Category: 620-92-8

Development and validation of a method for determination of 17 endocrine disrupting chemicals in milk, water, blood serum and feed by UHPLC-MS/MS was written by Di Marco Pisciottano, Ilaria;Albrizio, Stefania;Guadagnuolo, Grazia;Gallo, Pasquale. And the article was included in Food Additives & Contaminants, Part A in 2022.Quality Control of 4,4′-Methylenediphenol The following contents are mentioned in the article:

The concern for human exposure to bisphenol A (BPA) has led to the introduction of other bisphenols to be used as substitutes in industrial processes. These compounds show activity similar to BPA as endocrine disruptors and could be already widespread both in the environment and in food. To monitor their possible occurrence in the food chain, an anal. method based on affinity chromatog. clean-up and UHPLC coupled to tandem mass spectrometry detection was developed and inhouse validated according to European law, for simultaneous determination of 17 bisphenols in milk and blood serum from bovine and buffalo, in drinking water and in feed. The anal. performance parameters of the method for these matrixes were determined The results showed satisfactory precision in terms of relative standard deviation (3.3%-21.4%), overall good trueness as mean percentage recoveries (77.0%-119.4%), with the only exception of bisphenol PH and bisphenol S in milk and BPA diglycidyl ether in serum. The high specificity and sensitivity of the method allowed us to determine the analytes at very low concentrations, i.e., 0.01-1.0 ng/mL in water, 0.1-2.0 ng/mL in milk, 0.01-1.0 ng/g in blood serum and 1.0-10.0 ng/g in feed. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Quality Control of 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of 4,4′-Methylenediphenol

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Development of smart epoxy coating through click reaction using a vegetable oil was written by Ramezanpour, Javad;Ataei, Shahla;Khorasani, Saied Nouri. And the article was included in Progress in Organic Coatings in 2022.Electric Literature of C13H12O2 The following contents are mentioned in the article:

Two-component microcapsules of acrylated epoxidized soybean oil as a healing agent and trimethylolpropane tris(3-mercaptopropionate) as hardener, were encapsulated with the poly(Me methacrylate) shell by solvent evaporation method. The chem. structure and morphologies of the core/shell microcapsules were confirmed using Fourier-transform IR spectroscopy and Field emission SEM, resp. The thermal properties of the microcapsules were investigated through thermogravimetric anal. FE-SEM confirmed that both types of microcapsules have a spherical shape with an average diameter of approx. 6.2μm. The two-component microcapsules were included in epoxy resin, and the healing performance of the system was assessed. From Electrochem. impedance spectroscopy and salt spray test, the best self-healing performance was obtained for 0.5 wt% two-component microcapsules. For epoxy coatings containing 0.5 weight% of microcapsules, after five months of exposure under salt water 3.5%, no corrosion effect was observed on the epoxy coating, indicating that there are enough high-performance materials in the microcapsules to heal cracks and the click reaction has been a very effective reaction to create this healing resin. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Electric Literature of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Electric Literature of C13H12O2

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Effects of consumer products chemicals ingredients and their mixtures on the estrogen receptor/androgen receptor transcriptional activation was written by Lee, Handule;Park, Juyoung;Park, Kwangsik. And the article was included in Chemosphere in 2022.Recommanded Product: 620-92-8 The following contents are mentioned in the article:

Unlike the environmental pollutants or industrial chems., the chems. in consumer products may pose higher levels of risks, depending on how the chems. are used in the products and how humans interact with the products. Recently, endocrine disrupting chems. in cosmetics, personal care products, cleaners, sunscreens, and vinyl products were anal. quantified and many active chems. including phthalates, parabens and bisphenols were detected. This indicates a wide range of exposures from common products. In this study, 35 chems. known to be ingredients of consumer products were selected and screened for the transactivation of estrogen receptors and androgen receptors. From the results of individual chems., the activity of binary/ternary mixture prepared from the agonists for the ER transcription activity was measured, and compared to the predicted values obtained by the full logistic model. The measured and the predicted values were found to be very similar. This study may suggest that prediction of mixture activity by proper models would be one of the supportive tools for the risk assessment and sound regulation of chem. mixtures which have potential endocrine disrupting effects in consumer products. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Recommanded Product: 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 620-92-8

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Sex-specific changes in oxidative stress parameters and longevity produced by Bisphenol F and S compared to Bisphenol A in Drosophila melanogaster was written by Musachio, Elize Aparecida Santos;Poetini, Marcia Rosula;Janner, Dieniffer Espinosa;Meichtry, Luana Barreto;Poleto, Ketnne Hanna;Fernandes, Eliana Jardim;Guerra, Gustavo Petri;Prigol, Marina. And the article was included in Comparative Biochemistry and Physiology in 2022.COA of Formula: C13H12O2 The following contents are mentioned in the article:

Female and male Drosophila melanogaster were exposed sep. for seven days to Bisphenol A (BPA), Bisphenol F (BPF), and Bisphenol S (BPS) at concentrations of 0.25, 0.5, and 1 mM. We observed that males exposed to 0.5 and 1 mM BPS showed lower catalase (CAT) activity and higher superoxide dismutase (SOD) and reactive species (RS); CAT activity decreased for BPF 0.5 and 1 mM. Nevertheless, BPA 0.5 and 1 mM decreased CAT activity, increased RS and lipid peroxidation (LPO), and reduced mitochondrial viability. None of the bisphenols altered the cell viability of male flies, although BPA 0.5 and 1 mM reduced longevity. In female flies, BPA and BPS 0.5 and 1 mM increased RS and LPO levels and decreased CAT activity and glutathione-S-transferase (GST), which may have contributed to lower mitochondrial and cell viability. Furthermore, BPS decreased SOD activity at the 1 mM concentration, and BPA reduced the SOD activity at concentrations of 0.5 and 1 mM. In the BPF 1 mM group, there was a reduction in GST activity and an increase in RS and LPO levels. The toxicol. effects were different between sexes, and BPA was more harmful than BPF and BPS in male flies. Thus, our findings showed that females were more susceptible to oxidative cell damage when exposed to BPA and BPS than to BPF, and daily exposure to BPA and BPS at all concentrations reduced female longevity, as well as in BPF 1 mM. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8COA of Formula: C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C13H12O2

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Assessment of the impact of aquaculture facilities on transplanted mussels (Mytilus galloprovincialis): Integrating plasticizers and physiological analyses as a biomonitoring strategy was written by Rios-Fuster, Beatriz;Alomar, Carme;Capo, Xavier;Paniagua Gonzalez, Gema;Garcinuno Martinez, Rosa Maria;Soliz Rojas, Dulce Lucy;Silva, Monica;Fernandez Hernando, Pilar;Sole, Montserrat;Freitas, Rosa;Deudero, Salud. And the article was included in Journal of Hazardous Materials in 2022.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

The growing plastic production and its continuous use is a significant problem. In addition, aquaculture practices have experienced a considerable growth and plastic is widely used in these activities, hence plasticizers must be considered due to their potential ecotoxicol. impacts on species. Mussels placed inside an Integrated Multi-Trophic Aquaculture (IMTA) system and at two control locations were employed to quantify the ingestion of anthropogenic particles and associated chem. plasticizers, such as bisphenol A (BPA) jointly to bisphenol F (BPF) and bisphenol S (BPS), and phthalates represented by di-Et phthalate (DEP), di-Bu phthalate (DBP) and bis(2-ethylhexyl) phthalate (DEHP). In addition, some metabolism and oxidative stress related parameters were measured in mussels whole soft tissue. Anthropogenic particle ingestion of mussels increased over time at the three locations and the following order of abundance of pollutants was observed: BPA> BPF> DEHP> DBP> BPS> DEP. Even though no differences according to location were found for pollutants occurrence, time trends were evidenced for BPA and DEHP. On the other hand, a location effect was observed for biomarkers with highest values detected in mussels located at the vicinities of the aquaculture facility. In addition, a reduced detoxification activity was observed over time parallel to BPA decrease. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Category: alcohols-buliding-blocks).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Category: alcohols-buliding-blocks

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Occurrence, spatial distribution, and main source identification of ten bisphenol analogues in the dry season of the Pearl River, South China was written by Wang, Hao;Tang, Zhao;Liu, Ze-hua;Zeng, Feng;Zhang, Jun;Dang, Zhi. And the article was included in Environmental Science and Pollution Research in 2022.Safety of 4,4′-Methylenediphenol The following contents are mentioned in the article:

