Category: 620-92-8

Environmental level of bisphenol F induced reproductive toxicity toward zebrafish was written by Mu, Xiyan;Qi, Suzhen;Liu, Jia;Wang, Hui;Yuan, Lilai;Qian, Le;Li, Tiejun;Huang, Ying;Wang, Chengju;Guo, Yuanming;Li, Yingren. And the article was included in Science of the Total Environment in 2022.Reference of 620-92-8 The following contents are mentioned in the article:

Bisphenol F (BPF), as an important bisphenol A substitute, is being increasingly used for industrial production Here we performed large scale fecundity test for zebrafish that are continuous exposed to environmental levels of BPF (0.5, 5 and 50μg/L) from embryonic stage, and identified suppressed spawning capacity of females and reduced fertility rate of males in adulthood. Although pathol. change is only observed in female gonads, the transcriptional change in the hypothalamic-pituitary-gonad axis genes occurred in the gonads of both female and male fish at 150 days post-exposure. F1 generation embryos showed abnormal developmental outcomes including decreased heart rate, reduced body length, and inhibition of spontaneous movement after parental exposure to BPF. RNA-sequencing showed that the genes involved in skeletal/cardiac muscle development were significantly altered in F1 embryos spawned by BPF-treated zebrafish. The advanced pathway anal. showed that cancer and tumor formation were the most enriched pathways in the offspring of 0.5 and 5.0μg/L groups; organismal development and cardiovascular system development were mainly affected after parental exposure to 50μg/L of BPF; these changes were mediated by several involved regulators such as GATA4, MYF6, and MEF2C. These findings confirmed that long-term exposure to BPF at environment relevant concentration would result in reproductive toxicity among zebrafish indicating the urgent demand for the control of BPA substitutes. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Reference of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 620-92-8

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Associations of bisphenol exposure with the risk of gestational diabetes mellitus: a nested case-control study in Guangxi, China was written by Tang, Peng;Liang, Jun;Liao, Qian;Huang, Huishen;Guo, Xiaojing;Lin, Mengrui;Liu, Bihu;Wei, Bincai;Zeng, Xiaoyun;Liu, Shun;Huang, Dongping;Qiu, Xiaoqiang. And the article was included in Environmental Science and Pollution Research.Synthetic Route of C13H12O2 The following contents are mentioned in the article:

A growing number of epidemiol. studies have estimated the associations between endocrine-disrupting chems. and gestational diabetes mellitus (GDM). However, reports on the association between bisphenol A (BPA) substitutes and GDM are limited. This investigation aimed to explore the associations of maternal serum BPA, bisphenol B (BPB), bisphenol F (BPF), bisphenol S (BPS), and tetrabromobisphenol A (TBBPA) with the risk of GDM. A nested case-control study was performed among 500 pregnant women. In conditional logistic regression models, the OR for BPS was significantly increased in the medium exposure groups (OR = 1.77; 95% CI: 1.01, 3.13) compared with the reference group, while BPA (OR: 0.38, 95%CI: 0.29, 0.50) and TBBPA (OR: 0.67, 95%CI: 0.54, 0.85) were neg. associated with the risk of GDM. In the Bayesian kernel machine regression (BKMR) anal., the joint effect of bisphenols was pos. associated with the risk of GDM. BPS showed pos. relationship, while BPA and TBBPA showed neg. relationship, resp. The quantile g-computation revealed a statistically significant and neg. joint effect of the five bisphenols on the risk of GDM (OR: 0.57; 95% CI: 0.46, 0.72) with BPA (70.2%), TBBPA (21.3%), and BPB (8.5%) had pos. contribution to the overall effect. These findings suggested that BPS had a pos. effect on the risk of GDM, while BPA and TBBPA had neg. effect on the risk of GDM. Moreover, exposure to the mixture of the five bisphenols was neg. associated with the risk of GDM. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Synthetic Route of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Synthetic Route of C13H12O2

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Rapid and reagent-free bioassay using autobioluminescent yeasts to detect agonistic and antagonistic activities of bisphenols against rat androgen receptor and progesterone receptor was written by Huang, Yuan;Zhang, Wei;Zhang, Chengdong;Cui, Na;Xiao, Zhiming;Wang, Ruiguo;Su, Xiaoou. And the article was included in Journal of Steroid Biochemistry and Molecular Biology in 2022.Safety of 4,4′-Methylenediphenol The following contents are mentioned in the article:

Bisphenol A (BPA) and its analogs have been classified as endocrine disruptors via binding to nuclear receptors. Two novel bioassays, BLYrARS and BLYrPRS, were developed for rapid detection of agonistic and antagonistic activities of BPA and five of its analogs binding rat androgen receptor (rAR) and rat progesterone receptor (rPR). The reporter bioassay was based on two autonomously bioluminescent strains of the yeast Saccharomyces cerevisiae, recombined with a bacterial luciferase reporter gene cassette (lux) that can produce autofluorescence, regulated by the corresponding hormone response element acting as the responsive promoter. The bioluminescent signal is autonomous and continuous without cell lysis or addition of exogenous reagents. The AR agonist R1881 could be detected at 4 h with a half-maximal effective concentration (EC50) of ∼9.4 nM. The PR agonist progesterone could be determined at 4 h with an EC50 of ∼2.74 nM. None of the sixteen bisphenols presented agonistic activities against rAR and rPR. However, thirteen BPs were rAR antagonists and eleven BPs acted as rPR antagonists with different potency. The BLYrARS and BLYrPRS bioassay characterized by automated signal acquisition without addnl. manipulations or cost can be applied for simple and rapid detection of agonistic and antagonistic activities of BPs and other compounds acting as agonists or antagonists of rAR and rPR. Based on data derived by use of this bioassay endocrine-disrupting activities of some BPA analogs are more potent than BPA. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Safety of 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Safety of 4,4′-Methylenediphenol

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Quantum Chemical Calculation and Evaluation of Partition Coefficients for Classical and Emerging Environmentally Relevant Organic Compounds was written by Salthammer, Tunga;Grimme, Stefan;Stahn, Marcel;Hohm, Uwe;Palm, Wolf-Ulrich. And the article was included in Environmental Science & Technology in 2022.COA of Formula: C13H12O2 The following contents are mentioned in the article:

Octanol/water (K_OW), octanol/air (K_OA), and hexadecane/air (K_HdA) partition coefficients are calculated for 67 organic compounds of environmental concern using computational chem. The extended CRENSO workflow applied here includes the calculation of extensive conformer ensembles with semiempirical methods and refinement through d. functional theory, taking into account solvation models, especially COSMO-RS, and thermostatistical contributions. This approach is particularly advantageous for describing large and nonrigid mols. With regard to K_OW and K_HdA, one can refer to many exptl. data from direct and indirect measurement methods, and very good matches with results from our quantum chem. workflow are evident. In the case of the K_OA values, however, good matches are only obtained for the exptl. determined values. Larger systematic deviations between data computed here and available, nonexperimental quant. structure-activity relationship literature data occur in particular for phthalic acid esters and organophosphate esters. From a critical anal. of the coefficients calculated in this work and comparison with available literature data, we conclude that the presented quantum chem. composite approach is the most powerful so far for calculating reliable partition coefficients because all phys. contributions to the conformational free energy are considered and the structure ensembles for the two phases are generated independently and consistently. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8COA of Formula: C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.COA of Formula: C13H12O2

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Comparing the effects of bisphenol A, C, and F on bovine theca cells in vitro was written by Tyner, Miles D. W.;Maloney, Madeline O.;Kelley, Brendan J. B.;Combelles, Catherine M. H.. And the article was included in Reproductive Toxicology in 2022.SDS of cas: 620-92-8 The following contents are mentioned in the article:

Endocrine disrupting chems. (EDCs) target aspects of hormone activity. Tightly coordinated crosstalk between two somatic cells of the ovary, granulosa and theca cells, governs steroid hormone production and plays a critical role in reproduction It is thus pertinent to understand the impact of EDCs on granulosa and theca cells. Bisphenol A (BPA), a well-known EDC, is widely used in the manufacturing of consumer products with humans routinely exposed. Strong evidence of the adverse effects of BPA on the female reproductive system has emerged and as a result, manufacturers have begun replacing BPA with other bisphenols, such as BPC and BPF. The safety of these analogs is currently unclear and should be investigated independently. Although much is known about the impact of BPA on granulosa cells, similar study of theca cells has been neglected. Further, there is a lack of studies on the impact of BPC and BPF on the female reproductive system. To fill these gaps, the present study compared the effect of BPA, BPC, and BPF on the viability and steroid production of theca cells from bovine, a clin. relevant model for human reproduction We show that BPC is more detrimental to theca cell viability and progesterone production compared to BPA. Surprisingly, we also found that BPF induces an increase in progesterone production compared to a decrease with BPA and BPC. To determine safety for the reproductive system, we conclude that a major shift away from BPA to bisphenol analogs should be investigated more thoroughly. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8SDS of cas: 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 620-92-8

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Novel nanohybrids for effervescence enhanced magnetic solid-phase microextraction of wide-polarity organic pollutants in roasted meat samples was written by Liu, Tingting;AgyeKum, Evans;Ma, Sai;Ye, Hanzhang;Li, Jiani;Gao, Ming;Ni, Min;Zhang, Xiaofan;Wang, Xuedong. And the article was included in Journal of Separation Science in 2021.Synthetic Route of C13H12O2 The following contents are mentioned in the article:

To simultaneously and efficiently extract pollutants with differential polarities, we herein fabricated and characterized a multifunctional nanocomposite. The novel nanohybrids used NiFe2O4 as magnetic cores, and NH2-MIL-101(Al), β-cyclodextrin and graphene oxide as functional components combined with magnetic cores. With the aid of graphene oxides large π-conjugated system, NH2-MIL-101(Al)s strong adsorption to moderately/strongly polar chems., and β-cyclodextrins specific recognition effect, the nanohybrids realized synergistically efficient extraction of polyaromatic hydrocarbons and bisphenols with a logKow range of 3-6. Combined with acidic and alk. sources, the nanohybrids-based effervescent tablets were prepared Based on effervescent reaction-enhanced nanohybrids-based efficient adsorption/extraction and high performance liquid chromatog. and fluorescence detection, we successfully developed an excellent microextraction method for the simultaneous determination of both polyaromatic hydrocarbons and bisphenols in roasted meat samples. Several important variables were optimized as follows: Na2CO3 and tartaric acid as acidic and alk. sources, 900μLof the mixed solvent (acetone and hexane at 2:1 by volume/volume) as the eluent, 5 min of elution time. Under optimized conditions, the novel method gave low limits of detection (0.07-0.30μg kg-1), satisfactory recoveries (86.9-103.9%), and high precision (relative standard deviations of 1.9-6.7%) in roasted lamb, beef, pork, chicken, and sausage samples. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Synthetic Route of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C13H12O2

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Alcohol – Wikipedia,
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Transcriptome changes and potential immunotoxicity analysis in RAW264.7 macrophages caused by bisphenol F was written by Chen, Huiling;Zhang, Yanchao;Li, Xing;Zhang, Wei;He, Haoqi;Du, Bohai;Li, Tianlan;Tang, Huanwen;Liu, Yungang;Li, Li;Shi, Ming. And the article was included in Frontiers in Pharmacology in 2022.Formula: C13H12O2 The following contents are mentioned in the article:

As a viable substitute for bisphenol A (BPA), BPF has been widely used in the plastic industry and daily consumer goods, resulting in its detection in humans at a comparable concentration Evidence reveals that BPF and BPA may have similar toxic effects due to their similar structures. However, there is less information about BPF and its latent implications on the immune system, which is associated with many disorders. In this study, the in vitro toxicity of BPF on RAW264.7 macrophages was explored. The cells were treated with different concentrations of BPF (5, 10, 20, 50, 100, and 200 μM), the cell viability and apoptosis were detected, the gene expression profile was analyzed by wholetranscriptome sequencing, and the mRNA levels were detected by qRT-PCR. The results showed a high concentration of BPF could significantly reduce the survival rate of RAW264.7 macrophages. Although the medium concentration (20-50 μM) of BPF seemed to have no impact on the cell activity of macrophages, it caused the occurrence of apoptosis. The results of differential transcription showed that compared with the control group, 121 genes were upregulated and 82 genes were downregulated in the BPF group. The significantly changed gene functions were mainly concentrated in cell cycle, phagosome, lysosome, and antigen processing and presentation. These findings provide valuable information for correctly understanding the immunotoxicity risk of BPF and may help to improve the hazard identification of bisphenol compounds This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Formula: C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C13H12O2

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Study of eighteen typical bisphenol analogues as agonist or antagonist for androgen and glucocorticoid at sub-micromolar concentrations in vitro was written by Ma, Mengmeng;Zhao, Wenyu;Tan, Tianjiao;Hitabatuma, Aloys;Wang, Peilong;Wang, Ruiguo;Su, Xiaoou. And the article was included in Science of the Total Environment in 2022.Related Products of 620-92-8 The following contents are mentioned in the article:

