowledge about the correlation between BPF and obesity is very limited. This study was aimed to explore the effects of BPF on glucose metabolism and insulin sensitivity in mammalian tissues, using a mouse 3T3-L1 adipocyte line as the model. Differentiated 3T3-L1 adipocytes were treated with BPF at various concentrations for 24 h or 48 h, followed by the measurement of cell viability, lipid accumulation, expression levels of adipocytokines, glucose consumption, and impairment of the insulin signaling pathway. The results indicated that BPF had no effect on the size of 3T3-L1 adipocytes, but the expression of leptin, adiponectin and apelin was decreased, while that of chemerin and resistin was increased after 48 h of BPF treatment. Moreover, BPF inhibited the glucose consumption, the expression of GLUT4, and its translocation to the plasma membranes in 3T3-L1 adipocytes. Western blot anal. indicated that the activation of IRS-1/PI3K/AKT signaling pathway was inhibited by BPF, which resulted in reduced GLUT4 translocation. In conclusion, our data suggest that exposure of adipocytes to BPF may alter the expression of calorie metabolism-related adipokines and suppress insulin-stimulated glucose metabolism by impairing the insulin signaling (IRS-1/PI3K/AKT) pathway. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Formula: C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Formula: C13H12O2

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cytotoxicity and mutagenicity of particulate matter from the open burning of pruning wastes was written by Vicente, Estela D.;Figueiredo, Daniela;Goncalves, Catia;Vicente, Ana;Lopes, Isabel;Oliveira, Helena;Alves, Celia A.. And the article was included in Air Quality, Atmosphere & Health in 2022.Reference of 620-92-8 The following contents are mentioned in the article:

Burning vegetative debris is a worldwide long-standing practice. The current study was designed to examine the cytotoxicity and mutagenicity of particulate matter with an aerodynamic diameter below 10 μm (PM10) released from the burning of pruning residues common in Portugal and other countries of the Mediterranean region. Field measurements were conducted to collect PM10 samples from open burning of vines, olive, willow and acacia pruning branches. To assess the cytotoxicity of the PM10 total organic extract, the A549 cell line, representative of the alveolar type II pneumocytes of the human lung, was used. The cytotoxicity was checked using two complementary methods: water-soluble tetrazolium (WST-8) test to evaluate the cell metabolic activity and lactate dehydrogenase (LDH) activity assay to assess the loss of cell membrane integrity. The mutagenicity of the PM10-bound polycyclic aromatic hydrocarbons (PAHs) was screened through the Ames test. PM10 organic extracts induced LDH release in a dose-dependent manner. Regarding the cellular metabolic activity, dose-dependency was lacking for the majority of the samples. Combined WST-8 and LDH data indicate that PM10 exposure induce a necrotic cell death pathway in which the cell membrane integrity is lost. Direct and indirect mutagenicity towards the TA98 Salmonella strain has been recorded for the PAH extracts of PM10 collected from combustion of vine and willow branches during the ignition/flaming combustion stage. Significant correlations were found between the cytotoxic responses (WST-8 and LDH) and the PM10 organic component. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Reference of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Reference of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Product specific thermal degradation kinetics of bisphenol F epoxy in inert and oxidative atmospheres using evolved gas analysis-mass spectrometry was written by Dwyer, Derek B.;Gallego, Nidia C.;Niedziela, Jennifer L.;Kapsimalis, Roger J.;Duckworth, Douglas C.. And the article was included in Journal of Analytical and Applied Pyrolysis in 2022.Reference of 620-92-8 The following contents are mentioned in the article:

Knowledge of the degradation kinetics for polymer materials is important for understanding thermal stability. Here, evolved gas anal.-mass spectrometry and pyrolysis gas-chromatog.-mass spectrometry were evaluated for the potential to deliver addnl. insight into thermal degradation kinetics of diglycidal ether of bisphenol F (DGEBF) epoxy thermoset under inert and oxidative atmospheres. Degradation products of selected precursor ions were evaluated for their uniqueness to the specific precursor using extracted ion thermographs. Unique mass peaks, solely attributed to a single reaction pathway of a specific product, were determined from extracted ion thermographs and used to determine both activation energy (E_a) and pre-exponential factors for the specific primary reaction pathways. These primary reaction pathways for DGEBF epoxy degradation were then evaluated in the context of transition state theory (TST) and related transition state enthalpies (ΔH‡) and entropies (ΔS‡) of activation to further elucidate the degradation process. It was determined under pyrolysis conditions, as suggested by the E_a, the formation of bisphenol F monomer was the rate-limiting step toward the formation of xanthene and phenol. In contrast, under thermo-oxidative conditions, reactions involving oxygen containing species were identified as the rate-limiting step for all observed products based on the large neg. ΔS‡ calculated from TST. This work demonstrates a powerful combination of technique and theory that can provide new insight into the degradation of polymer materials. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Reference of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts was written by Abellan, Alicia;Mensink-Bout, Sara M.;Garcia-Esteban, Raquel;Beneito, Andrea;Chatzi, Leda;Duarte-Salles, Talita;Fernandez, Mariana F.;Garcia-Aymerich, Judith;Granum, Berit;Iniguez, Carmen;Jaddoe, Vincent W. V.;Kannan, Kurunthachalam;Lertxundi, Aitana;Lopez-Espinosa, Maria-Jose;Philippat, Claire;Sakhi, Amrit K.;Santos, Susana;Siroux, Valerie;Sunyer, Jordi;Trasande, Leonardo;Vafeiadi, Marina;Vela-Soria, Fernando;Yang, Tiffany C.;Zabaleta, Carlos;Vrijheid, Martine;Duijts, Liesbeth;Casas, Maribel. And the article was included in Environment International in 2022.Related Products of 620-92-8 The following contents are mentioned in the article:

In utero exposure to bisphenols, widely used in consumer products, may alter lung development and increase the risk of respiratory morbidity in the offspring. However, evidence is scarce and mostly focused on bisphenol A (BPA) only. To examine the associations of in utero exposure to BPA, bisphenol F (BPF), and bisphenol S (BPS) with asthma, wheeze, and lung function in school-age children, and whether these associations differ by sex. We included 3,007 mother-child pairs from eight European birth cohorts. Bisphenol concentrations were determined in maternal urine samples collected during pregnancy (1999-2010). Between 7 and 11 years of age, current asthma and wheeze were assessed from questionnaires and lung function by spirometry. Wheezing patterns were constructed from questionnaires from early to mid-childhood. We performed adjusted random-effects meta-anal. on individual participant data. Exposure to BPA was prevalent with 90% of maternal samples containing concentrations above detection limits. BPF and BPS were found in 27% and 49% of samples. In utero exposure to BPA was associated with higher odds of current asthma (OR = 1.13, 95% CI = 1.01, 1.27) and wheeze (OR = 1.14, 95% CI = 1.01, 1.30) (p-interaction sex = 0.01) among girls, but not with wheezing patterns nor lung function neither in overall nor among boys. We observed inconsistent associations of BPF and BPS with the respiratory outcomes assessed in overall and sex-stratified analyses. This study suggests that in utero BPA exposure may be associated with higher odds of asthma and wheeze among school-age girls. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Related Products of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pharmacokinetics and toxicity evaluation following oral exposure to bisphenol F was written by Lee, Somin;An, Kyu Sup;Kim, Hye Jin;Noh, Hye Jin;Lee, JaeWon;Lee, Jiho;Song, Kyung Seuk;Chae, Chanhee;Ryu, Hyeon Yeol. And the article was included in Archives of Toxicology in 2022.COA of Formula: C13H12O2 The following contents are mentioned in the article:

Bisphenol F is a substitute material for bisphenol A and is widely used in household products as a raw material for polycarbonate resin, epoxy resin, and plastic reinforcement. It is known to be mainly used in food containers, thermal paper for receipts, and coatings for water pipes. In some countries, bisphenol F has been detected in drinking water and human urine samples. However, due to the lack of safety evaluation data on bisphenol F, it is difficult to establish appropriate guidelines for the proper use of the substance, and social anxiety is increasing accordingly. This study investigated the use, exposure route, and distribution flow of bisphenol F, a household chem. To determine the no-observed-adverse-effect level (NOAEL) and target organ of bisphenol F after exposure, a single-dose oral toxicity, dose-range finding (28 day oral), repeated dose toxicity (90 day oral), and genotoxicity (reverse mutation, chromosomal abnormality, in vivo micronucleus test) tests were performed. The pharmacokinetic profile was also obtained. The test results are as follows: in the pharmacokinetic study, it was confirmed that single oral exposure to BPF resulted in systemic exposure; in single oral dose toxicity test, the approx. LD was found to be 4000 mg/kg and confusion and convulsion was shown in the test animals; NOAEL was determined to be 2 mg/kg/day for male and 5 mg/kg/day for female, and the no-observed-effect level (NOEL) was determined to be 2 mg/kg/day for males and 1 mg/kg/day for females, and the target organ was the small intestine; genotoxicity tests confirmed that BPF does not induce genotoxicity. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8COA of Formula: C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.COA of Formula: C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts