Category: 616-29-5

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 1,3-Diaminopropan-2-ol

A solution of 1,3-diamino-2-propanol (3.15 g,0.035 mol) and Et3N (4.85 mE, 0.035 mol) in methanol (120mE) was heated to 45 C. To the solution, (l3oc)20 (17.05 g,0.078 mol) in methanol (80 mE) was dropwise added slowly.The reaction solution was stirred at 45 C. for 30 mm. Afteradditional stirring at room temperature for 1.5 h, the solventwas removed under reduced pressure. The crude productwas extracted with diethyl ether (200 mEx3) and dried oversodium sulfate to yield the compound 2 (9.94 g, 97.8%) asa white powdet EC-MS mlz (ES), 291.19 (M+H).

With the rapid development of chemical substances, we look forward to future research findings about 616-29-5.

Reference:
Patent; RC Biotechnologies, Inc.; HUANG, Chang Jiang; FANG, Jianmin; YE, Hui; ZHANG, Lezhi; (63 pag.)US2018/55948; (2018); A1;,
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Related Products of 616-29-5 ,Some common heterocyclic compound, 616-29-5, molecular formula is C3H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The Schiff base ligand, H2L, N,N0-bis(salicyaldehydene)-1,3-diaminopropan-2-ol was synthesized in a reported literature [19].Salisaldehyde (0.244 g, 2 mmol) was heated under reflux with1,3-diaminopropan-2-ol (0.089 g, 1 mmol) in 30 ml dehydratedalcohol. After 10 h the reaction solution was evaporated underreduced pressure to yield a gummy mass, which was dried undervacuum and stored over CaCl2 for subsequent use. Yield, 0.278 g(82.8%). Anal. Calc. for C17H18N2O3 (H2L): C, 68.48; H, 6.08; N,9.39. Found: C, 68.40; H, 6.02; N, 9.35%. 1H NMR (CDCl3) d = 3.68(dd, J = 12.4, 6.8 Hz, 2H), 3.84 (dd, J = 12.4, 4.0 Hz, 2H), 4.23-4.25(m, 1H), 6.88 (t, J = 7.2 Hz, 2H), 6.96 (d, J = 8.4 Hz, 2H), 7.25 (dd,J = 7.6, 1.6 Hz, 2H), 7.32 (td, J = 8.8, 1.6 Hz, 2H), 8.36 (s, 2H) ppm.13C NMR d, 62.9, 70.2, 117.0, 118.5, 118.6, 131.5, 132.5, 161.1,167.3 ppm. IR (KBr, cm1): 1634, 1611 (vCN), 3412 (vOH), UV-Vis(kmax, nm): 221, 267, 316, 410 nm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 616-29-5, 1,3-Diaminopropan-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Dey, Dhananjay; Kaur, Gurpreet; Patra, Moumita; Choudhury, Angshuman Roy; Kole, Niranjan; Biswas, Bhaskar; Inorganica Chimica Acta; vol. 421; (2014); p. 335 – 341;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 1,3-Diaminopropan-2-ol

Example 7 Preparation of 1,3-di(oleylamino)propan-2-ol Oleic acid (5.698 g, 0.020 mol) and 1,3-diaminopropan-2-ol (1 g, 0.011 mol) were placed in a flask and heated at 190 C. for 2 hours. The reaction mixture was cooled to room temperature, then taken up in chloroform and washed with water. The aqueous phase was extracted with chloroform and the organic phases were combined, dried on magnesium sulfate, filtered and evaporated to dryness to yield an oily black residue (6.64 g) which was purified by chromatography on silica gel (eluent:dichloromethane/methanol 99:1). The resulting product was then washed with ether and filtered. Yield: 23% Rf (dichloromethane/methanol 95:5): 0.43 IR: nuNH 3306 cm-1; nuCO amide 1646 and 1630 cm-1

With the rapid development of chemical substances, we look forward to future research findings about 616-29-5.

Reference:
Patent; Gentif; US2006/35977; (2006); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 1,3-Diaminopropan-2-ol

To a solution of 3-1 (3.00 g, 33.3 mmol) in dichloromethane (300 mL) was added triethylamine (5.10 mL, 36.6 mmol), 4-dimethylaminopyridine (DMAP, 40.7 mg, 0.333 mmol), and tert-butyldiphenylsilyl chloride (TBDPSCI, 9.13 mL, 35.0 mmol), and the mixture was stirred at room temperature for 5 hours. The solvent was removed by concentration in vacuo and chromatographed by flash chromatography on silica gel (chloroform/methanol = 5: 1) to give 3-2 (8.28 g, 76%). 1H MR (400 MHz, CDC13): delta 1.08 (s, 9H), 2.70-2.79 (m, 4H), 3.60-3.63 (m, 1H), 7.36-7.45 (m, 6H), 7.67-7.70 (m, 4H). MS (CI+) m/z: 329 (MH+).