Bisphenol A and its substitutions are commonly used to manufacture epoxy resins, plastic materials and different kinds of daily necessities. In this process, a large number of bisphenol analogs (BPs) are continuously released directly/indirectly into the environment. Through the chain of environment-feed-farmed-animals-livestock and poultry products, BPs present the low concentration but chronic exposure for surroundings and environment. In addition, BPs have been revealed by extensive studies as emerging endocrine disruptors, whose effects on androgens/glucocorticoids have rarely been mentioned in previous reports. The (anta-) agonist/antagonist properties of 18 classic BPs were investigated in vitro: We assessed the cytotoxicity and examined the luciferase induction values of BPs in MDA-kb2 cells, incubated single or co-incubated with dihydrotestosterone (DHT), dexamethasone, flutamide and RU486 for 24 h. From the concentration of 10-10 to 10-5 M, BPs had negligible cytotoxicity for MDA-kb2 cells, except for 4,4-(9-Fluorenylidene)diphenol with the IC50 1.32 μM. All 18 BPs had the response to androgen/glucocorticoid receptors (AR/GR). BPs at nanomolar and trace concentrations are agonists, while BPs at micromolar and higher concentrations are antagonists. Mol. docking showed that BPs interact with AR/GR through hydrophobic bonds, hydrogen bonds, T-type π-stacking and water-bridge. These exptl. data demonstrate the universality of the endocrine-disrupting effects of BPs and suggest the urgency of paying attention to the usages of BPs. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Related Products of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Related Products of 620-92-8

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Exposure of men and lactating women to environmental phenols, phthalates, and DINCH was written by Runkel, Agneta A.;Mazej, Darja;Snoj Tratnik, Janja;Tkalec, Ziga;Kosjek, Tina;Horvat, Milena. And the article was included in Chemosphere in 2022.Synthetic Route of C13H12O2 The following contents are mentioned in the article:

Phthalates and 1,2-Cyclohexane dicarboxylic acid diisononyl ester (DINCH), bisphenols (BPs), parabens (PBs), and triclosan (TCS) are high-production-volume chems. of pseudo-persistence that are concerning for the environment and human health. This study aims to assess the exposure to 10 phthalates, DINCH, and environmental phenols (3 BPs, 7 PBs, and TCS) of Slovenian men (n = 548) and lactating primiparous women (n = 536). We observed urinary concentrations comparable to studies from other countries and significant differences among the sub-populations. In our study, men had significantly higher levels of phthalates, DINCH, and BPs, whereas the concentrations of PBs in urine were significantly higher in women. The most significant determinant of exposure was the area of residence and the year of sampling (2008-2014) that mirrors trends in the market. Participants from urban or industrialized sampling locations had higher levels of almost all monitored analytes compared to rural locations. In an attempt to assess the risk of the population, hazard quotient (HQ) values were calculated for individual compounds and the chem. mixture Individual analytes do not seem to pose a risk to the studied population at current exposure levels, whereas the HQ value of the chem. mixture is near the threshold of 1 which would indicate a higher risk. We conclude that greater emphasis on the risk resulting from cumulative exposure to chem. mixtures and addnl. studies are needed to estimate the exposure of susceptible populations, such as children. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Synthetic Route of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C13H12O2

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Enhanced visible-light driven photocatalytic degradation of bisphenol A by tuning electronic structure of Bi/BiOBr was written by Wang, Qiao;Cao, Yiting;Yu, Yuemi;Zhang, Chao;Huang, Jiahao;Liu, Guoshuai;Zhang, Xuedong;Wang, Zhihong;Ozgun, Hale;Ersahin, Mustafa Evren;Wang, Wei. And the article was included in Chemosphere in 2022.Computed Properties of C13H12O2 The following contents are mentioned in the article:

Visible-light (VL) photocatalysis has been regarded as an intriguing technol. for the control of persistent environmental pollutants. In this study, the novel homogeneous Co doped-Bi/BiOBr nanocomposites (CB-X) were prepared via a facile one-step hydrothermal method, featured with a uniform 0D Bi nanodots distribution on 2D Co-doped BiOBr nanosheets, and the photocatalytic performance was evaluated by decomposing the BPA as a prototype contaminant. The degradation experiment indicated that the optimal CB-2 nanocomposite exhibited the best photocatalytic activity with a 94% removal efficiency of BPA under the VL irradiation of 30 min; And the corresponding apparent rate constant (k) was as high as 0.107 min-1, which was 10.7 times greater than that of Bi/BiOBr (0.010 min^-1). Benefiting from the modulation effect of Co-doping on the intrinsic electron configuration of Bi/BiOBr, the elevated VL adsorption capacity and accelerated h⁺/e^– pairs separation rate were achieved, which were evidenced by photoluminescence (PL) spectroscopy, photo-electrochem. measurements and d. functional theory (DFT) calculation Moreover, the major reactive species in CB-X/VL system were uncovered to be •O-2 and ¹O², whereas •OH and h⁺ presented a secondary contribution in the BPA elimination. Finally, the possible photocatalytic mechanism involved in CB-X nanocomposites and BPA degradation pathways were proposed on the basis of the various intermediates and products detected by LC-MS/MS. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Computed Properties of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Computed Properties of C13H12O2

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