Category: 620-92-8

Binding and activity of bisphenol analogues to human peroxisome proliferator-activated receptor β/δ was written by Li, Chuan-Hai;Zhang, Dong-Hui;Jiang, Li-Dan;Qi, Yuan;Guo, Liang-Hong. And the article was included in Ecotoxicology and Environmental Safety in 2021.Reference of 620-92-8 The following contents are mentioned in the article:

Several studies have indicated metabolic function disruption effects of bisphenol analogs through peroxisome proliferator-activated receptor (PPAR) alpha and gamma pathways. In the present study, we found for the first time that PPARβ/δ might be a novel cellular target of bisphenol analogs. By using the fluorescence competitive binding assay, we found seven bisphenol analogs could bind to PPARβ/δ directly, among which tetrabromobisphenol A (TBBPA, 18.38-fold) and tetrachlorobisphenol A (TCBPA, 12.06-fold) exhibited stronger binding affinity than bisphenol A (BPA). In PPARβ/δ-mediated luciferase reporter gene assay, the seven bisphenol analogs showed transcriptional activity toward PPARβ/δ. Bisphenol AF (BPAF), bisphenol F (BPF) and bisphenol B (BPB) even showed higher transcriptional activity than BPA, while TBBPA and TCBPA showed comparable activity with BPA. Moreover, in human liver HL-7702 cells, the bisphenol analogs promoted the expression of two PPARβ/δ target genes PDK4 and ANGPTL4. Mol. docking simulation indicated the binding potency of bisphenol analogs to PPARβ/δ might depend on halogenation and hydrophobicity and the transcriptional activity might depend on their binding affinity and hydrogen bond interactions. Overall, the PPARβ/δ pathway may provide a new mechanism for the metabolic function disruption of bisphenol analogs, and TBBPA and TCBPA might exert higher metabolic disruption effects than BPA via PPARβ/δ pathway. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Reference of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of bisphenol A and bisphenol F on porcine uterus contractility was written by Zygmuntowicz, Aleksandra;Markiewicz, Wlodzimierz;Grabowski, Tomasz;Jaroszewski, Jerzy. And the article was included in Journal of Veterinary Research in 2022.HPLC of Formula: 620-92-8 The following contents are mentioned in the article:

Bisphenols, as endocrine disruptors, may cause a wide range of health problems in humans, but so far, not all of them have been confirmed in animals, including pigs. Since animals are also exposed to bisphenols, we hypothesised that these substances may have an effect on uterine contractility in pigs. Therefore, the aim of the study was to investigate the effect of the most-used bisphenol, bisphenol A (BPA), and a selected analog, bisphenol F (BPF), on the contractile activity of the pig uterus. The investigation utilized smooth muscles from immature pigs (n = 6), cyclic pigs on days 12-14 of the oestrous cycle (n = 6) or early pregnant pigs on days 12-16 of pregnancy (n = 6). Strips of the myometrium were exposed to BPA and BPF at concentrations of 10-13-10-1 M. Smooth muscle contractility was determined with equipment for measuring isometric contractions. BPA caused a significant decrease in contraction amplitude, and frequency and in myometrial tension in all groups examined BPF caused a decrease in the amplitude and frequency of contractions in all groups and in myometrial tension in the early pregnant group. The obtained results indicate that both BPA and BPF relaxed the porcine myometrium, but these changes, especially in the amplitude and frequency of contractions, were more evident after BPF treatment. The extent of relaxation is dependent on the physiol. status of the animals. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8HPLC of Formula: 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 620-92-8

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tartaric Acid-Assisted Synthesis of Well-Dispersed Ni Nanoparticles Supported on Hydroxyapatite for Efficient Phenol Hydrogenation was written by Zhu, Longfei;Ye, Sen;Zhu, Jiazheng;Duan, Chengjie;Li, Kun;He, Guangke;Liu, Xiang. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

Developing highly active nonnoble-metal-based heterogeneous catalysts for selective hydrogenation is a long-sought goal due to the scarcity and high price of noble metals. Herein, well-dispersed and small-sized Ni nanoparticles (NPs) supported on hydroxyapatite (Ni-TA/HAP) were prepared using a simple tartaric acid (TA)-assisted impregnation method, which is based on the coupling interaction of strong electrostatic adsorption between the HAP and TA and reactive metal-ligand chelation between Ni and TA. Under mild conditions (e.g., 1 mol % Ni, 3 bar H₂ at 80°C), the as-synthesized Ni-TA/HAP exhibited excellent activity and selectivity (>99%) for the efficient hydrogenation of phenolic compounds to the corresponding cyclohexanols, as well as the controlled partial hydrogenation of N-heteroarenes. Characterization results revealed that TA addition could promote a better dispersion of Ni species and inhibit the aggregation of Ni NPs during the fabrication of the Ni-TA/HAP catalyst. An optimal TA dosage (n_TA/n_Ni = 0.5) as well as a low Ni loading (1.0 weight %) coconstructed the favorable microstructure of the well-dispersed Ni nanoparticles as the catalytic center. The hydrogenation was boosted by small-sized Ni nanoparticles with a high ability for H₂ activation and HAP with both base and acid sites for appreciating phenol absorption. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Category: alcohols-buliding-blocks).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of monomer rigidity on microstructures and properties of novel polyamide thin-film composite membranes prepared through interfacial polymerization for pervaporation dehydration was written by Lee, Jen-Yu;Huang, Ting-Yi;Belle Marie Yap Ang, Micah;Huang, Shu-Hsien;Tsai, Hui-An;Jeng, Ru-Jong. And the article was included in Journal of Membrane Science in 2022.COA of Formula: C13H12O2 The following contents are mentioned in the article:

In this study, thin-film composite (TFC) membranes were produced through interfacial polymerization between diamine and trimesoyl chloride on a polyetherimide (PEI) support. The TFC membranes with different diamines, 4,4′-((propane-2,2-diylbis(4,1-phenylene))bis(oxy))dianiline (BAPP), 4,4′-((methylene bis(4,1-phenylene))bis(oxy))dianiline (MPDA), and 6,6′-bis(4-aminopheoxy)-4,4,4′,4′,7,7′-hexamethyl-2,2′-spirobichroman (SBC), were denoted as TFC_PEI/B, TFC_PEI/M, and TFC_PEI/S, resp. These three aromatic diamines have different central moieties that affect reactivity during the interfacial polymerization reaction. The crosslinking degree of the TFC membranes increased in the following order: TFC_PEI/S < TFC_PEI/M < TFC_PEI/B. Positron annihilation lifetime spectroscopy anal. also unveils that TFC_PEI/B had the lowest free volume These results reveal that the appropriate steric structure of the diamine mols. can create less compact structure without impeding the formation of the crosslinked polyamide selective layer. Moreover, the TFC_PEI/B membrane had a flux of approx. 705±46 g•m^-2 h^-1, and the water concentration in the permeate was maintained at approx. 99.8% at 25° during the 70% isopropanol solution dehydration. Furthermore, the TFC_PEI/B membrane can be operated under broad operating conditions and possesses high long-term stability. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8COA of Formula: C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cellulose@PO₃H: As an Efficient and Recyclable Ionic Liquid-Enabled Catalytic Greener Approach to One-Step Synthesis of Flavoring Ketones was written by Naikwadi, Dhanaji R.;Mehra, Sanjay;Ravi, Krishnan;Kumar, Arvind;Biradar, Ankush V.. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.SDS of cas: 620-92-8 The following contents are mentioned in the article:

Cellulose (CL) is widely available from the renewable biomaterial on the earth with a large number of hydroxyl functionalities on its surface. The appropriate modification of these functionalities results in the acidic and basic nature of the surface. In this work, the phosphoric group-functionalized CL ionic liquid (IL) has been successfully synthesized through phosphorylation of the CL surface. The phosphorus functionalization of CL was carried out in two steps; first, synthesis of IL (3, 5-lutidinium Me phosphate [Lut][(MeO)(H)PO₂]), followed by phosphorylation of cellulose (CLP-IL). Subsequently, CLP-IL has been characterized by various physicochem. techniques. Significant changes in the activity were observed, with marginal changes in the structural and morphol. properties of the native CL. CLP-IL has been utilized to synthesize industrially important flavoring ketones (FKs) via one-step alkylation-decarboxylation of active methylene compounds with substituted benzyl alcs. and halides. The functionalized CL IL could be quickly recovered in water and recycled at least five times without losing the catalytic activity. The optimized protocol has been successfully employed for the synthesis of FKs with an excellent conversion of substituted benzyl carbons in the range (90-100%) with 70-90% isolated yield of desired market valuable products. Furthermore, the mechanism was established by identifying the intermediates by physicochem. methods. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8SDS of cas: 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.SDS of cas: 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bisphenol S promotes the progression of prostate cancer by regulating the expression of COL1A1 and COL1A2 was written by Liu, Shengdi;He, Bin;Li, Hua. And the article was included in Toxicology in 2022.Reference of 620-92-8 The following contents are mentioned in the article:

In recent decades, Bisphenol S (BPS), which was once thought to be an alternative for Bisphenol A (BPA) has been extensively used in personal care products, paper products, and food. However, there is an unclear association between bisphenol and tumors. Therefore, clarifying this relationship is critical for disease prevention and treatment. This work found a novel method that predicts a correlation between bisphenol interactive genes and tumors. First, the transcriptome profile and interactive genes of bisphenol were obtained from The Cancer Genome Atlas and Genotype-Tissue Expression, Comparative Toxicol. Genomics, and PharmMapper databases. Gene Ontol. and Kyoto Encyclopedia of Genes and Genomes anal. revealed that interactive genes are primarily enriched in prostate cancer. Gene targeted prediction and gene set variation anal. confirmed that bisphenol exerts potential effects on prostate cancer. The operating characteristic curves and survival anal. uncovered the role of COL1A1 and COL1A2 in predicting the prognosis of prostate cancer. Cell counting kit-8 assay revealed that BPS-treated cells could remarkably promote cell proliferation capacity in both PC-3 and LNCap cells. In addition, wound healing and transwell assays demonstrated that BPS-treated cells could significantly promote the cell invasion capacity of prostate cells. Notably, two key genes, i.e., COL1A1 and COL1A2 were significantly upregulated with BPS-treated PC-3 and LNCap cells. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Reference of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Co-exposure and health risks of several typical endocrine disrupting chemicals in general population in eastern China was written by Wei, Xianping;Hu, Yu;Zhu, Qingqing;Gao, Jia;Liao, Chunyang;Jiang, Guibin. And the article was included in Environmental Research in 2022.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

Human exposure to endocrine disrupting chems. (EDCs) is a health concern due to their wide use and interference with the human endocrine system. Parabens, bisphenols, benzophenones, triclosan (TCC), triclocarban (TCS), and tetrabromobisphenol-A (TBBPA) and its derivatives tetrachlorobisphenol-A (TCBPA) and tetrabromobisphenol-S (TBBPS), are typical EDCs that are frequently detected in environmental and human samples. However, only a few studies have assessed the co-exposure of these chems. in humans. In this study, urine samples were collected from the general population in the city of Wuxi (n = 121) and a county, Taishun (n = 120), eastern China, and analyzed for these EDCs. Parabens, bisphenols, TCS, and benzophenones were frequently detected in urine, whereas TBBPA and its derivatives were not detected. The geometric mean concentrations of parabens, bisphenols, and benzophenones in urine from the Wuxi population were 25.7, 2.45, and 2.34 ng/mL, resp., which were substantially higher than those from the Taishun population (17.2, 1.70, and 2.65 ng/mL). These results suggest an urban-rural difference in urinary EDCs. The exposure risks to these EDCs were estimated based on the measured urinary concentrations and acceptable daily intakes (ADIs). Hazard quotient values for EDCs in humans from both locations were generally less than 1, indicating a low exposure risk of EDCs in these regions. Nonetheless, the health risks caused by co-exposure to such EDCs cannot be ignored. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Category: alcohols-buliding-blocks).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Non-target, suspect and target screening of chemicals of emerging concern in landfill leachates and groundwater in Guangzhou, South China was written by Han, Yu;Hu, Li-Xin;Liu, Ting;Liu, Jing;Wang, Yu-Qing;Zhao, Jia-Hui;Liu, You-Sheng;Zhao, Jian-Liang;Ying, Guang-Guo. And the article was included in Science of the Total Environment in 2022.Product Details of 620-92-8 The following contents are mentioned in the article:

