Category: 617-94-7

Adding a certain compound to certain chemical reactions, such as: 617-94-7, 2-Phenyl-2-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C9H12O, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C9H12O

General procedure: In a round-bottom flask, benzylic alcohol 1a (10 mmol, 2.0 equiv.), benzenesulfonyl chloride 2a (13 mmol, 1.3 equiv.) and NMP (2.5 equiv.). Then, DCE (3 mL) were added. The mixture was stirred at 80 C for 1.5 h. After completion of the reaction (monitoredby TLC), water (10 mL) was added and the mixture was extracted with ethyl acetate (3*10 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and evaporated under reduced pressure. The crude product was purified by flash chromatography on silica gel to give the desired alkyl chlorides 3.

The synthetic route of 617-94-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zheng, Dagui; Mao, Liu-Liang; Zhu, Xian-Hong; Zhou, An-Xi; Synthetic Communications; vol. 48; 21; (2018); p. 2793 – 2800;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 617-94-7, Adding some certain compound to certain chemical reactions, such as: 617-94-7, name is 2-Phenyl-2-propanol,molecular formula is C9H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 617-94-7.

EXAMPLE 27 N-((lR,2S)-2-((S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-l- carbonyl)cyclohexyl)-c/s-3,4-dihydroxycyclopentanecarboxamideStep 1: 2-Phenylpropan-2-yl 2,2,2-trichloroacetimidate [00167] A suspension of 60% sodium hydride in mineral oil (0.42 g, 10.50 mmol) in diethyl ether (10 mL) was treated with the dropwise addition of a solution of 2- phenylpropan-2-ol (12.02 mL, 86 mmol) in diethyl ether (30 mL). Upon completion of addition, the mixture was stirred for 30 minutes, during which time a nearly clear solution was observed. After this time, the mixture was cooled to 0 0C and then treated with the dropwise addition of trichloroacetonitrile (8.18 mL, 82 mmol), which caused the mixture to turn dark brown. The reaction was allowed to warm to room temperature over 1 hour, and then was concentrated in vacuo to yield a residue. The residue was dissolved in hexanes (10 mL) and treated with methanol (0.424 mL, 10.48 mmol), and the resulting mixture was stirred vigorously for 5 minutes. The resulting black suspension was filtered through glass fiberglass filter paper, and the collected solids were rinsed 3X with hexanes. The combined filtrates were concentrated in vacuo to yield 2-phenylpropan-2-yl 2,2,2-trichloroacetimidate (23.8 g, 85 mmol, 99 % yield) as an amber oil which was used as-is in the next step.

According to the analysis of related databases, 617-94-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/15166; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 617-94-7, Adding some certain compound to certain chemical reactions, such as: 617-94-7, name is 2-Phenyl-2-propanol,molecular formula is C9H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 617-94-7.

EXAMPLE 27 N-((lR,2S)-2-((S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidine-l- carbonyl)cyclohexyl)-c/s-3,4-dihydroxycyclopentanecarboxamideStep 1: 2-Phenylpropan-2-yl 2,2,2-trichloroacetimidate [00167] A suspension of 60% sodium hydride in mineral oil (0.42 g, 10.50 mmol) in diethyl ether (10 mL) was treated with the dropwise addition of a solution of 2- phenylpropan-2-ol (12.02 mL, 86 mmol) in diethyl ether (30 mL). Upon completion of addition, the mixture was stirred for 30 minutes, during which time a nearly clear solution was observed. After this time, the mixture was cooled to 0 0C and then treated with the dropwise addition of trichloroacetonitrile (8.18 mL, 82 mmol), which caused the mixture to turn dark brown. The reaction was allowed to warm to room temperature over 1 hour, and then was concentrated in vacuo to yield a residue. The residue was dissolved in hexanes (10 mL) and treated with methanol (0.424 mL, 10.48 mmol), and the resulting mixture was stirred vigorously for 5 minutes. The resulting black suspension was filtered through glass fiberglass filter paper, and the collected solids were rinsed 3X with hexanes. The combined filtrates were concentrated in vacuo to yield 2-phenylpropan-2-yl 2,2,2-trichloroacetimidate (23.8 g, 85 mmol, 99 % yield) as an amber oil which was used as-is in the next step.

According to the analysis of related databases, 617-94-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/15166; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 617-94-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 617-94-7, name is 2-Phenyl-2-propanol. A new synthetic method of this compound is introduced below.

To sodium hydride (60% dispersion in mineral oil, 280 mg, 7.00 mmol, 0.5 equiv) in anhydrous diethyl ether (28 mL) was added freshly distilled 2-phenyl-2-propanol (4.20 g, 30.8 mmol, 2.2 equiv) at 0 C and the mixture was stirred for 1 h at room temperature. The reaction mixture was cooled to 0 C, 2,2,2-trichloroacetonitrile (2.80 mL, 28.0 mmol, 2.0 equiv) were added slowly and stirring was continued for 3 h at ambient temperature. The solvent was removed under reduced pressure and the residue re-dissolved in PE (7.0 mL), anhydrous MeOH (283 pL, 7.00 mmol, 0.5 equiv) was added and the solution was stirred for 10 min at room temperature. The mixture was filtered through a plug of Celite eluting with PE and the filtrate was concentrated in vacuo to give the crude imidate. To a suspension of Fmoc-Ala-OH (4.36 g, 14.0 mmol, 1.0 equiv) in CH CI (80 mL) was added a solution of the imidate in CH CI (15 mL) and the mixture was stirred for 16 h at room temperature. The reaction mixture was filtered through a plug of Celite eluting with CH CI , the solvent was removed in vacuo, and the residue was purified by column chromatograph (S O , PE/EtOAc 4:1) to give Fmoc-Ala-OCumyl (55) (6.00 g, 14.0 mmol, quant yield) contaminated with small amounts of 2-phenyl-2-propanol (~85:15 by 1H N MR) as a pale-yellow oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,617-94-7, 2-Phenyl-2-propanol, and friends who are interested can also refer to it.

Reference:
Patent; UNIVERSITY OF WARWICK; SHIPMAN, Michael; (96 pag.)WO2019/186174; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 617-94-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.617-94-7, name is 2-Phenyl-2-propanol, molecular formula is C9H12O, molecular weight is 136.191, as common compound, the synthetic route is as follows.

General procedure: The alcohol (2mmol) and the anhydride (2.2mmol) were mixed in a 10mL test tube and 1mol% of salt A (0.02mmol) was added. The tube was then capped (or under N2 purge) and the reaction mixture was stirred at room temperature (except for 1-methylcyclopentanol at 60C). After a couple of hours the acid effluent was evaporated in vacuum. The residue was then allowed to cool to room temperature and the salt was precipitated by adding 2mL hexane (or toluene). After filtration, salt was recovered, and then evaporating solvent from the filtrate afforded the crude ester product. The recovered salt was charged with the substrates, and the reaction mixture was then proceeded to the next run. The products were quantified with GC analysis by comparison to NMP as an internal standard. The products from the 1st run were further purified by column chromatography, and the isolated yields were compared with the GC/MS yields. They were all in good agreement.

Statistics shows that 617-94-7 is playing an increasingly important role. we look forward to future research findings about 2-Phenyl-2-propanol.

Reference:
Article; Lu, Norman; Chang, Wei-Hsuan; Wei, Rong-Jyun; Fang, Yung-Cheng; Han, Tu-Wen; Wang, Guo-Quan; Chang, Jia-Yaw; Wen, Yuh-Sheng; Liu, Ling-Kang; Tetrahedron; vol. 72; 24; (2016); p. 3468 – 3476;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

617-94-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 617-94-7, name is 2-Phenyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Bi(OTf)3 (1.0 mol%) was added to a solution of the appropriate secbenzylalcohol (1.0 equiv) and TMSN3 (1.2 equiv) in CH2Cl2 (4.0mL/mmol) at r.t. When the reaction was complete (TLC), the solventwas removed and the crude material was purified by column chromatography.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 617-94-7, 2-Phenyl-2-propanol.

Reference:
Article; Tummatorn, Jumreang; Thongsornkleeb, Charnsak; Ruchirawat, Somsak; Thongaram, Phanida; Kaewmee, Benyapa; Synthesis; vol. 46; 11; (2015);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

617-94-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 617-94-7, name is 2-Phenyl-2-propanol, molecular formula is C9H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of NaH (60 % dispersion in mineral oil, 105 mg, 9.61 mmol) in diethylether (9.5 ml)was added alpha,alpha-dimethyl benzenemethanol (3.04 g, 22.3 mmol) at 0 C. After stirring for 40 min atr oom temperature, trichloroacetonitrile (2.0 ml, 20.0 mmol) was added at 0 C. The reaction mixture was stirred for 3 h at room temperature and concentrated in vacuo. Hexane (2.5 ml) and MeOH (0.1ml) were added to the resulting residue. The mixture was filtered through Celite and concentrated invacuo to give S11 (4.85 g, 78%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 617-94-7, 2-Phenyl-2-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ota, Eisuke; Mikame, Yu; Hirai, Go; Nishiyama, Shigeru; Sodeoka, Mikiko; Synlett; vol. 27; 7; (2016); p. 1128 – 1132;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts