Category: 616-29-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C3H10N2O

A solution of 2-carboxybenzaldehyde (4.643 g, 30.00 mmol) and NaOH (1.200 g, 30.00 mmol) in 100 ml methanol was added to 1,3-diamino-propan-2-ol (1.424 g, 15.00 mmol) in 20 ml methanol. The yellowish mixture obtained was heated to 60 C while stirring for ?4 h. Then the reaction product was cooled in an ice-bath. Excess NaBH4 (1.500 g, 39.50 mmol) was added in portions to the cold solution while stirring. The yellow color was slightly discharged. After 30 min 2 ml conc. HCl was added drop wise to destroy the excess NaBH4. Acidification of the solution to pH ? 5 by further addition of conc. HCl resulted in the precipitation of white crystalline solid. The white solid was filtered out from mother liquor and washed with water and methanol, and dried at ?80 C. Yield: 4.95 g (87%). The compound was crystallized from methanol-water solution (1:1; v/v). The product was confirmed by the elemental analysis as H3cdp¡¤H2O. Anal. Calc. for C19H22N2O5.H2O: C, 60.63%; H, 6.43%; N, 7.44%. Found: C, 60.25%; H, 6.28%; N, 7.33%. 1H NMR for sodium salt of the compound (400 MHz, D2O, 25 C, delta): 7.46-7.32 (m, 8H), 3.92-3.80 (m, 1H), 2.63 (q, 4H), 2.55 (q, 4H).

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Reference:
Article; Patra, Ayan; Haldar, Shobhraj; Vijay Kumar, Gonela; Carrella, Luca; Ghosh, Aloke Kumar; Bera, Manindranath; Inorganica Chimica Acta; vol. 436; (2015); p. 195 – 204;,
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616-29-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

To a vigorously stirred ethanolic solution of salicylaldehyde (0.106 mL, 1 mmol) an ethanolic solution (20 mL) of 1,3-diamino-2-propanol (0.046 g, 0.5 mmol) was added dropwisely. The solution turned to light yellow and the mixture refluxed for 4 h. The resulting yellow powder was collected by filtration, washed with cold ethanol and ether and dried in the air ( Scheme 1 ). L2 was synthesized in order to compare with L1 from the point of view of the effect of substituent on DNA-binding measurements, cleavage activity, and cytotoxicity. Yield >70%; m.p. >250omicronC; F.W: 298.20, Color: yellow. Anal. calcd for C17H18N2O3: C, 68.44; H, 6.08; N,9.39%. Found: C, 68.04; H, 5.73, N, 9.56%. FT-IR (KBr, cm-1): 3394 (nuOH), 2893 (nuC-H), 1635 (nuC=N). UV-Vis (H2O): lambdamax (nm) = 386, 324. 1HNMR (250 MHz, DMSO-d6, room temperature): delta(ppm) = 13.52 (s, 2H, OH), 8.50 (s, 2H, HC=N), 7.42-6.85 (m, 8H, ArH), 5.17 (s, 1H, CHOH), 3.97 (s, 1H, CHOH), 3.76 (d, 2H, CH2), 3.57 (d, 2H, CH2).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 616-29-5, 1,3-Diaminopropan-2-ol.

Reference:
Article; Asadi, Zahra; Nasrollahi, Neda; Journal of Molecular Structure; vol. 1147; (2017); p. 582 – 593;,
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The common heterocyclic compound, 616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 616-29-5

Example 1 11- {[tert-Butyl (dimethyl) silyl] oxy}-9- (methylsulfonyl)-9, 10,11, 12-tetrahydro-8H [1, 4] diazepino [1′, 2′ : 1, 2] imidazo [4,5-c] quinolin-6-amine Part A Under a nitrogen atmosphere, a solution of di-tert-butyl dicarbonate (145. 35 g, 665.98 mmol) in 1,4-dioxane (400 mL) was added dropwise with stirring to a solution of 2-hydroxy-1, 3-diaminopropane (300.00 g, 332.85 mmol) in methanol (500 mL) over a period of six hours. The reaction was stirred overnight at ambient temperature and then concentrated under reduced pressure. The residue was dissolved in 10% citric acid in water, and additional citric acid was added to adjust the solution to pH 4. The resulting solution (1-1.5 L) was washed with dichloromethane (3 x 500 mL) and then adjusted to pH 12 with the addition of 50% aqueous sodium hydroxide. The basic solution was extracted with chloroform (7 x 500 mL), and the combined extracts were concentrated under reduced pressure and dried overnight under high vacuum to provide 108. 19 g of tert-butyl 3-amino-2-hydroxypropylcarbamate as a white solid.

The synthetic route of 616-29-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2005/66172; (2005); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, molecular weight is 90.12, as common compound, the synthetic route is as follows.616-29-5

Example 110; 8-r3-Bromophenyl)-3-hydroxy-8-(4-methoxvphenvD-3,4,7,8-tetrahydroimidazo[l,5- fllpvrimidine-6(2H)-thione0; 4-(3-Bromophenyl)-4-(4-methoxyphenyl)-l,3-thiazolidine-2,5-dithione (82 mg, 0.20 mmol), l,3-diaminopropan-2-ol (54 mg, 0.60 mmol) and triethylamine (139 muL, 1 mmol), was heated to 70 C in ethanol (2 mL) for 1 h. The mixture was concentrated in vacuo and the residue was diluted with ethyl acetate and washed with aqueous sodium carbonate, 0 brine, dried over sodium sulfate and concentrated in vacuo. The crude product was purified by column chromatography using an eluent with ethyl acetate in heptane (0-100 %) to give 83 mg (96 % yield): MS (AP) m/z 433 [M+l]+.

Statistics shows that 616-29-5 is playing an increasingly important role. we look forward to future research findings about 1,3-Diaminopropan-2-ol.

Reference:
Patent; ASTRAZENECA AB; ASTEX THERAPEUTICS LTD; WO2007/145569; (2007); A1;,
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616-29-5 , The common heterocyclic compound, 616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 13 delta-CS-BromophenvD-S-hvdroxy-delta-^-methoxyphenylVS^J^-tetrahydroimidazorLS- alpyrimidine-6(2H)-thione4-(3-Bromophenyl)-4-(4-methoxyphenyl)-l,3-thiazolidine-2,5-dithione (82 mg, 0.20 mmol), l,3-diaminopropan-2-ol (54 mg, 0.60 mmol) and triethylamine (139 muL, 1 mmol), was heated to 70 C in ethanol (2 mL) for 1 h. The mixture was concentrated in vacuo and the residue was diluted with ethyl acetate and washed with aqueous sodium carbonate, brine, dried over sodium sulfate and concentrated in vacuo. The crude product was purified by column chromatography using an eluent with ethyl acetate in heptane (0-100 %) to give 83 mg (96 % yield): MS (AP) m/z 433 [M+l]+.

According to the analysis of related databases, 616-29-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTEX THERAPEUTICS LTD; WO2007/145571; (2007); A1;,
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616-29-5 ,Some common heterocyclic compound, 616-29-5, molecular formula is C3H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The mixture of 1,2,3,4-tetrahydroacridine [38] (3/4; 1 eq) and different diaminoalkanes was heatedin phenol (0.5 eq) at 165-170 C for a period of 35¡À60 min in the presence of potassium iodide ina catalytic amount. After the completion of reactions, monitored on TLC and on consumption ofstarting material, the reaction mixture was allowed to come at room temperature. After cooling, thereaction mixture was dissolved into DCM and washed with 5% NaOH (3 75 mL) and brine solution,respectively. Finally, the DCM layer so obtained was dried over the anhydrous Na2SO4 and thenconcentrated under reduced pressure to give desired product in crude form. The column purificationof the crude product over silica gel (100-200 mesh) in 4-6% methanol/dichloromethane afforded thealkyl substituted tacrine amines (5-10) in a 60-75 % yield and their spectral data are presented in ourprevious publication [23].

According to the analysis of related databases, 616-29-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Rajeshwari, Rajeshwari; Chand, Karam; Candeias, Emanuel; Cardoso, Sandra M.; Chaves, Silvia; Amelia Santos; Molecules; vol. 24; 3; (2019);,
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616-29-5, Adding some certain compound to certain chemical reactions, such as: 616-29-5, name is 1,3-Diaminopropan-2-ol,molecular formula is C3H10N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 616-29-5.

General procedure: To a mixture of (3) (1 eq), and different aliphatic diamines (1,2-diaminoethane, 1,3-diaminopropane, 1,4-diaminobutane 4(a-f) and also 1,3-diaminopropan-2-ol) 5a (2.5 eq), phenol (0.5 eq) and a catalytic amount of KI were added. The mixture is heated at 180C for 35min, with completion of the reaction monitored by TLC. Then, the mixture was cooled to room temperature, treated with 5% NaOH solution, extracted with ethyl acetate and finally washed with water and brine. The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the crude product. Purification was performed by column chromatography, eluent: CH2Cl2/MeOH: 5-8%, 25%NH3 per 1L.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 616-29-5.

Reference:
Article; Hiremathad, Asha; Keri, Rangappa S.; Esteves, A. Raquel; Cardoso, Sandra M.; Chaves, Silvia; Santos, M. Amelia; European Journal of Medicinal Chemistry; vol. 148; (2018); p. 255 – 267;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. 616-29-5

Synthesis of 2,2,12,12-t-methyl-3,11-dioxo-4,10-dioxa-5,9-diazatridecan-7-ol (N,N’-di-t-boc-2-hydroxy-1,3-diaminopropane) Sodium hydrogencarbonate (8.3 g, 99 mmol) was dissolved in 1:1 acetonitrile:water mixture (190 mL) and the solution cooled to 4 C. in an ice bath. 1,3-diamino-2-hydroxypropane (2.5 g, 27 mmol) and di-tert-butyldicarbonate (12.8 g, 59 mmol) were dissolved in the same solvent system (65 mL). This mixture was then added to the chilled sodium hydrogencarbonate solution and stirred on ice for two hours. The reaction was then heated to room temperature and stirred overnight. The acetonitrile was removed by rotary evaporation and the protected amine extracted into dichloromethane (3*75 mL portions). The organic portions were combined, dried over sodium carbonate, and evaporated to dryness by rotary evaporation. The resulting oil was re-crystallised from diethylether/hexane,38 giving colourless crystals (7.2 g, 91% yield). The compound was characterised by 1H and 13C NMR and FT-IR spectroscopy. IR (cm-1): 3316 m br v(OH and NH), 2971 m and 2930 m v(CH3 and CH), 1681 s v(C=O). 1H NMR (400 MHz, CDCl3, 298 K) [delta, ppm]: 1.45 (s, 18H, H-1), 3.20 (m, 4H, H-5), 3.75 (m, 2H, H-6 and H-7), 5.20 (s br, 2H, H-4). 13C NMR (100 MHz, CDCl3, 298K) [delta, ppm]: 28.55 (C-1), 43.72 (C-2), 71.07 (C-5), 79.87 (C-6), 157.24 (C-3).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 616-29-5, 1,3-Diaminopropan-2-ol.

Reference:
Patent; UNIVERSITY OF KWAZULU-NATAL; Munro, Orde Quentin; Akerman, Kate Julie; Akerman, Piers; US2013/90472; (2013); A1;,
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