With the rapid development of chemical substances, we look forward to future research findings about 616-29-5.

Reference:
Patent; MERCK SHARP & DOHME CORP.; INTERVET INTERNATIONAL B.V.; KYORIN PHARMACEUTICAL CO. LTD.; SINGH, Sheo B.; WARRASS, Ralf; ULLRICH, Joachim; KAWASHIMA, Mikako; FUKUDA, Yasumichi; TAKANO, Hisashi; (92 pag.)WO2016/123146; (2016); A1;,
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Synthetic Route of 616-29-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 616-29-5, name is 1,3-Diaminopropan-2-ol. A new synthetic method of this compound is introduced below.

N- (3-CARBOXY-6-METHYLPHENYL)-S-METHYLISOTHIOUREA (17.0 g, 0.048 mol) and 1,3-diamino-2-hydroxypropane (12.96 g, 0.144 mol) and DMF (20 mL) were added to 200 mL flask equipped with condenser and drying tube. The solution was heated at 100 C for 36 h and was cooled and filtered. The solid was washed with ethyl acetate, then ether. The solid was added slowly to stirring 4N HCI in dioxane. The mixture was stirred for 2h. The reaction mixture became difficult to stir and the solution was concentrated and dried under high vacuum overnight. The solid was washed with ether three times, filtered, and dried. Yield 13. 31G (97%) 1H NMR (CD30D) a 7.13-7. 21 (m, 2H), 6.86 (m, 1H), 3.26 (m, 4H), 1.83 (m, 2H). Anal. Calcd for C11H1303N3 : MOL. Wt, 236.1005 (M+H, HRMS). Found: MOL. W, 236.1035 (M+H, HRMS).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,616-29-5, 1,3-Diaminopropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; PHARMACIA CORPRATION; WO2004/60376; (2004); A1;,
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Adding a certain compound to certain chemical reactions, such as: 616-29-5, 1,3-Diaminopropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 616-29-5, blongs to alcohols-buliding-blocks compound. Product Details of 616-29-5

Step 1 : Di-tert-butyl (2-hydroxypropane-l,3-diyl)dicarbamate [00217] A solution of l,3-diaminopropan-2-ol (3.0 g, 33.3 mmol) in water (7 mL) was added to a solution of di-tert-butyldicarbonate (16.0 g, 73.7 mmol) in dioxane (400 mL). The reaction mixture was stirred for 22 h at room temperature then concentrated in vacuo. The resulting solid was dissolved in CH2C12 (300 mL), washed with water (300 mL), and dried (MgS04). Concentration in vacuo gave di-tert-butyl (2-hydroxypropane-l,3- diyl)dicarbamate (9.0 g) as a faint-yellow oil, which was used without further purification. 1H NMR (300 MHz, CDC13) delta 5.09 (br, 2H), 3.78-3.73 (m, 1H), 3.55 (br, 1H), 3.34-3.12 (m, 4H), 1.46 (s, 18H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,616-29-5, its application will become more common.

Reference:
Patent; PRESAGE BIOSCIENCES, INC.; DECKWERTH, Thomas; KLEINMAN, Edward; RUAN, Fuqiang; BAKER, William; KLINGHOFFER, Richard; (126 pag.)WO2016/196393; (2016); A2;,
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Related Products of 616-29-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 616-29-5 as follows.

To a solution of l,3-diaminopropan-2-ol (5 g, 55.48 mmol) in MeOH (50 mL) was added TEA (16.84 g, 166.44 mmol, 23.17 mL) and Boc20 (31.48 g, 144.25 mmol, 33.14 mL) at 15 C. The mixture was stirred at 45C for 12 h under N2atmosphere. The reaction mixture was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, Petroleum ether/Ethyl acetate=20/l to 0: 1) to give /er/-butyl N-[3-(/er/- butoxycarbonylamino)-2-hydroxy-propyl] carbamate (15.47 g, 96.04% yield) as a white solid.1H NMR (400 MHz, CDCl3): d 5.03 (brs, 2H), 4.08-4.02 (m, 2H), 4.27 (s, 2H), 3.22-3.06 (m, 4H), 1.37 (s, 18H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,616-29-5, its application will become more common.

Reference:
Patent; ARBUTUS BIOPHARMA, INC.; BI, Yingzhi; DORSEY, Bruce D.; FAN, Yi; MOORE, Christopher Brooks; NGUYEN, Duyan; (169 pag.)WO2019/191624; (2019); A1;,
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Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 616-29-5, Name is 1,3-Diaminopropan-2-ol, molecular formula is , belongs to alcohols-buliding-blocks compound. In a document, author is Yang, Xingchuan, HPLC of Formula: https://www.ambeed.com/products/616-29-5.html.

Experimental and correlated liquid-liquid equilibrium data for water+1,6-hexanediol+1-pentanol/3-methyl-1-butanol/2-methyl-2-butanol at different temperatures

Liquid liquid equilibria (LLE) data for ternary systems of water + 1,6-hexanediol + 1-pentanol/ 3-methyl-1-butanol/ 2-methyl-2-butanol were measured at (293.15, 303.15, 313.15 and 323.15) K under 101.3 kappa Pa. Cloud-point method was applied to determine the solubility curves data. Distribution coefficient and separation factors for 1,6-hexanediol were calculated from the measured tie-line data to evaluate the extraction effect of alcohols on 1,6-hexanediol. The reliability of experimental LLE data were tested by Othmer-Tobias equation and Hand equation, NRTL and UNIQUAC models were applied to correlate the measured data and the calculated results show that both models can fit the experimental data very well. (C) 2020 Elsevier Ltd.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 616-29-5, in my other articles. HPLC of Formula: https://www.ambeed.com/products/616-29-5.html.

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Alcohol – Wikipedia,
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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Computed Properties of https://www.ambeed.com/products/616-29-5.html, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 616-29-5, Name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O. In an article, author is Thompson, Andrew,once mentioned of 616-29-5.

Associations between occupation and heavy alcohol consumption in UK adults aged 40-69 years: a cross-sectional study using the UK Biobank

Background Understanding the relationship between occupation and alcohol use offers opportunities to provide health promotion programmes based on evidence of need. We aimed to determine associations between occupation and heavy alcohol consumption in working individuals aged 40-69 years. Methods A cross-sectional study was conducted using 100,817 people from the UK Biobank: 17,907 participants categorised as heavy drinkers, defined as > 35 units/week for women and > 50 units/week for men, and 82,910 drinking controls. Prevalence ratios (PRs) and 95% CIs were calculated for gender-specific heavy drinking in 353 occupations using Standard Occupational Classification, V.2000. Results Seventy-seven occupations were associated with level of alcohol consumption in drinkers. The largest ratios for heavy drinkers were observed for publicans and managers of licenced premises (PR = 2.81, 95%CI 2.52-3.14); industrial cleaning process occupations (PR = 2.09, 1.33-3.28); and plasterers (PR = 2.07, 1.66-2.59). Clergy (PR = 0.20, 0.13-0.32); physicists, geologists and meteorologists (PR = 0.40, 0.25-0.65); and medical practitioners (PR = 0.40, 0.32-0.50) were least likely to be heavy drinkers. There was evidence of gender-specific outcomes with the proportion of jobs associated with heavy drinking accounted for by skilled trade occupations being 0.44 for males and 0.05 for females, and 0.10 for males and 0.40 for females when considering managers and senior officials. Conclusions In the largest study of its kind, we found evidence for associations between a wider variety of occupations and the risk of heavy alcohol consumption than identified previously, particularly in females, although causality cannot be assumed. These results help determine which jobs and broader employment sectors may benefit most from prevention programmes.

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Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 616-29-5, Name is 1,3-Diaminopropan-2-ol. In a document, author is Bakhshaie, Jafar, introducing its new discovery. Recommanded Product: 1,3-Diaminopropan-2-ol.

Obsessive-compulsive symptoms and problematic alcohol use: The explanatory role of drinking motives

The purpose of the present investigation was to examine the unique explanatory role of alcohol use motives above the effects of each other, using a multiple mediation model, for the relationship between obsessive-compulsive symptomatology and problematic alcohol use among a young ethno-racially diverse sample of college students with current (past-month) alcohol use. Participants were 454 college students (81.72% female, Mage = 22.46, SD = 4.71). Results indicated that coping motives significantly explained the relationship between obsessive-compulsive symptoms, and alcohol consumption (past year), risky drinking, and recent alcohol use (past month) as behavioral indices of problematic drinking after controlling for the variance accounted for by recent cannabis use, smoking, and anxiety and depressive symptoms (with small to medium effect sizes). These findings are discussed in terms of the development of specialized treatments to specifically target coping oriented alcohol use motives in the context of obsessive-compulsive symptoms among young adults with clinically significant OCD symptoms and comorbid problematic alcohol use.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 616-29-5 help many people in the next few years. Recommanded Product: 1,3-Diaminopropan-2-ol.

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