Bisphenol analogs (BPs) including bisphenol a (BPA) have been broadly utilized as industrial feedstocks and unavoidably discharged into water bodies. However, there is little published data on the occurrence, distribution, and environmental risks of other BPs in surface water. In this study, ten BPs besides BPA were analyzed in surface water from the Pearl River, South China. Among these detected BPs, BPA, bisphenol F (BPF), bisphenol AF (BPAF), and bisphenol S (BPS) were the most frequently detected compounds The median concentrations of the measured BPs were ranked in the order of BPA (34.9 ng/L) > BPS (24.8 ng/L) > BPAF (10.1 ng/L) > bisphenol F (BPF) (9.0 ng/L) > bisphenol B (BPB) (7.6 ng/L) > bisphenol C (BPC) (1.2 ng/L). Among them, BPA and BPS were predominant BPs, contributing 68% of the total ten BPs in surface water of the Pearl River. These results demonstrated that BPA and BPS were the most extensively utilized and manufactured BPs in this region. The source anal. of BPs suggested that the BPs may be originated from domestic wastewater, wastewater treatment plant (WWTP) effluent, and the leaching of microplastic in surface water of the Pearl River. The calculated BP-derived estrogenic activity exhibited low to medium risks in surface water, but their combined estrogenic effects with other endocrine disrupting compounds should not be ignored. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Safety of 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Safety of 4,4′-Methylenediphenol

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Non-radical mechanism and toxicity analysis of β-cyclodextrin functionalized biochar catalyzing the degradation of bisphenol A and its analogs by peroxydisulfate was written by Pei, Xuan-Yuan;Ren, Hong-Yu;Liu, Guo-Shuai;Cao, Guang-Li;Xie, Guo-Jun;Xing, De-Feng;Ren, Nan-Qi;Liu, Bing-Feng. And the article was included in Journal of Hazardous Materials in 2022.Application In Synthesis of 4,4′-Methylenediphenol The following contents are mentioned in the article:

Bisphenols (BPs) are distributed in worldwide as typical environmental hormones, which potentially harm the ecol. environment and human health. In this study, four BPs, i.e., bisphenol A, bisphenol F, bisphenol S, and bisphenol AF, were used as prototypes to identify the intrinsic differences in degradation mechanisms correlated with the mol. structures in peroxydisulfate (PDS)-based advanced oxidation processes (AOPs). Electron transfer was the main way of modified biochar to trigger the heterogenous catalysis of PDS, which can cause the degradation of BPs. Phenolic hydroxyl groups on bisphenol pollutants were considered as possible active sites, and the existence of substituents was the main reason for the differentiation in the degradation efficiency of various bisphenols. Results of ecotoxicity prediction showed that most intermediates produced by the degradation of BPs in the β-SB/PDS system, which was dominated by the electron transfer pathway, had a lower toxicity than the parent mols., while the toxicity of several ring cleavage intermediates was higher. This study presents a simple modification scheme for the conversion of biochar into functional catalysts and provides insights into the mechanism of heterogeneous catalytic degradation mediated by modified biochar as well as the degradation differences of bisphenol pollutants and their potential ecotoxicity. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Application In Synthesis of 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of 4,4′-Methylenediphenol

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Studies on nitrile substituted bisphenol-F and bisphenol-Z based benzoxazines with enhanced thermal and hydrophobic properties was written by Appasamy, Subasri;Arumugam, Hariharan;Govindraj, Latha;G, Rathika;Krishnasamy, Balaji;Muthukaruppan, Alagar. And the article was included in Journal of Macromolecular Science in 2022.Name: 4,4′-Methylenediphenol The following contents are mentioned in the article:

Two types of structurally different benzoxazines (BF-abn and BZ-abn) have been developed using bisphenol-F and bisphenol-Z with 4-aminobenzonitrile and paraformaldehyde through Mannich condensation reaction under an appropriate exptl. conditions. Mol. structure of benzoxazine was confirmed by FTIR and ¹H-NMR spectral analyses. Cure behavior and thermal stability were studied using differential scanning calorimetry (DSC) and thermogravimetric anal. (TGA) resp. The results from DSC anal. indicated that these benzoxazines exhibit marginally lower polymerization temperature than that of conventional benzoxazines. Further, the curing behavior of both benzoxazine samples were studied at two different heating rates viz. 10°C/min and 20°C/min to ascertain their heat releasing properties. The formation of polybenzoxazine was confirmed by FTIR anal. after the thermal curing through the cleavage of benzoxazine ring and subsequently led to the formation of three dimensional cross-linked network structure. Results from TGA infers that among the benzoxazines studied, poly(BF-abn) possess better thermal stability than that of poly(BZ-abn). Further, the values of LOI calculated using char yield obtained at 850°C from TGA for poly(BF-abn) and poly(BZ-abn) are 41% and 30% resp. The values of water contact angle obtained for poly(BF-abn) and poly(BZ-abn) are 138° and 140° resp. Both benzoxazine samples exhibit an excellent hydrophobic behavior. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Name: 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: 4,4′-Methylenediphenol

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Occurrence and sorption behaviour of bisphenols and benzophenone UV-filters in e-waste plastic and vehicle fluff was written by Runde, Kristin;Castro, Gabriela;Vike-Jonas, Kristine;Gonzalez, Susana Villa;Asimakopoulos, Alexandros G.;Arp, Hans Peter H.. And the article was included in Journal of Hazardous Materials in 2022.Computed Properties of C13H12O2 The following contents are mentioned in the article:

Bisphenols and benzophenone UV-filters are hazardous, high production volume chems. There is concern that these contaminants could leach into the environment or be recycled into new products during waste management. To investigate this, nine bisphenols and five benzophenones were quantified in Norwegian e-waste and car fluff. To understand their leachability, equilibrium passive sampling methodol., using polyoxymethylene (POM), was calibrated for these substances, many of which for the first time. This method can differentiate freely dissolved substances in the aqueous phase from those sorbed to suspended colloids and microplastics in the leachate water. Equilibrium POM partitioning was reached within 14 days of shaking; all bisphenols and benzophenone UV-filters exhibited linear isotherms (R2 ranged from 0.83 to 1.0), when deriving POM-water partition coefficients (KPOM). Bisphenol A and bisphenol F displayed the highest concentrations, with maximum levels of 246,000 and 42,400 ng g^-1, resp. Logarithms of waste-water partition coefficients (log Kwaste) ranged from 1.7 (benzophenone 2) to 4.5 (bisphenol P). The established KPOM values agreed with measured Kwaste values (within a factor of ∼3), unlike octanol-water partition coefficients This indicated that POM is a better surrogate for waste plastic partitioning than octanol. Results are discussed in the context of assessing risks from waste management in a circular economy. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Computed Properties of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Computed Properties of C13H12O2

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CHCl₃/triethanolamine: a new mixed solvent for preparing high-molecular-weight main-chain benzoxazines through Mannich-type polycondensation was written by Wang, Ping;Liu, Xuya;Lai, Hua;Li, Wei;Huang, Geng;Li, Yulin;Yang, Po. And the article was included in Polymer Journal (Tokyo, Japan) in 2022.Application of 620-92-8 The following contents are mentioned in the article:

Abstract: Mannich-type polycondensation with 4,4′-diaminodiphenylmethane (DDM), 2,2-bis(4-hydroxyphenol) propane (BPA) and paraformaldehyde (PF) in different solvents was carried out to prepare main-chain benzoxazines. When pure CHCl3 was used as the solvent, the decomposition rate of PF in CHCl3 was very slow, thus preventing gelation caused by the formation of triazine in the early reaction, producing P(B-D)1 composed of partially closed and unclosed structures. The addition of alk. triethylamine into CHCl3 (CHCl3/triethylamine = 6:1) greatly enhanced the decomposition rate of PF but gave a large triazine gel. The introduction of triethanolamine into CHCl3 was found to promote the decomposition of PF, enhance the polymerization rate, and prevent gelation caused either by the formation of triazine or by the ring-opening of oxazine ring through a solvation effect. Polymers P(B-D) 6P(B-D)8 obtained in CHCl3/triethanolamine had a high-oxazine content and a high number mol. weight (Mn) near 8000. Further optimization of Mannich-type polycondensation in CHCl3/triethanolamine gave preferred conditions: a CHCl3/triethanolamine ratio of 4:1, a PF of 1.2 equiv and a reaction time of 24 h. Compared with P(B-D)1 and P(B-D)3 (obtained in toluene/ethanol), P(B-D)9 obtained under the optimized conditions showed a higher Mn (10,000) and a higher yield (97.0%). The optimized conditions were also applicable for other kinds of diamines and bisphenols. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Application of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 620-92-8

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