Landfill sites have been regarded as a significant source of chems. of emerging concern (CECs) in groundwater. However, our understanding about the compositions of CECs in landfill leachate and adjacent groundwater is still very limited. Here we investigated the CECs in landfill leachates and groundwater of Guangzhou in South China by target, suspect and non-target anal. using high-resolution mass spectrometry (HRMS). A variety of CECs (n = 242), including pharmaceuticals (n = 64), pharmaceutical intermediates (n = 18), personal care products (n = 9), food additives (n = 18), industrial chems. (n = 82, e.g., flame retardants, plasticizers, antioxidants and catalysts), pesticides (n = 26), transformation products (n = 8) and other organic compounds (n = 17) were (tentatively) identified by non-target and suspect screening. 142 CECs were quantitated with target anal., and among them 37, 24 and 27 CECs were detected resp. in the raw leachate (272-1780μg/L), treated leachate (0.25-0.81μg/L) and groundwater (0.10-53.7μg/L). The CECs in the raw leachates were efficiently removed with the removal efficiencies greater than 88.7%. Acesulfame, bisphenol F and ketoprofen were the most abundant compounds in both treated leachate and groundwater. The CECs in groundwater was found most likely to be originated from the landfill sites. Our results highlight the importance of non-target screening in identifying CECs, and reveal the contamination risk of groundwater by landfill leachate. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Product Details of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Product Details of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Toxicity screening of bisphenol A replacement compounds: cytotoxicity and mRNA expression in LMH 3D spheroids was written by Sharin, Tasnia;Crump, Doug;O’Brien, Jason M.. And the article was included in Environmental Science and Pollution Research in 2022.Computed Properties of C13H12O2 The following contents are mentioned in the article:

Previously, we showed that the chicken LMH cell line cultured as 3D spheroids may be a suitable animal free alternative to primary chicken embryonic hepatocytes (CEH) for avian in vitro chem. screening. In this study, cytotoxicity and mRNA expression were determined in LMH 3D spheroids following exposure to bisphenol A (BPA), five BPA replacement compounds (BPF, TGSH, DD-70, BPAF, BPSIP), and 17βestradiol (E2). Results were compared to an earlier study that evaluated the same endpoints for these chems. in CEH. BPA and the replacement compounds had LC50 values ranging from 16.6 to 81.8μM; DD-70 and BPAF were the most cytotoxic replacements (LC50 = 17.23 ± 4.51 and 16.6 ± 4.78μM). TGSH and DD-70 modulated the greatest number of genes, although fewer than observed in CEH. Based on the expression of apovitellenin and vitellogenin, BPAF was the most estrogenic compound followed by BPF, BPSIP, and BPA. More estrogen-responsive genes were modulated in LMH spheroids compared to CEH. Concentration-dependent gene expression revealed that DD-70 and BPAF altered genes related to lipid and bile acid regulation. Overall, cytotoxicity and clustering of replacements based on gene expression profiles were similar between LMH spheroids and CEH. In addition to generating novel gene expression data for five BPA replacement compounds in an in vitro avian model, this research demonstrates that LMH spheroids may represent a useful animal free alternative for avian toxicity testing. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Computed Properties of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Computed Properties of C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Three-dimensional (3D) thermal controlled polymer for simplified dispersive liquid-liquid microextraction in phthalic acid easters detection of straw was written by Liu, Qian;Wei, Liulin;Chen, Xiaomei;Xu, Yidong;Gao, Xueyun;Zhao, Jingchan. And the article was included in Microchemical Journal in 2022.Product Details of 620-92-8 The following contents are mentioned in the article:

In this paper, a three-dimensional (3D) polyfunctional group and thermal controlled polymer p(POSS-co-DMAEMA) was prepared based on the chem. structure of the phthalic acid easters (PAEs) and applied as an extractant for dispersive liquid-liquid microextraction (DLLME) in combination with HPLC-UV. The polymer with good biocompatibility can be dispersed and aggregated by shaking and heating based on the thermal controlled properties without the assistance of instruments, which shortened the DLLME process as low as 5 min. The feasibility of the developed method was verified using 5 PAEs as targets in simulated water samples, which showed good precision (RSD%, 1.3-10.0, n = 3) and low detection limit (0.19-0.52 ng mL-1) under the optimal extraction conditions. This proposed method was successfully applied in analyzing four straws and good spiked recoveries over the range of 91.60-128.00% were obtained. Furthermore, mol. docking was employed to explore the mol. interactions and calculate binding energies between the polymer and organic pollutants, ensuring the synthesized polymer has a strong extraction ability for PAEs. The satisfied extraction efficiency can be attributed to the fact that the p(POSS-co-DMAEMA) is water-soluble at room temperature but hydrophobic at high temperature, and the high extraction ability can be achieved by the strong intermol. forces between the polymer and PAEs. The exptl. results suggest that the proposed method holds good promise for the trace anal. of PAEs. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Product Details of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts