Category: 616-29-5

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 616-29-5, name is 1,3-Diaminopropan-2-ol, the common compound, a new synthetic route is introduced below. COA of Formula: C3H10N2O

First a 30mL methanol solution of salicyldehyde (30 mmol,3.66 g) was added to a 15mL methanol solution of 1,3-diamino-2-propanol (15 mmol, 1.35 g). The resulting orange solution wasthen refluxed for 1 h, and after cooling down, the solvent wasremoved under reduced pressure to afford an orange crystallinesolid which was collected as the ligand. Yield: 69%. Anal. Calc. forC17H18N2O3: C, 68.42; H, 6.09; N, 9.39. Found: C, 68.77; H, 5.73; N,9.71%.

The synthetic route of 616-29-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Das, Kuheli; Massera, Chiara; Garribba, Eugenio; Frontera, Antonio; Datta, Amitabha; Journal of Molecular Structure; vol. 1199; (2020);,
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Electric Literature of 616-29-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 616-29-5, name is 1,3-Diaminopropan-2-ol. A new synthetic method of this compound is introduced below.

Example 2 To 13.5 g (0.15 mol) of 1,3-diaminopropan-2-ol and 14.4 g (0.36mol) of NaOH in 400 ml THF and 200 ml H2O at 0 C. was added 72 g (0.33 mol) of Boc2O in portions. The reaction mixture was warmed up to RT and stirred overnight. To this mixture was added 300 ml of EtOAc. The layers were separated and the aqueous layer was extracted with 200 ml EtOAc. The combined organic layer was dried with MgSO4 and concentrated to give di-tert-butyl 2-hydroxypropane-1,3-diyldicarbamate in quantitative yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,616-29-5, 1,3-Diaminopropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; Morgan, Bradley P.; Muci, Alex; Kraynack, Erica; Lu, Pu-Ping; Tochimoto, Todd; Morgans, David J.; US2007/66626; (2007); A1;,
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Related Products of 616-29-5, Adding some certain compound to certain chemical reactions, such as: 616-29-5, name is 1,3-Diaminopropan-2-ol,molecular formula is C3H10N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 616-29-5.

VII. 1 (3-tert-Butoxycarbonylamino-2-hydroxy-propyl)-carbamic acid tert-butyl esterDi-tert-butyl dicarbonate (41 .5g) was dissolved in dichloromethane (40.0 ml), a solution of 1 ,3- diamino-propan-2-ol (8.0g) and triethylamine (1 .5 ml) indichloromethane/methanol (1 :5; 100 ml) was added and the reaction mixture was stirred at room temperature overnight. The solution was concentrated in vacuo and the residue was dissolved in dichlormethane. The organic layer was washed with water, separated, dried and concentrated in vacuo. The residue was purfied by chromatography (silica / dichloromethane: methanol 25:1 ).Yield: 17 gESI mass spectrum: m/z = 291 (M+H)+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 616-29-5, 1,3-Diaminopropan-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HECKEL, Armin; HIMMELSBACH, Frank; KLEY, Joerg; LEHMANN-LINTZ, Thorsten; REDEMANN, Norbert; SAUER, Achim; THOMAS, Leo; WIEDENMAYER, Dieter; BLACK, Phillip; BLACKABY, Wesley; LINNEY, Ian; AUSTEN, Matthias; DANILEWICZ, John; SCHNEIDER, Martin; SCHREITER, Kay; WO2011/104340; (2011); A1;,
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Reference of 616-29-5 ,Some common heterocyclic compound, 616-29-5, molecular formula is C3H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The Schiff base ligand, H2L was prepared prepared according to literature method [15]. To prepare the Schiff base ligand, 2-hydroxy-1,3-diaminopropane (0.0890g, 1mmol) was refluxed with O-vanilin (0.3046g, 2mmol) in 20ml dehydrated alcohol for 6h and after 7-10 days yellowish orange colored compound was isolated from solution, which was dried and stored in vaccuo over CaCl2 for subsequent use. Yield: 3.420g (87%). Anal. Calc. for C19H22N2O5 (H2L): IR (KBr, cm-1): 3365 (vOH), 1618 (vC=N), 1333, 1245 (vPhO); UV-Vis (lambdamax, nm): 255, 315, 403; 1H NMR (delta ppm, 400Mz, DMSO-d6) delta=13.55 (s, 2H), 9.92 (s, 2H), 7.26-6.90 (Ar-H, 6H), 5.94 (s, 1H), 3.93 (s, 6H) ppm. EI-MS (m/z) 359.16 [H2L+H+]+ (see Scheme 1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 616-29-5, 1,3-Diaminopropan-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Pal, Sukanta; Chowdhury, Biswajit; Patra, Moumita; Maji, Milan; Biswas, Bhaskar; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 144; (2015); p. 148 – 154;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 616-29-5, name is 1,3-Diaminopropan-2-ol, the common compound, a new synthetic route is introduced below. COA of Formula: C3H10N2O

Step 1[00207] l,3-diamino-2-propanol (XXXIX) (1.6 g, 17.75 mmol) was dissolved in water (3 ml/mmol, 53 mL) and then aq. 5% NaHC03 was added until pH was ~9, followed by acetone. The mixture was cooled to 0 C before adding a solution of B0C2O (7.74 g, 35.5 mmol) in acetone (2 mL/mmol, 35.5 ml) slowly dropwise over 2 h. The reaction mixture was allowed to warm to room temperature and stirred overnight. The acetone was evaporated under vacuum and the aqueous residue was washed with Et20 (x3). The organic layers were combined and dried over anhydrous MgS04. The solvent was removed under reduced pressure to give the crude product as a dark yellow oil. The crude product was crystallized from Et20/hexane to give tert- butyl 2-hydroxypropane-l,3-diyldicarbamate (XL) (3.71 g, 12.78 mmol,72% yield). 1H NMR (CDCI3) delta ppm 1.40 (s,18H), 3.06-3.27 (m, 4H), 3.61-3.67 (m, 1H), 4.00 (brs, 1H), 5.16-5.4 (m, 2H). ESIMS found for Ci3H26N205 m/z 313.6 (M+Na).

The synthetic route of 616-29-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; REMPEX PHARMACEUTICALS, INC.; GLINKA, Tomasz; HIGUCHI, Robert; HECKER, Scott; EASTMAN, Brian; RODNY, Olga; WO2012/109164; (2012); A1;,
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Application of 616-29-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 21A (7 g, 77.7 mmol), and di-tert-butyldicarbonate (35.6 g, 163 mmol) were stirred in methylene chloride (100 ml_) at25 C for 2 hr. Saturated aqueous NaCI (150 mL) was added. The aqueouslayer was extracted with CHaCfe (100 ml) twice. The organic phase waswashed with brine (100 mL), dried over Na2SO4. The solvent was removed byrotary evaporator to give compound 21B (17g, 76%) which was used withoutfurther purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 616-29-5, 1,3-Diaminopropan-2-ol.

Reference:
Patent; SCHERING CORPORATION; WO2006/19768; (2006); A1;,
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Reference of 616-29-5, Adding some certain compound to certain chemical reactions, such as: 616-29-5, name is 1,3-Diaminopropan-2-ol,molecular formula is C3H10N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 616-29-5.

1,3-diaminopropan-2-ol (3 g, 0.033 mol) was dissolved in methanol (300 ml) followed by the addition of triethylamine (33 ml dropwise) and di-tert-butyl dicarbonate [(BOC)2O] (21.793 g, 0.100 mol). The reaction medium was heated at 40-50 C. for 20 min then stirred at room temperature for 1 hour. After evaporation of the solvent, the colorless oil residue was purified by chromatography on silica gel (eluent: dichloromethane/methanol 95:5). The reaction yielded a colorless oil which crystallized slowly. Yield: quantitative Rf (dichloromethane/methanol 95:5): 0.70 IR: nuNH 3368 cm-1; nuCO carbamate 1690 cm-1 MP: 98-100 C. NMR (1H, CDCl3): 1.45 (multiplet, 18H, -CH3- (BOC)); 3.02 (sl, 1H, OH); 3.15-3.29 (multiplet, 4H, BOCNH-CH2-CH-CH2-NHBOC); 3.75 (m, 1H, BOCNH-CH2-CH-CH2-NHBOC); 5.16 (multiplet, 2H, -NHBOC). MS (MALDI-TOF): M+1=291 (M+H+); M+23=313 (M+Na+); M+39=329 (M+K+)

According to the analysis of related databases, 616-29-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Darteil, Raphael; Caumont-Bertrand, Karine; Najib, Jamila; US2006/69156; (2006); A1;,
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Alcohols – Chemistry LibreTexts

Reference of 616-29-5, Adding some certain compound to certain chemical reactions, such as: 616-29-5, name is 1,3-Diaminopropan-2-ol,molecular formula is C3H10N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 616-29-5.

1,3-diaminopropan-2-ol (3 g, 0.033 mol) was dissolved in methanol (300 ml) followed by the addition of triethylamine (33 ml dropwise) and di-tert-butyl dicarbonate [(BOC)2O] (21.793 g, 0.100 mol). The reaction medium was heated at 40-50 C. for 20 min then stirred at room temperature for 1 hour. After evaporation of the solvent, the colorless oil residue was purified by chromatography on silica gel (eluent: dichloromethane/methanol 95:5). The reaction yielded a colorless oil which crystallized slowly. Yield: quantitative Rf (dichloromethane/methanol 95:5): 0.70 IR: nuNH 3368 cm-1; nuCO carbamate 1690 cm-1 MP: 98-100 C. NMR (1H, CDCl3): 1.45 (multiplet, 18H, -CH3- (BOC)); 3.02 (sl, 1H, OH); 3.15-3.29 (multiplet, 4H, BOCNH-CH2-CH-CH2-NHBOC); 3.75 (m, 1H, BOCNH-CH2-CH-CH2-NHBOC); 5.16 (multiplet, 2H, -NHBOC). MS (MALDI-TOF): M+1=291 (M+H+); M+23=313 (M+Na+); M+39=329 (M+K+)

According to the analysis of related databases, 616-29-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Darteil, Raphael; Caumont-Bertrand, Karine; Najib, Jamila; US2006/69156; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 616-29-5, name is 1,3-Diaminopropan-2-ol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

Preparation of (3-tert-Butoxycarbonylamino-2-hydroxy-propyl)-carbamic Acid Tert-Butyl Ester: To a solution of 1,3 diamino-2-hydroxypropane (10 g, 0.11 mol) in methanol (500 ml) was added di-tert-butyl dicarbonate (48 g, 0.22 mumol) and the reaction stirred for 2 hours at room temperature under a N2 atmosphere. The mixture was concentrated to afford the product as a light yellow oil (31.9 g, 100%). 1H-NMR (CD3OD) delta 1.44 (s, 18H), 3.10 (m, 4H), 3.63 (m, 1H).

The synthetic route of 616-29-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.; US2004/19058; (2004); A1;,
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Related Products of 616-29-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, molecular weight is 90.12, as common compound, the synthetic route is as follows.

General procedure: Three di-Schiff base ligands, H2L1, H2L2 and H2L3 weresynthesized in our laboratory by standard methods [10b].Salicylaldehyde (1.05 mL, 10 mM) was mixed with respectivediammines viz. 1,3-diaminopentane (0.596 mL, 5 mM), 1,3-propanediamine (0.42 mL, 5 mM), 1,3-diaminopropan-2-ol(0.295 g, 5 mM) in methanol (20 mL) and the resulting mixtureswere refluxed for ca. 1.5 h and allowed to cool to roomtemperature. The desired yellow crystalline ligands were filteredoff from each solution, washed with methanol, and dried in avacuum desiccator containing anhydrous CaCl2.

Statistics shows that 616-29-5 is playing an increasingly important role. we look forward to future research findings about 1,3-Diaminopropan-2-ol.

Reference:
Article; Seth, Piya; Figuerola, Albert; Jover, Jesus; Ruiz, Eliseo; Ghosh, Ashutosh; Polyhedron; vol. 117; (2016); p. 57 – 63;,
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